Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

No abstract is available for this paper.

• Publication year

  2005

• Venue

  EMBO Journal

• Publication date

  2005-01-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.emboj.7600535PMID 15635447PMCID PMC545821
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ribbons.

  2019cited by this paper
• Ribbons

  2007cited by this paper
• Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.

  2004cited by this paper
• Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.

  2004influential reference
• IRSp53/Eps8 Complex Is Important for Positive Regulation of Rac and Cancer Cell Motility/Invasiveness

  2004influential reference
• Structural basis for vinculin activation at sites of cell adhesion

  2004cited by this paper
• Vinculin activation by talin through helical bundle conversion

  2004influential reference
• Structure of the actin crosslinking core of fimbrin.

  2004cited by this paper
• BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

  2004influential reference
• Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.

  2004cited by this paper
• A Novel Actin Bundling/Filopodium-forming Domain Conserved in Insulin Receptor Tyrosine Kinase Substrate p53 and Missing in Metastasis Protein*

  2004influential reference
• Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD‐95

  2004influential reference
• Cellular motility driven by assembly and disassembly of actin filaments.

  2003cited by this paper
• IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena

  2003influential reference
• MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.

  2003cited by this paper
• MALS is a binding partner of IRSp53 at cell–cell contacts

  2003influential reference
• Novel Espin Actin-Bundling Proteins Are Localized to Purkinje Cell Dendritic Spines and Bind the Src Homology 3 Adapter Protein Insulin Receptor Substrate p53

  2003influential reference
• The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.

  2002influential reference
• Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility.

  2002cited by this paper
• ARP/wARP's model-building algorithms. I. The main chain.

  2002cited by this paper
• Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle.

  2002cited by this paper
• The lamellipodium: where motility begins.

  2002influential reference
• Automated structure solution, density modification and model building.

  2002influential reference
• WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.

  2002influential reference
• ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53

  2002influential reference
• Crystal structure of the alpha-actinin rod reveals an extensive torsional twist.

  2001cited by this paper
• Use of TLS parameters to model anisotropic displacements in macromolecular refinement.

  2001influential reference
• The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Cdc42hs Facilitates Cytoskeletal Reorganization and Neurite Outgrowth by Localizing the 58-Kd Insulin Receptor Substrate to Filamentous Actin

  2001influential reference
• Crystal Structure of the α-Actinin Rod Reveals an Extensive Torsional Twist

  2001cited by this paper
• Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.

  2001influential reference
• IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

  2000influential reference
• Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.

  2000cited by this paper
• Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins.

  2000cited by this paper
• Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2.

  2000influential reference
• The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges.

  2000cited by this paper
• The design and implementation of SnB version 2.0

  1999cited by this paper
• Crystal structure of the vinculin tail suggests a pathway for activation.

  1999cited by this paper
• Automated MAD and MIR structure solution

  1999influential reference
• Touring protein fold space with Dali/FSSP

  1998cited by this paper
• A Cluster of Basic Repeats in the Dystrophin Rod Domain Binds F-actin through an Electrostatic Interaction*

  1998cited by this paper
• Sedimentation analysis of noninteracting and self-associating solutes using numerical solutions to the Lamm equation.

  1998cited by this paper
• Rho GTPases and the actin cytoskeleton.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

  1997cited by this paper
• The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

  1997cited by this paper
• Crystal structure of a calponin homology domain

  1997cited by this paper
• SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997influential reference
• Cortexillins, major determinants of cell shape and size, are actin-bundling proteins with a parallel coiled-coil tail.

  1996cited by this paper
• Characterization and Cloning of a 58/53-kDa Substrate of the Insulin Receptor Tyrosine Kinase (*)

  1996cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Analytical ultracentrifugation in biochemistry and polymer science

  1992cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• Accurate Bond and Angle Parameters for X-ray Protein Structure Refinement

  1991cited by this paper
• The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.

  1971cited by this paper

• Slik sculpts the plasma membrane into cytonemes to control cell-cell communication

  2025cites this paper
• ARIES domains: functional signaling units of type I interferon responses

  2025cites this paper
• De novo missense variants in BAIAP2 are associated with developmental and epileptic encephalopathies

  2025cites this paper
• Dimerization of the BAR domain–containing protein FAM92A modulates lipid binding and interaction with CBY1

  2025cites this paper
• BAIAP2L2 promotes the malignancy of hepatocellular carcinoma via GABPB1-mediated reactive oxygen species imbalance

  2024cites this paper
• STRIPAK controls cell-cell communication by promoting cytoneme biogenesis through the membrane-sculpting function of Slik

  2024cites this paper
• HIV-1 assembly - when virology meets biophysics.

