Epithelial Sodium Channel: Mendelian Versus Essential Hypertension

No abstract is available for this paper.

• Publication year

  2008

• Venue

  HYPERTENSION

• Publication date

  2008-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/HYPERTENSIONAHA.107.097147PMID 18711011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research

  2009cited by this paper
• Expression, Transcription, and Possible Antagonistic Interaction of the Human Nedd4L Gene Variant: Implications for Essential Hypertension

  2008cited by this paper
• Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research.

  2008cited by this paper
• CHAPTER 32 – Mineralocorticoid Action in the Aldosterone-Sensitive Distal Nephron

  2008cited by this paper
• Early transcriptional control of ENaC (de)ubiquitylation by aldosterone.

  2008cited by this paper
• A not-so-modest proposal that a "modest" increase in aldosterone causes hypertension and more.

  2008cited by this paper
• Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research.

  2008cited by this paper
• Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.

  2008cited by this paper
• Nighttime Blood Pressure and Nocturnal Dipping Are Associated With Daytime Urinary Sodium Excretion in African Subjects

  2008cited by this paper
• Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome

  2008cited by this paper
• Rare independent mutations in renal salt handling genes contribute to blood pressure variation

  2008cited by this paper
• Selective Genotyping Reveals Association Between the Epithelial Sodium Channel γ-Subunit and Systolic Blood Pressure

  2007cited by this paper
• Still building on candidate-gene strategy in hypertension?

  2007cited by this paper
• A polymorphic GT short tandem repeat affecting beta-ENaC mRNA expression is associated with low renin essential hypertension.

  2007cited by this paper
• A genome-wide association study identifies novel risk loci for type 2 diabetes

  2007cited by this paper
• A novel epithelial sodium channel γ‐subunit de novo frameshift mutation leads to Liddle syndrome

  2007cited by this paper
• Polymorphism in NEDD4L Is Associated with Increased Salt Sensitivity, Reduced Levels of P-renin and Increased Levels of Nt-proANP

  2007cited by this paper
• A novel epithelial sodium channel gamma-subunit de novo frameshift mutation leads to Liddle syndrome.

  2007cited by this paper
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

  2007cited by this paper
• Renal sodium handling and nighttime blood pressure.

  2007cited by this paper
• Role of proteolysis in the activation of epithelial sodium channels

  2007cited by this paper
• Association of CYP3A5 genotypes with blood pressure and renal function in African families

  2006cited by this paper
• Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.

  2006cited by this paper
• Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

  2006cited by this paper
• Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm.

  2006cited by this paper
• 24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes.

  2006cited by this paper
• The genetic dissection of essential hypertension

  2006cited by this paper
• Mutation analysis of SCNN1B in a family with Liddle's syndrome

  2006cited by this paper
• The prevalence of a raised aldosterone–renin ratio (ARR) among new referrals to a hypertension clinic

  2006cited by this paper
• Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia

  2006cited by this paper
• Functional polymorphisms in the alpha-subunit of the human epithelial Na+ channel increase activity.

  2006cited by this paper
• Association of pre-eclampsia with the R563Q mutation of the beta-subunit of the epithelial sodium channel.

  2006cited by this paper
• Short communication: Association of pre‐eclampsia with the R563Q mutation of the β‐subunit of the epithelial sodium channel

  2006cited by this paper
• Functional polymorphisms in the α-subunit of the human epithelial Na + channel increase activity

  2006cited by this paper
• Impact of alphaENaC polymorphisms on the risk of ischemic cerebrovascular events: a multicenter case-control study.

  2005cited by this paper
• Central role for ENaC in development of hypertension.

  2005cited by this paper
• Liddle’s Syndrome Caused by a Novel Mutation in the Proline-Rich PY Motif of the Epithelial Sodium Channel β-Subunit

  2005cited by this paper
• Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension.

  2005cited by this paper
• Liddle's syndrome caused by a novel mutation in the proline-rich PY motif of the epithelial sodium channel beta-subunit.

