Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Human Reproduction

• Publication date

  2002-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/HUMREP/17.2.289PMID 11821265
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• World Health Organization Laboratory Manual for the Examination of Human Semen and Sperm‐Cervical Mucus Interaction, 4th ed.

  2000cited by this paper
• Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome.

  2000influential reference
• Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation.

  2000influential reference
• Insulin-lowering medications in polycystic ovary syndrome.

  2000cited by this paper
• Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome.

  1999influential reference
• Insulin action in the normal and polycystic ovary.

  1999cited by this paper
• Urinary follicle-stimulating hormone (FSH) versus recombinant FSH in clomiphene citrate-resistant, normogonadotropic,chronic anovulation: a prospective randomized study.

  1999cited by this paper
• Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome.

  1999influential reference
• Effects of the insulin sensitizing drug metformin on ovarian function, follicular growth and ovulation rate in obese women with oligomenorrhoea.

  1999influential reference
• The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome.

  1998cited by this paper
• Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome.

  1998influential reference
• Decreased serum leptin concentrations during metformin therapy in obese women with polycystic ovary syndrome.

  1998cited by this paper
• Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome.

  1998influential reference
• Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.

  1997influential reference
• Menstrual Cyclicity After Metformin Therapy in Polycystic Ovary Syndrome

  1997cited by this paper
• Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome.

  1997influential reference
• Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome.

  1996cited by this paper
• Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women.

  1996cited by this paper
• Can metformin reduce insulin resistance in polycystic ovary syndrome?

  1996influential reference
• Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women.

  1995influential reference
• Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy.

  1994influential reference
• Is there a place for the crossover design in infertility trials?

  1993cited by this paper
• A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome.

  1991cited by this paper
• Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia.

  1987cited by this paper
• Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism.

  1986cited by this paper
• Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function.

  1985cited by this paper
• Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose.

  1981cited by this paper
• Further clinical experience with clomiphene citrate.

  1968cited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study*

  year unknowncited by this paper

• Preconception and first trimester metformin on pregnancy outcomes in women with polycystic ovary syndrome: a systematic review and meta-analysis.

  2025cites this paper
• Influence of metformin on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials

  2023influential citation
• Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

  2022cites this paper
• Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

  2022cites this paper
• Sitagliptin/metformin improves the fertilization rate and embryo quality in polycystic ovary syndrome patients through increasing the expression of GDF9 and BMP15: A new alternative to metformin (a randomized trial).

  2022cites this paper
• Different pregnancy outcomes according to the polycystic ovary syndrome diagnostic criteria: a systematic review and meta-analysis of 79 studies.

  2022cites this paper
• Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: A systematic review and meta‐analysis of randomized controlled trials

  2021influential citation
• Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta‐analysis of randomized controlled trials

  2021influential citation
• The comparative effectiveness of 55 interventions in obese patients with polycystic ovary syndrome: A network meta-analysis of 101 randomized trials

  2021cites this paper
• Improvement of Insulin Sensitivity Increases Pregnancy Rate in Infertile PCOS Women: A Systemic Review

  2021cites this paper
• Impact of pharmacological Interventions on insulin resistance in women with polycystic ovary

  2021cites this paper
• Comparing the effect of sitagliptin and metformin on the oocyte and embryo quality in classic PCOS patients undergoing ICSI

  2020cites this paper
• The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  2020cites this paper
• Medical Approaches to Ovarian Stimulation for Infertility

  2019cites this paper
• Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome.

  2019cites this paper
• Insulin-Sensitising Drugs

  2018cites this paper
• Effects of placebo‐controlled insulin‐sensitizing drugs on hormonal parameters in polycystic ovary syndrome patients: A network meta‐analysis

  2018cites this paper
• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  2017cites this paper
• Comparison of Dermatoglyphic Pattern among Cleft and Noncleft Children: A Cross-sectional Study

  2017cites this paper
• Effect of Resin Infiltration on Artificial Caries: An in vitro Evaluation of Resin Penetration and Microhardness

  2017cites this paper
• Comparison of the effects of Ginger extract with clomiphene citrate on sex hormones in rats with polycystic ovarian syndrome

