Increases in Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Induced Calcium Responses in Pulmonary Artery Smooth Muscle Cells

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Circulation Research

• Publication date

  2006-10-27

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1161/01.RES.0000247068.75808.3fPMID 17008601
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis.

  2005cited by this paper
• Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line*[boxs]

  2005cited by this paper
• Hypoxia-inducible factor-1 (HIF-1).

  2005cited by this paper
• Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

  2005cited by this paper
• A new ATS committee: competing in the marketplace of ideas.

  2005cited by this paper
• Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.

  2005cited by this paper
• Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle.

  2004cited by this paper
• Structural characterization, tissue distribution, and functional expression of murine aminoacylase III.

  2004cited by this paper
• Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus.

  2004cited by this paper
• Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor.

  2004cited by this paper
• The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism.

  2004cited by this paper
• Hypoxic Pulmonary Vasoconstriction

  2004cited by this paper
• Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries.

  2003cited by this paper
• Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.

  2003cited by this paper
• Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat

  2003cited by this paper
• Ca(2+) release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs.

  2002cited by this paper
• Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing

  2002cited by this paper
• Mitochondrial Reactive Oxygen Species Trigger Calcium Increases During Hypoxia in Pulmonary Arterial Myocytes

  2002cited by this paper
• Hypoxic constriction of porcine distal pulmonary arteries: endothelium and endothelin dependence.

  2001cited by this paper
• Reducing the Environmental Sensitivity of Yellow Fluorescent Protein

  2001cited by this paper
• Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor

  2001cited by this paper
• Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain.

  2001cited by this paper
• GPx-1 Gene Delivery Modulates NFκB Activation Following Diverse Environmental Injuries Through a Specific Subunit of the IKK Complex

  2001cited by this paper
• Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing

  2001cited by this paper
• Myxothiazol Induces H2O2 Production from Mitochondrial Respiratory Chain

  2001cited by this paper
• Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle.

  2001cited by this paper
• Overexpression of Catalase in the Mitochondrial or Cytosolic Compartment Increases Sensitivity of HepG2 Cells to Tumor Necrosis Factor-α-induced Apoptosis*

  2000cited by this paper
• Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries.

  2000cited by this paper
• Free radical production in hypoxic pulmonary artery smooth muscle cells.

  2000cited by this paper
• Lucigenin: Redox Potential in Aqueous Media and Redox Cycling with O−2 Production1☆

  2000cited by this paper
• Mass Spectrometry Unravels Disulfide Bond Formation as the Mechanism That Activates a Molecular Chaperone*

  2000cited by this paper
• Reactive oxygen species in cell signaling.

  2000cited by this paper
• Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation.

  2000cited by this paper
• Voltage‐independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat

  2000cited by this paper
• Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2).

  2000cited by this paper
• Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels

  2000cited by this paper
• Lucigenin: redox potential in aqueous media and redox cycling with O-(2) production.

  1999cited by this paper
• Dynamic and quantitative Ca2+ measurements using improved cameleons.

  1999cited by this paper
• Redox Gene Therapy Protects Human IB-3 Lung Epithelial Cells Against Ionizing Radiation-Induced Apoptosis

  1998cited by this paper
• Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.

  1998cited by this paper
• Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation

  1998cited by this paper
• Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

  1998cited by this paper
• Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

  1997cited by this paper
• Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction.

  1996cited by this paper
• The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels

  1995cited by this paper
• A redox-based O2 sensor in rat pulmonary vasculature.

  1993cited by this paper
• Association of cytoplasmic free Ca2+ gradients with subcellular organelles

  1992cited by this paper
• [Hypoxic pulmonary vasoconstriction].

  1985cited by this paper
• Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs.

  1984cited by this paper
• Some Statistical Methods Useful in Circulation Research

  1980cited by this paper
• Observations on the Pulmonary Arterial Blood Pressure in the Cat

  1946cited by this paper

• Affordable, cleanroom-free millifluidic production of targeted lipid nanocarriers via additive manufacturing

  2026cites this paper
• Mechanisms Underlying Altitude-Induced and Group 3 Pulmonary Hypertension

  2026cites this paper
• A hypoxia-on-a-chip platform for modeling ischemic arrhythmogenesis and evaluating the effects of levosimendan and OR-1896 on ischemic human iPSC-derived cardiomyocytes

  2025cites this paper
• Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

  2025cites this paper
• The Role of ROS and Its Sources in Tumorigenesis: Friend or Foe?

