Akt mediates self-renewal division of mouse spermatogonial stem cells

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Development

• Publication date

  2007-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.003004PMID 17428826
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells.

  2006cited by this paper
• Identifying genes important for spermatogonial stem cell self-renewal and survival.

  2006cited by this paper
• Long-Term Culture of Mouse Male Germline Stem Cells Under Serum-or Feeder-Free Conditions1

  2005cited by this paper
• RET tyrosine kinase signaling in development and cancer.

  2005cited by this paper
• Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID.

  2005cited by this paper
• Genetic Selection of Mouse Male Germline Stem Cells In Vitro: Offspring from Single Stem Cells1

  2005influential reference
• Genetic and epigenetic properties of mouse male germline stem cells during long-term culture

  2005influential reference
• Self-renewal of teratocarcinoma and embryonic stem cells

  2004cited by this paper
• Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis

  2004cited by this paper
• Essential role of Plzf in maintenance of spermatogonial stem cells

  2004cited by this paper
• Plzf is required in adult male germ cells for stem cell self-renewal

  2004cited by this paper
• Regulation of Embryonic Stem Cell Self-renewal by Phosphoinositide 3-Kinase-dependent Signaling*

  2004cited by this paper
• Generation of pluripotent stem cells from neonatal mouse testis.

  2004influential reference
• Embryonic stem cells

  2004cited by this paper
• The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.

  2003cited by this paper
• Long-Term Proliferation in Culture and Germline Transmission of Mouse Male Germline Stem Cells1

  2003influential reference
• The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands

  2003cited by this paper
• Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

  2003cited by this paper
• Transplantation of testis germinal cells into mouse seminiferous tubules.

  2003influential reference
• Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro.

  2003cited by this paper
• Allogeneic Offspring Produced by Male Germ Line Stem Cell Transplantation into Infertile Mouse Testis1

  2003influential reference
• Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells

  2002cited by this paper
• Signaling through Extracellular Signal-regulated Kinase Is Required for Spermatogonial Proliferative Response to Stem Cell Factor*

  2001cited by this paper
• Involvement of the D-Type Cyclins in Germ Cell Proliferation and Differentiation in the Mouse1

  2000cited by this paper
• Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

  2000cited by this paper
• Stem Cell Factor/c-kit Up-regulates Cyclin D3 and Promotes Cell Cycle Progression via the Phosphoinositide 3-Kinase/p70 S6 Kinase Pathway in Spermatogonia*

  2000cited by this paper
• Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility

  2000cited by this paper
• All you wanted to know about spermatogonia but were afraid to ask.

  2000cited by this paper
• Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

  1999influential reference
• beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells.

  1999cited by this paper
• β1- and α6-integrin are surface markers on mouse spermatogonial stem cells

  1999cited by this paper
• Spermatogonial stem cells.

  1998cited by this paper
• Mouse oocytes injected with testicular spermatozoa or round spermatids can develop into normal offspring.

  1995influential reference
• NCAM mediates adhesion between gonocytes and Sertoli cells in cocultures from testes of neonatal rats.

  1995cited by this paper
• Spermatogenesis following male germ-cell transplantation.

  1994cited by this paper
• Multiple pathways of deletion formation in Escherichia coli.

  1993cited by this paper
• Derivation of Pluripotential Embryonic Stem Cells from Murine Primordial Germ Cells in Culture.

  1993cited by this paper
• A quantitative study of spermatogonial multiplication and stem cell renewal in the C3H/101 F1 hybrid mouse.

  1993influential reference
• A quantitative study of spermatogonial multiplication and stem cell renewal in the C3H/101 F1 hybrid mouse

  1993cited by this paper
• Long-term proliferation of mouse primordial germ cells in culture

  1992cited by this paper
• Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture.

  1992influential reference
• The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene.

  1988cited by this paper

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  2026cites this paper
• The Biology and Regulation of Spermatogonial Stem Cells in the Niche.

  2025cites this paper
• Spermatogonia: a unique stem cell orchestrating species-specific transition from pluripotency to sperm production.

