The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

The ubiquitin-proteasome system (UPS) has been implicated in neurodegenerative diseases based on the presence of deposits consisting of ubiquitylated proteins in affected neurons. It has been postulated that aggregation-prone proteins associated with these disorders, such as α-synuclein, β-amyloid peptide, and polyglutamine proteins, compromise UPS function, and delay the degradation of other proteasome substrates. Many of these substrates play important regulatory roles in signaling, cell cycle progression, or apoptosis, and their inadvertent stabilization due to an overloaded and improperly functioning UPS may thus be responsible for cellular demise in neurodegeneration. Over the past decade, numerous studies have addressed the UPS dysfunction hypothesis using various model systems and techniques that differ in their readout and sensitivity. While an inhibitory effect of some disease proteins on the UPS has been demonstrated, increasing evidence attests that the UPS remains operative in many disease models, which opens new possibilities for treatment. In this review, we will discuss the paradigm shift that repositioned the UPS from being a prime suspect in the pathophysiology of neurodegeneration to an attractive therapeutic target that can be harnessed to accelerate the clearance of disease-linked proteins.

• Publication year

  2014

• Venue

  Frontiers in Molecular Neuroscience

• Publication date

  2014-07-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.3389/fnmol.2014.00070PMID 25132814PMCID 4117186
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system.

  2014cited by this paper
• Regulated protein turnover: snapshots of the proteasome in action

  2014cited by this paper
• Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies

  2014cited by this paper
• The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model

  2014cited by this paper
• The unique functions of tissue-specific proteasomes.

  2014cited by this paper
• Perilous journey: a tour of the ubiquitin-proteasome system.

  2014cited by this paper
• Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

  2014cited by this paper
• Reactive glia show increased immunoproteasome activity in Alzheimer's disease.

  2013cited by this paper
• Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes*

  2013cited by this paper
• VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.

  2013cited by this paper
• Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration

  2013influential reference
• Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function.

  2013cited by this paper
• Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains.

  2013cited by this paper
• Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases

  2013cited by this paper
• Development of hybrid small molecules that induce degradation of estrogen receptor‐alpha and necrotic cell death in breast cancer cells

  2013cited by this paper
• RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

  2013cited by this paper
• Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

  2013cited by this paper
• Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

  2013cited by this paper
• Nanobodies: natural single-domain antibodies.

  2013cited by this paper
• Ubiquitin - omics reveals novel networks and associations with human disease.

  2013cited by this paper
• A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases

  2013cited by this paper
• Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7.

  2013cited by this paper
• Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy.

  2013cited by this paper
• The androgen receptor in health and disease.

  2013cited by this paper
• Why do cellular proteins linked to K63‐polyubiquitin chains not associate with proteasomes?

  2013cited by this paper
• Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

  2012cited by this paper
• The immunology of neurodegeneration.

  2012influential reference
• Heterozygosity for the proteasomal Psmc1 ATPase is insufficient to cause neuropathology in mouse brain, but causes cell cycle defects in mouse embryonic fibroblasts.

  2012cited by this paper
• Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin.

  2012cited by this paper
• The pathways of mitophagy for quality control and clearance of mitochondria

  2012cited by this paper
• Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress*

  2012cited by this paper
• Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

  2012cited by this paper
• Non-canonical ubiquitin-based signals for proteasomal degradation

  2012cited by this paper
• RPN-6 determines C. elegans longevity under proteotoxic stress conditions

  2012cited by this paper
• Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688

  2012cited by this paper
• Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

  2012cited by this paper
• The ubiquitin code.

  2012influential reference
• Treatment with a coinducer of the heat shock response delays muscle denervation in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

  2012cited by this paper
• Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease

  2012cited by this paper
• Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease

  2012cited by this paper
• Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

  2012cited by this paper
• The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.

  2011cited by this paper
• The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

  2011cited by this paper
• The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together

  2011cited by this paper
• Alzheimer's Disease‐Associated Ubiquilin‐1 Regulates Presenilin‐1 Accumulation and Aggresome Formation

  2011cited by this paper
• Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

  2011influential reference
• Cdc48: a power machine in protein degradation.

