Insulin Resistance and Hyperinsulinemia

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Diabetes Care

• Publication date

  2008-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/dc08-s264PMID 18227495
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.

  2009cited by this paper
• Insulin action in patients with insulinoma influenced by pharmacological and surgical therapy.

  2009cited by this paper
• Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

  2006cited by this paper
• Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes

  2006cited by this paper
• Central insulin action in energy and glucose homeostasis.

  2006cited by this paper
• The Somogyi phenomenon revisited using continuous glucose monitoring in daily life

  2005cited by this paper
• Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans.

  2005cited by this paper
• Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.

  2004cited by this paper
• C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring Study

  2004cited by this paper
• Inflammation: the link between insulin resistance, obesity and diabetes.

  2004cited by this paper
• The obesity pandemic: where have we been and where are we going?

  2004cited by this paper
• Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial.

  2003cited by this paper
• A New Role for SOCS in Insulin Action

  2003cited by this paper
• Role of Ser/Thr kinases in the uncoupling of insulin signaling

  2003cited by this paper
• Reduced (cid:1) -cell mass and altered glucose sensing impair insulin-secretory function in (cid:1) IRKO mice

  2003cited by this paper
• β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

  2002cited by this paper
• beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.

  2002cited by this paper
• Insulin resistance: a phosphorylation-based uncoupling of insulin signaling.

  2001cited by this paper
• Insulin resistance as a predictor of age-related diseases.

  2001cited by this paper
• Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

  1999cited by this paper
• Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects.

  1998cited by this paper
• Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity

  1996cited by this paper
• Lessons from Animal Diabetes VI

  1996cited by this paper
• Comparison of Insulin Sensitivity in Patients with Insulinoma and Obese Type 2 Diabetes Mellitus

  1996cited by this paper
• Immunoassay of endogenous plasma insulin in man.

  1996cited by this paper
• Chronic primary hyperinsulinaemia is associated with altered insulin receptor mRNA splicing in muscle of patients with insulinoma

  1996cited by this paper
• Chorionic tumors.

  1996cited by this paper
• Pulsatile intravenous insulin replacement in streptozotocin-diabetic rats is more efficient than continuous delivery: effects on glycaemic control, insulin-mediated glucose metabolism and lipolysis

  1996cited by this paper
• Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.

  1994cited by this paper
• Mechanisms of fasting hypoglycemia and concomitant insulin resistance in insulinoma patients.

  1993cited by this paper
• The glucose clamp technique for the study of patients with hypoglycemia: insulin resistance as a feature of insulinoma

  1990cited by this paper
• Six-year results of luteinizing hormone releasing hormone (LHRH) agonist treatment in children with LHRH-dependent precocious puberty.

  1989cited by this paper
• Alternative splicing of human insulin receptor messenger RNA.

  1989cited by this paper
• Pulsatile insulin delivery is more efficient than continuous infusion in modulating islet cell function in normal subjects and patients with type 1 diabetes.

  1988cited by this paper
• Rapid Reduction and Return of Surface Insulin Receptors After Exposure to Brief Pulses of Insulin in Perifused Rat Hepatocytes

  1988cited by this paper
• Hyperinsulinemia Is Characterized by Jointly Disturbed Plasma VLDL, LDL, and HDL Levels: A Population‐Based Study

  1988cited by this paper
• Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

  1988cited by this paper
• Role of Insulin Resistance in Human Disease

  1988influential reference
• Banting lecture 1988. Role of insulin resistance in human disease.

  1988cited by this paper
• Greater efficacy of pulsatile insulin in type I diabetics critically depends on plasma glucagon levels.

  1987cited by this paper
• Postprandial oscillations of plasma glucose, insulin and C-peptide in man

  1987cited by this paper
• Efficacy of Pulsatile Versus Continuous Insulin Administration on Hepatic Glucose Production and Glucose Utilization in Type I Diabetic Humans

  1986cited by this paper
• Glucose uptake and pulsatile insulin infusion: euglycaemic clamp and [3-3H]glucose studies in healthy subjects.

  1986cited by this paper
• Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

  1985cited by this paper
• Production of insulin resistance by hyperinsulinaemia in man

  1985cited by this paper
• Hyperinsulinaemia and insulin insensitivity: studies in subjects with insulinoma

  1985cited by this paper
• Pulsatile Insulin Has Greater Hypoglycemic Effect Than Continuous Delivery

  1983cited by this paper
• Insulin stimulates phosphorylation of serine residues in soluble insulin receptors.

  1983cited by this paper
• Receptor and postreceptor insulin resistance induced by in vivo hyperinsulinemia.

  1983cited by this paper
• Rapid oscillations in plasma insulin, glucagon, and glucose in obese and normal weight humans.

  1982cited by this paper
• The effect of insulin on renal sodium metabolism

  1981cited by this paper
• Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level.

  1980cited by this paper
• Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings.

  1979cited by this paper
• Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes.

  1978cited by this paper
• Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration.

  1977cited by this paper
• Effect of Fasting and Streptozotocin in the Obese-hyperglycemic (ob/ob) Mouse: Apparent Lack of a Direct Relationship Between Insulin Binding and Insulin Effects

  1977cited by this paper
• Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary.

  1976cited by this paper
• Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

  1976cited by this paper
• Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

  1974cited by this paper
• Insulin interactions with its receptors: experimental evidence for negative cooperativity.

  1973cited by this paper
• ROLES OF INSULIN AND GROWTH HORMONE, BASED ON STUDIES ON FOREARM METABOLISM IN MAN

  1963cited by this paper
• Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism.

  1962cited by this paper
• Insulin antagonists.

  1960cited by this paper
• Insulin and an inhibitor of glucose uptake, in protein fractions of normal human plasma.

  1960cited by this paper
• Plasma-insulin and insulin resistance.

  1957cited by this paper
• [Insulin antagonists].

  1957cited by this paper
• Insulin resistance; a review of the subject and presentation of two cases.

  1950cited by this paper
• Insulin resistance. The mechanisms involved and the influence of infection and refrigeration.

  1950cited by this paper
• A case of coexisting insulin allergy and insulin resistance.

  1950cited by this paper
• IMMUNOLOGIC STUDIES IN INSULIN RESISTANCE I. REPORT OF A CASE EXHIBITING VARIATIONS IN RESISTANCE AND ALLERGY TO INSULIN.

  1944cited by this paper

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