The chemical and biological versatility of riboflavin.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Biochemical Society Transactions

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BST0280283PMID 10961912
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• On the interpretation of quantitative structure-function activity relationship data for lactate oxidase.

  2000cited by this paper
• Influence of Flavin Analogue Structure on the Catalytic Activities and Flavinylation Reactions of Recombinant Human Liver Monoamine Oxidases A and B*

  1999cited by this paper
• Molecular characterization of mitochondrial apoptosis-inducing factor

  1999cited by this paper
• A Homolog of Old Yellow Enzyme in Tomato

  1999cited by this paper
• Substrate recognition by "password" in p-hydroxybenzoate hydroxylase.

  1999cited by this paper
• Use of free energy relationships to probe the individual steps of hydroxylation of p-hydroxybenzoate hydroxylase: studies with a series of 8-substituted flavins.

  1999cited by this paper
• The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis.

  1998cited by this paper
• The Oxidative Half-reaction of Old Yellow Enzyme

  1998cited by this paper
• Molecular cloning and characterization of 12-oxophytodienoate reductase, an enzyme of the octadecanoid signaling pathway from Arabidopsis thaliana. Structural and functional relationship to yeast old yellow enzyme.

  1997cited by this paper
• Flavin conformational changes in the catalytic cycle of p-hydroxybenzoate hydroxylase substituted with 6-azido- and 6-aminoflavin adenine dinucleotide.

  1997cited by this paper
• Three-dimensional structure of porcine kidney D-amino acid oxidase at 3.0 A resolution.

  1996cited by this paper
• Crystal structure of D-amino acid oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2.

  1996cited by this paper
• Bacterial morphinone reductase is related to Old Yellow Enzyme.

  1995cited by this paper
• Structure and mechanism of para‐hydroxybenzoate hydroxylase

  1995cited by this paper
• Old Yellow enzyme: aromatization of cyclic enones and the mechanism of a novel dismutation reaction.

  1995cited by this paper
• A New Old Yellow Enzyme of Saccharomyces cerevisiae(*)

  1995cited by this paper
• Structure and mechanism of action of the Acyl‐CoA dehydrogenases 1

  1995cited by this paper
• Xanthine oxidase and xanthine dehydrogenase

  1995cited by this paper
• FLAVINS AND FLAVOPROTEINS 1993

  1994cited by this paper
• Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring.

  1994cited by this paper
• The mobile flavin of 4-OH benzoate hydroxylase.

  1994cited by this paper
• Old yellow enzyme at 2 A resolution: overall structure, ligand binding, and comparison with related flavoproteins.

  1994cited by this paper
• Spectral detection of an intermediate preceding the excited state in the bacterial luciferase reaction.

  1993cited by this paper
• Old Yellow Enzyme. The discovery of multiple isozymes and a family of related proteins.

  1993cited by this paper
• The reaction of no with superoxide.

  1993cited by this paper
• Purification and properties of milk xanthine dehydrogenase.

  1992cited by this paper
• Communication between the active sites in dimeric mercuric ion reductase: an alternating sites hypothesis for catalysis.

  1991cited by this paper
• Molecular structure of flavocytochrome b2 at 2.4 A resolution.

  1990cited by this paper
• Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase.

  1990cited by this paper
• The active site of spinach glycolate oxidase.

  1989cited by this paper
• Differences in redox and kinetic properties between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase.

  1989cited by this paper
• Riboflavin-binding proteins.

  1988cited by this paper
• Stereochemistry and accessibility of prosthetic groups in flavoproteins.

  1988cited by this paper
• DNA repair catalyzed by Escherichia coli DNA photolyase containing only reduced flavin: elimination of the enzyme's second chromophore by reduction with sodium borohydride.

  1987cited by this paper
• Lessons from biodegradation.

  1987cited by this paper
• The heterogeneity of brewer's yeast old yellow enzyme.

  1986cited by this paper
• New flavins for old: artificial flavins as active site probes of flavoproteins.

  1986cited by this paper
• Potentiometric studies of native and flavin-substituted Old Yellow Enzyme.

  1985cited by this paper
• The voyage of the challenger.

  1983cited by this paper
• Pregnancy suppression by active immunization against gestation-specific riboflavin carrier protein.

  1982cited by this paper
• Mechanistic studies on cyclohexanone oxygenase.

  1982cited by this paper
• Oxidation-reduction states of FMN and FAD in NADPH-cytochrome P-450 reductase during reduction by NADPH.

  1982cited by this paper
• Lipoamide dehydrogenase from pig heart. Pyridine nucleotide induced changes in monoalkylated two-electron reduced enzyme.

  1981cited by this paper
• Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase.

  1981cited by this paper
• Active site probes of flavoproteins. Determination of the solvent accessibility of the flavin position 8 for a series of flavoproteins.

