Agent‐based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor‐β1

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Wound Repair and Regeneration

• Publication date

  2007-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1524-475X.2007.00271.x
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The Molecular and Cellular Biology of Wound Repair

  2012cited by this paper
• THE ACUTE INFLAMMATORY RESPONSE IN DIVERSE SHOCK STATES

  2005cited by this paper
• Integrating the Results of Phase IV (Postmarketing) Clinical Trial With Four Previous Trials Reinforces the Position that Regranex (Becaplermin) Gel 0.01% Is an EffectiveAdjunct to the Treatment of Diabetic Foot Ulcers

  2005influential reference
• Agent-based computational modeling of wounded epithelial cell monolayers

  2004cited by this paper
• Mathematical models of the acute inflammatory response

  2004cited by this paper
• The epitheliome: agent-based modelling of the social behaviour of cells.

  2004cited by this paper
• In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling*

  2004cited by this paper
• In silico design of clinical trials: A method coming of age

  2004cited by this paper
• Wound healing: an overview of acute, fibrotic and delayed healing.

  2004influential reference
• Making sense of latent TGFbeta activation.

  2003influential reference
• Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity.

  2003influential reference
• Genetic Susceptibility to Keloid Disease and Hypertrophic Scarring: Transforming Growth Factor &bgr;1 Common Polymorphisms and Plasma Levels

  2003cited by this paper
• Human epidermal growth factor enhances healing of diabetic foot ulcers.

  2003cited by this paper
• Current and future use of anti-TNF agents in the treatment of autoimmune, inflammatory disorders.

  2003cited by this paper
• Making sense of latent TGFβ activation

  2003cited by this paper
• Wound-healing trajectories.

  2003cited by this paper
• Growth factors in the treatment of diabetic foot ulcers

  2003cited by this paper
• Growth factors: the wound healing therapy of the future.

  2003cited by this paper
• IL-6 signal transduction and its physiological roles: the signal orchestration model.

  2003cited by this paper
• Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection

  2002cited by this paper
• Inflammation. 2: Its role in the healing of chronic wounds.

  2002cited by this paper
• Points of control in inflammation

  2002cited by this paper
• Nitric oxide and wound repair: role of cytokines?

  2002cited by this paper
• Diabetic Foot Ulcers : Pathogenesis and Management

  2002cited by this paper
• Inflammation. 1: Its role in the healing of acute wounds.

  2002cited by this paper
• Transforming growth factor‐beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers

  2002influential reference
• Theoretical models of wound healing: past successes and future challenges.

  2002cited by this paper
• Wound healing: biologic features and approaches to maximize healing trajectories.

  2001cited by this paper
• Modeling the effects of transforming growth factor‐β on extracellular matrix alignment in dermal wound repair

  2001cited by this paper
• TGFß and IL-10: inhibitory cytokines regulating immunity and the response to infection

  2000cited by this paper
• Mathematical modelling of nitric oxide activity in wound healing can explain keloid and hypertrophic scarring.

  2000cited by this paper
• Novel Cytokine Inhibitors

  2000cited by this paper
• Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice

  2000cited by this paper
• Regulation of transforming growth factor b1 by nitric oxide

  1999influential reference
• Incidence, outcomes, and cost of foot ulcers in patients with diabetes.

  1999influential reference
• The diabetic neuropathic ulcer: an overview.

  1999cited by this paper
• Mechanism of action and in vivo role of platelet-derived growth factor.

  1999cited by this paper
• Diabetic foot ulcers: A framework for prevention and care

  1999cited by this paper
• The diabetic neuropathic ulcer: an overview.

  1999cited by this paper
• Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts.

  1998cited by this paper
• Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.

  1998cited by this paper
• Prevalence of Diabetes, Impaired Fasting Glucose, and Impaired Glucose Tolerance in U.S. Adults: The Third National Health and Nutrition Examination Survey, 1988–1994

  1998cited by this paper
• Time-dependent expression of interleukin-10 (IL-10) mRNA during the early phase of skin wound healing as a possible indicator of wound vitality

  1998cited by this paper
• Modifying the wound healing response with exogenous growth factors.

