Chromosome rearrangements via template switching between diverged repeated sequences

Anand et al. examined break-induced replication (BIR) and template switching between highly diverged sequences in S. cerevisiae, induced during repair of a site-specific double-strand break (DSB). Template switches between highly divergent sequences appear to be mechanistically distinct from the initial strand invasions that establish BIR. BIR traversing repeated DNA sequences frequently results in complex translocations analogous to those seen in mammalian cells. These results suggest that template switching among repeated genes is a potent driver of genome instability and evolution.

• Publication year

  2014

• Venue

  Genes & Development

• Publication date

  2014-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.250258.114PMID 25367035PMCID 4215184
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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