Ghrelin controls hippocampal spine synapse density and memory performance

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature Neuroscience

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nn1656PMID 16491079
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Is ghrelin a signal for the development of metabolic systems?

  2005cited by this paper
• Ghrelin: structure and function.

  2005cited by this paper
• Mice lacking ghrelin receptors resist the development of diet-induced obesity.

  2005cited by this paper
• Absence of ghrelin protects against early-onset obesity.

  2005cited by this paper
• Intravenous heroin self‐administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats

  2004cited by this paper
• Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

  2004cited by this paper
• Attenuation of scopolamine-induced impairment of spontaneous alternation behaviour by antagonist but not inverse agonist and agonist β-carbolines

  2004cited by this paper
• Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.

  2004cited by this paper
• Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice

  2004cited by this paper
• Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.

  2004cited by this paper
• High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

  2003cited by this paper
• An 18-year follow-up of overweight and risk of Alzheimer disease.

  2003cited by this paper
• Ghrelin as a potential anti-obesity target.

  2003cited by this paper
• The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

  2003cited by this paper
• A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor.

  2003cited by this paper
• Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients.

  2002cited by this paper
• Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure

  2002cited by this paper
• The human hippocampus and spatial and episodic memory.

  2002cited by this paper
• Fluctuations in brain glucose concentration during behavioral testing: dissociations between brain areas and between brain and blood.

  2001cited by this paper
• Minireview: Ghrelin and the Regulation of Energy Balance-A Hypothalamic Perspective.

  2001cited by this paper
• Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administration.

  2001cited by this paper
• Circulating ghrelin levels are decreased in human obesity.

  2001cited by this paper
• A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.

  2001cited by this paper
• Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary.

  2001cited by this paper
• Activate your online subscription

  2000cited by this paper
• Ghrelin induces adiposity in rodents

  2000cited by this paper
• Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task.

  2000cited by this paper
• Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention.

  2000cited by this paper
• Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory.

  2000cited by this paper
• β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory

  2000cited by this paper
• Effect of growth hormone secretagogue LY444711 on IGF‐1, growth hormone, and cortisol levels in beagle dogs after one and seven daily oral doses

  2000cited by this paper
• Attenuation of morphine-induced behavioral changes in rodents by D- and L-glucose.

  1999cited by this paper
• Ghrelin is a growth-hormone-releasing acylated peptide from stomach

  1999cited by this paper
• Memory Modulation Across Neural Systems: Intra-Amygdala Glucose Reverses Deficits Caused by Intraseptal Morphine on a Spatial Task But Not on an Aversive Task

  1998cited by this paper
• Impaired recognition memory in patients with lesions limited to the hippocampal formation.

  1997cited by this paper
• Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

  1997cited by this paper
• Glucose injections into the medial septum reverse the effects of intraseptal morphine infusions on hippocampal acetylcholine output and memory.

  1995cited by this paper
• Pyruvate infusions into the septal area attenuate spontaneous alternation impairments induced by intraseptal morphine injections.

  1995cited by this paper
• Opioid modulation of working memory: intraseptal, but not intraamygdaloid, infusions of beta-endorphin impair performance in spatial alternation.

  1995cited by this paper
• Glucose attenuates a morphine-induced decrease in hippocampal acetylcholine output: an in vivo microdialysis study in rats.

  1994cited by this paper
• Spontaneous alternation and inhibitory avoidance impairments with morphine injections into the medial septum. Attenuation by glucose administration.

  1992cited by this paper
• Effects of opioid microinjections into the medial septal area on spatial memory in rats.

  1988cited by this paper
• Exploratory behavior and reaction to novelty in rats with hippocampal perforant path systems disrupted.

  1988cited by this paper
• REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

  1966cited by this paper

• Ghrelin’s role in sleep and sleep deprivation: a narrative review

  2026cites this paper
• Dietary medium chain triglycerides impairs orexigenic action of ghrelin in mice

  2026cites this paper
• Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.

  2026cites this paper
• The Injection of Ghrelin (OXE-103) Improves Subacute Concussion Symptom Burden and Quality of Life

  2025cites this paper
• Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy.

  2025cites this paper
• Parkinson's disease and the gut-brain connection: unveiling pathways, mechanisms and promising therapies.

  2025cites this paper
• The role of orexin and MCH neurons in the hypothalamus in sleep-wake regulation and learning-forgetting balance

  2025cites this paper
• What's in your plate?AMPA receptors modulation at the crossroads of homeostatic and hedonic eating.