  2024cites this paper
• Distinct mechanisms regulate ventricular and atrial chamber wall formation

  2024cites this paper
• MTSS1: beyond the integration of actin and membrane dynamics

  2024cites this paper
• A single-particle analysis method for detecting membrane remodelling and curvature sensing

  2024cites this paper
• Nanoscale in silico and in vitro modeling of lipid bilayers for curvature induction and sensing

  2024cites this paper
• Molecular Relay Stations in Membrane Nanotubes: IRSp53 Involved in Actin-Based Force Generation

  2023cites this paper
• MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation

  2023cites this paper
• The Functionality of Membrane-Inserting Proteins and Peptides: Curvature Sensing, Generation, and Pore Formation

  2023cites this paper
• A NanoCurvS platform for quantitative and multiplex analysis of curvature-sensing proteins.

  2023cites this paper
• Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions

  2022cites this paper
• IRSp53 promotes postsynaptic density formation and actin filament bundling

  2022cites this paper
• BAIAP2L2 is activated by NFκB1 and promotes the malignancy of hepatocellular carcinoma by suppressing the ubiquitin-mediated degradation of GABPB1 to activate TRET transcription

  2022cites this paper
• A lysine-rich cluster in the N-BAR domain of ARF GTPase-activating protein ASAP1 is necessary for binding and bundling actin filaments

  2022cites this paper
• Mechanical regulation of synapse formation and plasticity.

  2022cites this paper
• Ena/VASP clustering at microspike tips involves lamellipodin but not I-BAR proteins, and absolutely requires unconventional myosin-X

  2022cites this paper
• Sweat Proteomics in Cystic Fibrosis: Discovering Companion Biomarkers for Precision Medicine and Therapeutic Development

  2022cites this paper
• Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells.

  2021cites this paper
• Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish

  2021cites this paper
• Mechanism of negative membrane curvature generation by I-BAR domains.

  2021cites this paper
• On the Role of Curved Membrane Nanodomains and Passive and Active Skeleton Forces in the Determination of Cell Shape and Membrane Budding

  2021cites this paper
• BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways

  2021cites this paper
• Self-organized cell migration across scales - from single cell movement to tissue formation.

  2021cites this paper
• Mechanism of negative membrane curvature generation by the IRSP53 I-BAR domain

  2020cites this paper
• The actin cytoskeleton orchestra in Entamoeba histolytica

  2020influential citation
• IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.

  2020cites this paper
• Molecular architecture of postsynaptic Interactomes.

  2020cites this paper
• The BAR domain of the Arf GTPase-activating protein ASAP1 directly binds actin filaments

  2020cites this paper
• Membrane-mediated forces can stabilize tubular assemblies of I-Bar proteins

  2020cites this paper
• Curving the cells inside and out: Roles of BAR-domain proteins in intracellular trafficking, shaping organelles, and cancer

  2020cites this paper
• Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin

  2020cites this paper
• MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination

  2020cites this paper
• Light-inducible generation of membrane curvature in live cells with engineered BAR domain proteins

  2020cites this paper
• Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion

  2020cites this paper
• Lipid-composition mediated forces can stabilize tubular assemblies of I-BAR proteins.

  2020cites this paper
• Mechanochemical self-organization determines search pattern in migratory cells

  2019cites this paper
• Mechanochemical self-organization determines search pattern in migratory cells

  2019cites this paper
• Curving Cells Inside and Out: Roles of BAR Domain Proteins in Membrane Shaping and Its Cellular Implications.

  2019cites this paper
• PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli

  2019cites this paper
• Kobe University Repository : Kernel タイトル Tit le Mechanisms of membrane deformat ion by lipid-binding domains 著者

  2019cites this paper
• The plasma membrane as a mechanochemical transducer

  2019cites this paper
• The ArfGAP ASAP1 Controls Actin Stress Fiber Organization via Its N-BAR Domain

  2019cites this paper
• Biological Functions of Novel Mitochondrial Proteins

  2019cites this paper
• IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration

  2019cites this paper
• Quantitative investigation of negative membrane curvature sensing and generation by I-BARs in filopodia of living cells.

  2019cites this paper
• ROLE OF IRSP53 IN EPITHELIAL POLARITY ESTABLISHMENT AND LUMEN MORPHOGENESIS

  2019cites this paper
• Unusual Organization of I-BAR Proteins on Tubular and Vesicular Membranes

  2019cites this paper
• Superresolution microscopy reveals distinct localisation of full length IRSp53 and its I-BAR domain protein within filopodia

  2019cites this paper
• Structure Versus Stochasticity-The Role of Molecular Crowding and Intrinsic Disorder in Membrane Fission.

