The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Clinical Cancer Research

• Publication date

  2003-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12960124
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Growth factor receptors and their ligands

  2005cited by this paper
• Greenfield's Neuropathology

  2002cited by this paper
• A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma.

  2002cited by this paper
• PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans

  2001cited by this paper
• A chromosomal region 7 p 11 . 2 transcript map : Its development and application to the study of EGFR amplicons in glioblastoma 1

  2001cited by this paper
• Cytogenetic and molecular abnormalities in astrocytic gliomas (Review).

  2000cited by this paper
• Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

  2000cited by this paper
• The relevance of cell proliferation, vascular endothelial growth factor, and basic fibroblast growth factor production to angiogenesis and tumorigenicity in human glioma cell lines.

  2000cited by this paper
• Functional and molecular analyses of 10q deletions in human gliomas

  1999cited by this paper
• Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression.

  1999cited by this paper
• Molecular pathogenesis of malignant gliomas.

  1999cited by this paper
• Frequent Co‐Alterations of TP53, p16/CDKN2A, p14ARF, PTEN Tumor Suppressor Genes in Human Glioma Cell Lines.

  1999cited by this paper
• Advances in Brief Differential Expression of MMAC / PTEN in Glioblastoma Multiforme : Relationship to Localization and Prognosis 1

  1999cited by this paper
• Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas

  1998cited by this paper
• PAX6 mutations reviewed

  1998cited by this paper
• Pathology and Genetics of Tumours of the Nervous System

  1998cited by this paper
• MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

  1997cited by this paper
• Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

  1997cited by this paper
• A Molecular Genetic Model of Astrocytoma Histopathology

  1997cited by this paper
• Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients.

  1996cited by this paper
• Pax genes and their roles in cell differentiation and development.

  1996cited by this paper
• Subsets of Glioblastoma Multiforme Defined by Molecular Genetic Analysis

  1993cited by this paper
• Analysis of the functional role of chromosome 10 loss in human glioblastomas.

  1993cited by this paper
• Loss of heterozygosity for 10q loci in human gliomas

  1992cited by this paper
• Correlation of cytogenetic analysis and loss of heterozygosity studies in human diffuse astrocytomas and mixed oligo‐astrocytomas

  1992cited by this paper
• Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region.

  1991cited by this paper
• Grading of astrocytomas: A simple and reproducible method

  1988cited by this paper
• Tumours of the Nervous System

  1986cited by this paper
• Tumours of the nervous system.

  1974cited by this paper

• Epigenetic, Genetic, and Functional Germline Alterations of PAX Genes in Human Pathology: A Comprehensive Update.

  2026cites this paper
• Pax6 as a Therapeutic Target: Convergent Molecular Pathways in the Regulation of Aniridia, Neurogenesis, Neurodegeneration and Oncology.

  2026cites this paper
• Investigation of the Expression and Regulation of SCG5 in the Context of the Chromogranin-Secretogranin Family in Malignant Tumors.

  2024cites this paper
• Role of renin angiotensin system inhibitors and metformin in Glioblastoma Therapy: a review

  2024cites this paper
• The PAX Genes: Roles in Development, Cancer, and Other Diseases

  2024cites this paper
• Whole brain morphologic features improve the predictive accuracy of IDH status and VEGF expression levels in gliomas.

  2024cites this paper
• Nanoselenium attenuates renal ischemia-reperfusion injury in rats

  2023cites this paper
• Expression pattern of phosphatase and tensin homolog and epidermal growth factor receptor in patients with brain tumor

  2023cites this paper
• Epidermal growth factor receptor (EGFR) expression in high grade glioma and relationship with histopathologic findings, a cross sectional study

  2022cites this paper
• Differential role of Pax6 and its interaction with Shh–Gli1–IDH2 axis in regulation of glioma growth and chemoresistance

  2022cites this paper
• Microglia-Derived Olfactomedin-like 3 Is a Potent Angiogenic Factor in Primary Mouse Brain Endothelial Cells: A Novel Target for Glioblastoma

  2022influential citation
• PAX6 is frequently expressed in ependymal tumours and associated with prognostic relevant subgroups

  2021cites this paper
• Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

  2021cites this paper
• Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

  2021cites this paper
• Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases.

  2020cites this paper
• Dynamic Enhancement Pattern on CT for Predicting Pancreatic Neuroendocrine Neoplasms with Low PAX6 Expression: A Retrospective Observational Study

  2020cites this paper
• Prospective evaluation of contrast-enhanced ultrasound of breast BI-RADS 3–5 lesions

  2020cites this paper
• Advances in drug development for targeted therapies for glioblastoma.

