Embryonic expression of an Nkx2‐5/Cre gene using ROSA26 reporter mice

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Genesis

• Publication date

  2001-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gene.10022PMID 11783008
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.

  2001cited by this paper
• Cre recombinase: The universal reagent for genome tailoring

  2000cited by this paper
• Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart.

  2000cited by this paper
• An Nkx-dependent enhancer regulates cGATA-6 gene expression during early stages of heart development.

  2000cited by this paper
• Bone Morphogenetic Proteins Induce Cardiomyocyte Differentiation through the Mitogen-Activated Protein Kinase Kinase Kinase TAK1 and Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4

  1999cited by this paper
• Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5.

  1999influential reference
• The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.

  1999cited by this paper
• Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription.

  1999influential reference
• Generalized lacZ expression with the ROSA26 Cre reporter strain

  1999cited by this paper
• A role for GATA-4/5/6 in the regulation of Nkx2.5 expression with implications for patterning of the precardiac field.

  1999cited by this paper
• Formation of the atrioventricular septal structures in the normal mouse.

  1998cited by this paper
• Serum response factor is essential for mesoderm formation during mouse embryogenesis

  1998cited by this paper
• The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

  1998cited by this paper
• GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression

  1998cited by this paper
• Parsing the heart: genetic modules for organ assembly.

  1997cited by this paper
• CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.

  1997cited by this paper
• The cardiac transcription factors Nkx2‐5 and GATA‐4 are mutual cofactors

  1997cited by this paper
• Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish.

  1997cited by this paper
• Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.

  1997influential reference
• Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

  1997cited by this paper
• Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development.

  1996cited by this paper
• Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription

  1996cited by this paper
• The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium

  1996cited by this paper
• Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm.

  1996cited by this paper
• Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements.

  1996cited by this paper
• Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

  1995cited by this paper
• Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

  1995influential reference
• Identification of Novel DNA Binding Targets and Regulatory Domains of a Murine Tinman Homeodomain Factor, nkx-2.5(*)

  1995influential reference
• Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.

  1993influential reference
• tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.

  1993cited by this paper
• The development of the myocardium and endocardium in mouse embryos

  1992cited by this paper
• A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila.

  1990cited by this paper

• Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction

  2025cites this paper
• A retinoic acid:YAP1 signaling axis controls atrial lineage commitment

  2025cites this paper
• At early stages of heart development, the first and second heart fields are a continuum of lateral head mesoderm-derived, cardiogenic cells.

  2025cites this paper
• The open and closed case for Class I HDACs in cardiac development.

  2025cites this paper
• Tunneling nanotube-like structures regulate distant cellular interactions during heart formation.

  2025cites this paper
• Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics

  2025cites this paper
• Establishment and functional studies of a model of cardiomyopathy with cardiomyocyte-specific conditional knockout of Arhgef18

  2025cites this paper
• Fetal heart as a new local site for hematopoiesis and macrophage formation.

  2025cites this paper
• β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation

  2024influential citation
• A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment

  2024cites this paper
• Mitochondrial non-energetic function and embryonic cardiac development

  2024cites this paper
• The role of sonic hedgehog signaling in the oropharyngeal epithelium during jaw development

  2024cites this paper
• Beyond genomic studies of congenital heart defects through systematic modelling and phenotyping

  2024cites this paper
• Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5

  2023cites this paper
• γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

  2023cites this paper
• Deletion of PDK_1 Caused Cardiac Malmorphogenesis and Heart Defects Due to Profound Protein Phosphorylation Changes Mediated by SHP_2

  2023cites this paper
• Role of MicroRNAs in Arrhythmogenic Cardiomyopathy: translation as biomarkers into clinical practice.

  2023cites this paper
• Mapping oto-pharyngeal development in a human inner ear organoid model

  2023cites this paper
• The H2Bub1-deposition complex is required for human and mouse cardiogenesis

  2023cites this paper
• Sall1/4 cooperatively interact with Myocd/SRF to promote cardiomyocyte proliferation by regulating CDK/cyclin genes.

  2023cites this paper
• Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy.

  2023cites this paper
• FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells

  2023cites this paper
• WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation

  2022cites this paper
• Dynamic tissue-speci c H2Bub1 is required for human and mouse cardiogenesis

  2022cites this paper
• Functional roles of epitranscriptomic marks in the cardiovascular system and disease: a narrative review

  2022cites this paper
• Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression

  2022cites this paper
• Effects of constitutively active IKKβ on cardiac development.

  2022cites this paper
• Tissue‐Specific Roles for the Slit–Robo Pathway During Heart, Caval Vein, and Diaphragm Development

  2022cites this paper
• RBFOX2 is required for establishing RNA regulatory networks essential for heart development

  2022cites this paper
• Rho Kinases in Embryonic Development and Stem Cell Research

  2022cites this paper
• CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart

  2022cites this paper
• Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice

  2021cites this paper
• CHD4 is recruited by GATA4 and NKX2-5 silencers to repress non-cardiac gene programs in the developing heart

  2021cites this paper
• Characterization of a common progenitor pool of the epicardium and myocardium

  2021cites this paper
• Smyd1 Orchestrates Early Heart Development Through Positive and Negative Gene Regulation

  2021cites this paper
• Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology.