  2005cited by this paper
• Improvement in Blood Pressure With Inhibition of the Epithelial Sodium Channel in Blacks With Hypertension

  2005cited by this paper
• Impact of αENaC Polymorphisms on the Risk of Ischemic Cerebrovascular Events: A Multicenter Case–Control Study

  2005cited by this paper
• Liddle syndrome caused by P616R mutation of the epithelial sodium channel β subunit

  2005cited by this paper
• Minireview: regulation of epithelial Na+ channel trafficking.

  2005cited by this paper
• A novel epithelial sodium channel β-subunit mutation associated with hypertensive Liddle syndrome

  2005cited by this paper
• Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives.

  2004cited by this paper
• Genome-Wide Scan for Blood Pressure Suggests Linkage to Chromosome 11, and Replication of Loci on 16, 17, and 22

  2004cited by this paper
• The epithelial sodium channel: activation by membrane-bound serine proteases.

  2004cited by this paper
• A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes.

  2004cited by this paper
• T594M variant of the epithelial sodium channel beta-subunit gene and hypertension in individuals of African ancestry in South Africa.

  2003cited by this paper
• The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Major outomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic.

  2003cited by this paper
• Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome.

  2003cited by this paper
• Mineralocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome.

  2003cited by this paper
• WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

  2003cited by this paper
• A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension

  2003cited by this paper
• Hyperaldosteronism Among Black and White Subjects With Resistant Hypertension

  2002cited by this paper
• Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors.

  2002cited by this paper
• Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel γ subunit

  2002cited by this paper
• Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.

  2002cited by this paper
• Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

  2002cited by this paper
• Diagnosis of Liddle syndrome by genetic analysis of beta and gamma subunits of epithelial sodium channel--a report of five affected family members.

  2001cited by this paper
• Genome-Wide Linkage Analysis of Pulse Pressure in Mexican Americans

  2001cited by this paper
• Angiotensinogen in essential hypertension: from genetics to nephrology.

  2001cited by this paper
• Mutations in the Na-Cl Cotransporter Reduce Blood Pressure in Humans

  2001cited by this paper
• Molecular genetics of salt-sensitivity and hypertension.

  2001cited by this paper
• Evaluation of selected polymorphisms of the Mendelian hypertensive disease genes in the Japanese population.

  2001cited by this paper
• Molecular Mechanisms of Human Hypertension

  2001cited by this paper
• Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.

  2000cited by this paper
• Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension.

  1999cited by this paper
• Quantitative trait loci for blood pressure exist near the IGF-1, the Liddle syndrome, the angiotensin II-receptor gene and the renin loci in man.

  1999cited by this paper
• Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension.

  1999cited by this paper
• An extreme-sib-pair genome scan for genes regulating blood pressure.

  1999cited by this paper
• On the mechanism of action of aldosterone on sodium transport: the role of protein synthesis. 1963.

  1999cited by this paper
• Molecular basis of human salt sensitivity: the role of the 11beta-hydroxysteroid dehydrogenase type 2.

  1999cited by this paper
• Seven lessons from two candidate genes in human essential hypertension: angiotensinogen and epithelial sodium channel.

  1999cited by this paper
• Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel.

  1999cited by this paper
• Association of the G(s)alpha gene with essential hypertension and response to beta-blockade.

  1999cited by this paper
• Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: the PEGASE study.

  1999cited by this paper
• A mouse model for Liddle's syndrome.

  1999cited by this paper
• Association of the Gsα Gene With Essential Hypertension and Response to β-Blockade

  1999cited by this paper
• G proteins and hypertension: an alternative candidate gene approach.

  1998cited by this paper
• α-Adducin polymorphisms and renal sodium handling in essential hypertensive patients

  1998cited by this paper
• Alpha-adducin polymorphisms and renal sodium handling in essential hypertensive patients.

  1998cited by this paper
• Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London.

  1998cited by this paper
• Association of a human G-protein β3 subunit variant with hypertension

  1998cited by this paper
• Genotype–phenotype analysis of a newly discovered family with Liddle's syndrome

  1997cited by this paper
• Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus.

  1997cited by this paper
• Brief report: Liddle's syndrome revisited--a disorder of sodium reabsorption in the distal tubule.

  1994cited by this paper
• Molecular basis of human hypertension: role of angiotensinogen.