  1981cited by this paper
• Studies on the catalytic mechanism of lactate oxidase. Formation of enantiomeric flavin-N(5)-glycollyl adducts via carbanion intermediates.

  1980cited by this paper
• Properties of flavins where the 8-methyl group is replaced by mercapto- residues.

  1979cited by this paper
• 8-Mercaptoflavins as active site probes of flavoenzymes.

  1979cited by this paper
• Identification of the high and low potential flavins of liver microsomal NADPH-cytochrome P-450 reductase.

  1978cited by this paper
• Reaction of 3O2 with dihydroflavins. 1. N3,5-dimethyl-1,5-dihydrolumiflavin and 1,5-dihydroisoalloxazines.

  1977cited by this paper
• Flavin-oxygen derivatives involved in hydroxylation by p-hydroxybenzoate hydroxylase.

  1976cited by this paper
• Interaction of phenols with old yellow enzyme. Physical evidence for charge-transfer complexes.

  1976cited by this paper
• The mechanism of action of xanthine oxidase.

  1974cited by this paper
• Redox properties of the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 and reduced nicotinamide adenine dinucleotide-cytochrome b5 reductases.

  1974cited by this paper
• Milk xanthine oxidase type D (dehydrogenase) and type O (oxidase). Purification, interconversion and some properties.

  1973cited by this paper
• Studies on the elimination reaction of D-amino acid oxidase with -amino- -chlorobutyrate. Further evidence for abstraction of substrate -hydrogen as a proton.

  1973cited by this paper
• Spectral properties of an oxygenated luciferase-flavin intermediate isolated by low-temperature chromatography.

  1973cited by this paper
• Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate.

  1973cited by this paper
• Studies on the mechanism of action of D-amino acid oxidase. Evidence for removal of substrate -hydrogen as a proton.

  1971cited by this paper
• On the existence of spectrally distinct classes of flavoprotein semiquinones. A new method for the quantitative production of flavoprotein semiquinones.

  1966cited by this paper

• Riboflavin modification of zero-valent iron turns peroxydisulfate activation pathway toward dominant singlet oxygen production for targeted tetracycline resistance elimination

  2026cites this paper
• The Reductive Power of Flavin Mononucleotide Does Not Dictate the Product Profile of the Nitroreductase, NfsA.

  2026cites this paper
• Organic Cofactors in the Electron Transport Chain: Properties and Connection to the Prebiotic World

  2026cites this paper
• Measurement and Control of Crossed Potentials in a Flavoprotein.

  2026cites this paper
• Photoenzymatic Csp3-Csp3 bond formation via enzyme-templated radical-radical coupling.

  2026cites this paper
• Alteration of Flavin Homeostasis in Uterine Cancer

  2026cites this paper
• It's not all about PFAS: Metal(loid)s are associated with physiological and metabolic changes in a native frog from conservation wetlands.

  2025cites this paper
• Blue Light (λ = 453 nm) Significantly Reduces TGF-β-Induced Fibroblast Differentiation Through Reversible Disruption of Mitochondrial Respiration, Glycolysis, and ATP Production Rate

  2025cites this paper
• A scalable equivariant graph network framework for precise protein function prediction

  2025cites this paper
• Structure and reaction mechanisms of a two-component indole monooxygenase from Acinetobacter baumannii.

  2025cites this paper
• Introduction of magneto-fluorescence fluctuation microspectroscopy for investigating quantum effects in biology

  2025cites this paper
• Entabolons: How Metabolites Modify the Biochemical Function of Proteins and Cause the Correlated Behavior of Proteins in Pathways

  2025cites this paper
• Flavin transferase ApbE: From discovery to applications

  2025cites this paper
• Riboflavin-sensitized photoinduced degradation of donepezil hydrochloride: kinetic and computational insights for pharmaceutical formulation

  2025cites this paper
• π-π stacking interactions in tryptophan-lumiflavin-tyrosine: a structural model for riboflavin insertion into riboflavin-binding protein

  2025cites this paper
• Shining light on flavin mononucleotide

  2025cites this paper
• Microbial 2-Enoate Reductases Containing Covalently Bound Flavin Mononucleotide

  2025influential citation
• Engineering Tetrahydrodaidzein Reductase to Eliminate Reverse Catalysis for Efficient Biosynthesis of (S)-Equol.

  2025cites this paper
• Phosphorus counters arsenic phytotoxicity in wheat by activating riboflavin-mediated defense response rather than reducing arsenic accumulation.

