PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy homeostasis, inflammation, as well as cell proliferation and differentiation. In the past decade, intensive study of PPARs has shed novel insight into prevention and treatment of dyslipidemia, insulin resistance, and type 2 diabetes. Recently, a large body of research revealed that PPARs are also functionally expressed in reproductive organs and various parts of placenta during pregnancy, which strongly suggests that PPARs might play a critical role in reproduction and development, in addition to their central actions in energy homeostasis. In this review, we summarize recent findings elucidating the role of PPARs in female reproduction, with particular focus on evidence from gene knockout and transgenic animal model study.

• Publication year

  2008

• Venue

  PPAR Research

• Publication date

  2008-04-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2008/723243PMID 18401459PMCID 2288756
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PPAR Ligands: Are They Potential Agents for Cardiovascular Disorders?

  2007cited by this paper
• PPARs and the placenta.

  2007cited by this paper
• Stimulation of embryo hatching and implantation by prostacyclin and peroxisome proliferator-activated receptor delta activation: implication in IVF.

  2007cited by this paper
• Stimulation of embryo hatching and implantation by prostacyclin and peroxisome proliferator-activated receptor d activation: implication in IVF

  2007cited by this paper
• Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk.

  2007cited by this paper
• Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.

  2007cited by this paper
• Oxysterol Nuclear Receptor LXRβ Regulates Cholesterol Homeostasis and Contractile Function in Mouse Uterus*

  2007cited by this paper
• Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk

  2007cited by this paper
• Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.

  2006cited by this paper
• Nutrition and reproduction in women.

  2006cited by this paper
• The role of the leptin in reproduction

  2006cited by this paper
• Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.

  2006cited by this paper
• PPARγ and human metabolic disease

  2006cited by this paper
• Peroxisome Proliferator-Activated Receptor α Deficiency Increases the Risk of Maternal Abortion and Neonatal Mortality in Murine Pregnancy with or without Diabetes Mellitus: Modulation of T Cell Differentiation

  2006cited by this paper
• Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes.

  2006cited by this paper
• Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor β/δ

  2006cited by this paper
• Developmental regulation of prostacyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation period.

  2006cited by this paper
• Nuclear receptor expression links the circadian clock to metabolism.

  2006cited by this paper
• Peroxisome Proliferator-Activated Receptor-γ Activates p53 Gene Promoter Binding to the Nuclear Factor-κB Sequence in Human MCF7 Breast Cancer Cells

  2006cited by this paper
• PPAR gamma and human metabolic disease.

  2006cited by this paper
• Modulation of peroxisome proliferator-activated receptor delta and gamma transcripts in swine endometrial tissue during early gestation.

  2006cited by this paper
• Sorting out the roles of PPARα in energy metabolism and vascular homeostasis

  2006influential reference
• Effects of luteinizing hormone on peroxisome proliferator-activated receptor gamma in the rat ovary before and after the gonadotropin surge.

  2006cited by this paper
• Nutrition and reproduction in women

  2006cited by this paper
• Peroxisome proliferator-activated receptor alpha deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: Modulation of T cell differentiation.

  2006cited by this paper
• Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia.

  2006cited by this paper
• Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells.

  2006cited by this paper
• The pleiotropic function of PPARγ in the placenta

  2006cited by this paper
• Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice.

  2006cited by this paper
• The pleiotropic function of PPAR gamma in the placenta.

  2006cited by this paper
• Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition.

  2006cited by this paper
• Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reduces clinical inflammatory responses in type 2 diabetes with coronary artery disease after coronary angioplasty.

  2005cited by this paper
• Therapeutic roles of peroxisome proliferator-activated receptor agonists.

  2005cited by this paper
• Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome.

  2005cited by this paper
• PPAR-γ agonists and diabetic nephropathy

  2005cited by this paper
• Peroxisome Proliferator-activated Receptor-binding Protein Null Mutation Results in Defective Mammary Gland Development*

  2005cited by this paper
• A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

  2005cited by this paper
• Peroxisome proliferator–activated receptor-γ agonist rosiglitazone reduces clinical inflammatory responses in type 2 diabetes with coronary artery disease after coronary angioplasty

  2005cited by this paper
• The many faces of PPARgamma.

  2005cited by this paper
• Peroxisome proliferator-activated receptor (PPAR)γ is highly expressed in normal human pituitary gland

  2005cited by this paper
• Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation.

  2005cited by this paper
• Gaining weight: the Keystone Symposium on PPAR and LXR.

  2005cited by this paper
• PPAR signaling exacerbates mammary gland tumor development

  2004cited by this paper
• PPARalpha agonists clofibrate and gemfibrozil inhibit cell growth, down-regulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells.

  2004cited by this paper
• Expression and function of PPARγ in rat placental development

  2004cited by this paper
• Expression and function of PPARgamma in rat placental development.