  2020cites this paper
• Anti-angiogenic therapies in the management of glioblastoma

  2020cites this paper
• N6-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling

  2019cites this paper
• Radiosensitizers in the temozolomide era for newly diagnosed glioblastoma.

  2019cites this paper
• Radiation Responses of 2D and 3D Glioblastoma Cells: A Novel, 3D-specific Radioprotective Role of VEGF/Akt Signaling through Functional Activation of NHEJ

  2019cites this paper
• Changing paradigms for targeted therapies against diffuse infiltrative gliomas: tackling a moving target

  2019cites this paper
• Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress

  2018influential citation
• DHQZ‐17, a potent inhibitor of the transcription factor HNF4A, suppresses tumorigenicity of head and neck squamous cell carcinoma in vivo

  2018cites this paper
• Microrna-136 promotes proliferation and invasion ingastric cancer cells through Pten/Akt/P-Akt signaling pathway.

  2018cites this paper
• The possibilities of contrast-enhanced ultrasoud in the diagnostic algorithm of breast lesions

  2018cites this paper
• Bevacizumab in temozolomide refractory high-grade gliomas: single-centre experience and review of the literature

  2018cites this paper
• Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer

  2018cites this paper
• EGFR as a clinical marker in glioblastomas and other gliomas

  2018cites this paper
• Vessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas

  2018cites this paper
• The role of interleukin-6-STAT3 signalling in glioblastoma

  2018cites this paper
• 12 Transcription Factor Targets as Treatment for Medulloblastoma

  2018cites this paper
• [Construction of a lentiviral vector carrying short?hairpin RNA targeting PAX6 and its effect on proliferation of glioma U251 cells in vitro].

  2017cites this paper
• The anatomical and molecular characterisation of vascular ingression in the embryonic vertebrate brain

  2017cites this paper
• TRPS1 gene alterations in human subependymoma

  2017cites this paper
• Angiogenesis inhibitors in tackling recurrent glioblastoma

  2017cites this paper
• Implication of downregulation and prospective pathway signaling of microRNA-375 in lung squamous cell carcinoma.

  2017cites this paper
• Impact of VEGFA polymorphisms on glioma risk in Chinese.

  2017cites this paper
• Bevacizumab : A Review of Use in High Grade Gliomas

  2017cites this paper
• Impact of VEGFA polymorphisms on glioma risk in Chinese

  2017cites this paper
• Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines.

  2017cites this paper
• PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma

  2016cites this paper
• Genetic Variants of VEGF (rs201963 and rs3025039) and KDR (rs7667298, rs2305948, and rs1870377) Are Associated with Glioma Risk in a Han Chinese Population: a Case-Control Study

  2016cites this paper
• Role of miR-223/paired box 6 signaling in temozolomide chemoresistance in glioblastoma multiforme cells

  2016cites this paper
• Angiopoietin-2 May Be Involved in the Resistance to Bevacizumab in Recurrent Glioblastoma

  2016influential citation
• Radiologic Features and Expression of Vascular Endothelial Growth Factor Stratify Survival Outcomes in Patients with Glioblastoma

  2016cites this paper
• PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer.

  2015cites this paper
• Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment

  2015cites this paper
• PKCδ maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback

  2015cites this paper
• Investigating the Influence of HUVECs in the Formation of Glioblastoma Spheroids in High-Throughput Three-Dimensional Microwells

  2015cites this paper
• Contrast-Enhanced Ultrasonography Features of Breast Malignancies with Different Sizes: Correlation with Prognostic Factors

  2015cites this paper
• Patient outcome in the Belgian medical need program on bevacizumab for recurrent glioblastoma

  2015cites this paper
• Association of the PTEN IVS 4 ( rs 3830675 ) Gene Polymorphism with Reduced Risk of Cancer : Evidence from a Meta-analysis

  2015cites this paper
• Association of the PTEN IVS4 (rs3830675) gene polymorphism with reduced risk of cancer: evidence from a meta-analysis.

  2015cites this paper
• Chronic inflammation: is it the driver or is it paving the road for malignant transformation?

  2015cites this paper
• mRNA expression levels of hypoxia-induced and stem cell-associated genes in human glioblastoma.

