Attenuation of Angiotensin II Signaling Recouples eNOS and Inhibits Nonendothelial NOX Activity in Diabetic Mice

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Diabetes

• Publication date

  2007-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2337/db06-0288PMID 17192473
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.

  2006cited by this paper
• Blockade of the renin–angiotensin–aldosterone system: a key therapeutic strategy to reduce renal and cardiovascular events in patients with diabetes

  2006cited by this paper
• Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy.

  2006cited by this paper
• Effect of angiotensin II type 1 receptor antagonism on endothelial function: role of bradykinin and nitric oxide

  2006cited by this paper
• Animal models of diabetes mellitus

  2005cited by this paper
• Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences.

  2005cited by this paper
• Can murine diabetic nephropathy be separated from superimposed acute renal failure?

  2005cited by this paper
• NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease.

  2005cited by this paper
• Peroxisome Proliferator-Activated Receptor-β and its Agonists in Hypertension and Atherosclerosis

  2005cited by this paper
• Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications.

  2005cited by this paper
• Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.

  2005cited by this paper
• Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase.

  2005influential reference
• Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII.

  2004cited by this paper
• Protein Glycation: A Firm Link to Endothelial Cell Dysfunction

  2004cited by this paper
• Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.

  2004cited by this paper
• Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells.

  2003cited by this paper
• New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy.

  2003cited by this paper
• The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases.

  2003influential reference
• Glycation, Inflammation, and RAGE: A Scaffold for the Macrovascular Complications of Diabetes and Beyond

  2003cited by this paper
• Hypoxia and high glucose upregulate AT1 receptor expression and potentiate ANG II-induced proliferation in VSM cells.

  2003influential reference
• Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.

  2003cited by this paper
• NAD(P)H Oxidase-derived Hydrogen Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II*

  2002cited by this paper
• Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E–Deficient Mice

  2002influential reference
• Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model

  2002cited by this paper
• Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus: Role of NAD(P)H Oxidase and Endothelial Nitric Oxide Synthase

  2002cited by this paper
• Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation: Potential Mechanisms for Atrial Thrombosis and Stroke

  2002cited by this paper
• The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation.

  2002cited by this paper
• Blood Pressure Control Early In Diabetes: A Balance Between Angiotensin Ii And Nitric Oxide

  2002cited by this paper
• Hyperglycaemia-induced intrarenal RAS activation: the contribution of metabolic pathways

  2002cited by this paper
• What should the role of ACE inhibitors be in the treatment of diabetes? Lessons from HOPE and MICRO‐HOPE

  2002cited by this paper
• Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

  2001cited by this paper
• Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice

  2001cited by this paper
• The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO‐MCBN, the American Diabetes Association and the German Diabetes Society

  2001cited by this paper
• Angiotensin-Converting Enzyme Inhibition With Enalapril Slows Progressive Intima-Media Thickening of the Common Carotid Artery in Patients With Non–Insulin-Dependent Diabetes Mellitus

  2001cited by this paper
• Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease.

  2001cited by this paper
• Protein kinase C and the development of diabetic vascular complications

  2001cited by this paper
• Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

  2001cited by this paper
• Reactive oxygen species as mediators of angiotensin II signaling.

  2000cited by this paper
• Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.

  2000cited by this paper
• Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice.

  2000cited by this paper
• Hereditary catalase deficiencies and increased risk of diabetes.

  2000cited by this paper
• Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice.

  1999cited by this paper
• Chronic Angiotensin II Infusion Promotes Atherogenesis in Low Density Lipoprotein Receptor −/− Mice

  1999cited by this paper
• Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus.

  1999cited by this paper
• Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice.

  1999cited by this paper
• Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis.

  1999cited by this paper
• Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.

  1998cited by this paper
• Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

  1996cited by this paper
• Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

  1994cited by this paper
• Impaired Endothelium‐Dependent Vasodilation in Patients With Insulin‐Dependent Diabetes Mellitus

  1993cited by this paper
• Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta.

  1991cited by this paper
• Diabetes mellitus in mice induced by multiple subdiabetogenic doses of streptozotocin: age and sex dependence.

  1982cited by this paper

• Angiotensin-Converting Enzyme (ACE) Inhibitors and Statins Mitigate Negative Cardiovascular and Pulmonary Effects of Particulate Matter in a Mouse Exposure Model

  2026cites this paper
• Alleviation of accelerated diabetic atherogenesis in STZ-treated apoE/NOX1 DKO mice, apoE−/−/tg-EC-DHFR mice, and by folic acid

  2025cites this paper
• Pelargonidin-3-O-Glucoside Restores Nitric Oxide Production via Interaction with circHMGCS1 to Ameliorate Endothelial Dysfunction.

