The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular and Cellular Biology

• Publication date

  2007-03-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01432-06PMID 17339329PMCID PMC1899991
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

  2006cited by this paper
• Functions of histone-modifying enzymes in development.

  2006cited by this paper
• Control of developmental regulators by Polycomb in human embryonic stem cells.

  2006influential reference
• Polycomb complexes repress developmental regulators in murine embryonic stem cells

  2006influential reference
• Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.

  2006cited by this paper
• Developmental cell biology: Regulatory networks in embryo-derived pluripotent stem cells

  2005cited by this paper
• Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

  2005cited by this paper
• Core transcriptional regulatory circuitry in human embryonic stem cells.

  2005cited by this paper
• The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.

  2005cited by this paper
• The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.

  2004cited by this paper
• Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin.

  2004cited by this paper
• Generation and characterization of methyl-lysine histone antibodies.

  2004cited by this paper
• Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

  2004cited by this paper
• SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

  2004cited by this paper
• Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development

  2004cited by this paper
• Oct‐4 Knockdown Induces Similar Patterns of Endoderm and Trophoblast Differentiation Markers in Human and Mouse Embryonic Stem Cells

  2004cited by this paper
• Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.

  2003cited by this paper
• EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer

  2003cited by this paper
• The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.

  2003cited by this paper
• Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

  2003cited by this paper
• Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

  2002cited by this paper
• Histone methyltransferase activity of a Drosophila Polycomb group repressor complex.

  2002cited by this paper
• Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

  2002cited by this paper
• Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.

  2002cited by this paper
• The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development

  2001influential reference
• Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants.

  2001cited by this paper
• Cell and tissue requirements for the gene eed during mouse gastrulation and organogenesis

  2001cited by this paper
• The Polycomb-Group GeneEzh2 Is Required for Early Mouse Development

  2001cited by this paper
• Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

  2000cited by this paper
• Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status.

  1999cited by this paper
• The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo.

  1998cited by this paper
• Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.

  1996cited by this paper
• E(z): a polycomb group gene or a trithorax group gene?

  1996cited by this paper
• In vitro differentiation of embryonic stem cells.

  1995cited by this paper
• The eed mutation disrupts anterior mesoderm production in mice.

  1995cited by this paper
• A gene product required for correct initiation of segmental determination in Drosophila

  1981cited by this paper

• Knockdown of histone H2A deubiquitinase BAP1 in human embryonic stem cells restricts their differentiation repertoire but is dispensable for maintaining their undifferentiated state.

  2026cites this paper
• Acute Depletion of Cited2 in Embryonic Stem Cells Disrupts Gene Networks Controlling Self-Renewal, Homeostasis, and Early Cell Fate Commitment

  2026cites this paper
• Novel modifiers of oncoprotein-mediated Polycomb inhibition in Drosophila melanogaster.

  2025cites this paper
• Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

  2025cites this paper
• EZH2 variants derived from cryptic splice sites govern distinct epigenetic patterns during embryonic development

  2025cites this paper
• Polycomb repressive complex 2 (PRC2) pathway’s role in cancer cell plasticity and drug resistance

  2025influential citation
• Double stranded RNA sensing is silenced during early embryonic development

  2025cites this paper
• Epigenetic control of cell identities from epiblast to gastrulation

  2025cites this paper
• Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment

  2025cites this paper
• Epigenetic regulation in early embryo development: from zygotic genome activation to the first lineage specification.

  2025cites this paper
• PRC1 and PRC2 proximal interactome in mouse embryonic stem cells.

  2025cites this paper
• KINDLE: Knowledge-Guided Distillation for Prior-Free Gene Regulatory Network Inference

  2025cites this paper
• Investigating oncoprotein-mediated chromatin dysregulation in Drosophila melanogaster uncovers novel modifiers of the developmental impact of H3 K27M and EZHIP

  2025cites this paper
• H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation

  2024cites this paper
• The apparent loss of PRC2 chromatin occupancy as an artefact of RNA depletion

  2024cites this paper
• Polycomb function in early mouse development

  2024cites this paper
• Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay.

