Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Neuron

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0896-6273(00)80905-8PMID 10719896
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ensheathing glia transplants promote dorsal root regeneration and spinal reflex restitution after multiple lumbar rhizotomy

  1999cited by this paper
• Induction of Eph B3 after spinal cord injury.

  1999cited by this paper
• Co-localization of substance P and dopamine beta-hydroxylase with growth-associated protein-43 is lost caudal to a spinal cord transection.

  1999cited by this paper
• Regeneration of Adult Rat Corticospinal Axons Induced by Transplanted Olfactory Ensheathing Cells

  1998cited by this paper
• Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats

  1998cited by this paper
• Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord

  1998cited by this paper
• Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury.

  1998cited by this paper
• Long-Distance Axonal Regeneration in the Transected Adult Rat Spinal Cord Is Promoted by Olfactory Ensheathing Glia Transplants

  1998cited by this paper
• Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions

  1998cited by this paper
• Evidence for a Role of the Chemorepellent Semaphorin III and Its Receptor Neuropilin-1 in the Regeneration of Primary Olfactory Axons

  1998cited by this paper
• Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan

  1998cited by this paper
• Spinal cord repair: from experimental models to human application

  1998cited by this paper
• Regeneration of brainstem-spinal axons after lesion and immunological disruption of myelin in adult rat.

  1998cited by this paper
• Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissue.

  1998cited by this paper
• Regeneration in the spinal cord.

  1998cited by this paper
• Transplants and neurotrophic factors prevent atrophy of mature CNS neurons after spinal cord injury.

  1998cited by this paper
• Olfactory ensheathing glia: properties and function.

  1998cited by this paper
• Regeneration of adult axons in white matter tracts of the central nervous system

  1997cited by this paper
• Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.

  1997cited by this paper
• Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory molecules.

  1997cited by this paper
• Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury

  1997cited by this paper
• Regeneration in the adult central nervous system: Experimental repair strategies

  1997cited by this paper
• The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord.

  1997cited by this paper
• Tenascin‐C expression and axonal sprouting following injury to the spinal dorsal columns in the adult rat

  1997cited by this paper
• Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth

  1997cited by this paper
• Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection.

  1996cited by this paper
• Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

  1996cited by this paper
• Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord.

  1996cited by this paper
• A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord.

  1995cited by this paper
• Effects of astrocyte implantation into the hemisected adult rat spinal cord.

  1995cited by this paper
• The Basic, Somatic, And Emotional Components Of The Motor System In Mammals.

  1995cited by this paper
• Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors

  1995cited by this paper
• Olfactory bulb ensheathing glia: A unique cell type with axonal growth‐promoting properties

  1995cited by this paper
• A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

  1995cited by this paper
• Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

  1994cited by this paper
• Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord.

  1994cited by this paper
• Inhibitory molecules in development and regeneration

  1994cited by this paper
• Regeneration into the spinal cord of transected dorsal root axons is promoted by ensheathing glia transplants.

  1994cited by this paper
• Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.

  1994cited by this paper
• Methods to assess the development and recovery of locomotor function after spinal cord injury in rats.

  1993cited by this paper
• Inhibitors of neurite growth.

  1993cited by this paper
• In Vitro Enfolding of Olfactory Neurites by p75 NGF Receptor Positive Ensheathing Cells from Adult Rat Olfactory Bulb

  1993cited by this paper
• Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury.

  1992cited by this paper
• Chapter 31: CNS glial scar tissue: a source of molecules which inhibit central neurite outgrowth

  1992cited by this paper
• Biotinylated dextran amine as an anterograde tracer for single- and double-labeling studies.

  1992cited by this paper
• Hoechst 33342 a suitable fluorescent marker for Schwann cells after transplantation in the mouse spinal cord.

  1991cited by this paper
• PNS‐CNS transitional zone of the first cranial nerve

  1991cited by this paper
• Criteria for Assessing Recovery of Function After Spinal Cord Injury: Behavioral Methods*,†

  1990cited by this paper
• Immunohistochemical distribution of serotonin in spinal autonomic nuclei: I. Fiber patterns in the adult rat

  1989cited by this paper
• Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway.