  2025cites this paper
• Deletion of RAP1 affects iron homeostasis, azole resistance, and virulence in Candida albicans

  2025cites this paper
• Blue light-promoted photodegradation of decyl-riboflavin in methanolic solutions

  2025cites this paper
• Investigating Bioinspired Flavin Analogues as DNA Intercalating Agent

  2025cites this paper
• Pyrite stimulates the growth and sulfur oxidation capacity of anoxygenic phototrophic sulfur bacteria in euxinic environments

  2025cites this paper
• Linear free energy relationship between reduction potential and photoreduction rate: studies on Drosophila cryptochrome

  2025cites this paper
• Vitamin B2 Catabolism: Nature’s Route from Riboflavin to Acetoacetate and Pyruvate

  2025cites this paper
• Catalytic reduction of NAD(P)+ to NAD(P)H.

  2025cites this paper
• Exploring the impact of flavin homeostasis on cancer cell metabolism.

  2024cites this paper
• Rational design of a flavoenzyme for aerobic nicotine catabolism

  2024cites this paper
• Current understanding of enzyme structure and function in bacterial two-component flavin-dependent desulfonases: cleaving C-S bonds of organosulfur compounds.

  2024cites this paper
• Evolutionary history of tyrosine-supplementing endosymbionts in pollen-feeding beetles

  2024cites this paper
• Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic Activity

  2024cites this paper
• Fast singlet excited-state deactivation pathway of flavin with a trimethoxyphenyl derivative

  2024cites this paper
• Pt(IV) Prodrug Photoactivation: A Promising Strategy for Cancer Therapy.

  2024cites this paper
• Electronic Structure Methods for Simulating Flavin’s Spectroscopy and Photophysics: Comparison of Multi-reference, TD-DFT, and Single-Reference Wave Function Methods

  2024cites this paper
• Exposure of Bladder Cancer Cells to Blue Light (λ = 453 nm) in the Presence of Riboflavin Synergistically Enhances the Cytotoxic Efficiency of Gemcitabine

  2024cites this paper
• Exogenous Riboflavin Application at Different Growth Stages Regulates Photosynthetic Accumulation and Grain Yield in Fragrant Rice

  2024cites this paper
• Engineering of LOV-domains for their use as protein tags.

  2024cites this paper
• Role of Vitamin B in Healthy Ageing and Disease.

  2024cites this paper
• Rapid reaction studies on the chemistry of flavin oxidation in urocanate reductase

  2024cites this paper
• Bio‐inspired Catalyst‐Modified Photocathode for Bias‐Free Photoelectrochemical NADH Regeneration

  2024cites this paper
• Bioinspired photoelectrochemical NADH regeneration based on a molecular catalyst-modified photocathode.

  2024cites this paper
• RIBOFLAVIN INDUCED PHOTOCATALYSED SYNTHESIS OF XANTHENE DERIVATIVES

  2024cites this paper
• pH modulates efficiency of singlet oxygen production by flavin cofactors

  2024cites this paper
• On the production of singlet oxygen by the isoalloxazine ring in free and protein-bound flavin cofactors.

  2024cites this paper
• Riboflavin Crystals with Extremely High Water Solubility.

  2024cites this paper
• Habitat- and lifestyle-dependent structural and functional characteristics of viruses in mangrove wetlands of different functional zonings.

  2024cites this paper
• Rational Design of a Flavoenzyme for Aerobic Nicotine Catabolism

  2024cites this paper
• Coupling and regulation mechanisms of the flavin-dependent halogenase PyrH observed by infrared difference spectroscopy

  2024cites this paper
• Determining Excited-State Absorption Properties of a Quinoid Flavin by Polarization-Resolved Transient Spectroscopy

  2024cites this paper
• Effect of tryptophan mutation on the structure of LOV1 domain of phototropin1 protein of Ostreococcus tauri: A combined molecular dynamics simulation and biophysical approach.

  2023cites this paper
• Regulation of respiratory complex I assembly by FMN cofactor targeting

  2023cites this paper
• Application of Box-Behnken Design for Development and Evaluation of Gastric Floating Tablets of Riboflavin

  2023cites this paper
• A Computational Study of a Prebiotic Synthesis of D-Riboflavin (Vitamin B2)

  2023cites this paper
• Spin Dynamics of Flavoproteins

  2023cites this paper
• Magnetic coupling modulation in meta-nitroxide-functionalized isoalloxazine magnets with redox-active units as efficient side-modulators.

  2023cites this paper
• Straightforward synthesis of quinoxaline-furan bis-heterocyclic structures via a multicomponent reaction

  2023cites this paper
• Small molecules as cancer targeting ligands: Shifting the paradigm.

