Epistatic Rescue of Nkx2.5 Adult Cardiac Conduction Disease Phenotypes by Prospero-Related Homeobox Protein 1 and HDAC3

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Circulation Research

• Publication date

  2012-07-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.111.260695PMID 22647876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

  2011cited by this paper
• Structural remodelling of the sinoatrial node in obese old rats

  2010cited by this paper
• Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate.

  2010cited by this paper
• Developmental Origin, Growth, and Three-Dimensional Architecture of the Atrioventricular Conduction Axis of the Mouse Heart

  2010cited by this paper
• Common Variants in Cardiac Ion Channel Genes Are Associated With Sudden Cardiac Death

  2010cited by this paper
• Genome-wide association study of PR interval

  2010cited by this paper
• Heterogeneity of Genetic Modifiers Ensures Normal Cardiac Development

  2010cited by this paper
• COUP‐TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction

  2009cited by this paper
• Measuring left ventricular function in the normal, infarcted and CORM-3-preconditioned mouse heart using complex admittance-derived pressure volume loops.

  2009cited by this paper
• Specification of the Cardiac Conduction System by Transcription Factors

  2009cited by this paper
• Prox1 maintains muscle structure and growth in the developing heart

  2009cited by this paper
• Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice.

  2008cited by this paper
• Modulation of transcriptional corepressor activity of prospero‐related homeobox protein (Prox1) by SUMO modification

  2008cited by this paper
• Abstract 5272: Perinatal Loss of Nkx2-5 Results in Rapid Conduction and Contraction Defects

  2008cited by this paper
• A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.

  2007cited by this paper
• An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

  2007cited by this paper
• Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system.

  2007cited by this paper
• Virus-induced gene silencing as a tool for functional analyses in the emerging model plant Aquilegia (columbine, Ranunculaceae)

  2007cited by this paper
• Propagated Endothelial Ca2+ Waves and Arteriolar Dilation In Vivo: Measurements in Cx40BAC-GCaMP2 Transgenic Mice

  2007cited by this paper
• Chromatin immunoprecipitation: optimization, quantitative analysis and data normalization

  2007cited by this paper
• Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2‐5 expression

  2006cited by this paper
• In Brief

  2006cited by this paper
• Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants.

  2005cited by this paper
• Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis.

  2005cited by this paper
• Homeobox Protein Hop Functions in the Adult Cardiac Conduction System

  2005cited by this paper
• Haploinsufficiency of the cardiac transcription factor Nkx2‐5 variably affects the expression of putative target genes

  2005cited by this paper
• Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

  2005cited by this paper
• Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules.

  2005cited by this paper
• Architectural and functional asymmetry of the His-Purkinje system of the murine heart.

  2004cited by this paper
• The Cardiac Determination Factor, Nkx2-5, Is Activated by Mutual Cofactors GATA-4 and Smad1/4 via a Novel Upstream Enhancer*

  2004cited by this paper
• Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene.

  2004cited by this paper
• Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.

  2004cited by this paper
• Function follows form: cardiac conduction system defects in Nkx2-5 mutation.

  2004cited by this paper
• Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ‐F1 homologue

  2004cited by this paper
• Differential Regulation of Hand1 Homodimer and Hand1-E12 Heterodimer Activity by the Cofactor FHL2

  2004cited by this paper
• Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.

  2004cited by this paper
• Site of Origin and Molecular Substrate of Atrioventricular Junctional Rhythm in the Rabbit Heart

  2003cited by this paper
• Molecular and functional maturation of the murine cardiac conduction system.

  2003cited by this paper
• Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome.

  2003cited by this paper
• A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.

  2002cited by this paper
• Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site.

  2002cited by this paper
• Cardiac HCN channels: structure, function, and modulation.

  2002cited by this paper
• Elevated expression of Nkx‐2.5 in developing myocardial conduction cells

  2001cited by this paper
• Antagonistic action of Six3 and Prox1 at the γ-crystallin promoter

  2001cited by this paper
• Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.

  2001cited by this paper
• Embryonic expression of an Nkx2‐5/Cre gene using ROSA26 reporter mice

  2001cited by this paper
• The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.