  2004cited by this paper
• PPAR gamma signaling exacerbates mammary gland tumor development.

  2004cited by this paper
• Troglitazone attenuates hypoxia-induced injury in cultured term human trophoblasts.

  2004cited by this paper
• Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome.

  2004cited by this paper
• PPARα agonists clofibrate and gemfibrozil inhibit cell growth, down-regulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells

  2004cited by this paper
• Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis.

  2004cited by this paper
• Peroxisome Proliferator-Activated Receptor γ Controls Muc1 Transcription in Trophoblasts

  2004cited by this paper
• Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts.

  2004cited by this paper
• Fenofibrate, a ligand for PPARα, inhibits aromatase cytochrome P450 expression in the ovary of mouse Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.M200327-JLR200

  2003cited by this paper
• Fenofibrate, a ligand for PPARalpha, inhibits aromatase cytochrome P450 expression in the ovary of mouse.

  2003cited by this paper
• Prostacyclin enhances embryo hatching but not sperm motility.

  2003cited by this paper
• Peroxisome proliferator‐activated receptor delta expression and regulation in mouse uterus during embryo implantation and decidualization

  2003cited by this paper
• Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells.

  2003cited by this paper
• PPAR-γ receptor ligands: novel therapy for pituitary adenomas

  2003cited by this paper
• PPAR-gamma receptor ligands: novel therapy for pituitary adenomas.

  2003cited by this paper
• Differential expression of peroxisome proliferator-activated receptor delta at implantation sites and in decidual cells of rat uterus.

  2003cited by this paper
• Dual activation of PPARα and PPARγ by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells

  2003cited by this paper
• A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy.

  2002cited by this paper
• Expression of PPAR and RXR isoforms in the developing rat and human term placentas.

  2002cited by this paper
• Loss of the Peroxisome Proliferation-activated Receptor gamma (PPARγ) Does Not Affect Mammary Development and Propensity for Tumor Formation but Leads to Reduced Fertility*

  2002cited by this paper
• Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.

  2002cited by this paper
• Peroxisome proliferator–activated receptor α in the human breast cancer cell lines MCF‐7 and MDA‐MB‐231

  2002cited by this paper
• Optimizing ovulation induction in women with polycystic ovary syndrome

  2002cited by this paper
• Peroxisome proliferator-activated receptor beta expression in human breast epithelial cell lines of tumorigenic and non-tumorigenic origin.

  2002cited by this paper
• Localization and Expression of Messenger RNAs for the Peroxisome Proliferator-Activated Receptors in Ovarian Tissue from Naturally Cycling and Pseudopregnant Rats1

  2002cited by this paper
• A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor-γ Gene in a Patient with Familial Partial Lipodystrophy

  2002cited by this paper
• PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.

  2002cited by this paper
• Differential Expression of Peroxisome Proliferator-Activated Receptors (PPARs): Tissue Distribution of PPAR-a, $3, and -y in the Adult Rat*

  2001cited by this paper
• Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

  2001cited by this paper
• Intrauterine infection and preterm delivery.

  2000cited by this paper
• Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells.

  2000cited by this paper
• Placental peroxisome proliferator-activated receptor-γ is up-regulated by pregnancy serum

  2000cited by this paper
• Placental peroxisome proliferator-activated receptor-gamma is up-regulated by pregnancy serum.

  2000cited by this paper
• Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.

  1999influential reference
• PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

  1999influential reference
• The dental patient with hemostatic disorders. A review of hemostasia physiopathology for dental professionals.

  1999cited by this paper
• PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.

  1999cited by this paper
• A Role for Leptin in Sexual Maturation and Puberty?

  1999cited by this paper
• PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

  1999cited by this paper
• El paciente dental con alteraciones de la hemostasia. Revisión de la fisiopatología de la hemostasia para odontólogos

  1999cited by this paper
• PPAR gamma is required for placental, cardiac, and adipose tissue development.

  1999cited by this paper
• Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

  1999cited by this paper
• Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin.

  1998cited by this paper
• Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells.

  1998cited by this paper
• Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development.

  1998cited by this paper
• Differential Expression of Peroxisome Proliferator-Activated Receptor- , - , and - during Rat Embryonic Development

  1998cited by this paper
• Leptin, puberty and reproductive function: lessons from animal studies and observations in humans.

  1998cited by this paper
• Expression of peroxisome proliferator activated receptor mRNA in normal and tumorigenic rodent mammary glands.

  1998cited by this paper
• Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

  1997cited by this paper
• Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses.

  1997cited by this paper
• Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen‐activated protein kinase

  1997cited by this paper
• Defects of the Chorioallantoic Placenta in Mouse RXRα Null Fetuses

  1997cited by this paper
• Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor.

  1997cited by this paper
• Cell death in the mammalian blastocyst.

