Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Cell

• Publication date

  1999-04-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0092-8674(00)80748-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996cited by this paper
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  1995cited by this paper
• The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

  1995cited by this paper
• Evidence for apoptotic cell death in Alzheimer's disease.

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