  1998cited by this paper
• Platelet releasate treatment improves skin healing in diabetic rats through endogenous growth factor secretion.

  1998influential reference
• The Molecular and Cellular Biology of Wound Repair

  1997cited by this paper
• General principles of wound healing.

  1997cited by this paper
• Randomised placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection.

  1997cited by this paper
• Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation.

  1997cited by this paper
• Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group.

  1996cited by this paper
• Increased Mortality Associated with Diabetic Foot Ulcer

  1996cited by this paper
• Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

  1996influential reference
• The effect of tumor necrosis factor-alpha on wound healing. An experimental study.

  1996cited by this paper
• A Mechanochemical Model for Adult Dermal Wound Contraction and the Permanence of the Contracted Tissue Displacement Profile

  1995cited by this paper
• Effect of Topical Basic Fibroblast Growth Factor on the Healing of Chronic Diabetic Neuropathic Ulcer of the foot: A pilot, randomized, double-blind, placebo-controlled study

  1995cited by this paper
• Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl‐l‐histidyl‐l‐lysine copper

  1994cited by this paper
• THE HEALING PROCESS

  1993cited by this paper
• Diabetic foot ulcers: pathogenesis and management.

  1993cited by this paper
• Mechanistic model of wound contraction.

  1993cited by this paper
• Cellular automata approaches to biological modeling.

  1993cited by this paper
• Randomized Prospective Double-Blind Trial in Healing Chronic Diabetic Foot Ulcers: CT-102 activated platelet supernatant, topical versus placebo

  1992cited by this paper
• Continuum model of fibroblast-driven wound contraction: inflammation-mediation.

  1992cited by this paper
• Macrophage deactivation by interleukin 10

  1991cited by this paper
• Diabetes impairs the late inflammatory response to wound healing.

  1991cited by this paper
• Wound healing in diabetes mellitus.

  1990influential reference
• Use of homologous platelet factors in achieving total healing of recalcitrant skin ulcers.

  1990cited by this paper
• Models of epidermal wound healing

  1990influential reference
• PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

  1990influential reference
• Transforming Growth Factor‐β

  1990cited by this paper
• Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats.

  1988influential reference
• Mechanochemical models for generating biological pattern and form in development

  1988cited by this paper
• Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

  1987cited by this paper
• Inhibition of fibroblast chemotaxis by recombinant human interferon γ and interferon α

  1987cited by this paper
• Inhibition of fibroblast chemotaxis by recombinant human interferon gamma and interferon alpha.

  1987cited by this paper
• Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF).

  1986cited by this paper

• TeraAgent: A Distributed Agent-Based Simulation Engine for Simulating Half a Trillion Agents

  2025cites this paper
• A mathematical model for wound healing in the reef-building coral Pocillopora damicornis.

  2024cites this paper
• Understanding the regulation of chronic wounds by tissue inhibitors of matrix metalloproteinases through mathematical modelling

  2024cites this paper
• Biochemical assessment of amniotic membrane extract for optimal application in regenerative medicine

  2024cites this paper
• Modelling the Effect of Matrix Metalloproteinases in Dermal Wound Healing

  2023cites this paper
• Extracorporeal Shockwave Therapy (ESWT) in the Management of Diabetic Foot Ulcer: A prospective randomised clinical trial.

  2023cites this paper
• Towards systems immunology of critical illness at scale: from single cell 'omics to digital twins.

  2023cites this paper
• Improvement of Skin Wound Healing for Diabetic Mice with Thermosensitive Hydrogel Combined with Insulin Injection

  2022cites this paper
• Role of Skin Stretch on Local Vascular Permeability in Murine and Cell Culture Models

  2022cites this paper
• Inhibition of TGFβ1/Smad pathway by NF-κB induces inflammation leading to poor wound healing in high glucose.