  2025cites this paper
• Novel and superior treatment of pulmonary hypertension with netrin-1 derived, modified and improved small peptides

  2025cites this paper
• Downregulation of Neuronal Nitric Oxide Synthase (nNOS) within the Paraventricular Nucleus in Ins2Akita-type-1 Diabetic Mice Contributes to Sympatho-excitation.

  2024cites this paper
• Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR

  2024cites this paper
• Sodium nitrite induces tolerance in the mouse aorta: involvement of the renin-angiotensin system, nitric oxide synthase, and reactive oxygen species.

  2024cites this paper
• Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies

  2023cites this paper
• Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

  2023cites this paper
• Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage

  2023cites this paper
• Novel and robust treatment of pulmonary hypertension with netrin-1 and netrin-1-derived small peptides

  2022cites this paper
• Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability

  2022cites this paper
• Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-mediated eNOS Monomerization.

  2022cites this paper
• Neuropeptides, New Ligands of SARS-CoV-2 Nucleoprotein, a Potential Link between Replication, Inflammation and Neurotransmission

  2022cites this paper
• Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms

  2022cites this paper
• Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication

  2022cites this paper
• Angiotensin II Induces Oxidative Stress and Endothelial Dysfunction in Mouse Ophthalmic Arteries via Involvement of AT1 Receptors and NOX2

  2021cites this paper
• Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system

  2021cites this paper
• ACE Inhibitory Peptide from Skin Collagen Hydrolysate of Takifugu bimaculatus as Potential for Protecting HUVECs Injury

  2021cites this paper
• The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury

  2021cites this paper
• Oxidative Stress and Antioxidant Strategies in Human Diseases

  2021cites this paper
• Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells

  2021cites this paper
• Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation

  2021cites this paper
• Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1

  2021cites this paper
• Comparative study of the efficacy of captopril, simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial

  2021cites this paper
• Diabetic Kidney Disease

  2020cites this paper
• Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction

  2020cites this paper
• The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.

  2020cites this paper
• Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics

  2020cites this paper
• Discussion on the Effectiveness of Elevating HDL-C in Treating Cardiovascular Diseases of Patients with Type 2 Diabetes Mellitus

  2019cites this paper
• Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction

  2019cites this paper
• Progress in Research on Nonalcoholic Fatty Liver and Gestational Diabetes

  2019cites this paper
• Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage.

  2019cites this paper
• Catalytic Microgelators for Decoupled Control of Gelation Rate and Rigidity of the Biological Gels.

  2019cites this paper
• NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

  2019cites this paper
• Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

  2019cites this paper
• eNOS Uncoupling: A Therapeutic Target For Ischemic Foot of Diabetic Rat

  2018cites this paper
• Mécanismes impliqués dans la modulation de la néovascularisation post-ischémique : rôle de la rénine et des microARNs

  2018cites this paper
• A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes.

  2018cites this paper
• Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm

  2018cites this paper
• Anti-Inflammatory Effect of Centella asiatica Extract on Prevented Aortic Intima-Media Thickening in Diabetic Rats

  2018cites this paper
• Measurement of Reactive Oxygen Species (ROS) and Mitochondrial ROS in AMPK Knockout Mice Blood Vessels.

  2018cites this paper
• NADPH oxidase 4 and endothelial nitric oxide synthase contribute to endothelial dysfunction mediated by histone methylations in metabolic memory

  2018cites this paper
• Oxidative Stress in Atherosclerosis

  2017cites this paper
• Uncoupling of eNOS in Cardiovascular Disease

  2017cites this paper
• Angiotensin II stimulates superoxide production by nitric oxide synthase in thick ascending limbs

  2016cites this paper
• Calpain / PTP 1 B axis in VEGFR 2 regulation and angiogenesis 1 PTP 1 B in Calpain-dependent Feedback Regulation of VEGFR 2 in Endothelial Cells : Implication in VEGF-dependent Angiogenesis and Diabetic Wound Healing

  2016cites this paper
• Angiotensin-converting enzyme inhibitors reduce oxidative stress intensity in hyperglicemic conditions in rats independently from bradykinin receptor inhibitors

  2016cites this paper
• [Stable Nitric Oxide Metabolites Levels in Hypertensive Patients With Obesity and High Leptin Level].

  2016cites this paper
• NOX isoforms in the development of abdominal aortic aneurysm

  2016cites this paper
• Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr

  2016cites this paper
• Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases

  2016cites this paper
• Attenuation of neointimal formation with netrin-1 and netrin-1 preconditioned endothelial progenitor cells

  2016cites this paper
• Diabetes and Kidney Disease: Role of Oxidative Stress

  2016cites this paper
• Protein Phosphotyrosine Phosphatase 1B (PTP1B) in Calpain-dependent Feedback Regulation of Vascular Endothelial Growth Factor Receptor (VEGFR2) in Endothelial Cells

  2016cites this paper
• Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities.