  2025cites this paper
• Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke

  2025cites this paper
• GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice

  2025cites this paper
• A novel butyrylcholinesterase inhibitor induces antidepressant, pro-cognitive, and anti-anhedonic effects in Flinders Sensitive Line rats: The role of the ghrelin-dopamine cascade.

  2025cites this paper
• Ghrelin Increases Glutamate Release at the Perforant Path‐Dentate Gyrus Granule Cell Synapses by Cross‐Activating Dopamine D1 Receptors

  2025influential citation
• Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI

  2025cites this paper
• LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.

  2025cites this paper
• The sex-specific relationship of ghrelin and cognition in Chinese han first-episode drug-naive major depressive disorder

  2025cites this paper
• Ventral hippocampus neurons encode meal-related memory

  2025cites this paper
• Growth hormone and IGF-1 actions in the brain and neuropsychiatric diseases.

  2025cites this paper
• Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease

  2025cites this paper
• The protective PLCG2 variants delay Alzheimer's disease onset age in APOE ϵ4 carriers

  2025cites this paper
• Astrocytes of the hippocampus and responses to periprandial neuroendocrine hormones.

  2025cites this paper
• Characterization of a Bovine Serum Albumin‐Derived Pro‐Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD‐Fed Mice via CCK Signaling Through the Gut‐Brain Axis

  2025cites this paper
• The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study

  2024cites this paper
• The olfactory bulb: A neuroendocrine spotlight on feeding and metabolism

  2024cites this paper
• Des-acyl ghrelin reduces alcohol intake and alcohol-induced reward in rodents

  2024cites this paper
• The hormesis principle of neuroplasticity and neuroprotection.

  2024cites this paper
• Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives.

  2024cites this paper
• Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide-induced Depression-like Behavior in Mice

  2024cites this paper
• Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain

  2024cites this paper
• Metabolic Biomarkers of Appetite Control in Parkinson's Disease Patients With and Without Cognitive Impairment.

  2024cites this paper
• Gut Hormones: Possible Mediators of Addictive Disorders?

  2024cites this paper
• Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction.

  2024cites this paper
• New antidepressant mechanism of Yueju Pill: Increasing ghrelin level by inhibiting gastric mTOR/S6K signaling pathway and sensitizing hippocampal GHS-R

  2024cites this paper
• Rikkunshito improves anorexia through ghrelin‐ and orexin‐dependent activation of the brain hypothalamus and mesolimbic dopaminergic pathway in rats

  2024cites this paper
• Assessment of Executive Function Skills in Children with Isolated Growth Hormone Deficiency: A Cross-sectional Study

  2024cites this paper
• Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.

  2024cites this paper
• Growth hormone-releasing hormone and its analogues in health and disease

  2024cites this paper
• Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications

  2024cites this paper
• Nuezhenide of the fruits of Nuzhenzi (Ligustrum lucidum Ait.) is a functional analog of ghrelin.

  2024cites this paper
• Ghrelin.

  2024cites this paper
• Ghrelin Modulates Voltage-Gated Ca2+ Channels through Voltage-Dependent and Voltage-Independent Pathways in Rat Gastric Vagal Afferent Neurons

  2024cites this paper
• Ghrelin in Depression: A Promising Therapeutic Target

  2024cites this paper
• Ventral hippocampus neurons encode meal-related memory

  2023cites this paper
• Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease

  2023cites this paper
• Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

  2023cites this paper
• Food Restriction Level and Reinforcement Schedule Differentially Influence Behavior during Acquisition and Devaluation Procedures in Mice

  2023cites this paper
• Metabolic, neuroendocrine and behavioral effects of social defeat in male and female mice using the chronic non-discriminatory social defeat stress model.

  2023cites this paper
• Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats.

  2023cites this paper
• Neurotrophic Factors and Dendritic Spines.

  2023cites this paper
• Orexin and MCH neurons: regulators of sleep and metabolism

  2023cites this paper
• Internal-state-dependent control of feeding behavior via hippocampal ghrelin signaling

  2023cites this paper
• Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline

  2023cites this paper
• Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation

  2023cites this paper
• Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells

  2023cites this paper
• Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging

  2023cites this paper
• The intersection between ghrelin, metabolism and circadian rhythms

  2023cites this paper
• Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism

  2023cites this paper
• MIT Open Access

  2022cites this paper
• Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones

  2022cites this paper
• Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding

  2022cites this paper
• The Interplay between Ghrelin and Microglia in Neuroinflammation: Implications for Obesity and Neurodegenerative Diseases

  2022cites this paper
• The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice

  2022cites this paper
• Hypothalamic-pituitary-adrenal (HPA) axis activity and anxiety-like behavior during aging: a test of the glucocorticoid cascade hypothesis in amyloidogenic APPswe/PS1dE9 mice.