  2022cites this paper
• Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications

  2021cites this paper
• Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine

  2021cites this paper
• Diabetic Wound-Healing Science

  2021cites this paper
• Machine learning and mechanistic computational modeling of inflammation as tools for designing immunomodulatory biomaterials

  2021cites this paper
• Towards in silico Models of the Inflammatory Response in Bone Fracture Healing

  2021cites this paper
• Impact of microRNA-210 on wound healing among the patients with diabetic foot ulcer

  2021cites this paper
• Agent-based model provides insight into the mechanisms behind failed regeneration following volumetric muscle loss injury

  2021cites this paper
• Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models

  2021cites this paper
• In silico disease model: from simple networks to complex diseases

  2020cites this paper
• Integrating Data-Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma

  2020cites this paper
• Agent-Based Modeling of Wound Healing: Examples for Basic and Translational Research

  2020cites this paper
• Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing.

  2020cites this paper
• In Silico Trials and Personalized Therapy for Sepsis and Trauma

  2020cites this paper
• Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment

  2019cites this paper
• EPO protects mesenchymal stem cells from hyperglycaemic injury via activation of the Akt/FoxO3a pathway

  2019cites this paper
• The Cellular Immunity Agent Based Model (CIABM): Replicating the cellular immune response to viral respiratory infection

  2019cites this paper
• DETERMINATION OF OPTIMAL PARAMETER ESTIMATES FOR MEDICAL INTERVENTIONS IN HUMAN METABOLISM AND INFLAMMATION

  2019cites this paper
• Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization

  2019cites this paper
• The role of microRNAs in the healing of diabetic ulcers

  2019cites this paper
• Immune aging in diabetes and its implications in wound healing.

  2019cites this paper
• A mathematical model of the use of supplemental oxygen to combat surgical site infection.

  2019cites this paper
• Towards a complex systems approach in sports injury research: simulating running-related injury development with agent-based modelling

  2018cites this paper
• Wound healing and cutaneous scarring models of the human skin

  2018cites this paper
• Computational methods to model complex systems in sports injury research: agent-based modelling (ABM) and systems dynamics (SD) modelling

  2018cites this paper
• The Impact of Stochasticity and Its Control on a Model of the Inflammatory Response

  2018cites this paper
• Non‐animal models of wound healing in cutaneous repair: In silico, in vitro, ex vivo, and in vivo models of wounds and scars in human skin

  2017cites this paper
• Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome

  2017cites this paper
• Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies

  2017cites this paper
• MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing

  2017cites this paper
• Predictive Analysis of Mechanistic Triggers and Mitigation Strategies for Pathological Scarring in Skin Wounds

  2017cites this paper
• Multiscale Modeling in the Clinic: Drug Design and Development

  2016cites this paper
• Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting.

  2016cites this paper
• Erythropoietin-activated mesenchymal stem cells promote healing ulcers by improving microenvironment.

  2016cites this paper
• Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

  2016cites this paper
• Impaired T-cell differentiation in diabetic foot ulceration

  2016cites this paper
• Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis

  2016cites this paper
• Examining the Relationship between Pre-Malignant Breast Lesions, Carcinogenesis and Tumor Evolution in the Mammary Epithelium Using an Agent-Based Model

  2016cites this paper
• Computational modeling of chemo-bio-mechanical coupling: a systems-biology approach toward wound healing

  2016cites this paper
• Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death

  2016cites this paper
• Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing

  2016cites this paper
• Computational Modeling of Muscle Regeneration and Adaptation to Advance Muscle Tissue Regeneration Strategies

  2016cites this paper
• A genetic programming approach to solving optimization problems on agent-based models

  2016cites this paper
• Agent-Based Modeling and High Performance Computing

  2016cites this paper
• Mechanistic modeling of inflammation

  2016cites this paper
• Mechanistic Modeling of Critical Illness Using Equations

  2015cites this paper
• Towards Anatomic Scale Agent-Based Modeling with a Massively Parallel Spatially Explicit General-Purpose Model of Enteric Tissue (SEGMEnT_HPC)

  2015cites this paper
• The cytokine milieu of diabetic wounds

  2015cites this paper
• Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection

  2015cites this paper
• Modeling the effects of systemic mediators on the inflammatory phase of wound healing.

