Ubiquitin crosstalk connecting cellular processes

The polypeptide ubiquitin is used in many processes as different as endocytosis, multivesicular body formation, and regulation of gene transcription. Conjugation of a single ubiquitin moiety is typically used in these processes. A polymer of ubiquitin moieties is required for tagging proteins for proteasomal degradation. Besides its role in protein degradation, ubiquitin is also engaged as mono- or polymer in intracellular signalling and DNA repair. Since free ubiquitin is present in limiting amounts in cells, changes in the demands for ubiquitin in any of these processes is likely to indirectly affect other ubiquitin modifications. For example, proteotoxic stress strongly increases poly-ubiquitylated proteins at the cost of mono-ubiquitylated histones resulting in chromatin remodelling and altered transcription. Here we discuss the interconnection between ubiquitin-dependent processes and speculate on the functional significance of the ubiquitin equilibrium as a signalling route translating cellular stress into molecular responses.

• Publication year

  2006

• Venue

  Cell Division

• Publication date

  2006-09-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1747-1028-1-21PMID 17007633PMCID 1613237
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

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• Role of Doa1 in the Saccharomyces cerevisiae DNA Damage Response

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• Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules

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• Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

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• Reading protein modifications with interaction domains

  2006cited by this paper
• Regulation of DNA repair by ubiquitylation

  2006cited by this paper
• Roles for NF-kappaB in nerve cell survival, plasticity, and disease.

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• A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

  2006influential reference
• Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

  2006cited by this paper
• Roles for NF-κB in nerve cell survival, plasticity, and disease

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• Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

  2006cited by this paper
• DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

  2006cited by this paper
• The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

  2006cited by this paper
• Drug discovery in the ubiquitin–proteasome system

  2006cited by this paper
• Proteasome inhibitors as therapeutics.

  2005cited by this paper
• Ubiquitylation and cell signaling

  2005cited by this paper
• A genomic and functional inventory of deubiquitinating enzymes.

  2005cited by this paper
• Ubiquitin and control of transcription.

  2005cited by this paper
• The nucleosome: from genomic organization to genomic regulation.

  2004cited by this paper
• Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.

  2004cited by this paper
• Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

  2004cited by this paper
• Role of histone H2A ubiquitination in Polycomb silencing

  2004cited by this paper
• CRE-Mediated Transcription Is Increased in Huntington's Disease Transgenic Mice

  2004cited by this paper
• Molecular pathways to neurodegeneration

  2004cited by this paper
• Inefficient degradation of truncated polyglutamine proteins by the proteasome

  2004cited by this paper
• Decreased cAMP Response Element-mediated Transcription

  2004cited by this paper
• Transcriptional regulation by histone ubiquitination and deubiquitination.

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• The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

  2003cited by this paper
• Ubiquitin Depletion as a Key Mediator of Toxicity by Translational Inhibitors

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• A proteomics approach to understanding protein ubiquitination

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• Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport.

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• Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

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• Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

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• [A cryptic protease couples deubiquitination and degradation by the proteasome].

  2003cited by this paper
• Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.

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• Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

  2002cited by this paper
• Review Histone Methylation: Dynamic or Static?

  2002cited by this paper
• A cryptic protease couples deubiquitination and degradation by the proteasome

  2002cited by this paper
• Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome

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• Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

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• Histone methylation: dynamic or static?

  2002cited by this paper
• Fusion Proteins with COOH-terminal Ubiquitin Are Stable and Maintain Dual Functionality in Vivo *

  2002cited by this paper
• Translating the Histone Code

  2001cited by this paper
• Mechanisms underlying ubiquitination.

  2001cited by this paper
• Ubiquitin and proteasomes: Themes and variations on ubiquitylation

  2001cited by this paper
• Impairment of the ubiquitin-proteasome system by protein aggregation.

  2001cited by this paper
• Ubiquitin and proteasomes: Protein regulation by monoubiquitin

  2001cited by this paper
• Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing.

  2001cited by this paper
• Recognition of the polyubiquitin proteolytic signal

  2000cited by this paper
• Ubiquitin in chains.

  2000cited by this paper
• Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome.

  2000cited by this paper
• Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.

  2000cited by this paper
• Getting across the nuclear pore complex.

  1999cited by this paper
• Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

  1999cited by this paper
• The ubiquitin-proteasome pathway and pathogenesis of human diseases.

  1999cited by this paper
• The ubiquitin system.

  1998cited by this paper
• Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

  1997cited by this paper
• Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response.

  1997cited by this paper
• Ubiquitin-dependent protein degradation.

  1996cited by this paper
• Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock

  1987cited by this paper
• The dynamics of ubiquitin pools within cultured human lung fibroblasts.

  1987cited by this paper
• The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates.

  1985cited by this paper
• Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the Drosophila genome.

  1982cited by this paper
• The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis.

  1982cited by this paper
• Ubiquitin — protein conjugates

  1981cited by this paper
• ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.

  1980cited by this paper
• THE QUANTITATIVE HISTOCHEMISTRY OF ENZYMES OF THE PENTOSE PHOSPHATE PATHWAY IN THE CENTRAL NERVOUS SYSTEM OF THE RAT 1

  1972cited by this paper

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  2024cites this paper
• A strict requirement in proteasome substrates for spacing between ubiquitin tag and degradation initiation elements

  2023cites this paper
• ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis

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• Genetic disruption of mammalian endoplasmic reticulum‐associated protein degradation: Human phenotypes and animal and cellular disease models

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• Ubiquitination and SUMOylation: protein homeostasis control over cancer.

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• DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers

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• Skeletal muscle atrogenes: from rodent models to human pathologies.

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• Multiple chemo-genetic interactions between a toxic metabolite and the ubiquitin pathway in yeast

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• Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome

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  2017cites this paper
• Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome system.

  2017cites this paper
• SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

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• Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity.

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• The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

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• Illuminating the ubiquitin/proteasome system.

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• Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI

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• Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

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• Upregulation and maintenance of gap junctional communication in lens cells.

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• Selective Accumulation of Aggregation-Prone Proteasome Substrates in Response to Proteotoxic Stress

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• The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation

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• Ischemia-related changes in naive and mutant forms of ubiquitin and neuroprotective effects of ubiquitin in the hippocampus following experimental transient ischemic damage.

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• The UBA-UIM Domains of the USP25 Regulate the Enzyme Ubiquitination State and Modulate Substrate Recognition

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• Identification of a Functional Network of Human Epigenetic Silencing Factors*

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• Ubiquitylation and cancer development.

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• Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.

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• Active-site directed probes to report enzymatic action in the ubiquitin proteasome system

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• Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI).

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