  1992cited by this paper
• Williams Textbook of Endocrinology

  1987cited by this paper
• ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESIS.

  1963cited by this paper
• ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF RNA SYNTHESIS.

  1963cited by this paper
• Supporting Online Material Materials and Methods Figs. S1 to S8 Tables S1 to S10 References a Genome-wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

  year unknowncited by this paper

• Genetics of Hypertension: From Monogenic Analysis to GETomics

  2024cites this paper
• Update in genetic and epigenetic causes of hypertension

  2024cites this paper
• Therapeutic management of congenital forms of endocrine hypertension.

  2023cites this paper
• Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology

  2022cites this paper
• Role of environmental toxicants in the development of hypertensive and cardiovascular diseases

  2022cites this paper
• Factors Associated with Primary Hypertension in Pediatric Patients: An Up-to-Date.

  2021cites this paper
• The importance of the epithelial sodium channel in determining salt sensitivity in people of African origin

  2020cites this paper
• MARCKS-Like Protein-1(MLP-1) regulates ENaC Activity in Renal Distal Convoluted Tubule Cells.

  2020cites this paper
• Hypertension Drug Therapy.

  2020cites this paper
• Coronary Artery Disease: Therapeutics and Drug Discovery

  2020cites this paper
• Metabolic Disorder-Related Hypertension

  2019cites this paper
• Epithelial sodium channel blockade and new β-ENaC polymorphisms among normotensive and hypertensive adult Nigerians

  2019cites this paper
• Medical therapy refractory salt-sensitive hypertension: Liddle’s syndrome

  2019cites this paper
• Overview of Monogenic or Mendelian Forms of Hypertension

  2019cites this paper
• Genetic Programming of Hypertension

  2018cites this paper
• 2018 Genetic Programming of Hypertension

  2018cites this paper
• The Precision of the Rare Diseases

  2018cites this paper
• Detection of Urinary Epithelial Sodium Channel (ENaC) Protein

  2018cites this paper
• Secondary Hypertension: Primary Hyperaldosteronism and Mineralocorticoid Excess States

  2018cites this paper
• Pathophysiological Links Between Diabetes and Blood Pressure.

  2018cites this paper
• Obesity-Associated Hypertension: the Upcoming Phenotype in African-American Women

  2017cites this paper
• Development and Diseases of the Collecting Duct System.

  2017cites this paper
• Screening for Endocrine Hypertension: An Endocrine Society Scientific Statement

  2017cites this paper
• Liddle Syndrome in Association with Aortic Dissection

  2017cites this paper
• Hypertension in blacks: insights from Africa.

  2017cites this paper
• FACULTAD DE MEDICINA UNIVERSIDAD DE CANTABRIA

  2017cites this paper
• Functional and therapeutic importance of purinergic signaling in polycystic kidney disease.

  2016cites this paper
• Salt Sensitivity: Challenging and Controversial Phenotype of Primary Hypertension

  2016cites this paper
• In Liddle Syndrome, Epithelial Sodium Channel Is Hyperactive Mainly in the Early Part of the Aldosterone-Sensitive Distal Nephron

  2016influential citation
• regulation by EGF, insulin, and IGF-1 ROS production as a common mechanism of ENaC

  2016cites this paper
• Epigenetics of epithelial Na(+) channel-dependent sodium uptake and blood pressure regulation.

  2015cites this paper
• Norepinephrine stimulates the epithelial Na+ channel in cortical collecting duct cells via α2-adrenoceptors.

  2015cites this paper
• Triamterene Enhances the Blood Pressure Lowering Effect of Hydrochlorothiazide in Patients with Hypertension

  2015cites this paper
• Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.

  2015cites this paper
• mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.

  2015cites this paper
• Contributor to Systemic Hypertension Renin-Angiotensin System is the Dominant Counterpoint: Activation of the Intrarenal

  2015cites this paper
• Vasopressin regulation of sodium transport in the distal nephron and collecting duct.

  2015cites this paper
• NEDD4-2 and salt-sensitive hypertension

  2015cites this paper
• DEVELOPMENTAL ORIGINS OF RENAL CONNECTING TUBULE AND COLLECTING DUCT: ROLE OF AQP2+ PROGENITOR CELLS

  2015cites this paper
• Regulatory roles of nitric oxide and angiotensin II on renal tubular transport.

