GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cell

• Publication date

  2006-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CELL.2006.09.048PMID 17129787PMCID PMC2646406
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

  2006cited by this paper
• Genetic regulatory networks programming hematopoietic stem cells and erythroid lineage specification.

  2006cited by this paper
• Hormonal and local control of mammary branching morphogenesis.

  2006cited by this paper
• Candidate regulators of mammary branching morphogenesis identified by genome‐wide transcript analysis

  2006cited by this paper
• The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors

  2006cited by this paper
• Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland

  2006cited by this paper
• Generation of a functional mammary gland from a single stem cell

  2006cited by this paper
• Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos.

  2005cited by this paper
• Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.

  2005cited by this paper
• Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.

  2005cited by this paper
• MET and MYC cooperate in mammary tumorigenesis.

  2005cited by this paper
• Identification of molecular apocrine breast tumours by microarray analysis

  2005cited by this paper
• From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response.

  2005cited by this paper
• Contingent gene regulatory networks and B cell fate specification.

  2005cited by this paper
• Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis.

  2005cited by this paper
• Mutation of GATA3 in human breast tumors

  2004cited by this paper
• Essential role of Gata transcription factors in sympathetic neuron development

  2004cited by this paper
• Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland.

  2004cited by this paper
• GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

  2004cited by this paper
• Stem cells and breast cancer: A field in transit

  2003cited by this paper
• Breast cancer classification and prognosis based on gene expression profiles from a population-based study

  2003cited by this paper
• Spotted long oligonucleotide arrays for human gene expression analysis.

  2003influential reference
• Repeated observation of breast tumor subtypes in independent gene expression data sets

  2003cited by this paper
• Critical roles for transcription factor GATA-3 in thymocyte development.

  2003influential reference
• Stromal Effects on Mammary Gland Development and Breast Cancer

  2002cited by this paper
• GATA6 regulates differentiation of distal lung epithelium.

  2002cited by this paper
• Gene expression profiling predicts clinical outcome of breast cancer

  2002cited by this paper
• T helper cell differentiation: on again, off again.

  2002cited by this paper
• The GATA family (vertebrates and invertebrates).

  2002cited by this paper
• Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium.

  2002cited by this paper
• A Genomic Regulatory Network for Development

  2002cited by this paper
• Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.

  2002cited by this paper
• Associations between gene expressions in breast cancer and patient survival

  2002cited by this paper
• Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice

  2001cited by this paper
• Hematopoietic development: a balancing act.

  2001cited by this paper
• Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns.

  2001cited by this paper
• Anoikis mechanisms.

  2001cited by this paper
• Predicting the clinical status of human breast cancer by using gene expression profiles

  2001cited by this paper
• Molecular portraits of human breast tumours

  2000cited by this paper
• Gene expression profiling of primary breast carcinomas using arrays of candidate genes.

  2000cited by this paper
• Temporal, spatial, and cell type–specific control of Cre-mediated DNA recombination in transgenic mice

  1999cited by this paper
• GATA‐3 is expressed in association with estrogen receptor in breast cancer

  1999cited by this paper
• Generating green fluorescent mice by germline transmission of green fluorescent ES cells.

  1998cited by this paper
• Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli.

  1996cited by this paper
• Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

  1995cited by this paper

• FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.

  2026cites this paper
• GATA-3 localization shapes lymphocyte function.

  2026cites this paper
• Roles of Post-Translational Modifications of Transcription Factors Involved in Breast Cancer Hypoxia

  2025cites this paper
• ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

  2025cites this paper
• Top-k Feature Importance Ranking

  2025cites this paper
• Classification of Breast Cancer Through the Perspective of Cell Identity Models.

  2025cites this paper
• METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation

  2025cites this paper
• GATA3 promotes ferroptosis resistance by repressing integrin β1 signaling.

  2025cites this paper
• Mycn Is Essential for Pubertal Mammary Gland Development and Promotes the Activation of Bcl11b-Maintained Quiescent Stem Cells

  2025cites this paper
• Non-Coding RNA-GATA Axis: Mechanisms and Implications in Cancer Progression and Metastases

  2025cites this paper
• Adipo-epithelial transdifferentiation: old data and new perspectives.