  2024cites this paper
• H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation

  2024cites this paper
• Activation of automethylated PRC2 by dimerization on chromatin

  2024cites this paper
• Multiomic analyses reveal new targets of polycomb repressor complex 2 in Schwann lineage cells and malignant peripheral nerve sheath tumors

  2024cites this paper
• The molecular basis of cell memory in mammals: The epigenetic cycle

  2024cites this paper
• Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis

  2024cites this paper
• H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development

  2023cites this paper
• SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development

  2023cites this paper
• RUNX3 in Stem Cell and Cancer Biology

  2023cites this paper
• A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis

  2023cites this paper
• Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development

  2023cites this paper
• Epigenetic Modification Factors and microRNAs Network Associated with Differentiation of Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Cardiomyocytes: A Review

  2023cites this paper
• A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCs

  2023cites this paper
• Endotype Characterization Reveals Mechanistic Differences Across Brain Regions in Sporadic Alzheimer’s Disease

  2023cites this paper
• Alternative splicing decouples local from global PRC2 activity

  2023cites this paper
• SAFB associates with nascent RNAs and can promote gene expression in mouse embryonic stem cells

  2023cites this paper
• The impact of SWI/SNF and NuRD inactivation on gene expression is tightly coupled with levels of RNA polymerase II occupancy at promoters

  2023cites this paper
• Differentiation of hPSCs to Study PRC2 Role in Cell-Fate Specification and Neurodevelopment.

  2023cites this paper
• Imagawa–Matsumoto syndrome: SUZ12‐related overgrowth disorder

  2023cites this paper
• Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts

  2023cites this paper
• Molecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124

  2023cites this paper
• YTHDF1 facilitates PRC1‐mediated H2AK119ub in human ES cells

  2023cites this paper
• Beneficial effects of physical exercise and an orally active mGluR2/3 antagonist pro-drug on neurogenesis and behavior in an Alzheimer's amyloidosis model

  2023cites this paper
• PGC7 regulates H3K27 me3 modification by inhibiting the interaction of YY1 with PRC2.

  2023cites this paper
• RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression

  2022cites this paper
• MIT Open Access Articles Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

  2022cites this paper
• An Unanticipated Modulation of Cyclin-Dependent Kinase Inhibitors: The Role of Long Non-Coding RNAs

  2022cites this paper
• A Facile Total Synthesis of Kilogram-Scale Production of SKLB1039: A Novel and Selective Hexahydroisoquinolin-Containing EZH2 Inhibitor.

  2022cites this paper
• Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer’s disease mouse model

  2022cites this paper
• The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

  2022influential citation
• Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

  2022cites this paper
• SAFB associates with nascent RNAs to promote gene expression in mouse embryonic stem cells

  2022influential citation
• H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes

  2022cites this paper
• CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site

  2022cites this paper
• Balance between autophagy and cell death is maintained by Polycomb‐mediated regulation during stem cell differentiation

  2022cites this paper
• De Novo Polycomb Recruitment and Repressive Domain Formation

  2022influential citation
• Regulation, functions and transmission of bivalent chromatin during mammalian development

  2022cites this paper
• Snip1 and PRC2 coordinate intrinsic apoptosis, cell division, and neurogenesis in the developing brain

  2022cites this paper
• The Role of Polycomb Proteins in Cell Lineage Commitment and Embryonic Development

  2022cites this paper
• PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function

  2022cites this paper
• Polycomb Directed Cell Fate Decisions in Development and Cancer

  2022cites this paper
• Comparative proteomic analysis of insulin receptor isoform A and B signaling.

  2022cites this paper
• RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling.