  2017cites this paper
• Eruption Chronology in Children: A Cross-sectional Study

  2017cites this paper
• داروهای حساس کننده انسولین (متفورمین، روزیگلیتازون، پیوگلیتازون، D – کایرو - اینوسیتول) برای زنان مبتلا به سندرم تخمدان پلیکیستیک، الیگوآمنوره و کمبارور

  2017cites this paper
• A Review on the Assessment of the Efficacy of Common Treatments in Polycystic Ovarian Syndrome on Prevention of Diabetes Mellitus

  2017cites this paper
• Effect of Casein Phosphopeptide-amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: An in vitro Study

  2017cites this paper
• Effect of Dentin Disinfection with 2% Chlorhexidine Gluconate and 0.3% Iodine on Dentin Bond Strength: An in vitro Study

  2017cites this paper
• Clinical and Radiographic Evaluation of Four Different Pulpotomy Agents in Primary Molars: A Longitudinal Study

  2017cites this paper
• Comparison of Antimicrobial Efficacy of Green Tea, Garlic with Lime, and Sodium Fluoride Mouth Rinses against Streptococcus mutans, Lactobacilli species, and Candida albicans in Children: A Randomized Double-blind Controlled Clinical Trial

  2017cites this paper
• Emerging Understanding of Emotional Intelligence of Teenagers

  2017cites this paper
• Polycystic Ovary Syndrome and Metformin

  2016cites this paper
• Polycystic Ovary Syndrome and Metformin

  2016cites this paper
• N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: an alternative to metformin.

  2016cites this paper
• The Reconstruction Purposes Implant Deficits Bone Ridge Edentulous

  2015cites this paper
• Metformin and Weight Loss in Patients with Polycystic Ovary Syndrome

  2015cites this paper
• Oxygen Hyperbaric Exposure Induces GLUT4 Expression Reduction and No Folliculogenesis Alterations in Rat PCOS with Insulin Resistance Model

  2015cites this paper
• Implant-supported Overdenture using Resilient Reliner

  2015cites this paper
• A systematic review and meta‐analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures

  2015cites this paper
• ROLE OF INSULIN SENSITIZERS ON CARDIOVASCULAR RISK FACTORS IN POLYCYSTIC OVARIAN SYNDROME: A META-ANALYSIS.

  2015cites this paper
• Brachial-to-ankle pulse wave velocity as an independent prognostic factor for ovulatory response to clomiphene citrate in women with polycystic ovary syndrome

  2014cites this paper
• Co-Administration of Metformin and N-Acetyl Cysteine Fails to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI

  2014cites this paper
• Insulin Lowering Agents

  2014cites this paper
• Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials

  2014influential citation
• Pretreatment and co‐administration of oral anti‐diabetic agent with clomiphene citrate or rFSH for ovulation induction in clomiphene‐citrate‐resistant polycystic ovary syndrome

  2013cites this paper
• Comparison of antiproliferative effects of metformine and progesterone on estrogen-induced endometrial hyperplasia in rats

  2013cites this paper
• Metformina e o papel no tratamento da infertilidade em mulheres com síndrome do ovário poliquistico.

  2012cites this paper
• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  2012cites this paper
• Prognostic value of total testosterone for pregnancy during treatment in patients with clomiphene-citrate-resistant polycystic ovary syndrome: a pilot study

  2011cites this paper
• Difficult-to-treat women for controlled ovarian hyperstimulation: tips and tricks

  2011cites this paper
• Achieving a successful pregnancy in women with polycystic ovary syndrome.

  2011cites this paper
• Increased circulating soluble P-selectin in polycystic ovary syndrome.

  2010cites this paper
• Clinical Outcomes of Ovulation Induction with Metformin, Clomiphene Citrate and Human Menopausal Gonadotrophin in Polycystic Ovary Syndrome

  2010cites this paper
• Visfatin and retinol-binding protein 4 concentrations in lean, glucose-tolerant women with PCOS.

  2010cites this paper
• Ovulation Induction in Anovulatory Patients with Polycystic Ovary Syndrome

  2010cites this paper
• Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia: A Prospective Pilot Study of Seven Cases

  2010cites this paper
• The Role of Insulin-Sensitizing Agents in the Treatment of Polycystic Ovary Syndrome

  2009cites this paper
• Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.