  2015cites this paper
• Anti-EGFR function of EFEMP1 in glioma cells and patient prognosis

  2014cites this paper
• Excessive levels of diverse phytoestrogens can modulate steroidogenesis and cell migration of KGN human granulosa-derived tumor cells

  2014cites this paper
• LIN28 Is Involved in Glioma Carcinogenesis and Predicts Outcomes of Glioblastoma Multiforme Patients

  2014cites this paper
• in cells

  2014cites this paper
• Evaluation of dynamic contrast-enhanced MRI derived microvascular permeability in recurrent glioblastoma treated with bevacizumab

  2014cites this paper
• Low pathogenic human enteroviruses as novel anti-cancer agents against malignant glioma

  2014influential citation
• Large volume reirradiation as salvage therapy for glioblastoma after progression on bevacizumab

  2014cites this paper
• PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells.

  2014cites this paper
• Glucose modulates Pax6 expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells.

  2014cites this paper
• Nanoparticle based strategies for the treatment of Glioblastoma

  2014cites this paper
• Downregulation of PAX6 by shRNA Inhibits Proliferation and Cell Cycle Progression of Human Non-Small Cell Lung Cancer Cell Lines

  2014cites this paper
• Efficacy and safety of bevacizumab and etoposide combination in patients with recurrent malignant gliomas who have failed bevacizumab

  2014cites this paper
• Genetic and epigenetic markers of gliomas

  2013cites this paper
• Difluorinated-Curcumin (CDF) Restores PTEN Expression in Colon Cancer Cells by Down-Regulating miR-21

  2013cites this paper
• Antivascular endothelial growth factor antibody for treatment of glioblastoma multiforme.

  2013cites this paper
• Patterns of failure after concurrent bevacizumab and hypofractionated stereotactic radiation therapy for recurrent high-grade glioma.

  2013cites this paper
• Correlation of Nrf2 and HIF-1α in glioblastoma and their relationships to clinicopathologic features and survival

  2013cites this paper
• Chemotherapeutic Agent for Glioma

  2013cites this paper
• Bevacizumab for the treatment of glioblastoma

  2013cites this paper
• Molecular prognostic factors in glioblastoma: state of the art and future challenges.

  2013cites this paper
• The Role of the Transcription Factor Pax6 in Brain Development and Evolution: Evidence and Hypothesis

  2013cites this paper
• Exploration Into the Effects of Hypoxia in an In Vitro Canine Glioblastoma Model

  2013cites this paper
• Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma.

  2013cites this paper
• Radioimmunotherapy in Brain Tumors

  2013cites this paper
• Prognostic Significance of EGFR Gene Amplification and Overexpression in Diffuse Astrocytomas—A Literature Study

  2012cites this paper
• A 205-Nucleotide Deletion in the 3′ Untranslated Region of Avian Leukosis Virus Subgroup J, Currently Emergent in China, Contributes to Its Pathogenicity

  2012cites this paper
• CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy

  2012cites this paper
• Progesterone receptor and SRC-1 participate in the regulation of VEGF, EGFR and Cyclin D1 expression in human astrocytoma cell lines.

  2012cites this paper
• Recent developments on immunotherapy for brain cancer

  2012cites this paper
• Molecular characteristics and pathways of Avastin for the treatment of glioblastoma multiforme.

  2012cites this paper
• Frequent epigenetic inactivation of the chaperone SGNE1/7B2 in human gliomas

  2012cites this paper
• Anti-VEGF strategies - from antibodies to tyrosine kinase inhibitors: background and clinical development in human cancer.

  2012cites this paper
• The Complexities of Resistance to Bevacizumab

  2012cites this paper
• 3T3 Cell Lines Stably Expressing Pax6 or Pax6(5a) – A New Tool Used for Identification of Common and Isoform Specific Target Genes

  2012cites this paper
• Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis

  2012cites this paper
• Risk and prognostic factors for malignant glioma

  2012cites this paper
• Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF‐induced oligodendroglioma

  2012cites this paper
• Regulation of the FABP7 gene by PAX6 in malignant glioma cells.

  2012cites this paper
• Reduced proliferation and excess astrogenesis of Pax6 heterozygous neural stem/progenitor cells.

  2012cites this paper
• MARCKS Regulates Growth and Radiation Sensitivity and Is a Novel Prognostic Factor for Glioma

  2012cites this paper
• IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas

  2012cites this paper
• Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies.

  2011cites this paper
• Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

  2011cites this paper