  2025cites this paper
• Integrating multimodal cancer data using deep latent variable path modelling

  2025cites this paper
• Tauroursodeoxycholic Acid Induces Liver Regeneration and Alleviates Fibrosis Through GATA3 Activation

  2025cites this paper
• Epigenetic Therapy in Hormone Positive Breast Cancer: The Role of PIK3CA

  2025cites this paper
• A Genomic Alteration in GATA3 Affects Treatment Responses with a CDK4/6 Inhibitor Collaborating with p18INK4C Expression in Advanced Breast Carcinoma

  2025cites this paper
• Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.

  2025cites this paper
• SOX9, GATA3, and GATA4 Overexpression in Liposarcomas: Insights into the Molecular Biology of Adipocytic Sarcomas

  2025cites this paper
• Pioneering new enhancers by GATA3: role of facilitating transcription factors and chromatin remodeling.

  2025cites this paper
• Genomic and proteomic profiling of GATA3 mutant metastatic hormone receptor-positive breast cancer and impact on clinical outcomes

  2025cites this paper
• Discovery of epigenetically silenced tumour suppressor genes in aggressive breast cancer through a computational approach

  2025cites this paper
• Epigenetic Subtypes of High-Grade T1 Bladder Cancer Reveal Intra-Tumor Heterogeneity and Distinct Interactions with Tumor Microenvironment

  2025cites this paper
• GATA3 and E2F6 negatively regulate WDR77 expression to inhibit prostate cancer cell growth

  2025cites this paper
• Mechanisms of Regulation of Cell Fate in Breast Development and Cancer.

  2025cites this paper
• GATA3 and TGF-β in normal placenta and pre-eclampsia.

  2024cites this paper
• The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer

  2024cites this paper
• Immunohistochemical marker profiles for the differentiation of collagenous spherulosis from adenoid cystic carcinoma of the breast.

  2024cites this paper
• GATA3: Orchestrating cellular fate through differentiation and proliferation.

  2024cites this paper
• Codonopsis lanceolata polysaccharide ameliorates high-fat diet induced-postpartum hypogalactia via stimulating prolactin receptor-mediated Jak2/Stat5 signaling.

  2024cites this paper
• Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer.

  2024cites this paper
• A Comparative Evaluation of TRPS1 and GATA3 in adenoid cystic, secretory, and acinic cell carcinomas of the breast and salivary gland.

  2024cites this paper
• Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic Potential

  2024cites this paper
• GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer

  2024cites this paper
• Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications

  2024cites this paper
• TRPS1 is a useful marker in differentiating metastatic breast carcinoma from pancreatic adenocarcinoma in fine-needle aspiration specimens.

  2024cites this paper
• Deregulation of miR‐1245b‐5p and miR‐92a‐3p and their potential target gene, GATA3, in epithelial–mesenchymal transition pathway in breast cancer

  2024cites this paper
• A metabolic-epigenetic mechanism directs cell fate and therapeutic sensitivity in breast cancer.

  2024cites this paper
• Altered Mammary Gland Development and Pro-Tumorigenic Changes in Young Female Mice Following Prenatal BPAF Exposure.

  2024cites this paper
• Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

  2024cites this paper
• AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution

  2024cites this paper
• Progesterone receptor is constitutively expressed in induced Pluripotent Stem Cells (iPSCs)

  2024cites this paper
• GATA3 and markers of epithelial-mesenchymal transition predict long-term benefit from tamoxifen in ER-positive breast cancer

  2024cites this paper
• Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

  2024cites this paper
• The role of Pm-miR-184-3p in regulating the immune response in the pearl oyster Pinctada fucata martensii.

  2024cites this paper
• Mammary Alveolar Proliferation and Differentiation During Early Pregnancy is Regulated by E2F5

  2024cites this paper
• Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.

  2024cites this paper
• Adipo-Epithelial Transdifferentiation in In Vitro Models of the Mammary Gland

  2024cites this paper
• Bioinformatic and experimental analyses of GATA3 and its regulatory miRNAs in breast Cancer

  2024cites this paper
• TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis.

  2023cites this paper
• METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3

  2023cites this paper
• ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

  2023cites this paper
• Genetic marker identification of SEC13 gene for milk production traits in Chinese holstein

  2023cites this paper
• Predicting transcription factor activity using prior biological information

  2023cites this paper
• TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity

  2023cites this paper
• Gene of the month: GATA3

  2023cites this paper
• Characterization of Cancer Evolution Landscape Based on Accurate Detection of Somatic Mutations in Single Tumor Cells

  2023cites this paper
• Proposing a novel molecular subtyping scheme for predicting distant recurrence-free survival in breast cancer post-neoadjuvant chemotherapy with close correlation to metabolism and senescence

  2023cites this paper
• Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

  2023cites this paper
• A comprehensive analysis of GATA3 expression in carcinomas of various origins with emphasis on lung carcinomas.

