Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature

• Publication date

  2007-06-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature05911PMID 17554300PMCID PMC2719288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Pathophysiology of coronary artery disease].

  2008cited by this paper
• [On bipolar disorder].

  2008cited by this paper
• The genetics of essential hypertension.

  2008cited by this paper
• "Genes"

  2008cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006influential reference
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Genome-wide association studies for common diseases and complex traits

  2005influential reference
• A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study.

  2005cited by this paper
• A haplotype map of the human genome

  2005cited by this paper
• Neurological channelopathies

  2005cited by this paper
• Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.

  2005cited by this paper
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  2005cited by this paper
• Genome-wide strategies for detecting multiple loci that influence complex diseases

  2005cited by this paper
• Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase.

  2005cited by this paper
• Protein tyrosine phosphatases and the immune response

  2005cited by this paper
• The ADAMTS proteases, extracellular matrix, and vascular disease: waking the sleeping giant(s)!

  2005cited by this paper
• Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

  2005cited by this paper
• The genetics of schizophrenia and bipolar disorder: dissecting psychosis

  2005cited by this paper
• How many genes underlie the occurrence of common complex diseases in the population?

  2005cited by this paper
• Dynamic model based algorithms for screening and genotyping over 100K SNPs on oligonucleotide microarrays

  2005cited by this paper
• Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Assessing the probability that a positive report is false: an approach for molecular epidemiology studies.

  2004cited by this paper
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  2004cited by this paper
• The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Genetics of atherosclerosis.

  2004cited by this paper
• Population stratification in the candidate gene study: fatal threat or red herring?

  2004cited by this paper
• Genetics of Hypertension: Lessons Learnt from Mendelian and Polygenic Syndromes

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• The heritability of bipolar affective disorder and the genetic relationship to unipolar depression.

  2003cited by this paper
• A haplotype map of the human genome

  2003cited by this paper
• A haplotype map of the human genome.

  2003cited by this paper
• Human Mitochondrial C1-Tetrahydrofolate Synthase

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

  2003cited by this paper
• Genome-wide mapping of human loci for essential hypertension.

  2003cited by this paper
• Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study.

  2003cited by this paper

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