Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6‐aminonicotinamide

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Neuroscience Research

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jnr.20154PMID 15197737
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• General aspects of neurodegeneration.

  2003cited by this paper
• Metallothioneins in human tumors and potential roles in carcinogenesis.

  2003cited by this paper
• Metallothionein‐I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte‐targeted interleukin‐6 expression

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• Astrocyte‐targeted expression of interleukin‐6 protects the central nervous system during neuroglial degeneration induced by 6‐aminonicotinamide

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• Mitochondrial fission in apoptosis, neurodegeneration and aging.

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• Induced adaptive resistance to oxidative stress in the CNS: a discussion on possible mechanisms and their therapeutic potential.

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• The role of metallothionein II in neuronal differentiation and survival.

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• Metallothionein-IIA Promotes Initial Neurite Elongation and Postinjury Reactive Neurite Growth and Facilitates Healing after Focal Cortical Brain Injury

  2003influential reference
• Cytokines: Powerful Regulators of Glial Cell Activation

  2003influential reference
• Metallothionein‐I Overexpression Decreases Brain Pathology in Transgenic Mice with Astrocyte‐Targeted Expression of Interleukin‐6

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• Mitochondrial Dysfunction and Reactive Oxygen Species in Excitotoxicity and Apoptosis: Implications for the Pathogenesis of Neurodegenerative Diseases

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• High positive frequency of antibodies to metallothionein and heat shock protein 70 in sera of patients with metal allergy

  2003cited by this paper
• M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment.

  2002cited by this paper
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  2002cited by this paper
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• Antioxidants as treatment for neurodegenerative disorders

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• Metallothionein expression and oxidative stress in the brain.

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• Degeneration of neuronal cells due to oxidative stress--microglial contribution.

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• Serial Analysis of Gene Expression Identifies Metallothionein-II as Major Neuroprotective Gene in Mouse Focal Cerebral Ischemia

  2002influential reference
• Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice.

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• Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6‐aminonicotinamide

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• Metallothionein-1+2 protect the CNS after a focal brain injury.

  2002cited by this paper
• Metallothionein-1+2 Deficiency Increases Brain Pathology in Transgenic Mice with Astrocyte-Targeted Expression of Interleukin 6

  2002influential reference
• METALLOTHIONEIN EXPRESSION AND ROLES IN THE CENTRAL NERVOUS SYSTEM

  2002cited by this paper
• Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain.

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• Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes.

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• Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose‐dependent manner

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• Immune function of astrocytes

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• Lack of interleukin-6 expression is not protective against focal central nervous system ischemia.

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• IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment.

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• Antioxidant role of metallothioneins: a comparative overview.

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• Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosis.

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• Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression.

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• Interleukin-6 expression and regulation in astrocytes.

  1999cited by this paper
• Evidence for a protective role of metallothionein-1 in focal cerebral ischemia.

  1999influential reference
• Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development.

  1999cited by this paper
• Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes.

  1999cited by this paper
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  1999cited by this paper
• Spongiform neuropathy induced in dogs by prolonged, low-level administration of 6-aminonicotinamide (6-ANA).

  1998cited by this paper
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  1998cited by this paper
• Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNS a

  1998cited by this paper
• Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6.

  1998cited by this paper
• Inhibition of NADPH supply by 6‐aminonicotinamide: effect on glutathione, nitric oxide and superoxide in J774 cells

  1998influential reference
• Metallothionein (MT) isoforms in the central nervous system (CNS): regional and cell-specific distribution and potential functions as an antioxidant.

  1998influential reference
• Effect of 6-aminonicotinamide on metabolism of astrocytes and C6-glioma cells

  1997cited by this paper
• Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice.

  1997cited by this paper
• Age-dependent susceptibility of CNS glial populations in situ to the antimetabolite 6-aminonicotinamide.

  1995cited by this paper
• Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

  1994cited by this paper
• Experimental gliopathy in the adult rat CNS: Effect on the blood‐spinal cord barrier

  1994cited by this paper
• Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

  1993cited by this paper
• Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice

  1993cited by this paper
• Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein.

  1989cited by this paper
• Glucose utilization in the central nervous system in the acute gliopathy due to 6-aminonicotinamide.

  1981cited by this paper
• Glucose utilization in the central nervous system in the acute gliopathy due to 6-aminonicotinamide.

  1981cited by this paper

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