The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Chemico-Biological Interactions

• Publication date

  1999-05-14

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0009-2797(99)00055-1PMID 10421480
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• “A” esterases and their role in regulating the toxicity of organophosphates

  2004cited by this paper
• Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity.

  1999cited by this paper
• Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

  1998influential reference
• Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.

  1997cited by this paper
• Paraoxonase (PON1) gene in mice: sequencing, chromosomal localization and developmental expression.

  1997cited by this paper
• A 192Arg variant of the human paraoxonase (HUMPONA) gene polymorphism is associated with an increased risk for coronary artery disease in the Japanese.

  1997cited by this paper
• The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.

  1996cited by this paper
• Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos.

  1996cited by this paper
• Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.

  1996cited by this paper
• The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.

  1996cited by this paper
• Paraoxonase gene polymorphism in Japanese subjects with coronary heart disease.

  1996cited by this paper
• The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin

  1996cited by this paper
• Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.

  1995cited by this paper
• Paraoxonase protects against chlorpyrifos toxicity in mice.

  1995influential reference
• A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.

  1995cited by this paper
• Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes.

  1995cited by this paper
• Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.

  1993cited by this paper
• Serum paraoxonase status: a major factor in determining resistance to organophosphates.

  1993cited by this paper
• The molecular basis of the human serum paraoxonase activity polymorphism

  1993cited by this paper
• Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification.

  1993cited by this paper
• Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures.

  1992cited by this paper
• PURIFICATION OF HUMAN SERUM PARAOXONASE/ARYLESTERASE

  1991cited by this paper
• Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence.

  1991cited by this paper
• Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.

  1991cited by this paper
• Purification of rabbit and human serum paraoxonase.

  1991cited by this paper
• Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides.

  1991cited by this paper
• Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats.

  1990cited by this paper
• Distribution and some biochemical properties of rat paraoxonase activity.

  1990cited by this paper
• The human serum paraoxonase—Polymorphism and specificity

  1988cited by this paper
• Species Differences in Serum Paraoxonase Correlate with Sensitivity to Paraoxon Toxicity

  1987cited by this paper
• Toxicology of Pesticides

  1987cited by this paper
• An improved method for phenotyping individuals for the human serum paraoxonase arylesterase polymorphism.

  1986cited by this paper
• Toxicology and the Newborn

  1985cited by this paper
• Paraoxon hydrolysis in human serum mediated by a genetically variable arylesterase and albumin.

  1984cited by this paper
• Plasma paraoxonase polymorphism: a new enzyme assay, population, family, biochemical, and linkage studies.

  1983cited by this paper
• Influence of pregnancy on parathion toxicity and disposition.

  1983cited by this paper
• A‐esterase activities in relation to the differential toxicity of pirimiphos‐methyl to birds and mammals

  1980cited by this paper
• Genetic polymorphism and interethnic variability of plasma paroxonase activity.

  1976cited by this paper
• The influence of age on the toxicity and metabolism of methyl parathion and parathion in male and female rats.

  1975cited by this paper
• Comparative toxicity of some selected pesticides in neonatal and adult rats.

  1975cited by this paper
• [Letter: Comments in response to genetically determined polymorphism of human serum paraxonase (EC 3.1.1.2) (author's transl)].

  1973cited by this paper
• Metabolic studies on the mechanisms of increased susceptibility of weaning rats to parathion.

  1972cited by this paper
• [Enzymatic hydrolysis of diethyl-p-nitrophenylphosphate (E 600) by human serum].

  1968cited by this paper
• Enzymatische Hydrolyse von Diäthyl-p-nitrophenylphosphat (E 600) durch menschliches Serum

  1968cited by this paper
• Toxicity of pesticides in young versus adult rats.

  1965cited by this paper
• COMPARISON OF ACUTE TOXICITY OF ANTICHOLINESTERASE INSECTICIDES TO WEANLING AND ADULT MALE RATS.

  1964cited by this paper
• Comparison of Acute Toxicity of Anticholinesterase Insecticides to Weanling and Adult Male Rats.∗

  1963cited by this paper
• AGE VARIATION IN PLASMA ARYLESTERASE ACTIVITY IN CHILDREN.

