Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Human Molecular Genetics

• Publication date

  2005-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/DDI215PMID 15961413
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic association studies.

  2005cited by this paper
• Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

  2004influential reference
• Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

  2004cited by this paper
• Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease.

  2004cited by this paper
• The C-terminal Tail of Presenilin Regulates Omi/HtrA2 Protease Activity*

  2004cited by this paper
• Genes influencing Parkinson disease onset

  2004cited by this paper
• Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi.

  2004cited by this paper
• Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi*

  2003influential reference
• Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

  2003influential reference
• DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

  2003cited by this paper
• OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain.

  2003cited by this paper
• A haplotype at the PARK3 locus influences onset age for Parkinson’s disease

  2003cited by this paper
• Neuronal degeneration and mitochondrial dysfunction.

  2003cited by this paper
• Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

  2002cited by this paper
• PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study.

  2002cited by this paper
• A susceptibility gene for late‐onset idiopathic Parkinson's disease

  2002cited by this paper
• HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*

  2002cited by this paper
• Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction*

  2002cited by this paper
• Progressive loss of striatal neurons causes motor dysfunction in MND2 mutant mice and is not prevented by Bcl-2.

  2002cited by this paper
• The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif*

  2002cited by this paper
• A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.

  2001cited by this paper
• Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes

  2001cited by this paper
• Genetic association studies

  2001cited by this paper
• Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

  2000cited by this paper
• Energetics in the pathogenesis of neurodegenerative diseases.

  2000cited by this paper
• Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia.

  1999cited by this paper
• A susceptibility locus for Parkinson's disease maps to chromosome 2p13

  1998cited by this paper
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  1998cited by this paper
• GENEPOP (version 1.2): population genetic software for exact tests and ecumenicism

  1995cited by this paper
• E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels.

  1993cited by this paper
• Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid beta-protein.

  1989cited by this paper
• IMMUNOREACTIVITY OF NEURONAL LIPOFUSCIN WITH MONOCLONAL ANTIBODIES TO THE AMYLOID BETA PROTEIN

  1988cited by this paper
• The effect of uranyl acetate on human lymphoblastoid cells (RPMI 6410) and HeLa cells.

  1982cited by this paper
• The effect of uranyl acetate on human lymphoblastoid cells (RPMI 6410) and HeLa cells.

  1982cited by this paper

• HtrA2/Omi: potential therapeutic targets for neurodegenerative diseases

  2026cites this paper
• Bases moléculaires de la maladie de Parkinson

  2026cites this paper
• An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.

  2026cites this paper
• Pathogenesis of Parkinson's Disease.

  2025cites this paper
• Genetic Variation Analysis of Essential Tremor: Insights from the China Essential Tremor Alliance Cohort

  2025cites this paper
• Identification and validation of autophagy-related genes in sepsis based on bioinformatics studies

  2025cites this paper
• Mitochondria in aging and age-associated diseases.

  2025cites this paper
• Unravelling the Role of Tyrosine and Tyrosine Hydroxylase in Parkinson's Disease: Exploring Nanoparticle-based Gene Therapies.

  2025cites this paper
• Genetic predispositions and nutritional strategies: a review of nutrigenomics in Parkinson's disease.

  2025cites this paper
• Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson’s Disease

  2025cites this paper
• Allosteric regulation of proteolytic machines unveiled by the synergy between cryo-EM and solution NMR spectroscopy

  2025cites this paper
• Mitochondrial protein import stress

  2025cites this paper
• Intracellular Effects of Lithium in Aging Neurons.

  2024cites this paper
• Formononetin Exerts Neuroprotection in Parkinson’s Disease via the Activation of the Nrf2 Signaling Pathway

  2024cites this paper
• Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson’s Disease

  2024cites this paper
• HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

  2024cites this paper
• Mitochondrial proteases modulate mitochondrial stress signalling and cellular homeostasis in health and disease.

  2024cites this paper
• Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets

  2024cites this paper
• Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease

  2024cites this paper
• Post-translational modification and mitochondrial function in Parkinson’s disease

  2024cites this paper
• Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway

  2024cites this paper
• Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease

  2024cites this paper
• Parkinson’s Disease, Parkinsonisms, and Mitochondria: the Role of Nuclear and Mitochondrial DNA

  2023cites this paper
• Upregulation of DJ-1 in Dopaminergic Neurons by a Physically-Modified Saline: Implications for Parkinson’s Disease

  2023cites this paper
• Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins

  2023cites this paper
• Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson’s Disease

  2023cites this paper
• Spoonbill positively regulates JNK signalling mediated apoptosis in Drosophila melanogaster.

  2023cites this paper
• Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders.

  2023cites this paper
• Gene signals and SNPs associated with Parkinson's disease: A nutrigenomics and computational prospective insights.

  2023cites this paper
• Insights into the Promising Prospect of Pharmacological Approaches Targeting Mitochondrial Dysfunction in Major Human Diseases: At a Glance

  2023cites this paper
• Insights on the Correlation between Mitochondrial Dysfunction and the Progression of Parkinson's Disease.

  2023cites this paper
• A Next-Generation Sequencing Study in a Cohort of Sicilian Patients with Parkinson’s Disease

  2023cites this paper
• Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo.