  2011cited by this paper
• The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

  2011cited by this paper
• Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis

  2011cited by this paper
• Fluorescent fusion protein knockout mediated by anti-GFP nanobody

  2011cited by this paper
• The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity

  2011influential reference
• B2 attenuates polyglutamine‐expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy

  2010cited by this paper
• Assembly, structure, and function of the 26S proteasome.

  2010cited by this paper
• Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

  2010cited by this paper
• The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

  2010cited by this paper
• VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

  2010cited by this paper
• Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres.

  2010cited by this paper
• Exome sequencing reveals VCP mutations as a cause of familial ALS.

  2010influential reference
• Parkin Directly Modulates 26S Proteasome Activity

  2010cited by this paper
• Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.

  2010cited by this paper
• Selective autophagy: ubiquitin-mediated recognition and beyond

  2010cited by this paper
• Repeat expansion disease: progress and puzzles in disease pathogenesis

  2010influential reference
• Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14

  2010cited by this paper
• Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation

  2010influential reference
• Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome

  2010cited by this paper
• The small heat shock protein B 8 ( HspB 8 ) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis ( ALS )

  2010cited by this paper
• P2‐281: Alzheimer's disease‐associated ubiquilin‐1 regulates presenilin‐1 accumulation and aggresome formation

  2010cited by this paper
• VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death*

  2009cited by this paper
• The Ubiquitin-Proteasome Reporter GFPu Does Not Accumulate in Neurons of the R6/2 Transgenic Mouse Model of Huntington's Disease

  2009influential reference
• Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

  2009cited by this paper
• Recognition and processing of ubiquitin-protein conjugates by the proteasome.

  2009cited by this paper
• 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse.

  2009cited by this paper
• UvA-DARE ( Digital Academic Repository ) Dynamics of ataxin-1 in spinocerebellar ataxia type 1

  2009cited by this paper
• Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy.

  2009cited by this paper
• Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

  2009influential reference
• The role of ubiquitin linkages on α‐synuclein induced‐toxicity in a Drosophila model of Parkinson’s disease

  2009cited by this paper
• Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis.

  2009influential reference
• Dynamics and diversity in autophagy mechanisms: lessons from yeast

  2009cited by this paper
• Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease*

  2009influential reference
• Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

  2009cited by this paper
• Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

  2009cited by this paper
• Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity.

  2008cited by this paper
• CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins.

  2008cited by this paper
• The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63 Linkages in Mixed Linkage Ubiquitin Chains*

  2008cited by this paper
• Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer

  2008cited by this paper
• Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice

  2008influential reference
• Proteasomes Cleave at Multiple Sites within Polyglutamine Tracts

  2008cited by this paper
• Aβ inhibits the proteasome and enhances amyloid and tau accumulation

  2008influential reference
• Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

  2008influential reference
• Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.

  2008cited by this paper
• Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.

  2008cited by this paper
• Misfolded proteins partition between two distinct quality control compartments

  2008cited by this paper
• Disease-associated prion protein oligomers inhibit the 26S proteasome.

  2007cited by this paper
• Trinucleotide repeat disorders.

  2007cited by this paper
• Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells

  2007influential reference
• Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

  2007influential reference
• Puromycin‐sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation

  2007cited by this paper
• Aggregation and proteasome: the case of elongated polyglutamine aggregation in spinal and bulbar muscular atrophy.

  2007cited by this paper
• Mutation of SOD1 in ALS: a gain of a loss of function.

  2007cited by this paper
• Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity.

  2007cited by this paper

• Novel Small-Molecule Analogues of IU1 Ameliorate Amyloid-β Mediated Toxicity in Alzheimer's Disease Cell and Worm Models.

  2026cites this paper
• Transcriptomic signatures of gray matter volume loss in cerebral small vessel disease.

  2026cites this paper
• Misfolded Proteins and Cognitive Decline: Mechanistic Insights into Neurodegenerative Disorders

  2026cites this paper
• Physiological and Transcriptomic Responses of the Freshwater Hydrozoan Craspedacusta sowerbii to Acute Antibiotic and Cadmium Exposure

  2026cites this paper
• Transcriptomic integration nominates FOXN2 as a candidate schizophrenia risk gene.

  2026cites this paper
• Small-molecule activators of NRF1 transcriptional activity prevent protein aggregation.

