The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst.

No abstract is available for this paper.

• Publication year

  1976

• Venue

  Journal of Clinical Investigation

• Publication date

  1976-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1172/JCI108553PMID 9426PMCID PMC333263
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidation of epinephrine by a cell-free system from human granulocytes.

  1976cited by this paper
• Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement.

  1976cited by this paper
• Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes.

  1975cited by this paper
• Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.

  1975cited by this paper
• Pyridine nucleotide-dependent superoxide production by a cell-free system from human granulocytes.

  1975cited by this paper
• H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

  1975cited by this paper
• NADPH oxidase deficiency in X-linked chronic granulomatous disease.

  1975cited by this paper
• Effects of anaerobiosis and inhibitors on O2-production by human granulocytes.

  1975cited by this paper
• Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease.

  1975cited by this paper
• The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

  1975cited by this paper
• Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase.

  1975cited by this paper
• Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

  1975cited by this paper
• Production of hydrogen peroxide by phagocytizing human granulocytes.

  1975cited by this paper
• Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

  1975cited by this paper
• Defective superoxide production by granulocytes from patients with chronic granulomatous disease.

  1974cited by this paper
• The superoxide anion and singlet molecular oxygen: their role in the microbicidal activity of the polymorphonuclear leukocyte.

  1974cited by this paper
• Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes.

  1974cited by this paper
• Singlet oxygen: a unique microbicidal agent in cells.

  1973cited by this paper
• Chronic granulomatous disease--pieces of a cellular and molecular puzzle.

  1973cited by this paper
• Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.

  1973cited by this paper
• Mechanism of phagocytosis-associated oxidative metabolism in polymorphonuclear leucocytes and macrophages.

  1972cited by this paper
• Enzymatic basis of metabolic stimulation in leucocytes during phagocytosis: the role of activated NADPH oxidase.

  1971cited by this paper
• The statistical analysis of enzyme kinetic data.

  1967cited by this paper
• NADPH AND NADH OXIDATION BY GUINEA PIG POLYMORPHONUCLEAR LEUCOCYTES

  1963cited by this paper
• NADPH and NADH oxidation by guinea pig polymorphonuclear leucocytes.

  1963cited by this paper
• Biochemical Aspects of Phagocytosis

  1961cited by this paper
• The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes.

  1959cited by this paper
• Appendix—Spectrum of horse-heart cytochrome c

  1959cited by this paper
• Spectrum of horse-heart cytochrome c.

  1959cited by this paper
• [116] Isocitric dehydrogenase system (TPN) from pig heart:

  1955cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Live fast, die young: neutrophils streamline their metabolism to maximize inflammation

  2025cites this paper
• Enzymatic Oxidants, Antioxidants, and Inflammatory Bowel Disease

  2025cites this paper
• NADPH Oxidase 3: Beyond the Inner Ear

  2024cites this paper
• Neutrophils under the microscope: neutrophil dynamics in infection, inflammation, and cancer revealed using intravital imaging

  2024cites this paper
• Real-time in vivo ROS monitoring with luminescent nanoparticles reveals skin inflammation dynamics.

  2023cites this paper
• Rab26 promotes macrophage phagocytosis through regulation of MFN2 trafficking to mitochondria

  2023cites this paper
• Immunometabolism in biofilm infection: lessons from cancer

  2022influential citation
• Immunometabolism shapes B cell fate and functions

  2022cites this paper
• Fluorescence Spectroscopy for the Diagnosis of Endometritis in the Mare

  2022influential citation
• Semi-Solid Product of Medicinal Leech Enhances Wound Healing in Rats

  2021cites this paper
• Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

  2021cites this paper
• H2S and reactive sulfur signaling at the host-bacterial pathogen interface

  2020cites this paper
• NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis

  2020cites this paper
• Imaging the neutrophil: Intravital microscopy provides a dynamic view of neutrophil functions in host immunity.

  2020cites this paper
• Mechanistic computational modeling of the kinetics and regulation of NADPH oxidase 2 assembly and activation facilitating superoxide production

  2020cites this paper
• Cell-Free NADPH Oxidase Activation Assays: A Triumph of Reductionism.

  2020cites this paper
• A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production.