  2022cites this paper
• Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model

  2022cites this paper
• Blockade of ghrelin receptor signaling enhances conditioned passive avoidance and context-associated neural circuit activation in fasted male rats

  2022cites this paper
• GHSR1a deficiency suppresses inhibitory drive on dCA1 pyramidal neurons and contributes to memory reinforcement.

  2022cites this paper
• Acylation, a Conductor of Ghrelin Function in Brain Health and Disease

  2022cites this paper
• Systemic Ghrelin Treatment Induces Rapid, Transient, and Asymmetric Changes in the Metabolic Activity of the Mouse Brain

  2022cites this paper
• Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach

  2022cites this paper
• Effects of brain-derived neurotrophic factor (BDNF) on the Schizophrenia model of animals.

  2022cites this paper
• Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

  2022cites this paper
• Diverse and Complementary Effects of Ghrelin and Obestatin

  2022cites this paper
• Investigating the Contribution of Agouti-Related Peptide (AGRP) on Ghrelin’s Ability to Promote Social Interaction in Mice

  2022cites this paper
• Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats.

  2022cites this paper
• DOCK4 regulates ghrelin production in gastric X/A-like cells

  2022cites this paper
• Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice.

  2022cites this paper
• Testing Links of Food-Related Olfactory Perception to Peripheral Ghrelin and Leptin Concentrations

  2022cites this paper
• Virus-mediated GHS-R1a expression in the basolateral amygdala blocks extinction of conditioned taste aversion memory in rats.

  2022cites this paper
• Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis

  2022cites this paper
• “Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin

  2022cites this paper
• Investigating the Co-administration of Ghrelin and Nicotine Into the Medial Septum and Its Influencing on Morphine Amnestic Effect

  2022cites this paper
• Ghrelin mediated hippocampal neurogenesis.

  2022cites this paper
• Ghrelin receptor signaling contributes to fasting-induced suppression of conditioned avoidance behavior and neural circuit activation in male rats

  2022cites this paper
• GHS-R1a activity suppresses synaptic function of primary cultured hippocampal neurons.

  2022cites this paper
• Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus.

  2022cites this paper
• Ghrelin infusion into the basolateral amygdala suppresses CTA memory formation in rats via the PI3K/Akt/mTOR and PLC/PKC signaling pathways

  2022influential citation
• Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons

  2022cites this paper
• A Giant in Geriatrics: A Tribute to Professor John Edward Morley

  2022cites this paper
• Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages

  2022cites this paper
• Exerkines and long-term synaptic potentiation: mechanisms of exercise-induced neuroplasticity.

  2022cites this paper
• New Aspects of Corpus Luteum Regulation in Physiological and Pathological Conditions: Involvement of Adipokines and Neuropeptides

  2022cites this paper
• Ghrelin system in Alzheimer's disease.

  2022cites this paper
• Establishment of a Cell Line Stably Expressing the Growth Hormone Secretagogue Receptor to Identify Crocin as a Ghrelin Agonist

  2022cites this paper
• Ghrelin receptor signaling in health and disease: a biased view.

  2022cites this paper
• A review of glucoregulatory hormones potentially applicable to the treatment of Alzheimer’s disease: mechanism and brain delivery

  2022cites this paper
• Blockade of Ghrelin Receptor Signaling Enhances Conditioned Passive Avoidance and Context-Associated cFos Activation in Fasted Male Rats

  2022cites this paper
• Effects of ghrelin on sulfite induced changes in lipid peroxidation, spatial memory, and locomotor activity in rats

  2022cites this paper
• Title: The Effect of Intra-Medial Septum Co-Injection of Ghrelin and Nicotine on Morphine Induced Memory Impairment

  2022cites this paper
• Ghrelin mechanisms of food reward. Part 2. Interaction of ghrelin with hormones, neuropeptides and other endogenous ligands

  2022influential citation
• Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone.

  2022cites this paper
• Alteration of brain nuclei in obese children with and without Prader-Willi syndrome

  2022cites this paper