  2025cites this paper
• Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage

  2025cites this paper
• Control of bioenergetic balance in mouse spermatogonial stem cells by alanine metabolism.

  2025cites this paper
• The regulatory repertoire of ZBTB16 in porcine immature spermatogonia.

  2025cites this paper
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  2025cites this paper
• A Review and New Insights Into Spermatogenesis From Single-Cell RNA Sequencing.

  2025cites this paper
• An in vitro three-dimensional (3D) testicular organoid culture system for efficient gonocyte maintenance and propagation using frozen/thawed neonatal bovine testicular tissues

  2024cites this paper
• Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells

  2024cites this paper
• Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis.

  2024cites this paper
• A behind-the-scenes role of BDNF in the survival and differentiation of spermatogonia

  2024cites this paper
• Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system.

  2024cites this paper
• Identification and Manipulation of Spermatogonial Stem Cells with the Aim of Inducing Spermatogenesis in Vitro

  2024cites this paper
• Tissue engineering studies in male infertility disorder

  2023cites this paper
• PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation

  2023cites this paper
• BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate

  2023cites this paper
• Generation of Haploid Spermatids on Silk Fibroin-Alginate-Laminin-Based Porous 3D Scaffolds.

  2023cites this paper
• Signal regulatory protein alpha is a conserved marker for mouse and rat spermatogonial stem cells

  2023cites this paper
• Osteopontin Concentration in Prostates Fractions: A Novel Marker of Sperm Quality in Dogs

  2023cites this paper
• Characteristics of piRNAs and their comparative profiling in testes of sheep with different fertility

  2022cites this paper
• Study on the SHP2-Mediated Mechanism of Promoting Spermatogenesis Induced by Active Compounds of Eucommiae Folium in Mice

  2022cites this paper
• Effects of Pgam1-mediated glycolysis pathway in Sertoli cells on Spermatogonial stem cells based on transcriptomics and energy metabolomics

  2022cites this paper
• Regulation of spermatogonial stem cell self-renewal and proliferation in mammals.

  2022cites this paper
• Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal

  2022cites this paper
• Integrated analysis of miRNA and mRNA expression profiles in testes of Landrace and Hezuo boars

  2022cites this paper
• RNA‐binding protein ELAVL2 plays post‐transcriptional roles in the regulation of spermatogonia proliferation and apoptosis

  2021cites this paper
• AKT3 and related molecules as potential biomarkers responsible for cryptorchidism and cryptorchidism-induced azoospermia

  2021cites this paper
• Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis

  2021cites this paper
• The involvement of bioactive factors in the self-renewal and stemness maintenance of spermatogonial stem cells

  2021cites this paper
• Unique metabolic phenotype and its transition during maturation of juvenile male germ cells

  2021cites this paper
• Testicular Stem Cell Niche

  2021cites this paper
• Phosphatidylinositol 3-Kinase δ-Specific Inhibitor-Induced Changes in the Ovary and Testis in the Sprague Dawley Rat and Cynomolgus Monkey

  2021cites this paper
• NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells

  2021cites this paper
• Actions and Roles of FSH in Germinative Cells

  2021cites this paper
• MKK7-mediated phosphorylation of JNKs regulates the proliferation and apoptosis of human spermatogonial stem cells

  2021cites this paper
• Redox signaling as a modulator of germline stem cell behavior: Implications for regenerative medicine.

  2021cites this paper
• microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials

  2021influential citation
• Metabolic Requirements for Spermatogonial Stem Cell Establishment and Maintenance In Vivo and In Vitro

  2021cites this paper
• Busulfan Suppresses Autophagy in Mouse Spermatogonial Progenitor Cells via mTOR of AKT and p53 Signaling Pathways

  2020cites this paper
• Transcriptome profiling reveals signaling conditions dictating human spermatogonia fate in vitro

  2020cites this paper
• The aging spermatogonial stem cell niche

  2020cites this paper
• Molecular Regulation of Sperm Production Cascade

  2020cites this paper
• Self-renewal and differentiation of spermatogonial stem cells

  2020cites this paper
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  2020cites this paper
• p53 inhibits the proliferation of male germline stem cells from dairy goat cultured on poly-L-lysine.