  2018cites this paper
• Guided by curvature: shaping cells by coupling curved membrane proteins and cytoskeletal forces

  2018cites this paper
• BAR domain proteins—a linkage between cellular membranes, signaling pathways, and the actin cytoskeleton

  2018cites this paper
• Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors.

  2018cites this paper
• Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

  2018cites this paper
• Ivy1 is a negative regulator of Gtr-dependent TORC1 activation

  2018cites this paper
• BAR Domain Proteins Regulate Rho GTPase Signaling.

  2018cites this paper
• Theoretical study of vesicle shapes driven by coupling curved proteins and active cytoskeletal forces.

  2018cites this paper
• Polyphosphoinositide-Binding Domains: Insights from Peripheral Membrane and Lipid-Transfer Proteins.

  2018cites this paper
• IRTKS (BAIAP2L1) Elongates Epithelial Microvilli Using EPS8-Dependent and Independent Mechanisms.

  2018cites this paper
• Missing-in-metastasis B (MIM-B) combined with caveolin-1 promotes metastasis of hepatocellular carcinoma

  2017cites this paper
• Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature

  2017cites this paper
• Deciphering the BAR code of membrane modulators

  2017cites this paper
• IRSp53 accumulates at the postsynaptic density under excitatory conditions

  2017cites this paper
• Raft-dependent endocytic movement and intracellular cluster formation during T cell activation triggered by concanavalin A.

  2017cites this paper
• Bin1 directly remodels actin dynamics through its BAR domain

  2017cites this paper
• I-BAR protein IRSp53 regulates clathrin-independent endocytosis in a biphasic manner.

  2017cites this paper
• Linking up at the BAR: Oligomerization and F-BAR protein function

  2016cites this paper
• Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma

  2016cites this paper
• The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions

  2016cites this paper
• Mechanisms of membrane remodeling by bar proteins

  2016cites this paper
• Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer.

  2016cites this paper
• Closed membrane shapes with attached BAR domains subject to external force of actin filaments.

  2016cites this paper
• Regulation of dynamin-mediated membrane fission by the N-BAR protein endophilin

  2016cites this paper
• The Role of BAR Domain Proteins in the Regulation of Membrane Dynamics

  2016cites this paper
• IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders.

  2016cites this paper
• MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility

  2016cites this paper
• Depletion or over-expression of Sh3px1 results in dramatic changes in cell morphology

  2015cites this paper
• Functional analysis of the insulin receptor substrate protein of 53 kDa (IRSp53) in the brain of Mus musculus (Linnaeus 1758)

  2015influential citation
• Filopodia-based Wnt transport during vertebrate tissue patterning

  2015cites this paper
• Regulation of membrane-shape transitions induced by I-BAR domains.

  2015cites this paper
• PICK1 is implicated in organelle motility in an Arp2/3 complex–independent manner

  2015cites this paper
• Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo

  2015influential citation
• The identification and characterization of bacterial and host epithelial factors involved in the pathogenesis of invasive Francisella tularensis and extracellular enteropathogenic E. coli (EPEC)

  2015cites this paper
• Computational investigations of protein dynamics and its implication in cellular functions: Two cases on membrane sculpting by protein complexes and molecular origin of Parkinson's disease

  2015cites this paper
• IRSp53 senses negative membrane curvature and phase separates along membrane tubules

  2015cites this paper
• SH2B1 orchestrates signaling events to filopodium formation during neurite outgrowth

  2015cites this paper
• A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease*♦

  2014cites this paper
• Dynamin1 Is a Novel Target for IRSp53 Protein and Works with Mammalian Enabled (Mena) Protein and Eps8 to Regulate Filopodial Dynamics*

  2014cites this paper
• WAVE 2 Protein Complex Coupled toMembrane andMicrotubules

  2014cites this paper
• BAR domain proteins regulate Rho GTPase signaling

  2014cites this paper
• Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

  2014cites this paper
• Simiate is an Actin binding protein involved in filopodia dynamics and arborization of neurons

  2014cites this paper
• Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors

  2014cites this paper
• SH2B1 increases the numbers of IRSp53-induced filopodia.

  2014cites this paper
• The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and cytokinesis

  2014cites this paper
• Rôles des phosphoinositides dans l'intéraction membranaire de la protéine Rgd1 et la croissance polarisée des levures : étude structurale et interaction par RMN et cristallographie

  2014cites this paper