  2025cites this paper
• Hypoxia-Induced Mitochondrial ROS and Function in Pulmonary Arterial Endothelial Cells

  2024cites this paper
• Hypoxia decreases mitochondrial ROS production in cells.

  2024cites this paper
• Revisiting reactive oxygen species production in hypoxia

  2024cites this paper
• H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo

  2023cites this paper
• Acute oxygen sensing by vascular smooth muscle cells

  2023cites this paper
• Contribution of Mitochondrial Reactive Oxygen Species to Chronic Hypoxia-Induced Pulmonary Hypertension

  2023cites this paper
• Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III.

  2023cites this paper
• Mitochondria in hypoxic pulmonary hypertension, roles and the potential targets

  2023influential citation
• Metabolic reprogramming, oxidative stress, and pulmonary hypertension

  2023cites this paper
• Effects of salt and stress on blood pressure parameters and antioxidant enzyme function in the heart and aorta of borderline hypertensive rats

  2023cites this paper
• Impact of Zinc on Oxidative Signaling Pathways in the Development of Pulmonary Vasoconstriction Induced by Hypobaric Hypoxia

  2022cites this paper
• Important Functions and Molecular Mechanisms of Mitochondrial Redox Signaling in Pulmonary Hypertension

  2022cites this paper
• Role of mitochondrial reactive oxygen species in homeostasis regulation

  2022cites this paper
• Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition

  2022cites this paper
• Mitochondrial oxygen sensing of acute hypoxia in specialized cells - is there an unifying mechanism?

  2022cites this paper
• Interplay between mitochondrial reactive oxygen species, oxidative stress and hypoxic adaptation in facioscapulohumeral muscular dystrophy: Metabolic stress as potential therapeutic target

  2022cites this paper
• The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

  2021cites this paper
• Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

  2021cites this paper
• Cardiomyocyte Response to Ischemic Injury

  2021cites this paper
• Imatinib Mesylate induces apoptosis in chronic myeloid leukemia cells by triggering nitric oxide production

  2021cites this paper
• The role of mitochondrial reactive oxygen species in oxygen sensing in the pulmonary vasculature – use of novel genetic tools

  2021cites this paper
• Acetazolamide prevents hypoxia-induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle

  2021cites this paper
• Therapeutic implications of targeting antioxidants to mitochondria

  2021cites this paper
• Hypoxia Inducible Factors as Central Players in the Pathogenesis and Pathophysiology of Cardiovascular Diseases

  2021cites this paper
• Prenatal hypoxia induced ETBR activation and abnormal ROS signaling in pulmonary arteries and cells of rat offspring.

  2021cites this paper
• Interplay between mitochondria and reactive oxygen and nitrogen species in metabolic adaptation to hypoxia in facioscapulohumeral muscular dystrophy: potential therapeutic targets

  2021cites this paper
• Cellular and Molecular Processes in Pulmonary Hypertension.

  2021cites this paper
• Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

  2021cites this paper
• Systematic Understanding of Pathophysiological Mechanisms of Oxidative Stress-Related Conditions—Diabetes Mellitus, Cardiovascular Diseases, and Ischemia–Reperfusion Injury

  2021cites this paper
• Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung

  2020cites this paper
• Important Role of Sarcoplasmic Reticulum Ca2+ Release via Ryanodine Receptor-2 Channel in Hypoxia-Induced Rieske Iron–Sulfur Protein-Mediated Mitochondrial Reactive Oxygen Species Generation in Pulmonary Artery Smooth Muscle Cells

  2020cites this paper
• Competitive Interactions between Halothane and Isoflurane at the Carotid Body and TASK Channels

  2020cites this paper
• Activation of adenosine A3 receptors regulates vitamin C transport and redox balance in neurons.

  2020cites this paper
• Chapter 2 Mitochondrial KATP Channel Function under Hypoxia

  2019influential citation
• Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans.

  2019cites this paper
• Hypoxic Radioresistance: Can ROS Be the Key to Overcome It?