  1963cited by this paper
• The role of A-esterase in the acute toxicity of paraoxon, TEPP, and parathion.

  1956cited by this paper
• Serum esterases. II. An enzyme hydrolysing diethyl p-nitrophenyl phosphate (E600) and its identity with the A-esterase of mammalian sera.

  1953cited by this paper

• Impact of the nitric oxide substrate l-arginine alone and combined with atropine on malathion neuro and hepato-toxicity

  2025cites this paper
• Echinacea purpurea extract intervention for counteracting neurochemical and behavioral changes induced by bifenthrin

  2023cites this paper
• Evaluation of paraoxonase I and hemoglobin levels in farmers and agricultural workers in relation to organophosphorus and carbamate levels in their blood and urine samples: A cross sectional study

  2023cites this paper
• Chlorpyrifos and parathion regulate oxidative stress differentially through the expression of paraoxonase 2 in human neuroblastoma cell.

  2022cites this paper
• DNA damage in a Chilean population exposed to pesticides and its association with PON1 (Q192R and L55M) susceptibility biomarker

  2022cites this paper
• Effect of high fat diet on the toxicokinetics and toxicodynamics of chlorpyrifos following acute exposure in male C57BL/6J mice

  2022cites this paper
• Bioactivation and detoxification of organophosphorus pesticides in freshwater planarians shares similarities with humans

  2022cites this paper
• Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems

  2021cites this paper
• Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

  2021cites this paper
• Paraoxonase‐1 (PON1) Status Analysis Using Non‐Organophosphate Substrates

  2021cites this paper
• Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders

  2021influential citation
• The ameliorative effect of curcumin on hepatic CYP1A1 and CYP1A2 genes dysregulation and hepatorenal damage induced by fenitrothion oral intoxication in male rats.

  2021cites this paper
• Ontogeny of Drug-Metabolizing Enzymes.

  2021cites this paper
• Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment.

  2020cites this paper
• Prenatal maternal organophosphorus pesticide exposures, paraoxonase 1, and childhood adiposity in the Mount Sinai Children's Environmental Health Study.

  2020cites this paper
• Investigation of the possibilities of using PON1 enzyme activity in animal improvement

  2020cites this paper
• The effect of low dose amphetamine in rotenone-induced toxicity in a mice model of Parkinson’s disease

  2020cites this paper
• Biotransformation of warfare nerve agents

  2020cites this paper
• Methods and their Reliability for the Determination of Serum Paraoxonase 1 ( PON 1 ) Phenotypes in Acute Organophosphorus Compound Poisoning

  2019influential citation
• Paraoxonase-1 genetic polymorphisms in organophosphate metabolism.

  2019influential citation
• Characterization of Cholinesterases from Multiple Large Animal Species for Medical Countermeasure Development against Chemical Warfare Nerve Agents.

  2019cites this paper
• Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China

  2019cites this paper
• Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies.

  2019cites this paper
• Paraoxonase 1 (PON1) Q192R and L55M Polymorphisms as Potential Predisposition Factors for Chronic Lymphocytic Leukemia

  2019cites this paper
• Investigation of Potential Paraoxonase-I Inhibitors by Kinetic and Molecular Docking Studies: Chemotherapeutic Drugs.

  2019cites this paper
• Inhibition Effects of Phenolic Compounds on Human Serum Paraoxonase-1 Enzyme

  2019cites this paper
• Influence of genetic polymorphism on pesticide-induced oxidative stress

  2019cites this paper
• A New Perspective on Animal Improvement : Metabolomics

  2018cites this paper
• Cerebrolysin attenuates oxidative stress and neurodegeneration in acute malathion toxicity in the rat

  2018cites this paper
• Paraoxonase-1 polymorphisms and cerebral ischemic stroke: a pilot study in mexican patients

  2018cites this paper
• Novel Protective Effects of Brilliant Blue G in Acute Malathion Toxicity