  2019influential citation
• Importância do complexo 2 da via mTOR (mTORC2) nas funções efetoras e no metabolismo dos neutrófilos em modelo experimental de SEPSE

  2019cites this paper
• Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response

  2017cites this paper
• NADPH oxidase NOX2 mediates TLR2/ 6‐dependent release of GM‐CSF from endothelial cells

  2017cites this paper
• Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system

  2017cites this paper
• Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma*

  2016cites this paper
• The intimate and controversial relationship between voltage‐gated proton channels and the phagocyte NADPH oxidase

  2016cites this paper
• Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model

  2016cites this paper
• Myeloperoxidase Inhibitors as Potential Drugs.

  2015cites this paper
• Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation

  2015cites this paper
• Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors.

  2015cites this paper
• , Claus Lungs of Cystic Fibrosis Patients Growth of Pseudomonas aeruginosa in the Polymorphonuclear Leukocytes Restrict

  2014cites this paper
• On the biodegradability of polyethylene glycol, polypeptoids and poly(2-oxazoline)s.

  2014cites this paper
• Comparison of the effects of natural & synthetic an tioxidants on altered muscle tension of the rat aorta evoked by activated polymo rphonuclear leukocytes

  2014cites this paper
• Polymorphonuclear Leukocytes Restrict Growth of Pseudomonas aeruginosa in the Lungs of Cystic Fibrosis Patients

  2014cites this paper
• Elucidating functional interactions between the Russian wheat aphid (D. noxia Kurjumov) and bread wheat (Triticum aestivum L.)

  2014cites this paper
• Cell-free NADPH oxidase activation assays: "in vitro veritas".

  2014cites this paper
• ROS production in phagocytes: why, when, and where?

  2013cites this paper
• Iodine accumulation in sea urchin larvae is dependent on peroxide

  2013cites this paper
• Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family.

  2013cites this paper
• Oxidase Activity in Human Neutrophils Stimulated by Phorbol Myristate Acetate

  2013cites this paper
• Host responses in tissue repair and fibrosis.

  2013cites this paper
• Consequences of dimerization of the voltage-gated proton channel.

  2013cites this paper
• L-Triiodothyronine and L-Reverse-Triiodothyronine Generation in the Human Polymorphonuclear Leukocyte

  2013cites this paper
• PLASMA MEMBR LOCALISATION OF OXIDASE IN ELICITED ANE AND PHAGOSOME THE ACTIVATED NADPH OF THE PERITONEAL MACROPHAGES GUINEA-PIG

  2012cites this paper
• α‐Defensins in human innate immunity

  2012cites this paper
• Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury.

  2012cites this paper
• The Role of Fibrin Clot Properties and Fibrinogen Nitration in the Pathology of Venous Thromboembolism.

  2012cites this paper
• Resident Peritoneal Macrophages

  2012cites this paper
• THE ENZYME RESPONSIBLE FOR THE RESPIRATORY BURST IN ELICITED GUINEA PIG PERITONEAI

  2012cites this paper
• Doxycycline as a modulator of inflammation in chronic wounds.

  2012cites this paper
• Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.

  2011cites this paper
• Apoptosis: Physiology and Pathology

  2011cites this paper
• NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling

  2011cites this paper
• oxidase activity and deficient cytochrome-b Chronic granulomatous disease due to granulocytes with abnormal NADPH

  2011cites this paper
• replacement by newly activated enzyme sustains the respiratory burst Rapid deactivation of NADPH oxidase in neutrophils: continuous

  2011cites this paper
• BASIC CONCEPTS IN CARDIOLOGY The Oxygen Free Radical System: Potential Mediator of Myocardial Injury

  2010cites this paper
• Reactive Oxygen Species as Mediators of Tissue Protect ion and Injury

  2010cites this paper
• Moderate hypothermia suppressed excessive generation of superoxide anion radical and inflammatory reactions in blood and liver in heatstroke: Laboratory study in rats

  2010cites this paper
• Genetic and dietary effects on chicken heterophil function and immune response to Salmonella enteritidis

  2010cites this paper
• Coenzyme Q10 and male infertility

  2009cites this paper
• A Pathogenesis Assay Using Saccharomycescerevisiae and Caenorhabditiselegans Reveals Novel Roles for Yeast AP-1, Yap1, and Host Dual Oxidase BLI-3 in Fungal Pathogenesis