  2025cites this paper
• The Lenti-Prion hypothesis for sporadic Parkinson’s disease: integrating perinatal latent infection, triggered Alpha-synuclein misfolding/propagation, and the PNEI axis with selective dopaminergic vulnerability

  2025cites this paper
• Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neuropsychiatric disorders

  2025cites this paper
• Genotype-by-environment interactions shape ubiquitin-proteasome system activity

  2025cites this paper
• Proteostasis signatures in human diseases

  2025cites this paper
• Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?

  2025cites this paper
• Substrate structure determines p97- and RAD23A/B-mediated proteasomal degradation in human cells

  2025cites this paper
• Chemical and Biological Mechanisms Relevant to the Rescue of MG-132-Treated Neurons by Cysteine

  2025cites this paper
• DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies

  2025cites this paper
• Modulation of the Ubiquitin-Proteasome System by Circulating (Poly)phenol-Derived Metabolites: Implications for Chronic Diseases.

  2025cites this paper
• Next-generation cell lines for profiling different proteasome forms and their implications in cancer

  2025cites this paper
• Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders

  2025cites this paper
• Benchmarking In-Cell Proteomics for Profiling Neuroblastoma Cell Differentiation and the Ubiquitin-Proteasome System.

  2025cites this paper
• PEST Proteolysis Signals Containing Nuclear Protein Related Proteins in Eye and Eye Diseases:A Review.

  2025cites this paper
• Protein misfolding and neurodegeneration: Mechanisms, implications, and therapeutic strategies.

  2025cites this paper
• Molecular hallmarks of neurodegeneration in polyglutamine spinocerebellar ataxias

  2025cites this paper
• Protein quality control systems in neurodegeneration – culprits, mitigators, and solutions?

  2025cites this paper
• Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease

  2025cites this paper
• Aagab-driven SHIP2 degradation rescues mitochondrial dysfunction in hypoxic-ischemic encephalopathy.

  2025cites this paper
• Gene network analysis of Plasmodium falciparum ubiquitin-proteasomal system pathways reveals co-expression of the E1, E2 and E3 enzymes during intraerythrocytic cycle

  2025cites this paper
• Ubiquitin C‐Terminal Hydrolase L1 (UCHL1), Beyond Hydrolysis

  2025cites this paper
• Genotype-by-environment interactions shape ubiquitin-proteasome system activity

  2024cites this paper
• Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS

  2024cites this paper
• Recent pharmacological insights on abating toxic protein species burden in neurological disorders: Emphasis on 26S proteasome activation.

  2024cites this paper
• Proteostasis in neurodegenerative diseases.

  2024cites this paper
• Ketorolac disturbs proteasome functions and induces mitochondrial abnormality‐associated apoptosis

  2024cites this paper
• Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration

  2024cites this paper
• The Role of Ubiquitination in Osteosarcoma Development and Therapies

  2024cites this paper
• Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

  2024cites this paper
• AM404 Analogs as Activators of the 20S Isoform of the Human Proteasome

  2024cites this paper
• Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks

  2024cites this paper
• UBE3A: Bridging the gap between neurodevelopment, neural function, and neurodegenerative woes

  2024cites this paper
• Therapeutic approaches in proteinopathies.

  2024cites this paper
• A nuclear protein quality control system for elimination of nucleolus-related inclusions

  2024cites this paper
• Polyglutamine disorders: Pathogenesis and potential drug interventions.

  2024cites this paper
• Mitochondrial Dysfunction Causes Cell Death in Patients Affected by Fragile-X-Associated Disorders

  2024cites this paper
• Protacs in cancer therapy: mechanisms, design, clinical trials, and future directions

  2024cites this paper
• Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling.

  2023cites this paper
• Changes in the Activity and Content of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice

  2023cites this paper
• A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish

  2023cites this paper
• Parkinson’s Disease: Exploring Different Animal Model Systems

  2023cites this paper
• Copper homeostasis and the ubiquitin proteasome system

  2023cites this paper
• RNA polymerase II-associated proteins reveal pathways affected in VCP-related amyotrophic lateral sclerosis

  2023cites this paper
• The Involvement of Post-Translational Modifications in Regulating the Development and Progression of Alzheimer’s Disease

  2023cites this paper
• A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant.

  2023cites this paper
• Selective Inhibition of Kinase Activity in Mammalian Cells by Bioorthogonal Ligand Tethering.