  2021cites this paper
• PDGFRα-Signaling Is Dispensable for the Development of the Sinoatrial Node After Its Fate Commitment

  2021cites this paper
• The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis

  2021cites this paper
• Understanding the Adult Mammalian Heart at Single-Cell RNA-Seq Resolution

  2021cites this paper
• Direct Reprogramming of Cardiac Fibroblasts to Repair the Injured Heart

  2021cites this paper
• The Role of Cell Tracing and Fate Mapping Experiments in Cardiac Outflow Tract Development, New Opportunities through Emerging Technologies

  2021cites this paper
• Cholesterol metabolic enzyme Ggpps regulates epicardium development and ventricular wall architecture integrity in mice

  2021cites this paper
• Myocardium-Specific Deletion of Rac1 Causes Ventricular Noncompaction and Outflow Tract Defects

  2021cites this paper
• Mechanisms Underlying Cardiomyocyte Development: Can We Exploit Them to Regenerate the Heart?

  2021cites this paper
• Emergence of heart and branchiomeric muscles in cardiopharyngeal mesoderm.

  2021cites this paper
• Hierarchically Structured Polystyrene-Based Surfaces Amplifying Fluorescence Signals: Cytocompatibility with Human Induced Pluripotent Stem Cell

  2021cites this paper
• Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C

  2021cites this paper
• The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart

  2020cites this paper
• Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling

  2020cites this paper
• O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1

  2020cites this paper
• 12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling

  2020cites this paper
• NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway.

  2020cites this paper
• Conjugated activation of myocardial-specific transcription of Gja5 by a pair of Nkx2-5-Shox2 co-responsive elements

  2020influential citation
• Genetic Tools to Study Cardiovascular Biology

  2020cites this paper
• OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.

  2020cites this paper
• Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development

  2020influential citation
• Activation of amino acid metabolic program in response to impaired glycolysis in cardiac HIF1 deficient mice

  2020cites this paper
• Trim33 is required for appropriate development of pre-cardiogenic mesoderm.

  2019cites this paper
• Molecular mechanisms of arrhythmogenic cardiomyopathy

  2019cites this paper
• Metabolic reprogramming from glycolysis to amino acid utilization in cardiac HIF1α deficient mice

  2019cites this paper
• Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development

  2019cites this paper
• PAN-INTACT enables direct isolation of lineage-specific nuclei from fibrous tissues

  2019cites this paper
• Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage.

  2019influential citation
• Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development

  2019cites this paper
• Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice

  2019cites this paper
• Cardiomyocyte orientation modulated by the Numb family proteins–N-cadherin axis is essential for ventricular wall morphogenesis

  2019cites this paper
• Shox2 regulates osteogenic differentiation and pattern formation during hard palate development in mice

  2019cites this paper
• Control of p21Cip by BRAP is Critical for Cardiomyocyte Cell Cycle Progression and Survival.

  2019cites this paper
• Myocardial-specific ablation of Jumonji and AT-rich interaction domain–containing 2 (Jarid2) leads to dilated cardiomyopathy in mice

  2019cites this paper
• Complex Regulation of Mitochondrial Function During Cardiac Development

  2019cites this paper
• HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.

  2019cites this paper
• Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice.

  2018cites this paper
• The regulation and function of the Hippo pathway in heart regeneration

  2018cites this paper
• Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice.

  2018cites this paper
• Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches.

  2018cites this paper
• RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects

  2018cites this paper
• Competent for commitment: you've got to have heart!

  2018cites this paper
• CHD4 and the NuRD complex directly control cardiac sarcomere formation

  2018cites this paper
• Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development

  2018cites this paper
• Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis

  2018cites this paper
• HIC2 regulates isoform switching during maturation of the cardiovascular system

  2018cites this paper
• WDR1-regulated actin dynamics is required for outflow tract and right ventricle development.

  2018cites this paper
• Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification

  2018cites this paper
• G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.

  2018cites this paper
• Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth

  2018cites this paper
• The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration

  2018cites this paper
• Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart

  2018cites this paper
• The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice

  2017cites this paper
• Re-evaluation of hypoplastic left heart syndrome from a developmental and morphological perspective

  2017cites this paper
• Generation of Nkx2‐5/CreER transgenic mice for inducible Cre expression in developing hearts

  2017cites this paper
• Sonic hedgehog is required for neural crest-dependent patterning of the intrinsic tongue musculature

  2017cites this paper
• Aryl Hydrocarbon Receptor Ablation in Cardiomyocytes Protects Male Mice From Heart Dysfunction Induced by NKX2.5 Haploinsufficiency

  2017cites this paper
• Nkx2.5 regulates endothelin converting enzyme‐1 during pharyngeal arch patterning

  2017influential citation
• HSPB7 is indispensable for heart development by modulating actin filament assembly

  2017cites this paper
• An In-vivo Analysis of SLMAP Function in the Postnatal Mouse Myocardium

  2017cites this paper
• Development and maturation of the fibrous components of the arterial roots in the mouse heart

  2017influential citation
• Explorer The dynamics of spleen morphogenesis

  2017cites this paper
• Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs

  2017influential citation
• Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function

  2017cites this paper
• YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State

  2017cites this paper