  2015cites this paper
• Introduction of a Framework for Dynamic Knowledge Representation of the Control Structure of Transplant Immunology: Employing the Power of Abstraction with a Solid Organ Transplant Agent-Based Model

  2015cites this paper
• Trauma in silico: Individual-specific mathematical models and virtual clinical populations

  2015cites this paper
• Experimental and theoretical approaches

  2015cites this paper
• Agent-Based Modeling and Translational Systems Biology: An Evolution in Parallel

  2015cites this paper
• Computational Identification of Mechanistic Factors That Determine the Timing and Intensity of the Inflammatory Response

  2015cites this paper
• Computational Approach To Characterize Causative Factors and Molecular Indicators of Chronic Wound Inflammation

  2014cites this paper
• High serum concentration of interleukin-18 in diabetic patients with foot ulcers.

  2014cites this paper
• The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing

  2014cites this paper
• FABRICATION AND CHARACTERIZATION OF PHYTOCHEMICALS INCORPORATED ECM-POLYMER FUNCTIONAL FILMS FOR CHRONIC WOUND HEALING

  2014cites this paper
• A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression

  2014cites this paper
• Micro/Nano-Engineering of Cells for Delivery of Therapeutics

  2014cites this paper
• A road map for computational surgery: challenges and opportunities

  2014cites this paper
• Agent-Based Model: A Surging Tool to Simulate Infectious Diseases in the Immune System

  2014influential citation
• Agent-based model of fecal microbial transplant effect on bile acid metabolism on suppressing Clostridium difficile infection: an example of agent-based modeling of intestinal bacterial infection

  2014cites this paper
• Introduction: A road map for computational surgery: Challenges and opportunities

  2014cites this paper
• Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience

  2014cites this paper
• Systems-based approaches toward wound healing

  2013cites this paper
• Translational applications of evaluating physiologic variability in human endotoxemia

  2013cites this paper
• A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury

  2013cites this paper
• Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: potential benefits for wound healing

  2013cites this paper
• Agent-based model of epithelial host-pathogen interactions in anastomotic leak.

  2013cites this paper
• Hybrid Equation/Agent-Based Model of Ischemia-Induced Hyperemia and Pressure Ulcer Formation Predicts Greater Propensity to Ulcerate in Subjects with Spinal Cord Injury

  2013cites this paper
• Histological and Transcriptional Expression differences between Diabetic Foot and Pressure Ulcers

  2013cites this paper
• Agent-Based Modeling Approaches to Multi-Scale Systems Biology: An Example Agent-Based Model of Acute Pulmonary Inflammation

  2013cites this paper
• Agent-Based Models of Wound Healing

  2013cites this paper
• Multiscale Modeling in Vascular Disease and Tissue Engineering

  2013cites this paper
• In Silico Models

  2013cites this paper
• Heart rate variability and rhythmic influences in human endotoxemia

  2013cites this paper
• Using an Agent-Based Model to Examine the Role of Dynamic Bacterial Virulence Potential in the Pathogenesis of Surgical Site Infection

  2013cites this paper
• Computational Modeling of Inflammation and Wound Healing

  2013cites this paper
• At the Interface between Acute and Chronic Inflammation: Insights from Computational Modeling

  2012cites this paper
• Impacto perjudicial del exceso agudo y crónico de glucosa en células involucradas en la cicatrización: fibroblastos, miofibroblastos y células precursoras vasculares

  2012cites this paper
• Entrainment of peripheral clock genes by cortisol.

  2012cites this paper
• Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts

  2012cites this paper
• Systems immunology: a survey of modeling formalisms, applications and simulation tools

  2012cites this paper
• The effect of intense pulsed light treatment on the expression of transforming growth factor-β in acne vulgaris

  2012cites this paper
• Glucose Toxic Effects on Granulation Tissue Productive Cells: The Diabetics' Impaired Healing

  2012cites this paper
• New concepts in the prevention of pressure sores.

  2012cites this paper
• An agent-based model of inflammation and fibrosis following particulate exposure in the lung.

  2011cites this paper
• Dynamic Models of Disease Progression: Toward a Multiscale Model of Systemic Inflammation in Humans

  2011cites this paper
• Computational Modelling of Sperm Behaviour in a 3D Virtual Oviduct

  2011cites this paper