High glucose‐induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases

No abstract is available for this paper.

• Publication year

  2003

• Venue

  The FASEB Journal

• Publication date

  2003-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.02-0130fjePMID 12670885
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular motors

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  1998influential reference
• Fluorometric assay of nitrite and nitrate in brain tissue after traumatic brain injury and cerebral ischemia.

  1998cited by this paper
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• High Glucose Induces Antioxidant Enzymes in Human Endothelial Cells in Culture: Evidence Linking Hyperglycemia and Oxidative Stress

  1996cited by this paper
• Oxidative Stress and Diabetic Vascular Complications

  1996cited by this paper
• Literature Reviews: Endocrinology

  1994cited by this paper
• Enzymuria in non-insulin-dependent diabetic patients: signs of tubular cell dysfunction.

  1993cited by this paper
• Effect of posture and acute glycaemic control on the excretion of retinol-binding protein in normoalbuminuric insulin-dependent diabetic patients.

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• The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

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• Epidemiology of end-stage renal disease in patients with diabetes mellitus: from the dark ages to the middle ages.

  1992cited by this paper
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  1991cited by this paper
• Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes.

  1990cited by this paper
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  1988cited by this paper
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  1984cited by this paper
• Course of diabetic nephropathy. Factors related to development.

  1981cited by this paper

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