Hedgehog controls neural stem cells through p53‐independent regulation of Nanog

No abstract is available for this paper.

• Publication year

  2010

• Venue

  EMBO Journal

• Publication date

  2010-08-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2010.131PMID 20581804PMCID PMC2928686
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hedgehog beyond medulloblastoma and basal cell carcinoma.

  2010influential reference
• Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

  2010cited by this paper
• Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.

  2010cited by this paper
• Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis

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• NANOG is essential in human glioblastoma acting in a cross-functional network with GLI 1 and p 53

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• Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancer

  2010cited by this paper
• Functional Evidence that the Self‐Renewal Gene NANOG Regulates Human Tumor Development

  2009influential reference
• Depletion of embryonic stem cell signature by histone deacetylase inhibitor in NCCIT cells: involvement of Nanog suppression.

  2009cited by this paper
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  2009cited by this paper
• Linking the p53 tumor suppressor pathway to somatic cell reprogramming

  2009cited by this paper
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  2009cited by this paper
• Small but effective moves towards a greener China

  2009cited by this paper
• The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

  2009cited by this paper
• Evidence for cancer stem cells in human endometrial carcinoma.

  2009cited by this paper
• Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

  2009cited by this paper
• Direct cell reprogramming is a stochastic process amenable to acceleration

  2009cited by this paper
• Pluripotent Transcription Factors Possess Distinct Roles in Normal versus Transformed Human Stem Cells

  2009cited by this paper
• The Ink4/Arf locus is a barrier for iPS cell reprogramming

  2009cited by this paper
• A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

  2009influential reference
• Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.

  2008cited by this paper
• Medulloblastoma stem cells.

  2008cited by this paper
• Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

  2008cited by this paper
• Hedgehog signaling in development and cancer.

  2008cited by this paper
• Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.

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• Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

  2008influential reference
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  2007influential reference
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  2007cited by this paper
• Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells

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• Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

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  2006cited by this paper
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• Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.

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• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Developmental cell biology: Regulatory networks in embryo-derived pluripotent stem cells

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  2005influential reference
• Isolation of neural stem cells from the postnatal cerebellum

  2005influential reference
• p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

  2005influential reference
• p53 suppresses the self-renewal of adult neural stem cells

  2005cited by this paper
• GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.

  2004cited by this paper
• Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

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• The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.

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• Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.

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• Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex

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  2003influential reference
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• Molecular Properties of Zic Proteins as Transcriptional Regulators and Their Relationship to GLI Proteins*

  2001cited by this paper
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  2000influential reference
• Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum.

  1999influential reference
• Sonic hedgehog regulates the growth and patterning of the cerebellum.

  1999influential reference
• Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.

  1999cited by this paper
• Altered neural cell fates and medulloblastoma in mouse patched mutants.

  1997cited by this paper
• Tumor spectrum analysis in p53-mutant mice.

  1994cited by this paper
• Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.

  1993cited by this paper

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