  2018cites this paper
• Neuro- and Hepatoprotective Effects of Methylene Blue in Rats Treated with Lipopolysaccharide Endotoxin

  2018cites this paper
• Health Problems and Reproductive outcomes of Women Agricultural Workers Exposed to Organophosphate Pesticides

  2018cites this paper
• Neuroprotection by Montelukast against Rotenone-Induced Rat Brain Damage

  2018cites this paper
• Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1

  2017cites this paper
• Chapter 9 – Paraoxonase 1 and Its Clinical Relevance

  2017cites this paper
• Longitudinal assessment of occupational determinants of chlorpyrifos exposure in adolescent pesticide workers in Egypt.

  2017cites this paper
• Regain d’intérêt pour la grenade, un fruit majestueux aux multiples propriétés

  2017cites this paper
• Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers

  2016cites this paper
• Neuroprotection by Mast Cell Stabilizers and Histamine H1 Receptor Blockade in Rotenone-Induced Oxidative Stress and Nigrostriatal Damage

  2016cites this paper
• Reactive dopamine metabolites and neurotoxicity : the role of GAPDH and pesticide exposure in Parkinson's disease pathology

  2016cites this paper
• Toward optimal set of single nucleotide polymorphism investigation before IVF

  2016cites this paper
• Research Review: Environmental exposures, neurodevelopment, and child mental health - new paradigms for the study of brain and behavioral effects.

  2016cites this paper
• Methylene Blue as a Novel Neuroprotectant in Acute Malathion Intoxication

  2016cites this paper
• Multifactorial Origin of Neurodevelopmental Disorders: Approaches to Understanding Complex Etiologies

  2015cites this paper
• Correlation between PON1 gene polymorphisms and breast cancer risk: a Meta-analysis.

  2015cites this paper
• Correlation between PON 1 gene polymorphisms and breast cancer risk : a Meta-analysis

  2015cites this paper
• Approaches to Understanding Mechanisms between Environmental Chemical Exposure and Brain Development

  2015cites this paper
• Original Article Correlation between PON1 gene polymorphisms and breast cancer risk: a Meta-analysis

  2015cites this paper
• Stereospecific hydrolysis of a phosphoramidate used as an OPIDP model by human sera with PON1 192 alloforms

  2015cites this paper
• PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

  2015cites this paper
• BIO-MONITORING ON GENOTOXICITY AND GENETIC POLYMORPHISM OF XENOBIOTIC METABOLIZING GENES IN PESTICIDE EXPOSED WORKERS: A REVIEW

  2014cites this paper
• Paraoxonase 1 in neurological disorders

  2014cites this paper
• Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators

  2014cites this paper
• Gene-environment interaction and autism spectrum disorder

  2014cites this paper
• Sigara Bıraktırma İlacının ( Vareniklin ) İnsan Serum Paraoksonaz Enzimi ( PON 1 ) Üzerine Etkisi

  2014cites this paper
• Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers

  2014influential citation
• Genotyping Paraoxonase Polymorphisms in Iranian Farmers Exposed to Organophosphate Pesticides

  2014cites this paper
• Fenamiphos is recalcitrant to the hydrolysis by alloforms PON1 Q192R of human serum.

  2013cites this paper
• Prophylaxis and post-exposure treatment of intoxications caused by nerve agents and organophosphorus pesticides.

  2013cites this paper
• Cellular replacement therapy for liver disease

  2013cites this paper
• Integrating Biomarkers of Organophosphate Pesticides in an Agriculturally Exposed Population

  2013influential citation
• 1-1-2004 Structure / function analyses of human serum paraoxonase ( HuPON 1 ) mutants designed from a DFPase-like homology model

  2013cites this paper
• Longitudinal assessment of chlorpyrifos exposure and effect biomarkers in adolescent Egyptian agricultural workers

  2013cites this paper
• Ontogeny of mammalian metabolizing enzymes in humans and animals used in toxicological studies

  2012cites this paper
• PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos.