  2023cites this paper
• A Narrative Review of Breastfeeding and Its Correlation With Breast Cancer: Current Understanding and Outcomes

  2023cites this paper
• Role of GATA3 in Early-Stage Urothelial Bladder Carcinoma Local Recurrence

  2023cites this paper
• Case Report: Systemic treatment for breast and vulvar metastases from resected rectal signet ring cell carcinoma

  2023cites this paper
• ESR1 fusions and therapeutic resistance in metastatic breast cancer

  2023cites this paper
• Cell type and stage specific transcriptional, chromatin and cell-cell communication landscapes in the mammary gland

  2023cites this paper
• Characterization of GATA3 and Mammaglobin in breast tumors from African American women

  2023cites this paper
• Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis

  2023cites this paper
• Immunohistochemistry in the Diagnosis and Classification of Breast Tumors.

  2023cites this paper
• The urothelial gene regulatory network: understanding biology to improve bladder cancer management

  2023cites this paper
• Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis

  2023cites this paper
• Cancer invasion and metastasis: Insights from murine pubertal mammary gland morphogenesis.

  2023cites this paper
• GATA-3 expression in breast cancer is related to intratumoral M2 macrophage infiltration and tumor differentiation

  2023cites this paper
• P4HTM: A Novel Downstream Target of GATA3 in Breast Cancer

  2023cites this paper
• A genome-wide CRISPR screen maps endogenous regulators of PPARG gene expression in bladder cancer

  2023cites this paper
• ZNF503 combined with GATA3 is a prognostic factor in triple-negative breast cancer

  2023cites this paper
• Structure learning of exponential family graphical model with false discovery rate control

  2023cites this paper
• Arsenic reduces the GATA3 expression associated with an increase in proliferation and migration of mammary epithelial cell line MCF-10A.

  2023cites this paper
• Two Faces of Glutaminase GLS2 in Carcinogenesis

  2023cites this paper
• Breast Metastasis Arising from Ileal Neuroendocrine Tumor: an Unusual Presentation

  2023cites this paper
• Disruption of lineage integrity as a precursor to breast tumor initiation.

  2023cites this paper
• CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer

  2023cites this paper
• An Atypical Rash on the Chest.

  2022cites this paper
• Loss of function of GATA3 induces basal-like mammary tumors

  2022cites this paper
• Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin

  2022cites this paper
• A Missing Hallmark of Cancer: Dysregulation of Differentiation

  2022cites this paper
• Comparison of the expression of GATA-3 protein from the transcription factor family and pathological prognostic parameters in invasive ductal carcinomas of the breast

  2022cites this paper
• Genomic disparities between cancers in adolescent and young adults and in older adults

  2022cites this paper
• Parabolic relationship between SMAD3 expression level and the reprogramming efficiency of goat induced mammary epithelial cells

  2022cites this paper
• Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

  2022cites this paper
• FOXA1 in Breast Cancer: A Luminal Marker with Promising Prognostic and Predictive Impact

  2022cites this paper
• Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

  2022cites this paper
• Molecular-Genetic Bases of Mammary Gland Development Using the Example of Cattle and Other Animal Species: I. Embryonic and Pubertal Developmental Stage

  2022cites this paper
• Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.

  2022cites this paper
• FOXA1 in prostate cancer

  2022cites this paper
• The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection

  2022cites this paper
• Association Between GATA3 and Histopathological and Immunohistochemical Parameters in Early-Infiltrating Breast Carcinomas.

  2022cites this paper
• Upregulated GATA3/miR205-5p Axis Inhibits MFNG Transcription and Reduces the Malignancy of Triple-Negative Breast Cancer

  2022cites this paper
• Knockdown of FOXA1 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the ERK1/2 signalling pathway

  2022cites this paper
• Identification of conserved gene expression features between Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors murine mammary carcinoma models and human breast tumors you.

  2022cites this paper
• Diagnostic utility of PELP1 and GATA3 in primary and metastatic triple negative breast cancer

  2022cites this paper
• GATA3 Truncation Mutants Alter EMT Related Gene Expression via Partial Motif Recognition in Luminal Breast Cancer Cells

  2022cites this paper
• GATA3 Inhibits Viral Infection by Promoting MicroRNA-155 Expression

  2022cites this paper