  2020cites this paper
• Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells

  2020cites this paper
• Three-dimensional co-culture of human spermatogonial stem cells with Sertoli cells in soft agar culture system supplemented by growth factors and Laminin.

  2020cites this paper
• Applications and hazards associated with carbon nanotubes in biomedical sciences

  2020cites this paper
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  2020cites this paper
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  2020influential citation
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  2019cites this paper
• Molecular regulation of spermatogonial stem cell renewal and differentiation.

  2019cites this paper
• In Vitro and In Vivo Culture Systems for Development of Porcine Testis Cells and Tissue

  2019cites this paper
• m6A mRNA modification regulates mammalian spermatogenesis.

  2019cites this paper
• Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis

  2019cites this paper
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  2019cites this paper
• Tumor Suppressor PTEN Regulates Negatively Sertoli Cell Proliferation, Testis Size, and Sperm Production In Vivo.

  2019cites this paper
• Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species.

  2019cites this paper
• Loss of tyrosine kinase receptor Ephb2 impairs proliferation and stem cell activity of spermatogonia in culture†

  2019cites this paper
• Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System

  2019cites this paper
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  2019cites this paper
• Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion

  2019cites this paper
• Regulation of self-renewal activity of spermatogonial stem cells

  2019cites this paper
• Gametogenesis: A journey from inception to conception.

  2019cites this paper
• What has single-cell RNA-seq taught us about mammalian spermatogenesis?

  2019cites this paper
• Differentiation of spermatogonial stem cells by soft agar three-dimensional culture system

  2019cites this paper
• Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling

  2019cites this paper
• GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice†

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• Cep55 overexpression causes male‐specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling

  2018cites this paper
• Spermatogenesis and Its Significance in Reproductive Medicine

  2018cites this paper
• Reelin regulates male mouse reproductive capacity via the sertoli cells

  2018cites this paper
• Noncoding RNAs: Potential players in the self‐renewal of mammalian spermatogonial stem cells

  2018cites this paper
• Regulatable Lentiviral Hematopoietic Stem Cell Gene Therapy in a Mouse Model of Parkinson's Disease

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

  2018cites this paper
• Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis

  2018influential citation
• Culture and transplantation of spermatogonial stem cells.

  2018cites this paper
• VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2

  2018cites this paper
• Genomic and Epigenetic Aspects of Sex Determination in Half-Smooth Tongue Sole

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
• Epigenetic control of the male progenitor germline by the protein phosphatase PP1-NIP

  2017cites this paper
• The crosstalk between long non-coding RNAs and PI3K in cancer

  2017cites this paper
• Male germline stem cells in non-human primates

  2017cites this paper
• Yangjing Capsule extract promotes proliferation of GC-1 spg cells via up-regulated POU3F1 pathway.

  2017cites this paper
• RNA processing in the male germline: Mechanisms and implications for fertility.

  2017cites this paper
• The roles of microRNAs in regulation of mammalian spermatogenesis

  2017cites this paper
• Prenatal bisphenol a exposure leads to reproductive hazards on male offspring via the Akt/mTOR and mitochondrial apoptosis pathways

  2017cites this paper
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  2017cites this paper
• Standardized extract of Bacopa monnieri (CDRI-08): Effect on germ cell dynamics and possible mechanisms of its beneficial action on spermatogenesis and sperm quality in male mice.

  2017cites this paper
• Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway.

  2017cites this paper
• The GDNF Family: A Role in Cancer?

  2017cites this paper
• 13 Spermatogonial Stem Cells and Animal Transgenesis

  2017cites this paper
• Human spermatogonial markers.

  2017cites this paper
• The effect of fluoxetine on spermatogenesis and spermatogonial stem cells self-renewal in adult male rats

  2017cites this paper
• Gonocytes-to-spermatogonia transition initiates prior to birth in murine testes and it requires FGF signaling.

  2017cites this paper