  2012cites this paper
• Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk

  2012cites this paper
• The Past and Present of Paraoxonase Enzyme: Its Role in the Cardiovascular System and Some Diseases

  2012cites this paper
• Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes

  2012cites this paper
• Immobilization of paraoxonase onto chitosan and its characterization

  2012cites this paper
• In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity

  2012cites this paper
• Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides.

  2012cites this paper
• THE PAST AND PRESENT OF PARAOXONASE ENZYME: ITS ROLE IN THE CARDIOVASCULAR SYSTEM AND SOME DISEASES PRO(LOST I SADA(NJOST ENZIMA PARAOKSONAZE: NJENA ULOGA U KARDIOVASKULARNOM SISTEMU I NEKIM BOLESTIMA

  2012cites this paper
• Evidence for diazinon-mediated inhibition of cis-permethrin metabolism and its effects on reproductive toxicity in adult male mice.

  2012cites this paper
• PARAOXONASE 1 COULD REVERSE THE OXIDATIVE CHANGES INDUCED BY TRIGLYCERIDE-RICH LIPOPROTEINS IN DIABETES

  2012cites this paper
• Sex-based differences in gene expression in hippocampus following postnatal lead exposure.

  2011cites this paper
• Prenatal Exposure to Organophosphates, Paraoxonase 1, and Cognitive Development in Childhood

  2011cites this paper
• Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides.

  2011cites this paper
• Association between male infertility and genetic variability at the PON1/2 and GSTM1/T1 gene loci.

  2011cites this paper
• Serum Paraoxonase-1 (PON-1) Genotype and Exposure to Organophosphorous Insectides—Is There a High-Risk Population?

  2011influential citation
• Genetic polymorphisms of GSTM1, GSTT1 and GSTP1 and susceptibility to DNA damage in workers occupationally exposed to organophosphate pesticides.

  2011cites this paper
• Relationship between the paraoxonase (PON1) L55M and Q192R polymorphisms and obesity in a Mexican population: a pilot study

  2011cites this paper
• Human volunteer studies investigating the potential for toxicokinetic interactions between the pesticides deltamethrin; pirimicarb and chlorpyrifos-methyl following oral exposure at the acceptable daily intake.

  2011cites this paper
• Environmental neurotoxicants and developing brain.

  2011cites this paper
• Paraoxonase levels in acute mushroom poisoning cases treated in emergency department

  2011cites this paper
• The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status.

  2010cites this paper
• Some cardiovascular therapeutics inhibit paraoxonase 1 (PON1) from human serum.

  2010cites this paper
• Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and β3‐adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes—an 8‐year prospective cohort analysis of 1297 patients

  2010cites this paper
• Paraoxonase 1 Correlates with Butyrylcholinesterase and Gamma Glutamyl Transferase in Workers Chronically Exposed to Pesticides

  2010cites this paper
• Decreased serum arylesterase activity in autism spectrum disorders.

  2010cites this paper
• Paraoxonase status and plasma butyrylcholinesterase activity in chlorpyrifos manufacturing workers

  2010influential citation
• Sensory ataxia associated with chronic organophosphate pesticide exposure

  2010cites this paper
• Clinical Toxicology of Anticholinesterase Agents in Humans

  2010cites this paper
• Evaluation of difference in the neurotoxicity produced by dermal application of chlorpyrifos on the neonatal and adult mice

  2010cites this paper
• Understanding neuromuscular weakness of acute organophosphate poisoning: the significance of metabolic energy, muscle protein degradation and amino acids.

  2010cites this paper
• ‘Dippers' flu’ and its relationship to PON1 polymorphisms

  2010cites this paper
• Evaluation of difference in the neurotoxicity produced by dermal application of chlorpyrifos on the neonatal and adult mice.

  2010cites this paper
• Effect of some analgesics on Paraoxonase-1 purified from human serum

  2009cites this paper
• Developmental Disabilities – Impairment of Children ’ s Brain Development and Function : The Role of Environmental Factors

  2009cites this paper
• Human serum paraoxonase gene polymorphisms and association with chronic symptoms of pesticide toxicity in Indian farmers

  2009cites this paper