TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM

Serum globulin from donor sheep made nephritic by immunization with glomerular basement membrane and subsequently nephrectomized contained specific kidney-fixing antibody and was capable of inducing an immediate, although transient, glomerulonephritis when injected into unilaterally nephrectomized lambs. This nephritis was characterized by immediate proteinuria, PMN infiltration into the glomerulus, and localization of γG- and β1C-globulins in a linear fashion along the recipients' glomerular capillary walls. The nephritogenic property of the serum could be absorbed in vitro with isolated sheep glomerular basement membranes.

• Publication year

  1966

• Venue

  Journal of Experimental Medicine

• Publication date

  1966-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1084/JEM.124.3.431PMID 5922743PMCID 2138241
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spontaneous glomerulonephritis in sheep.

  1966cited by this paper
• A method of trace iodination of proteins for immunologic studies.

  1966cited by this paper
• Passive transfer of "allergic" encephalomyelitis with antibrain serum injected into the lateral ventricle of the brain.

  1965cited by this paper
• Passive Transfer of ‘Allergic’ Encephalomyelitis with Antibrain Serum injected into the Lateral Ventricle of the Brain

  1965cited by this paper
• Autoantibodies Resulting from Immunization with Kidney.∗

  1964cited by this paper
• EXPERIMENTAL GLOMERULONEPHRITIS

  1963cited by this paper
• AUTO-IMMUNIZATION AND THE LESIONS OF AUTO-IMMUNITY

  1962cited by this paper
• GLOMERULONEPHRITIS INDUCED IN SHEEP BY INJECTIONS OF HETEROLOGOUS GLOMERULAR BASEMENT MEMBRANE AND FREUND'S COMPLETE ADJUVANT

  1962cited by this paper
• Transfer of Experimental Auto-Immune Nephrosis in Rats.∗

  1962cited by this paper
• TRANSFER OF ALLERGIC ENCEPHALOMYELITIS IN RATS BY MEANS OF LYMPH NODE CELLS

  1960cited by this paper
• Production of Nephrotic Syndrome in Rats by Freund's Adjuvants and Rat Kidney Suspensions.∗

  1959cited by this paper
• A study of experimental encephalomyelitis employing mammalian and nonmammalian nervous tissues.

  1957cited by this paper
• Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts.

  1956cited by this paper
• The transfer of experimental allergic encephalomyelitis in the rat by means of parabiosis.

  1953cited by this paper
• ASPERMATOGENESIS IN THE GUINEA PIG INDUCED BY TESTICULAR TISSUE AND ADJUVANTS

  1953cited by this paper
• Experimental studies on sympathetic ophthalmia.

  1949cited by this paper
• Studies on the pathogenesis of rheumatic fever. I: Experimental production of autoantibodies to heart, skeletal muscle and connective tissue

  1948cited by this paper
• Studies on the pathogenesis of rheumatic fever; experimental production of autoantibodies to heart, skeletal muscle and connective tissue.

  1947cited by this paper

• Immune Mechanisms in Renal Disease

  2012cites this paper
• Starting in immunology by way of immunopathology.

  2011cites this paper
• What's in a name? Experimental encephalomyelitis: 'allergic' or 'autoimmune'.

  2010cites this paper
• Organ-specific inhibition of the in vitro migration of leucocytes in human glomerulonephritis.

  2009cites this paper
• AUTOIMMUNE PROLIUFERATIVE GLOMERULONEPHRITS IN MONKEYS

  2007cites this paper
• MEDICAL STAFF CONFERENCE Immunological Mechanisms of ri tis

  2006cites this paper
• Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis.

  2005cites this paper
• Glomerular antigens in glomerulonephritis

  2005cites this paper
• Inhibiting effect of foetal renal antigen on leukocyte migration in human glomerulonephritis

  2005cites this paper
• About the mechanisms of renoprotective effect of angiotensin inhibitors on lupus nephritis.

  2004cites this paper
• Anti-GBM glomerulonephritis: a T cell-mediated autoimmune disease?

  2004influential citation
• Membrane Antigens Antibodies to Diverse Glomerular Basement Response: Mechanism for Production of A Self T Cell Epitope Induces Autoantibody

  2004cites this paper
• The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family.

  2004cites this paper
• A Self T Cell Epitope Induces Autoantibody Response: Mechanism for Production of Antibodies to Diverse Glomerular Basement Membrane Antigens1

  2004cites this paper
• Antigens of the human glomerular basement membrane

  2004cites this paper
• Anti-glomerular basement membrane disease.

  2003cites this paper
• Point Mutations of Single Amino Acids Abolish Ability of α3 NC1 Domain to Elicit Experimental Autoimmune Glomerulonephritis in Rats*

  2003cites this paper
• Synthetic peptides of Goodpasture's antigen in antiglomerular basement membrane nephritis in rats.

  2002cites this paper
• The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis.

  1999cites this paper
• Induction of anti-GBM nephritis in rats by recombinant alpha 3(IV)NC1 and alpha 4(IV)NC1 of type IV collagen.

  1998cites this paper
• Induction of anti-GBM nephritis in rats by recombinant α3(IV)NC1 and α4(IV)NC1 of type IV collagen

  1998cites this paper
• Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice.

  1997cites this paper
• Goodpasture syndrome: selective removal of anti-alpha 3 (IV) collagen autoantibodies. A potential therapeutic alternative to plasmapheresis.

  1996cites this paper
• The alpha 3 chain of type IV collagen induces autoimmune Goodpasture syndrome.

  1994cites this paper
• Proliferative autoimmune glomerulonephritis in rats: a model for autoimmune glomerulonephritis in humans.

  1993cites this paper
• Pathology Reviews • 1990

  1990influential citation
• Pathogenesis of an experimental model of Goodpasture's haemorrhagic pneumonitis.

  1990cites this paper
• Pathogenesis of an experimental model of Goodpasture's hemorrhagic pneumonitis.

  1990cites this paper
• Non-systemic glomerulonephritis: exposure to nephro- and immunotoxic chemicals predispose to immunologic harassment.

  1989cites this paper
• Goodpasture syndrome: molecular architecture and function of basement membrane antigen.

  1989cites this paper
• Pathogenesis of anti-basement membrane glomerulopathy and immune-complex glomerulonephritis: dichotomy dissolved.

  1989cites this paper
• Biochemical and Immunological Characterization of Basement Membranes in Renal Disease

  1987cites this paper
• Glomerulonephritis induced in sheep by immunization with human glomerular basement membrane.

  1987cites this paper
• The Nephritogenic Immune Response and Renal Immunopathogenesis

  1986cites this paper
• Chronic Renal Disease

  1985cites this paper
• The Role of Fixed (Native) and Planted Antigens in Glomerular Disease

  1985cites this paper
• Role of prostaglandins and angiotensin II in experimental glomerulonephritis.

  1985cites this paper
• CHAPTER 13 – Autoimmune Kidney Diseases

  1985cites this paper
• Extracellular fluid expansion and autoregulation in nephrotoxic serum nephritis in rats.

  1984cites this paper
• Glomerulonephritis with coexistent immune deposits and antibasement membrane activity.

  1984cites this paper
• New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens.

  1984cites this paper
• Immunological Responses to Myelin and Myelin Components

  1984cites this paper
• Mesangial immune deposits induced in rats by antibodies to fibronectin.

  1984cites this paper
• Antitubular Basement Membrane Autoantibody in a Dog with Chronic Tubulointerstitial Nephritis

  1984cites this paper
• Experimental autoimmune glomerulonephritis induced by anti-glomerular basement membrane antibody. II. Effects of injecting heterologous, homologous, or autologous glomerular basement membranes and complete Freund's adjuvant into sheep.

  1983cites this paper
• Pathology and Pathophysiology of Proteinuric Glomerular Disease

  1983cites this paper
• Nephritogenic Immune Responses Involving Basement Membrane and Other Antigens in or of the Glomerulus

  1983cites this paper
• Experimental allergic neuritis: Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein

  1983cites this paper
• Experimental autoimmune antiglomerular basement membrane antibody-induced glomerulonephritis. I. The effects of injecting sheep with human, homologous or autologous lung basement membranes and complete Freund's adjuvant.

  1983cites this paper
• Experimental allergic neuritis. Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein.

  1983cites this paper
• The basement membrane in pathology.

  1983cites this paper
• Transfer of Lesions of Allergic Encephalomyelitis in Sheep with Cell‐Free Lymph from Animals Sensitized with Homologous Spinal Cord plus Adjuvant

  1982cites this paper
• Immunologic similarities between Goodpasture's and Steblay's antibodies.

  1982cites this paper
• Pulmonary renal syndromes. II. Etiology and pathogenesis.

  1982cites this paper
• Nephritogenic Antibody Mechanisms Involving Antigens within the Glomerulus

  1981cites this paper
• Immunologically Mediated Renal Disease

  1981cites this paper
• Anti-basement membrane antibodies in immunologic renal disease.

  1981cites this paper
• Specificities of antibodies eluted from human cadaveric renal allografts. Multiple mechanisms of renal allograft injury.

  1981cites this paper
• Drug-Associated Nephropathy

  1980cites this paper
• Spontaneous and induced autoantibodies to renal and nonrenal basement membranes in mice.