  1997cited by this paper
• Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

  1996cited by this paper

• Post–Mating Mefepronic acid treatment has no effect on Progesterone levels and fertility in early lactating ewes during the non–breeding season

  2025cites this paper
• [Adiponectin improves endometrial receptivity in rats with polycystic ovary syndrome by upregulating the PPARα/HOXA10 pathway].

  2024cites this paper
• Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetes

  2022cites this paper
• The effect of DDE and dieldrin and their parental substances (DDT and aldrin) on PGE2 and PGF2α release from bovine endometrial explants collected during 120 to 180 days of the gestational period.

  2021cites this paper
• Effect of rosiglitazone on developmental competence of mouse embryos treated with lipopolysaccharide.

  2020cites this paper
• Journal of Reproduction and Development

  2020cites this paper
• Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription

  2020cites this paper
• Peroxisome Proliferator-Activated Receptors (PPARs) levels in spermatozoa of normozoospermic and asthenozoospermic men

  2019cites this paper
• Prenatal androgen excess alters the uterine peroxisome proliferator-activated receptor (PPAR) system.

  2019cites this paper
• LIVER PROTEOMICS TO STUDY THE ONSET OF PUBERTY IN BRAHMAN HEIFERS

  2018cites this paper
• The influence of arachidonic acid metabolites on PPAR and RXR expression in bovine uterine cells.

  2018cites this paper
• Genetic Mouse Models for Female Reproductive Toxicology Studies

  2018cites this paper
• Aberrantly expressed long noncoding RNAs in recurrent implantation failure: A microarray related study

  2017cites this paper
• Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids

  2017cites this paper
• Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo.

  2016cites this paper
• PPAR ligand association with prostaglandin F2α and E2 synthesis in the pig corpus luteum-An in vitro study.

  2016cites this paper
• Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations

  2016cites this paper
• Shared Genetic Factors Involved in Celiac Disease, Type 2 Diabetes and Anorexia Nervosa Suggest Common Molecular Pathways for Chronic Diseases

  2016cites this paper
• Effects of clofibric acid alone and in combination with 17β-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout.

  2014cites this paper
• PPARs Integrate the Mammalian Clock and Energy Metabolism

  2014cites this paper
• Nutritional signals and reproduction.

  2014cites this paper
• Peroxisome proliferator activated receptor ligands affect progesterone and 17β-estradiol secretion by porcine corpus luteum during early pregnancy.

  2014cites this paper
• In vitro effect of peroxisome proliferator activated receptor (PPAR) ligands on prostaglandin E2 synthesis and secretion by porcine endometrium during the estrous cycle and early pregnancy.

  2013cites this paper
• FAM3A is a target gene of peroxisome proliferator-activated receptor gamma.

  2013cites this paper
• PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice

  2013cites this paper
• The biology of the peroxisome proliferator-activated receptor system in the female reproductive tract.

  2013cites this paper
• Role of nuclear receptors in blastocyst implantation.

  2013cites this paper
• The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium.

  2013cites this paper
• The effect of embryo presence on the expression of peroxisome proliferator activated receptor (PPAR) genes in the porcine reproductive system during periimplantation.

  2013cites this paper
• Tissue Distribution and Versatile Functions of PPARs

  2013cites this paper
• Expression of peroxisome proliferator activated receptor (PPAR) genes in porcine endometrium exposed in vitro to IL-6 and INFγ.

  2012cites this paper
• PPAR&ggr; as a therapeutic target in diabetic nephropathy and other renal diseases

  2012cites this paper
• The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract

  2012cites this paper
• Expression of peroxisome proliferator-activated receptor isoforms in the rat uterus during early pregnancy

  2011cites this paper
• The quantitative expression of peroxisome proliferator activated receptor (PPAR) genes in porcine endometrium through the estrous cycle and early pregnancy.

  2011cites this paper
• Peroxisome proliferator-activated receptors in endometrial cancer

  2011cites this paper
• Nuclear Receptors of the Peroxisome Proliferator-Activated Receptor (PPAR) Family in Gestational Diabetes: From Animal Models to Clinical Trials1

  2010cites this paper
• The Genetic Basis of Diabetes

  2009cites this paper
• Review of the expression of peroxisome proliferator-activated receptors alpha (PPAR alpha), beta (PPAR beta), and gamma (PPAR gamma) in rodent and human development.

  2009cites this paper
• Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation.

  2009cites this paper
• PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR LIGANDS AFFECT PROGESTERONE AND 17 β-ESTRADIOLSECRETION BYPORCINE CORPUS LUTEUM DURING EARLY PREGNANCY

  year unknowncites this paper
• Review Article Peroxisome Proliferator-activated Receptors in Female Reproduction and Fertility

  year unknowninfluential citation