TOR complex 2–Ypk1 signaling regulates actin polarization via reactive oxygen species

TORC2/Ypk1 signaling regulates actin polarization by controlling levels of ROS. Pkc1, an established regulator of actin, acts downstream of Ypk1 to prevent ROS. TORC2/Ypk1-dependent regulation of Pkc1 requires proper localization of the GEF Rom2, which in turn is dependent on the phospholipid flippase kinase Fpk1 and complex sphingolipids.

• Publication year

  2014

• Venue

  Molecular Biology of the Cell

• Publication date

  2014-12-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1091/mbc.E14-06-1122PMID 25253719PMCID 4244204
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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