  2023cites this paper
• Cytosolic retention of the mitochondrial protease HtrA2 during mitochondrial protein import stress (MPIS) triggers the DELE1-HRI pathway

  2023cites this paper
• Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative Diseases

  2023cites this paper
• A sporadic Parkinson’s disease model via silencing of the ubiquitin–proteasome/E3 ligase component, SKP1A

  2023cites this paper
• HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent

  2023cites this paper
• Identification of RNA markers associated with Parkinson's disease using multiplex gene expression analysis

  2022cites this paper
• Activation of the Mitochondrial Unfolded Protein Response: A New Therapeutic Target?

  2022cites this paper
• Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway

  2022cites this paper
• Non-Canonical Roles of Apoptotic Caspases in the Nervous System

  2022cites this paper
• Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease

  2022cites this paper
• Oxidative phosphorylation mediated pathogenesis of Parkinson's disease and its implication via Akt signaling.

  2022cites this paper
• The Unfolded Protein Responses in Health, Aging, and Neurodegeneration: Recent Advances and Future Considerations

  2022influential citation
• HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia.

  2022cites this paper
• α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword

  2022cites this paper
• Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2

  2022cites this paper
• The Novel Human HtrA2 Ortholog in Zebrafish: New Molecular Insight and Challenges into the Imbalance of Homeostasis.

  2022cites this paper
• Zinc Deficiency Exacerbates Behavioral Impediments and Dopaminergic Neuron Degeneration in a Mouse Model of Parkinson Disease.

  2022cites this paper
• Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches

  2022cites this paper
• Parkin as a Molecular Bridge Linking Alzheimer’s and Parkinson’s Diseases?

  2022cites this paper
• Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease

  2022cites this paper
• Exploration of Protein Aggregations in Parkinson's Disease Through Computational Approaches and Big Data Analytics.

  2022cites this paper
• Molecular genetics of Parkinson’s disease: Contributions and global trends

  2022cites this paper
• UQCRC1 engages cytochrome c for neuronal apoptotic cell death.

  2021cites this paper
• Etiology and pathogenesis of Parkinson disease

  2021cites this paper
• Clinical Trials In Parkinson's Disease

  2021cites this paper
• Safeguarding genome integrity under heat stress in plants.

  2021cites this paper
• Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson’s Disease

  2021cites this paper
• Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

  2021cites this paper
• Recalling the pathology of Parkinson's disease; lacking exact figure of prevalence and genetic evidence in Asia with an alarming outcome: A time to step‐up

  2021cites this paper
• Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein

  2021cites this paper
• Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR

  2021cites this paper
• Loss of GSK-3β mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype.

  2021cites this paper
• Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson's disease.

  2021cites this paper
• Understanding the Multiple Role of Mitochondria in Parkinson’s Disease and Related Disorders: Lesson From Genetics and Protein–Interaction Network

  2021cites this paper
• Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

  2021cites this paper
• Mitochondrial proteases in human diseases

  2021cites this paper
• Genetics of Parkinson's disease in the Polish population.

  2021cites this paper
• Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models

  2021cites this paper
• Connecting the dots between mitochondrial dysfunction and Parkinson’s disorder: focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity

  2021cites this paper
• TRAP1 in Oxidative Stress and Neurodegeneration

  2021cites this paper
• Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis

  2021cites this paper
• The Role of Intermittent Fasting in Parkinson's Disease

  2021cites this paper
• Parkinson's in the bone

  2021cites this paper
• Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR spectroscopy

  2021cites this paper
• Clinical overview and phenomenology of movement disorders

  2021cites this paper
• Ars moriendi: Proteases as sculptors of cellular suicide.

  2021cites this paper
• VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiology.

  2020cites this paper
• The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging

  2020cites this paper
• Systematic analysis of rare variants in mitochondrial function-associated genes for autosomal-dominant Parkinson’s disease in a Chinese population

  2020influential citation
• Neural regeneration therapies for Alzheimer's and Parkinson's disease-related disorders.

  2020cites this paper
• Cell death in animal development

  2020cites this paper
• Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era

  2020cites this paper
• Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.

  2020cites this paper
• Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.

  2020cites this paper
• PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction

  2020cites this paper
• Genetic testing of FUS, HTRA2, and TENM4 genes in Chinese patients with essential tremor

  2020cites this paper
• The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi

  2020cites this paper
• Genetic predispositions of Parkinson’s disease revealed in patient-derived brain cells

  2020cites this paper
• The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells

  2020cites this paper
• Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together

  2020cites this paper
• Mitochondrial unfolded protein response: an emerging pathway in human diseases.

  2020cites this paper
• Genetic predispositions of Parkinson’s disease revealed in patient-derived brain cells

  2020cites this paper
• Keeping α-Synuclein at Bay: A More Active Role of Molecular Chaperones in Preventing Mitochondrial Interactions and Transition to Pathological States?

  2020cites this paper
• Association of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's Disease

  2020cites this paper
• Biomarker detection of Parkinson’s disease: therapy and treatment using nanomaterials

  2020cites this paper
• The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology

  2020cites this paper
• HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis.

  2020cites this paper
• Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies

  2020cites this paper