  2009cites this paper
• Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance

  2009cites this paper
• WITHDRAWN: Insulin-sensitising drugs for polycystic ovary syndrome.

  2009cites this paper
• Short‐term metformin treatment for clomiphene citrate–resistant women with polycystic ovary syndrome

  2009cites this paper
• The effects of metformin on endogenous androgens and SHBG in women: a systematic review and meta‐analysis

  2009influential citation
• Endemic Fungal Infections in Patients Receiving Tumour Necrosis Factor-α Inhibitor Therapy

  2009cites this paper
• Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

  2009cites this paper
• Use of Metformin in Clomiphene Citrate (CC) Resistant Polycystic Ovary Syndrome (PCOS)

  2009cites this paper
• Inseminación artificial intrauterina en mujeres con síndrome de ovario poliquístico resistentes al citrato de clomifeno

  2009cites this paper
• [Impact of overweight on the outcome of ovarian stimulation].

  2008cites this paper
• PCOS and infertility.

  2008cites this paper
• Effective Regimens for Ovulation Induction in Polycystic Ovary Syndrome

  2008cites this paper
• [Treatment of infertility in women with polycystic ovary syndrome].

  2008cites this paper
• Influence de l’excès pondéral sur les approches d’induction de l’ovulation

  2008cites this paper
• Effect of metformin on IGF-1 and IGFBP-1 levels in obese patients with polycystic ovary syndrome.

  2008cites this paper
• Use of metformin in polycystic ovary syndrome.

  2008cites this paper
• Polycystic ovary syndrome in the Indian Subcontinent

  2008cites this paper
• Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis.

  2008influential citation
• Diabetes and infertility

  2008cites this paper
• Insulin Sensitizers Targeting Metabolic and Reproductive Consequences in Polycystic Ovary Syndrome

  2008cites this paper
• Metformin & glitazones : Do they really help PCOS patients?

  2007cites this paper
• Treatment of Infertility in Polycystic Ovary Syndrome

  2007cites this paper
• Metformin and glitazones: do they really help PCOS patients?

  2007cites this paper
• Polycystic Ovary Syndrome: Insulin sensitizers in the treatment of polycystic ovary syndrome

  2007cites this paper
• ENSAIO CLÍNICO SOBRE A EFETIVIDADE DA METFORMINA EM BAIXAS DOSES NA SÍNDROME DOS OVÁRIOS MICROPOLICÍSTICOS

  2007cites this paper
• Metformin&glitazones: Dotheyreallyhelp PCOSpatients?

  2007cites this paper
• Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome.

  2007cites this paper
• Tratamento da infertilidade em mulheres com síndrome dos ovários policísticos

  2007cites this paper
• Polycystic Ovary Syndrome: Ovulation induction for women with polycystic ovary syndrome

  2007cites this paper
• The role of metformin in polycystic ovary syndrome: a systematic review.

  2007cites this paper
• Insulin-Sensitizing Drugs for the Treatment of Infertility in Polycystic Ovary Syndrome

  2007cites this paper
• The use of metformin for women with PCOS undergoing IVF treatment.

  2006cites this paper
• Ovulatory disorders and infertility.

  2006cites this paper
• No more surrogate end‐points in randomised trials: The PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene

  2006cites this paper
• Metformin beyond diabetes: new life for an old drug.

  2006cites this paper
• Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?

  2006cites this paper
• Ovulation induction in normogonadotropic anovulation (PCOS).

  2006cites this paper
• Polycystic ovary syndrome and metformin in pregnancy

  2006cites this paper
• Polycystic ovarian syndrome--prognosis and outcomes.

  2006cites this paper
• A systematic review and meta-analysis of randomized controlled trials on metformin co-administration during gonadotrophin ovulation induction or IVF in women with polycystic ovary syndrome.

  2006influential citation
• Use of Insulin Sensitizers in the Polycystic Ovary Syndrome

  2006cites this paper
• Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome

  2006cites this paper
• Evidence of improving quality of reporting of randomized controlled trials in subfertility.

  2006cites this paper
• Anovulation and ovulation induction.

  2006cites this paper
• Aspects of Mono- and Multiple Dominant Follicle Development in the Human Ovary

  2005cites this paper