  2014cites this paper
• Genomics reveals the pathogenesis of hypertension : preparation for hypertension specialists

  2014cites this paper
• American Society of Hypertension Self-Assessment Guide Preparation for hypertension specialists: Genomics reveals the pathogenesis of hypertension

  2014cites this paper
• Pathophysiology, diagnosis, and treatment of mineralocorticoid disorders.

  2014cites this paper
• Bile acids increase the activity of the epithelial Na+ channel

  2014cites this paper
• Non Genetic Risk Factor and Polymorphism of Aldosterone Synthase T(-344)C Variant CYP11B2 Gene Promoter Region Essential Hypertension Patients at Coastal and Mountainous Areas

  2013cites this paper
• The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea

  2013cites this paper
• Investigation of transmembrane protein fused in lipid bilayer membranes supported on porous silicon

  2013cites this paper
• Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension.

  2013cites this paper
• Epoxyeicosatrienoic Acids (EETs) Regulate Epithelial Sodium Channel Activity by Extracellular Signal-regulated Kinase 1/2 (ERK1/2)-mediated Phosphorylation*

  2013cites this paper
• Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron

  2013cites this paper
• The Cyp2c44 Epoxygenase Regulates Epithelial Sodium Channel Activity and the Blood Pressure Responses to Increased Dietary Salt*

  2013cites this paper
• Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

  2013cites this paper
• Nedd4-2 and the Regulation of Epithelial Sodium Transport

  2012cites this paper
• Circadian clock-deficient mice as a tool for exploring disease etiology.

  2012cites this paper
• Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.

  2012cites this paper
• Role of βPix in the Kidney

  2012cites this paper
• ROS production as a common mechanism of ENaC regulation by EGF, insulin and IGF‐1

  2012cites this paper
• Analyse fonctionnelle de nouvelles mutations pathogènes du canal chlorure CLC-KB impliquées dans le syndrome de Bartter

  2012cites this paper
• Identification of Hypertension Genes Following a Genome-Wide Association Scan

  2012cites this paper
• Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel

  2012cites this paper
• Mechanisms of epithelial sodium channel (ENaC) regulation by cortactin: Involvement of dynamin

  2012cites this paper
• Gasotransmitters: Novel Regulators of Epithelial Na+ Transport?

  2012cites this paper
• An Inhibitory Peptide Derived from the α-subunit of the Epithelial Sodium Channel (ENaC) Shows a Helical Conformation

  2012cites this paper
• [A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors].

  2011cites this paper
• Protein Kinase B Alpha (PKBα) Stimulates the Epithelial Sodium Channel (ENaC) Heterologously Expressed in Xenopus laevis Oocytes by Two Distinct Mechanisms

  2011cites this paper
• Identification de QTL à pression artérielle dans le chromosome 18 du rat et analyse des gènes candidats Adrb2 et Nedd4l associés à l’hypertension essentielle

  2011cites this paper
• Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel (ENaC)

  2011cites this paper
• Hypertension finds a new rhythm

  2010cites this paper
• Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.

  2010cites this paper
• A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition

  2010cites this paper
• EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER‐2) receptor

  2010cites this paper
• The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension.

  2010cites this paper
• Role of the ubiquitin system in regulating ion transport

  2010cites this paper
• The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells

  2010cites this paper
• The renal H,K-ATPases

  2010cites this paper
• The R563Q Mutation of the Beta Subunit of the Epithelial Sodium Channel: Prevalence and Effect

  2009cites this paper
• Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC)

  2009cites this paper
• Salt and its effect on blood pressure and target organ damage: new pieces in an old puzzle.

  2009cites this paper
• Peroxisome Proliferator-Activated Receptor γ Antagonists Decrease Na+ Transport via the Epithelial Na+ Channel

  2009cites this paper
• Fifty years of thiazide diuretic therapy for hypertension.

  2009cites this paper
• Common and rare variants of the renin-angiotensin system and their relation to antihypertensive drug responses

  2009cites this paper