Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Infectious Diseases

• Publication date

  2010-09-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1086/655659PMID 20662717PMCID PMC3380613
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chloroquine resistance before and after its withdrawal in Kenya

  2009cited by this paper
• Artemisinin resistance in Plasmodium falciparum malaria.

  2009cited by this paper
• Low level genotypic chloroquine resistance near Malawi’s northern border with Tanzania

  2009cited by this paper
• INAUGURAL ARTICLE by a Recently Elected Academy Member:Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine

  2009cited by this paper
• A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria

  2009cited by this paper
• Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria

  2009influential reference
• Evidence of artemisinin-resistant malaria in western Cambodia.

  2008cited by this paper
• Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi.

  2007cited by this paper
• The Structure of Linkage Disequilibrium Around a Selective Sweep

  2007cited by this paper
• Pharmacologic Advances in the Global Control and Treatment of Malaria: Combination Therapy and Resistance

  2007cited by this paper
• Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum.

  2006cited by this paper
• Invasion of Africa by a single pfcrt allele of South East Asian type

  2006cited by this paper
• Progressive increase in point mutations associated with chloroquine resistance in Plasmodium falciparum isolates from India.

  2006cited by this paper
• Return of chloroquine antimalarial efficacy in Malawi.

  2006cited by this paper
• Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China.

  2005cited by this paper
• Selection strength and hitchhiking around two anti-malarial resistance genes

  2005influential reference
• Reduced variation around drug-resistant dhfr alleles in African Plasmodium falciparum.

  2005cited by this paper
• Linkage Disequilibrium as a Signature of Selective Sweeps

  2004cited by this paper
• Withdrawing antimalarial drugs: impact on parasite resistance and implications for malaria treatment policies.

  2004cited by this paper
• Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum.

  2004cited by this paper
• Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity

  2004cited by this paper
• Antifolate antimalarial resistance in southeast Africa: a population-based analysis.

  2003cited by this paper
• Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi.

  2003influential reference
• Detecting recent positive selection in the human genome from haplotype structure

  2002influential reference
• Detecting a local signature of genetic hitchhiking along a recombining chromosome.

  2002cited by this paper
• A microsatellite-based multilocus screen for the identification of local selective sweeps.

  2002cited by this paper
• Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America.

  2002influential reference
• Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

  2002influential reference
• A molecular marker for chloroquine-resistant falciparum malaria.

  2001cited by this paper
• A molecular marker for chloroquine-resistant falciparum malaria.

  2001cited by this paper
• Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria.

  2000cited by this paper
• Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

  2000cited by this paper
• Genetic hitchhiking.

  2000cited by this paper
• The effect of chloroquine treatment on the infectivity of Plasmodium chabaudi gametocytes.

  1999cited by this paper
• Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro

  1999cited by this paper
• Costs and benefits of resistance against antimalarial drugs.

  1998cited by this paper
• Variations in frequencies of drug resistance in Plasmodium falciparum.

  1997cited by this paper
• Adaptive changes in Plasmodium transmission strategies following chloroquine chemotherapy

  1997cited by this paper
• Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa.

  1993cited by this paper
• The hitch-hiking effect of a favourable gene.

  1974cited by this paper

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  2025cites this paper
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  2025cites this paper
• Stage-Dependent Expression and Vacuolar Localization of lasmodium berghei Chloroquine Resistance Transporter (CRT).

  2025cites this paper
• A Novel Plasmodium falciparum Kelch13 A675T Mutation and High Levels of Chloroquine and Sulfadoxine-Pyrimethamine Resistance in Burundi

  2025cites this paper
• Phenotypic assessment and genetic validation of Plasmodium falciparum molecular markers associated with malaria chemoprevention in Senegal

  2025cites this paper
• Prevalence of Plasmodium falciparum drug resistance markers pfcrt K76T and pfaat1 S258L in southern Rwanda, 2010 to 2023.

  2025cites this paper
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  2024cites this paper
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  2024cites this paper
• Dynamics of Pfcrt K76T and Pfmdr1N86Y fifteen years after the withdrawal of chloroquine in Mali

  2024cites this paper
• Temporal Patterns of Haplotypic and Allelic Diversity Reflect the Changing Selection Landscape of the Malaria Parasite Plasmodium falciparum

  2024cites this paper
• Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time

  2024cites this paper
• Two decades of molecular surveillance in Senegal reveal changes in known drug resistance mutations associated with historical drug use and seasonal malaria chemoprevention

  2023cites this paper
• Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana

  2023cites this paper
• Nanopore sequencing for real-time genomic surveillance of Plasmodium falciparum

  2023influential citation
• Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

  2023cites this paper
• Understanding the Intransigence of Malaria in Malawi

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022influential citation
• High burden of malaria among Malawian adults on antiretroviral therapy after discontinuing prophylaxis

  2022cites this paper
• Genetic Diversity of Plasmodium falciparum and Distribution of Antimalarial Drug Resistance Mutations in Symptomatic and Asymptomatic Infections

  2022cites this paper
• Malaria chemoprevention and drug resistance: a review of the literature and policy implications

  2022cites this paper
• Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Genomic Epidemiology of Antimalarial Drug Resistance in Plasmodium falciparum in Southern China

  2021cites this paper
• Antimalarial drug resistance markers in human immunodeficiency virus (HIV)-positive and HIV-negative adults with asymptomatic malaria infections in Port Harcourt, Nigeria.

  2021cites this paper
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  2021cites this paper
• Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia

  2021cites this paper
• Current and emerging strategies to combat antimalarial resistance

  2021cites this paper
• Antimalarial Drug Resistance and Implications for the WHO Global Technical Strategy

  2021cites this paper
• An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples [version 1; peer review: 2 approved]

  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Persistence of chloroquine resistance alleles in malaria endemic countries: a systematic review of burden and risk factors

  2019cites this paper
• Resistance to Artemisinin Combination Therapies (ACTs): Do Not Forget the Partner Drug!

  2019influential citation
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
• Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine

  2016influential citation
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  2016cites this paper
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  2016cites this paper
• Expert Consultation on Seasonal Malaria Chemoprevention ( SMC ) and next-generation chemoprevention medicines 13 – 14 January 2016

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016influential citation
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015influential citation
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper