The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Pharmacological Research

• Publication date

  2015-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.phrs.2015.04.006PMID 26003288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy

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• The role for autophagy in cancer.

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• Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.

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• GSK-3 as potential target for therapeutic intervention in cancer

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• Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis

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• Autophagy suppresses melanoma tumorigenesis by inducing senescence

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• RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.

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• Mitotic wnt signaling promotes protein stabilization and regulates cell size.

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• Lysosomal adaptation: how the lysosome responds to external cues.

  2014cited by this paper
• Complex regulation of autophagy in cancer - integrated approaches to discover the networks that hold a double-edged sword.

  2013cited by this paper
• Signals from the lysosome: a control centre for cellular clearance and energy metabolism

  2013influential reference
• Cancer-associated lysosomal changes: friends or foes?

  2013cited by this paper
• TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

  2013cited by this paper
• Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

  2013cited by this paper
• Lessons from the cancer genome.

  2013cited by this paper
• Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

  2013influential reference
• Wnt signaling in vertebrate axis specification.

  2013cited by this paper
• Down-Regulation of Autophagy-Related Protein 5 (ATG5) Contributes to the Pathogenesis of Early-Stage Cutaneous Melanoma

  2013cited by this paper
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  2013cited by this paper
• Directed phenotype switching as an effective antimelanoma strategy.

  2013cited by this paper
• Why is autophagy important for melanoma? Molecular mechanisms and therapeutic implications.

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• Wnt / b-Catenin Signaling and AXIN 1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV 600 E in Human Melanoma

  2012cited by this paper
• WNT signalling pathways as therapeutic targets in cancer

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• Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.

  2012cited by this paper
• A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

  2012cited by this paper
• Wnt/β-catenin signaling and disease.

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• The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

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• From genes to drugs: targeted strategies for melanoma

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• Role of autophagy in cancer

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• Deconvoluting the context-dependent role for autophagy in cancer

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• Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF.

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• Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma

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• Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

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• Advances in melanoma senescence and potential clinical application

  2011cited by this paper
• Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

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• A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

  2011cited by this paper
• Autophagy: Renovation of Cells and Tissues

  2011cited by this paper
• Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer.

  2011influential reference
• Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

  2011cited by this paper
• A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

  2011cited by this paper
• Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.

  2010cited by this paper
• Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization

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• Identification of targets of the Wnt pathway destruction complex in addition to β-catenin

  2009cited by this paper
• A Gene Network Regulating Lysosomal Biogenesis and Function

  2009cited by this paper
• An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta.

  2009cited by this paper
• Proteomics of the lysosome.

  2009cited by this paper
• Cell cycle control of wnt receptor activation.

  2009cited by this paper
• Lysosomal enhancement: A CLEAR answer to cellular degradative needs

  2009cited by this paper
• Rab7: roles in membrane trafficking and disease.

  2009cited by this paper
• Novel MITF targets identified using a two‐step DNA microarray strategy

  2008cited by this paper
• In vivo switching of human melanoma cells between proliferative and invasive states.

  2008cited by this paper
• Melanosomes — dark organelles enlighten endosomal membrane transport

  2007cited by this paper
• Autophagy: process and function.

  2007cited by this paper
• The Expression of Clcn7 and Ostm1 in Osteoclasts Is Coregulated by Microphthalmia Transcription Factor*

  2007cited by this paper
• Role of autophagy in cancer

  2007cited by this paper
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  2007cited by this paper
• Pediatric renal cell carcinoma: clinical, pathologic, and molecular abnormalities associated with the members of the mit transcription factor family.

  2006cited by this paper
• Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors.

  2006cited by this paper
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  2006cited by this paper
• Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.

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• Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.

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• From melanocytes to melanoma: The progression to malignancy

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• Neue Mutationen und Koppelungsgruppen bei der Hausmaus

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• Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

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• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• From Melanocytes to Melanoma : The Progression to Malignancy

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• Melanocytes and the microphthalmia transcription factor network.

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• The Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Mitf Is Conserved in Drosophila and Functions in Eye Development

  2004cited by this paper
• Autophagy: in sickness and in health.

  2004cited by this paper
• Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

  2003cited by this paper
• Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution.

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• Cytogenetic and morphologic typing of 58 papillary renal cell carcinomas: evidence for a cytogenetic evolution of type 2 from type 1 tumors.

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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Targeting the Microphthalmia Basic Helix-Loop-Helix–Leucine Zipper Transcription Factor to a Subset of E-Box Elements In Vitro and In Vivo

  1998cited by this paper
• Waardenburg syndrome.

  1997cited by this paper
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  1997cited by this paper
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  1994cited by this paper

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