  2016cites this paper
• B axis in VEGFR 2 regulation and angiogenesis 1 PTP 1 B in Calpain-dependent Feedback Regulation of VEGFR 2 in Endothelial Cells : Implication in VEGF-dependent Angiogenesis and Diabetic Wound Healing

  2016cites this paper
• Angiotensin antagonist drugs as "source antioxidants" - Down- regulation of nicotinamide adenine dinucleotide phosphate oxidase activation mediates many of their protective benefits, independent of hypertension control

  2015cites this paper
• Strategies to increase nitric oxide signalling in cardiovascular disease

  2015cites this paper
• Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus.

  2015influential citation
• Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension.

  2015cites this paper
• ACTIVATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (NADPH) OXIDASE (NOX) BY TYPE 1 RECEPTORS FOR ANGIOTENSIN II (ATII)

  2015cites this paper
• The Role of Endothelial Dysfunction in Aortic Aneurysms.

  2015cites this paper
• The effects of DPP-4 inhibitors on vascular endothelial function in diabetes

  2015cites this paper
• The therapeutic effect of dietary nitrate supplementation in healthy adults, individuals with type 2 diabetes mellitus and chronic obstructive pulmonary disease

  2015cites this paper
• Therapeutic potential of HDL in cardioprotection and tissue repair.

  2015cites this paper
• Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy.

  2015cites this paper
• Maternal-pup interaction disturbances induce long-lasting changes in the newborn rat pulmonary vasculature.

  2015cites this paper
• Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS.

  2015cites this paper
• Protective effect of captopril against clozapine-induced myocarditis in rats: role of oxidative stress, proinflammatory cytokines and DNA damage.

  2014cites this paper
• Pharmacological applications of antioxidants: lights and shadows.

  2014cites this paper
• Rational Design and Therapeutic Potential of a Novel Nox1 Inhibitor for the Treatment of Pulmonary Hypertension: In Vitro and In Vivo Effects of Nox1 Inhibition

  2014cites this paper
• Role of epidermal growth factor receptor in vascular structure and function

  2014cites this paper
• NADPH Oxidase 4 Induces Cardiac Arrhythmic Phenotype in Zebrafish*

  2014cites this paper
• The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents

  2014cites this paper
• LXR agonism improves TNF-α-induced endothelial dysfunction in the absence of its cholesterol-modulating effects.

  2014cites this paper
• Manipulation of the insulin-like growth factor 1 receptor on the vascular endothelium : the effect on whole body and endothelial specific insulin sensitivity

  2014cites this paper
• Oxidase Interactions in Cardiovascular Disease 37

  2014cites this paper
• 4 induces cardiac in zebrafish.

  2014cites this paper
• Nitric Oxide, Oxidative Stress, and p66Shc Interplay in Diabetic Endothelial Dysfunction

  2014cites this paper
• Pharmacological prevention of eNOS uncoupling.

  2014cites this paper
• NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications

  2014cites this paper
• Oxidative Stress in Diabetes Mellitus and Possible Interventions

  2014cites this paper
• Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function

  2014cites this paper
• Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.

  2014cites this paper
• Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome

  2014cites this paper
• Recoupling of eNOS with Folic Acid Prevents Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E Null Mice

  2014cites this paper
• Complications of Type 1 Diabetes Mellitus are Associated with Renin Angiotensin System: The Role of Physical Exercise as Therapeutic Tool

  2014cites this paper
• Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction.

  2013cites this paper
• Oxidative stress in vascular disease and its pharmacological prevention.

  2013cites this paper
• Nox as a target for diabetic complications.

  2013cites this paper
• Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease.

  2013cites this paper
• Propofol Increases Vascular Relaxation in Aging Rats Chronically Treated with the Angiotensin-Converting Enzyme Inhibitor Captopril

  2013cites this paper
• The influence of angiotensin-(1-7) peptidomimetic (AVE 0991) and nebivolol on angiotensin I metabolism in aorta of apoE-knockout mice.

  2013cites this paper
• Diabetes Alters Activation and Repression of Pro- and Anti-Inflammatory Signaling Pathways in the Vasculature

  2013cites this paper
• Site-Specific Antioxidative Therapy for Prevention of Atherosclerosis and Cardiovascular Disease

  2013cites this paper
• NO-Dependent Endothelial Dysfunction in Type II Diabetes Is Aggravated by Dyslipidemia and Hypertension, but Can Be Restored by Angiotensin-Converting Enzyme Inhibition and Weight Loss

  2013cites this paper
• Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase.

  2013cites this paper
• Developmental Programming of eNOS Uncoupling and Enhanced Vascular Oxidative Stress in Adult Rats After Transient Neonatal Oxygen Exposure

  2013cites this paper
• The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes

  2012influential citation