Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

B. Riley,S. Kaiser,T. Shaler,Aylwin Ng,Taichi Hara,M. Hipp,K. Lage,R. Xavier,K. Ryu,K. Taguchi,Masayuki Yamamoto,Keiji Tanaka,N. Mizushima,M. Komatsu,R. Kopito

Published 2010 in Journal of Cell Biology

ABSTRACT

Inactivation of the essential autophagy gene Atg5 results in selective accumulation of aggregation-prone proteins independently of substrate ubiquitination.

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