  1987cited by this paper
• The Rat nervous system

  1985cited by this paper
• The re-innervation of olfactory glomeruli following transection of primary olfactory axons in the central or peripheral nervous system.

  1983cited by this paper
• Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats.

  1981cited by this paper
• Neurogenesis and neuron regeneration in the olfactory system of mammals. III. Deafferentation and reinnervation of the olfactory bulb following section of thefila olfactoria in rat

  1980cited by this paper
• Degeneration and regeneration of the nervous system

  1960cited by this paper

• Beyond Transplantation: Engineering Neural Cell Therapies and Combination Strategies for Spinal Cord Repair

  2026cites this paper
• Hitchhiking Delivery Systems: Therapeutic Hydrogels as Advanced Tools for Immunomodulatory Applications.

  2025cites this paper
• Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

  2025cites this paper
• Inhibiting glucocorticoid receptors enhances adult spinal cord neural stem cell activity and improves outcomes in spinal cord injury

  2025cites this paper
• Progress and prospect of minicircle as a minimized non-viral DNA vector in gene therapy and regenerative medicine

  2025cites this paper
• Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway

  2025cites this paper
• Activation of Endogenous Spinal Cord Stem Cell Mediates Recovery Induced by Olfactory Ensheathing Cell Transplantation Following Spinal Cord Injury

  2025cites this paper
• The LINGO-1-deficient neural stem cell-derived neural tissueoid showed enhanced retention and neuronal relay in the transected spinal cord

  2024cites this paper
• The anti-inflammatory and immunomodulatory effects of olfactory ensheathing cells transplantation in spinal cord injury and concomitant pathological pain.

  2024cites this paper
• An injectable COL6-crosslinked HA-DTPH hydrogel promotes spinal tract-like structure organization during spinal cord regeneration

  2024cites this paper
• Functional nanoparticle-enabled non-genetic neuromodulation

  2023influential citation
• Differential expression of microRNAs and target genes analysis in olfactory ensheathing cell-derived extracellular vesicles versus olfactory ensheathing cells.

  2023cites this paper
• The Promising Role of a Zebrafish Model Employed in Neural Regeneration Following a Spinal Cord Injury

  2023cites this paper
• 3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration

  2023cites this paper
• Advances in Neurorestoratology-Current status and future developments.

  2023cites this paper
• Regulation of axonal regeneration after mammalian spinal cord injury

  2023cites this paper
• Three-dimensional Collagen Scaffolds in Cultures of Olfactory Ensheathing Cells Used for Severed Spinal Cord Regeneration

  2022cites this paper
• Recent Progress in Upconversion Nanomaterials for Emerging Optical Biological Applications.

  2022cites this paper
• Cell transplantation to repair the injured spinal cord.

  2022cites this paper
• Designing a Clinical Trial with Olfactory Ensheathing Cell Transplantation-Based Therapy for Spinal Cord Injury: A Position Paper

  2022cites this paper
• Nerve tissue engineering on degradable scaffold

  2022cites this paper
• Perspectives on preclinical evidence for translation in SCI

  2022cites this paper
• Association of Olfactory Bulb Transplantation with Systemic Drugs: Paclitaxel (Taxol), Ambroxol and Colchicine in a Mouse Acute Spinal Cord Injury Model: Summatory Synergy

  2022cites this paper
• Transplantation of Olfactory Ensheathing Cells: Properties and Therapeutic Effects after Transplantation into the Lesioned Nervous System

  2022cites this paper
• Transneuronal tracing to map connectivity in injured and transplanted spinal networks.

