A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury

In response to sterile liver injury, CCR2hiCX3CR1low inflammatory monocytes infiltrate the liver and form a ringlike structure around the injury site. The cells then transition into CCR2lowCX3CR1hi alternative monocytes that enter the injury site; this phenotypic transition was required for optimal repair.

• Publication year

  2015

• Venue

  Journal of Experimental Medicine

• Publication date

  2015-04-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20141539PMID 25800956PMCID 4387291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• CCR2hiCX3CR1low inflammatory monocytes transition into CCR2lowCX3CR1hi alternative monocytes within the injury context, and this phenotypic transition is required for optimal repair.

  Confidence 0.95

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• In sterile liver injury, CCR2hiCX3CR1low inflammatory monocytes infiltrate the liver and organize into a ringlike structure around the injury site.

  Confidence 0.97

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review

• ccr2hicx3cr1low inflammatory monocytes

  cell type, immune cell

  A monocyte subset characterized by high CCR2 and low CX3CR1 expression, representing the inflammatory infiltrating population in this paper.

  Aliases: CCR2+ inflammatory monocytes

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• ccr2lowcx3cr1hi alternative monocytes

  cell type, immune cell

  A monocyte subset characterized by low CCR2 and high CX3CR1 expression, representing the later state described in the injury site.

  Aliases: alternative monocytes

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• in situ reprogramming

  process, mechanism

  A local phenotypic change occurring within the tissue environment at the injury site.

  Aliases: local reprogramming

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• optimal repair

  outcome, biological process

  The level of tissue repair used as the favorable repair outcome in this injury setting.

  Aliases: repair

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• ringlike structure

  morphology, cellular structure

  A spatial arrangement in which cells accumulate in a ring around the injury site.

  Aliases: ring structure

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• sterile liver injury

  injury, condition

  Liver tissue damage without an infectious cause, used here as the injury context for monocyte responses.

  Aliases: sterile injury

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review

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