  2022cites this paper
• EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation

  2022cites this paper
• Autophagy-cell death balance is maintained by Polycomb-mediated regulation during stem cell differentiation

  2022cites this paper
• Snip1–PRC2 governs the intrinsic apoptosis program in the developing brain

  2022cites this paper
• Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals

  2022cites this paper
• Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered

  2022cites this paper
• 3D chromatin architecture and transcription regulation in cancer

  2022cites this paper
• The role and mechanisms of polycomb repressive complex 2 on the regulation of osteogenic and neurogenic differentiation of stem cells

  2021cites this paper
• Endometrial Stem/Progenitor cell (ES/PC) Marker Expression Profile in Adenosarcoma and Endometrial Stromal Sarcoma.

  2021cites this paper
• JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation

  2021cites this paper
• C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells

  2021cites this paper
• Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.

  2021cites this paper
• Zebrafish Polycomb repressive complex-2 critical roles are largely Ezh2- over Ezh1-driven and concentrate during early embryogenesis

  2021influential citation
• Mammalian SWI/SNF Chromatin Remodeling Complexes in Embryonic Stem Cells: Regulating the Balance Between Pluripotency and Differentiation

  2021cites this paper
• Rbbp4 Suppresses Premature Differentiation of Embryonic Stem Cells

  2021cites this paper
• Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation

  2021cites this paper
• Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation.

  2021cites this paper
• The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2

  2021cites this paper
• Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation

  2021cites this paper
• Title: In Vitro Assessment of the Gene Expression Level of EZH-2 and P300 During Motor Neuron Differentiation of Human Cord Blood Mesenchymal Stem Cells Running Title: Effects of Shh and RA on the expression of two epigenetic regulatory genes, EZH2

  2021cites this paper
• Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator

  2021cites this paper
• Mechanisms of DNA Methylation in Virus-Host Interaction in Hepatitis B Infection: Pathogenesis and Oncogenetic Properties

  2021cites this paper
• Multi-Tissue Methylation Clocks for Age and Sex Estimation in the Common Bottlenose Dolphin

  2021cites this paper
• Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells

  2021cites this paper
• L-carnitine in a certain concentration increases expression of cell surface marker CD34 and apoptosis in the rat bone marrow CD34+ hematopoietic stem cells.

  2021cites this paper
• Coordination of EZH2 and SOX2 specifies human neural fate decision

  2021cites this paper
• Exploiting epigenetic dependencies in ovarian cancer therapy

  2021influential citation
• An EZH2‐dependent transcriptional complex promotes aberrant epithelial remodelling after injury

  2021influential citation
• Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state

  2021cites this paper
• ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements

  2021cites this paper
• RBBP4 modulates gene activity through acetylation and methylation of histone H3 lysine 27

  2021cites this paper
• In Vitro Assessment of the Gene Expression of EZH-2 and P300 During Motor Neuron Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells

  2021cites this paper
• PRC2 loss of function confers a targetable vulnerability to BET proteins in T-ALL.

  2021cites this paper
• There is another: H3K27me3-mediated genomic imprinting.

  2021cites this paper
• Overcoming the effect of ASH1L haploinsufficiency on stem cells amenability to genome editing and differentiation into the neuronal lineage – a technical report

  2021cites this paper
• Chromatin Interaction Analyses Elucidate PRC2-bound Silencers’ Roles in Mouse Development

  2020cites this paper
• Hansel, Gretel, and the Consequences of Failing to Remove Histone Methylation Breadcrumbs

  2020cites this paper
• ChromID identifies the protein interactome at chromatin marks

  2020cites this paper
• ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators

  2020cites this paper
• DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.

  2020cites this paper
• Histone Lysine Demethylase JMJD2D/KDM4D and Family Members Mediate Effects of Chronic Social Defeat Stress on Mouse Hippocampal Neurogenesis and Mood Disorders

  2020cites this paper
• Polycomb repressor complex 2 function in breast cancer (Review)

  2020cites this paper