  2022cites this paper
• Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration

  2022cites this paper
• Are Cell-Based Therapies Safe and Effective in the Treatment of Neurodegenerative Diseases? A Systematic Review with Meta-Analysis

  2022influential citation
• Minocycline Enhance the Restorative Ability of Olfactory Ensheathing Cells by the Upregulation of BDNF and GDNF Expression After Spinal Cord Injury

  2021cites this paper
• Cell transplantation and secretome based approaches in spinal cord injury regenerative medicine

  2021cites this paper
• Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature

  2021cites this paper
• High-Yield Mucosal Olfactory Ensheathing Cells Restore Loss of Function in Rat Dorsal Root Injury

  2021cites this paper
• Human Embryonic Stem Cell–derived Neural Crest Cells Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats

  2021cites this paper
• Olfactory ensheathing cells: Unique glial cells promising for treatments of spinal cord injury

  2021cites this paper
• Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury.

  2021cites this paper
• Curcumin Loaded Polymeric vs. Lipid Nanoparticles: Antioxidant Effect on Normal and Hypoxic Olfactory Ensheathing Cells

  2021cites this paper
• Chemotactic TEG3 Cells’ Guiding Platforms Based on PLA Fibers Functionalized With the SDF-1α/CXCL12 Chemokine for Neural Regeneration Therapy

  2021cites this paper
• A bibliometric analysis of global research on spinal cord injury: 1999–2019

  2021cites this paper
• Combination of a Gellan Gum-Based Hydrogel With Cell Therapy for the Treatment of Cervical Spinal Cord Injury

  2020cites this paper
• Impact of Dual Cell Co-culture and Cell-conditioned Media on Yield and Function of a Human Olfactory Cell Line for Regenerative Medicine

  2020cites this paper
• Near-infrared light-triggered NO release for spinal cord injury repair

  2020cites this paper
• Regenerative medicine for spinal cord injury: focus on stem cells and biomaterials

  2020cites this paper
• EGCG modulates PKD1 and ferroptosis to promote recovery in ST rats

  2020cites this paper
• Experimental Treatment of Spinal Cord Injuries

  2020cites this paper
• Human olfactory mesenchymal stromal cells co-expressing horizontal basal and ensheathing cell proteins in culture

  2020cites this paper
• Sphingosine 1‐phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer

  2020cites this paper
• Effects of Ghrelin on Olfactory Ensheathing Cell Viability and Neural Marker Expression

  2020cites this paper
• Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration

  2020cites this paper
• Rat Models of Central Nervous System Injury

  2020cites this paper
• Dynamic changes in cytoskeleton proteins of olfactory ensheathing cells induced by radiofrequency electromagnetic fields

  2020cites this paper
• ChABC-Loaded PLGA Nanoparticles: A Comprehensive Study on Biocompatibility, Functional Recovery, and Axonal Regeneration in Animal Model of Spinal Cord Injury.

  2020cites this paper
• The plant natural product 2-methoxy-1,4-naphthoquinone stimulates therapeutic neural repair properties of olfactory ensheathing cells

  2020cites this paper
• Cell therapies for spinal cord injury regeneration

  2020cites this paper
• The leading edge: Emerging neuroprotective and neuroregenerative cell‐based therapies for spinal cord injury

  2020cites this paper
• A Brief Review of New Advances in the Treatment of Spinal Cord Injuries

  2019cites this paper
• Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection.

  2019cites this paper
• Temporal gene expression changes after acute and delayed ventral root avulsion-reimplantation

  2019cites this paper
• Spinal Cord Injury and Its Future Therapy - A Perspective

  2019cites this paper
• Electroacupuncture Facilitates the Integration of Neural Stem Cell-Derived Neural Network with Transected Rat Spinal Cord

  2019cites this paper
• Update on Stem Cell Applications in Spine Surgery

  2019cites this paper
• Monkey Recovery from Spinal Cord Hemisection: Nerve Repair Strategies for Rhesus Macaques.

  2019cites this paper
• Spinal Cord Injury (SCI) Repair Strategies

  2019cites this paper
• Transplantation of neural scaffolds consisting of dermal fibroblast-reprogrammed neurons and 3D silk fibrous materials promotes the repair of spinal cord injury.