  2001cited by this paper
• Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein.

  2001cited by this paper
• Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5

  2000cited by this paper
• Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.

  1999cited by this paper
• Prox1 function is required for the development of the murine lymphatic system.

  1999cited by this paper
• Child Marriage in Rajasthan

  1999cited by this paper
• Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis.

  1998cited by this paper
• Congenital heart disease caused by mutations in the transcription factor NKX2-5.

  1998cited by this paper
• NK-2 homeobox genes and heart development.

  1996cited by this paper
• Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

  1995cited by this paper
• Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.

  1994cited by this paper
• Properties of a clonal muscle cell line from rat heart.

  1976cited by this paper

• The cardiac conduction system: development, function and therapeutic targets.

  2026cites this paper
• Normal cardiac lymphatics and their mimics.

  2025cites this paper
• The open and closed case for Class I HDACs in cardiac development.

  2025cites this paper
• Role of histone deacetylase inhibitors in non-neoplastic diseases

  2024cites this paper
• Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis

  2024cites this paper
• Molecular Regulation of Cardiac Conduction System Development

  2024cites this paper
• Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases

  2023cites this paper
• Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression

  2023cites this paper
• Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy

  2023cites this paper
• HOP protein expression in the hippocampal dentate gyrus is acutely downregulated in a status epilepticus mouse model

  2021cites this paper
• Prox1 inhibits neurite outgrowth during central nervous system development

  2020cites this paper
• Development of the Cardiac Conduction System.

  2020cites this paper
• Gene-environment interaction impacts on heart development and embryo survival

  2019influential citation
• Homeobox Genes and Homeodomain Proteins: New Insights into Cardiac Development, Degeneration and Regeneration.

  2019cites this paper
• NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

  2018cites this paper
• Transcriptional regulation of the cardiac conduction system

  2018cites this paper
• Development and Function of the Cardiac Conduction System in Health and Disease

  2017cites this paper
• Transcription factor ETV1 is essential for rapid conduction in the heart.

  2016cites this paper
• Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects

  2016cites this paper
• MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

  2016cites this paper
• UNIVERSITY OF CALIFORNIA, SAN DIEGO Identification of microRNAs targeting PROX1 and their role in mediating Dilated Cardiomyopathy A thesis submitted in partial satisfaction of the requirements for the degree Master of Science in Bioengineering

  2016cites this paper
• Genetic variations involved in sudden cardiac death and their associations and interactions

  2016cites this paper
• Histone Deacetylase 3 Coordinates Heart Development Through Stage-Specific Roles in Cardiac Progenitor Cells

  2016cites this paper
• Title Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects

  2016cites this paper
• The formation and function of the cardiac conduction system

  2016cites this paper
• Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation

  2015cites this paper
• NKX2-5 Mutations in an Inbred Consanguineous Population: Genetic and Phenotypic Diversity

  2015cites this paper
• GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation

  2015cites this paper
• Ex vivo, microelectrode analysis of conduction through the AV node of wild‐type and Nkx2‐5 mutant mouse hearts as guided by a Cx40‐eGFP transgenic reporter

  2014cites this paper
• Copy number variants and the genetic enigma of congenital heart disease.

  2014cites this paper
• Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation

  2014cites this paper
• GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development

  2014cites this paper
• Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy

  2014cites this paper
• 29 – Cell Biology of the Specialized Cardiac Conduction System

  2014cites this paper
• Posttranslational modifications of histone deacetylases: implications for cardiovascular diseases.

  2014cites this paper
• DeGNServer: Deciphering Genome-Scale Gene Networks through High Performance Reverse Engineering Analysis

  2013cites this paper
• The Potential of the Epicardium to Act as a Source of Lymphatic Cells

  2013cites this paper
• Circulation Research Thematic Synopsis: Cardiac Arrhythmias

  2013cites this paper
• Circulation Research Thematic Synopsis Cardiac Arrhythmias

  2013cites this paper
• Recent advances in cardiovascular development.

  2013cites this paper
• Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation

  2013cites this paper
• Transcription factor NKX2-5: molecular structure and biological function in regulating cardiovascular precursor cells

  year unknowncites this paper