Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory

•  Perirhinal cortex (Prh) is critically involved in visual recognition memory and synaptic plasticity. •  Nitric oxide and endocannabinoids (eCBs) have been shown to act as retrograde messengers in synaptic plasticity in several brain areas, but no study has yet investigated their role in synaptic plasticity in Prh. •  Evidence is still lacking of a retrograde messenger involved in synaptic plasticity in Prh. •  In this study, we show that NO is involved in long‐term depression (LTD) but not in long‐term potentiation (LTP). Conversely, eCBs are involved in LTP but not in LTD. Crucially, inhibiition of NO signalling prevents visual recognition memory acquisition, whilst inhibition of eCB signalling does not affect recognition memory. •  These results suggest that LTD but not LTP is a neuronal correlate of visual recognition memory.

• Publication year

  2013

• Venue

  Journal of Physiology

• Publication date

  2013-05-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2013.254862PMID 23671159PMCID 3764640
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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