  2019cites this paper
• Development of strategies for isolation and functional testing of cell lines for neuronal regeneration

  2019influential citation
• Diffusion tensor imaging predicting neurological repair of spinal cord injury with transplanting collagen/chitosan scaffold binding bFGF

  2019cites this paper
• Three-dimensional cell culture can be regulated by vibration: low-frequency vibration increases the size of olfactory ensheathing cell spheroids

  2019cites this paper
• Neuroprotective Effects of Combined Treatment with Minocycline and Olfactory Ensheathing Cells Transplantation against Inflammation and Oxidative Stress after Spinal Cord Injury

  2019cites this paper
• Transplantation of cultured olfactory mucosal cells rescues optic nerve axons in a rat glaucoma model.

  2019cites this paper
• Reconstruction of the Damaged Dorsal Root Entry Zone by Transplantation of Olfactory Ensheathing Cells

  2019cites this paper
• Cranial Pair I: The Olfactory Nerve

  2019cites this paper
• Stem cell/cellular interventions in human spinal cord injury: Is it time to move from guidelines to regulations and legislations? Literature review and Spinal Cord Society position statement

  2019cites this paper
• MicroRNA-125b promotes the regeneration and repair of spinal cord injury through regulation of JAK/STAT pathway.

  2018cites this paper
• Therapeutic Effect of Cell Transplantation and Chondroitinase in Rat Spinal Cord Injury

  2018cites this paper
• A Modular Assembly of Spinal Cord–Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord

  2018cites this paper
• Bioprocessing strategies to enhance the challenging isolation of neuro-regenerative cells from olfactory mucosa

  2018cites this paper
• Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices.

  2018cites this paper
• Enhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins

  2018cites this paper
• Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation

  2018influential citation
• Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

  2018influential citation
• On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations

  2018cites this paper
• Co‐Transplantation of Adipose Tissue‐Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair

  2018cites this paper
• Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease

  2018cites this paper
• Repair of Spinal Cord Injury; Mesenchymal Stem Cells as an Alternative for Schwann Cells

  2018cites this paper
• Bioprocess optimisation improves identity and potency of olfactory ensheathing cells for neurologic regeneration

  2018cites this paper
• Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats.

  2018cites this paper
• Acute Transplantation of Human Olfactory Mucosa-Derived Olfactory Ensheathing Cells Fails to Improve Locomotor Recovery in Rats

  2018cites this paper
• Efficient generation of functional Schwann cells from adipose-derived stem cells in defined conditions

  2017cites this paper
• Human Schwann cells exhibit long‐term cell survival, are not tumorigenic and promote repair when transplanted into the contused spinal cord

  2017cites this paper
• Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries

  2017cites this paper
• THE SPINAL ANESTHESIA AND COMBINED SPINAL EPIDURAL ANESTHESIA VERSUS GENERAL ANESTHESIA FOR CESAREAN SECTION IN SEVERE PREECLAMPSIA: A RANDOMIZED CONTROLLED TRIAL

  2017influential citation
• Transplantation of Cultured Olfactory Bulb Cells Prevents Abnormal Sensory Responses during Recovery from Dorsal Root Avulsion in the Rat

  2017cites this paper
• TGF‐&bgr;1 enhances phagocytic removal of neuron debris and neuronal survival by olfactory ensheathing cells via integrin/MFG‐E8 signaling pathway

  2017cites this paper
• Development of practical functional electrical stimulation cycling systems based on an electromyography study of the Cybathlon 2016

  2017cites this paper
• Current Options for Cell Therapy in Spinal Cord Injury.

  2017cites this paper
• Chronic odorant exposure upregulates acquisition of functional properties in cultured embryonic chick olfactory sensory neurons

  2017cites this paper
• Traumatic spinal cord injury

  2017cites this paper
• TREATMENT OF PERIPHERAL VASCULAR as : A 3

  2017cites this paper
• Effect of VEGF on Inflammatory Regulation, Neural Survival, and Functional Improvement in Rats following a Complete Spinal Cord Transection

  2017cites this paper
• Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with Complete Spinal Cord Transection

  2017cites this paper
• Clinical translation of stem cell based interventions for spinal cord injury — Are we there yet?

  2017cites this paper
• The protective effect of curcumin in Olfactory Ensheathing Cells exposed to hypoxia

  2017influential citation