  1980cites this paper
• Antiglomerular Basement Membrane Antibody‐Mediated Glomerulonephritis and Goodpasture's Syndrome

  1979cites this paper
• Glomerulonephritis: Pathogenesis and Classification

  1979cites this paper
• Animal model of human disease: anti-glomerular-basement-membrane glomerulonephritis.

  1979cites this paper
• Spatial orientation and distribution of antigens within human glomerular basement membrane.

  1979cites this paper
• Reactivity of Antibodies Versus Streptococcal Carbohydrate and Protein Antigens and Human Glomerular Basement Membrane Carbohydrate and Protein Antigens in Mammalian Tissues

  1978cites this paper
• Exfoliation of endothelial cytoplasms in nephrotoxic serum nephritis. A study using antiserum against water-soluble glycoprotein isolated from the glomerular basement membrane.

  1978cites this paper
• Requirement of functional T-cells in the production of autoimmune glomerulotubular nephropathy in mice.

  1978cites this paper
• Estimation of relative glomerular capillary surface area in normal and hypertrophic rat kidneys.

  1978cites this paper
• Studies on acid eluates from kidneys of sheep with glomerulonephritis mediated by antibody to glomerular basement membrane.

  1977cites this paper
• Allergic Renal Diseases

  1976cites this paper
• Cellular and histopathologic consequences of immunologically induced experimental glomerulonephritis.

  1976cites this paper
• Guinea-pig nephrotoxic nephritis. I. The role of complement and polymorphonuclear leucocytes and the effect of antibody subclass and fragments in the heterologous phase.

  1975cites this paper
• Immunopathologic mechanisms of renal disease

  1975cites this paper
• Experimental allergic encephalitis: study of cellular immunity to the encephalitogenic determinant.

  1975cites this paper
• Determinants of glomerular filtration in experimental glomerulonephritis in the rat.

  1975cites this paper
• Immunopathology of glomerulonephritis.

  1974cites this paper
• Nephrotoxic canine glomerulonephritis.

  1974cites this paper
• Immunopathology and glomerulonephritis.

  1974cites this paper
• Glomerulonephritis (first of three parts).

  1974cites this paper
• Mesangiocapillary glomerulonephritis in lambs. I. Clinical and biochemical findings in a Finnish Landrace Flock.

  1974cites this paper
• Association of autoimmunity, immunodeficiency and aging in man, rabbits, and mice.

  1974cites this paper
• Evidence suggesting persistence of nephritogenic immunopathologic mechanisms in patients receiving renal allografts.

  1973cites this paper
• Transfer of Experimental Autoimmune Renal Cortical Tubular and Interstitial Disease in Guinea Pigs by Serum

  1973cites this paper
• Anti-glomerular basement membrane antibody-induced glomerulonephritis.

  1973cites this paper
• Cell-mediated immunity in nephrotic syndrome.

  1972cites this paper
• Immunoreproduction: concepts of immunology.

  1972cites this paper
• Self-reactive antisera in the rat in response to allografted tissues.

  1972cites this paper
• Induction of a progressive nephropathy in rats by injections of human lung extract in Freund's complete adjuvant

  1972cites this paper
• Immunological mechanisms of glomerulonephritis.

  1972cites this paper
• The detection of autoantibody-forming cells. II. Cells in lymph nodes and central nervous system containing antibody to myelin basic protein.

  1972cites this paper
• Presidential address. Pathogenesis of immunologic disease.

  1972cites this paper
• MODELS OF IMMUNOLOGIC DISEASES

  1972cites this paper
• Nephritogenic glycoprotein. II. Experimental production of membranous glomerulonephritis in rats by a single injection of homologous renal glycopeptide.

  1972cites this paper
• The detection of autoantibody-forming cells. I. An assay for plaque-forming cells to the basic protein of myelin in guinea-pigs.

  1972cites this paper
• Isolated glomerular basement membrane as antigen in indirect immunofluorescent test for identification of circulating rabbit anti-rat glomerular-basement membrane antibodies.

  1971cites this paper
• An immunopathologic study of rapidly progressive glomerulonephritis in the adult.

  1971cites this paper
• Antigens and the leukocyte migration test in renal transplantation.

  1971cites this paper
• Nephritogenic glycoprotein. I. Proliferative glomerulonephritis induced in rats by a single injection of the soluble glycoprotein isolated from homologous glomerular basement membrane.

  1971cites this paper
• EXPERIMENTAL GLOMERULONEPHRITIS INTHE MOUSE

  1971cites this paper
• Experimental glomerulonephritis in the mouse. I. The model.

  1971cites this paper