  2009cites this paper
• Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

  2009cites this paper
• pneumonia in cystic fibrosis aeruginosa Pseudomonas oxygen in sputum from chronic Polymorphonuclear leucocytes consume

  2009cites this paper
• ecanismo da interação entre a proteína dissulfeto isomerase e a NADPH oxidase : papel regulatório sobre a produção de espécies reativas de oxigênio em fagócitos profissionais

  2009cites this paper
• The role of the methoxyphenol apocynin, a vascular NADPH oxidase inhibitor, as a chemopreventative agent in the potential treatment of cardiovascular diseases.

  2008cites this paper
• An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey.

  2008cites this paper
• Oxygen derived free radicals in clinical context

  2008cites this paper
• The phagocytes: neutrophils and monocytes.

  2008cites this paper
• 2,2′,4,4′-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-κB

  2007cites this paper
• Presence of the distinct systems responsible for superoxide anion and hydrogen peroxide generation in red tide phytoplankton Chattonella marina and Chattonella ovata

  2007cites this paper
• 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB.

  2007cites this paper
• Hydrogen peroxide-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels

  2007cites this paper
• Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask".

  2007cites this paper
• Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation.

  2006cites this paper
• Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Diseases

  2006cites this paper
• Oxidative Stress Systems in Bacteria: Four Model Organisms

  2006cites this paper
• Immune response and immunotherapy to Cryptococcus infections

  2006cites this paper
• An update of Coenzyme Q10 implications in male infertility: Biochemical and therapeutic aspects

  2005cites this paper
• Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2.

  2005cites this paper
• Die Bildung zytoplasmatischer Vakuolen phagozytierender neutrophiler Granulozyten während Sauerstoff- und Stickstoff-Begasung im in vitro-Versuch

  2005cites this paper
• Redox modulation of tyrosine phosphorylation-dependent neutrophil adherence to endothelial cells

  2005cites this paper
• and kinetics of activation generating enzyme : localization in a plasma membrane enriched particle Activation of the guinea pig granulocyte NAD ( P ) H-dependent superoxide

  2005cites this paper
• Secondary Insults in Neurointensive Care of Patients with Traumatic Brain Injury

  2005cites this paper
• The pH dependence of NADPH oxidase in human eosinophils

  2005influential citation
• Effects of changes to the stable environment on the exhalation of ethane, carbon monoxide and hydrogen peroxide by horses with respiratory inflammation

  2005cites this paper
• Suppression of arthritis by an active center analogue of Cu2Zn2-superoxide dismutase

  2004cites this paper
• Superoxide production by phagocytic leukocytes: the scientific legacy of Bernard Babior.

  2004cites this paper
• The origin of hydrogen cyanide in breath

  2004cites this paper
• Allopurinol prevents ischaemia-dependent haemorheological changes

  2004cites this paper
• Superoxide production by polymorphonuclear leukocytes

  2004cites this paper
• Superoxide production by phagocytic leukocytes: the scientific legacy of Bernard Babior

  2004cites this paper
• Reactive oxygen species-mediated signal transduction in the endothelium.

  2004cites this paper
• Oxidative stress, antioxidants, and endothelial function.

  2004cites this paper
• Current and future uses of breath analysis as a diagnostic tool

  2004cites this paper
• A novel formulation of metal ions and citric acid reduces reactive oxygen species in vitro.

  2003cites this paper
• Beyond LDL oxidation: ROS in vascular signal transduction.

  2003cites this paper
• Chronic granulomatous disease.

  2003cites this paper
• 28 BACTERICIDAL ACTIVITY OF SUPEROXIDE ANION

  2003cites this paper
• Oxidative stress and infections.

  2002cites this paper
• Chapter 2 Apocynin , an inhibitor of NADPH oxidase-dependent ROS production in stimulated human neutrophils

  2001cites this paper
• Human Neutrophil-Mediated Nonoxidative Antifungal Activity against Cryptococcus neoformans

  2000cites this paper
• Reactive Oxygen Species Participation in Experimentally Induced Arthritis of the Temporomandibular Joint in Rats

  2000cites this paper
• Antioxidants and Endothelium-Derived Nitric Oxide Action

  2000cites this paper