We present a novel method for the geometric alignment of autoradiographs of the brain. The method is based on finding the spatial mapping and the one-to-one correspondences (or homologies) between point features extracted from the images and rejecting non-homologies as outliers. In this way, we attempt to account for the local, natural and artifactual differences between the autoradiograph slices. We have used the resulting automated algorithm on a set of left prefrontal cortex autoradiograph slices, specifically demonstrated its ability to perform point outlier rejection, validated its robustness property using synthetically generated spatial mappings and provided an anecdotal visual comparison with the well-known iterated closest-point (ICP) algorithm. Visualization of a stack of aligned left prefrontal cortex autoradiograph slices is also provided.
A robust point-matching algorithm for autoradiograph alignment
Anand Rangarajan,E. Mjolsness,S. Pappu,L. Davachi,P. Goldman-Rakic,J. Duncan
Published 1997 in Medical Image Anal.
ABSTRACT
PUBLICATION RECORD
- Publication year
1997
- Venue
Medical Image Anal.
- Publication date
1997-09-01
- Fields of study
Mathematics, Computer Science, Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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