  2023cites this paper
• A Synthesis Review of Vitamins Involved in the Fight against Covid‐19

  2023cites this paper
• DEVELOPMENT AND EVALUATION OF GASTRIC FLOATING TABLETS OF RIBOFLAVIN USING BOX-BEHNKEN DESIGN

  2023cites this paper
• The Riboflavin Metabolism in Four Saccharomyces cerevisiae Wine Strains: Assessment in Oenological Condition and Potential Implications with the Light-Struck Taste

  2023cites this paper
• The cysteine S–H stretching mode reports on long‐range conformational changes in pyruvate oxidase from E. coli

  2023cites this paper
• Metabolic engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol

  2023influential citation
• Der Einfluss von Vitaminen auf das Darmmikrobiom

  2023cites this paper
• Chiral Supramolecular Organogel Constructed Using Riboflavin and Melamine: Its Application in Photo-Catalyzed Colorimetric Chiral Sensing and Enantioselective Adsorption.

  2023cites this paper
• Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway

  2023cites this paper
• Bacillus subtilis strain producer preparation with increased accumulation of riboflavin

  2022cites this paper
• A statistical optimization by response surface methodology for the enhanced production of riboflavin from Lactobacillus plantarum–HDS27: A strain isolated from bovine milk

  2022cites this paper
• Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector

  2022cites this paper
• Progress of phototherapy for osteosarcoma and application prospect of blue light photobiomodulation therapy

  2022cites this paper
• The Diversity and Functional Capacity of Microbes Associated with Coastal Macrophytes

  2022cites this paper
• Biomarker signatures in pathophysiology and therapeutic interventions in inflammatory bowel diseases

  2022cites this paper
• Valence and core-level X-ray photoemission spectroscopy of light-sensitive molecules: Lumazine and alloxazine

  2022cites this paper
• The diversity and functional capacity of microbes associated with coastal phototrophs

  2022cites this paper
• Photoantimicrobials in agriculture.

  2022cites this paper
• Biohybrid photosynthetic charge accumulation detected by flavin semiquinone formation in ferredoxin-NADP+ reductase

  2022cites this paper
• Synthesis, characterization and photophysical studies of the flavopeptide conjugates as model for the covalently linked flavoenzymes

  2022cites this paper
• Mechanics of Biosurfactant Aided Liquid Phase Exfoliation of 2D Materials

  2022cites this paper
• RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth

  2022cites this paper
• Mining the Flavoproteome of Brucella ovis, the Brucellosis Causing Agent in Ovis aries

  2022cites this paper
• Biomarker signatures in pathophysiology and therapeutic interventions in inflammatory bowel diseases

  2022cites this paper
• Completing the Picture: Determination of 13C Hyperfine Coupling Constants of Flavin Semiquinone Radicals by Photochemically Induced Dynamic Nuclear Polarization Spectroscopy.

  2022cites this paper
• The effect of riboflavin supplementation on the systemic redox status in healthy volunteers: A post-hoc analysis of the RIBOGUT trial.

  2022cites this paper
• Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents.

  2022cites this paper
• Riboflavin integrates cellular energetics and cell cycle to regulate maize seed development

  2022cites this paper
• Magnetic field effects in biology from the perspective of the radical pair mechanism

  2022cites this paper
• Crystal structure of ArOYE6 reveals a novel C‐terminal helical extension and mechanistic insights into the distinct class III OYEs from pathogenic fungi

  2022cites this paper
• Molecular cloning, characterization and expression analysis of two 12-oxophytodienoate reductases (NtOPR1 and NtOPR2) from Nicotiana tabacum

  2022cites this paper
• Light/Dark and Temperature Cycling Modulate Metabolic Electron Flow in Pseudomonas aeruginosa Biofilms

  2022cites this paper
• A π-Stacking Based Fluorescent Probe for Labeling of Flavin Analogues in Live Cells through Unusual FRET Process.

  2022cites this paper
• Recent Advances in Light-Controlled Activation of Pt(IV) Prodrugs

  2022cites this paper
• Tuning the Photophysical Properties of Flavins by Attaching an Aryl Moiety via Direct C-C Bond Coupling.

  2022cites this paper
• Topologically and Chemically Engineered Conjugated Polymer with Synergistically Intensified Electron Generation, Transfer and Utilization for Photocatalytic Nicotinamide Cofactor Regeneration

  2022cites this paper
• Multistimuli-responsive Photochromism of Vinylene-linked Bisflavin based on the Aggregation and Redox Properties.

  2022cites this paper
• RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus growth inhibition by propionate

  2022cites this paper
• Riboflavin and Its Effect on Dentin Bond Strength: Considerations for Clinical Applicability—An In Vitro Study

  2022cites this paper
• Screening methods for enzyme-mediated alcohol oxidation

  2022cites this paper
• Dynamic association of flavin cofactors to regulate flavoprotein function

  2022cites this paper
• Single-step extraction of small-diameter single-walled carbon nanotubes in the presence of riboflavin

  2022cites this paper
• Insights into Flavoenzymes: Structure, classification and potential biotechnological applications

  2022cites this paper
• Continuous and Discontinuous Approaches to Study FAD Synthesis and Degradation Catalyzed by Purified Recombinant FAD Synthase or Cellular Fractions.

  2021cites this paper