  2023cites this paper
• Role of Cytokines and Reactive oxygen species in Brain Aging.

  2023cites this paper
• The Role of the Proteasome in Limiting Cellular Stress Associated with Protein Accumulation

  2023cites this paper
• Big versus small: The impact of aggregate size in disease

  2023cites this paper
• Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage

  2023cites this paper
• Insights into the promising prospect of medicinal chemistry studies against neurodegenerative disorders.

  2023cites this paper
• Cerebrospinal fluid ubiquitin as a biomarker for neurodegenerative diseases: A systematic review

  2023cites this paper
• Proteasome gene expression is controlled by the coordinated functions of multiple transcription factors

  2023cites this paper
• Changes in the Activities and Contents of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice

  2023cites this paper
• Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

  2023cites this paper
• 1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases.

  2023cites this paper
• Amyloidosis-history and development, emphasis on insulin and prion amyloids

  2023cites this paper
• Itraconazole Confers Cytoprotection Against Neurodegenerative Disease-Associated Abnormal Protein Aggregation

  2023cites this paper
• Methods for In Vivo Characterization of Proteostasis in the Mouse Retina.

  2023cites this paper
• Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness

  2023cites this paper
• RNA polymerase II-associated proteins reveal pathways affected in neural precursors with VCP mutation

  2023cites this paper
• Structural and biochemical alterations in dendritic spines as key mechanisms for severe mental illnesses.

  2023cites this paper
• The Role of Immunoproteasomes in Tumor-Immune Cell Interactions in Melanoma and Colon Cancer

  2022cites this paper
• Structural Basis for Chaperone‐Independent Ubiquitination of Tau Protein by Its E3 Ligase CHIP

  2022cites this paper
• Deubiquitinases in Neurodegeneration

  2022cites this paper
• Modulation of Ubiquitin Signaling in Innate Immune Response by Herpesviruses

  2022cites this paper
• Modulation of the Ubiquitin-Proteasome System Restores Plasticity in Hippocampal Pyramidal Neurons of the APP/PS1 Alzheimer’s Disease-Like Mice

  2022cites this paper
• Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson’s Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis

  2022cites this paper
• The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator

  2022influential citation
• Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD

  2022cites this paper
• APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease

  2022cites this paper
• Therapeutic Effects of Low-Level Laser Therapy on Cognitive Symptoms of Patients with Dementia: A Double-Blinded Randomized Clinical Trial

  2022cites this paper
• Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models

  2022cites this paper
• Mechanistic models of α-synuclein homeostasis for Parkinson's disease: A blueprint for therapeutic intervention

  2022cites this paper
• Disruption of male fertility-critical Dcaf17 dysregulates mouse testis transcriptome

  2022cites this paper
• Exploring the Role of Ubiquitin–Proteasome System in Parkinson's Disease

  2022cites this paper
• A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo

  2022cites this paper
• Role of Ubiquitin–Proteasome and Autophagy-Lysosome Pathways in α-Synuclein Aggregate Clearance

  2022cites this paper
• ALS sensitive spinal motor neurons enter a degenerative downward spiral of impaired splicing and proteostasis

  2022cites this paper
• Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering.

  2022cites this paper
• Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa

  2022cites this paper
• Novel gene–intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy

  2022cites this paper
• Cav3 T-Type Voltage-Gated Ca2+ Channels and the Amyloidogenic Environment: Pathophysiology and Implications on Pharmacotherapy and Pharmacovigilance

  2022cites this paper
• Phylogenomic analysis of 20S proteasome gene family reveals stress-responsive patterns in rapeseed (Brassica napus L.)

  2022cites this paper
• Targeting Alzheimer's disease neuronal mitochondria as a therapeutic approach

  2021cites this paper
• Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease

  2021cites this paper
• Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

  2021cites this paper
• Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson’s Disease

  2021cites this paper
• ‘A’

  2021cites this paper
• Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy

  2021cites this paper
• VPS35 Downregulation Alters Degradation Pathways in Neuronal Cells

  2021cites this paper
• A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease

  2021cites this paper
• Substrate-specific effects of natural genetic variation on proteasome activity

  2021cites this paper
• Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

  2021cites this paper
• Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system.

  2021cites this paper