  2019cites this paper
• Endoplasmic reticulum Ca2+ release causes Rieske iron–sulfur protein-mediated mitochondrial ROS generation in pulmonary artery smooth muscle cells

  2019cites this paper
• Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications

  2019cites this paper
• Retrograde response by reactive oxygen/nitrogen species in plants involving different cellular organelles

  2019cites this paper
• Development of a Gas-Tight Microfluidic System for Raman Sensing of Single Pulmonary Arterial Smooth Muscle Cells Under Normoxic/Hypoxic Conditions

  2018influential citation
• Change of voltage-gated potassium channel 1.7 expressions in monocrotaline-induced pulmonary arterial hypertension rat model

  2018cites this paper
• Hypoxic stabilization of mRNA is HIF-independent but requires mtROS

  2018cites this paper
• Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks.

  2018cites this paper
• Imatinib-induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress

  2018cites this paper
• Redox control of vascular smooth muscle cell function and plasticity

  2018cites this paper
• Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals.

  2018cites this paper
• The ROS controversy in hypoxic pulmonary hypertension revisited

  2018cites this paper
• PLC (cid:2) 1-PKC ε -IP 3 R1 signaling plays an important role in hypoxia-induced calcium response in pulmonary artery smooth muscle cells

  2018cites this paper
• PLCγ1-PKCε-IP3R1 signaling plays an important role in hypoxia-induced calcium response in pulmonary artery smooth muscle cells.

  2018cites this paper
• Hypoxic challenge of hyperoxic pulmonary artery myocytes increases oxidative stress due to impaired mitochondrial superoxide dismutase activity.

  2018cites this paper
• Gestational Hypoxia and Developmental Plasticity.

  2018cites this paper
• Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

  2018influential citation
• Mitochondrial KATP Channel Function under Hypoxia

  2018influential citation
• Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension

  2018cites this paper
• Role of green fluorescent proteins and their variants in development of FRET-based sensors

  2018cites this paper
• Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

  2018influential citation
• Role of ROS/Kv/HIF Axis in the Development of Hypoxia-Induced Pulmonary Hypertension.

  2017cites this paper
• Hydrogen peroxide is a critical regulator of the hypoxia-induced alterations of store-operated Ca2+ entry into rat pulmonary arterial smooth muscle cells.

  2017cites this paper
• The influence of sex on the in vivo and in vitro effects of treprostinil in pulmonary arterial hypertension

  2017cites this paper
• Identification Of Oxygen Optima For Mouse Trophoblast Stem Cells And Human Embryos And The Stress Responses Upon Departing Optima

  2017cites this paper
• THERAPEUTIC POTENTIAL OF TARGETING REACTIVE OXYGEN SPECIES (ROS) STRESS IN MYELODYSPLASTIC SYNDROME (MDS)

  2017cites this paper
• Redox signaling during hypoxia in mammalian cells

  2017cites this paper
• Metal Nanoclusters with Synergistically Engineered Optical and Buffering Activity of Intracellular Reactive Oxygen Species by Compositional and Supramolecular Design

  2017cites this paper
• Design considerations for open-well microfluidic platforms for hypoxic cell studies.

  2017cites this paper
• Cross Talk Between Mitochondrial Reactive Oxygen Species and Sarcoplasmic Reticulum Calcium in Pulmonary Arterial Smooth Muscle Cells.

  2017cites this paper
• Role of Transcription Factors in Pulmonary Artery Smooth Muscle Cells: An Important Link to Hypoxic Pulmonary Hypertension.

  2017cites this paper
• Subcellular Redox Signaling.

  2017cites this paper
• Decreasing SMPD1 activity in BEAS-2B bronchial airway epithelial cells results in increased NRF2 activity, cytokine synthesis and neutrophil recruitment.

  2017cites this paper
• Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension.

  2017cites this paper
• Techniques for Detecting Reactive Oxygen Species in Pulmonary Vasculature Redox Signaling.

  2017cites this paper
• Recent advances in oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction.

  2017cites this paper
• Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

  2017cites this paper
• O2 sensing, mitochondria and ROS signaling: The fog is lifting.

  2016cites this paper
• Lung Circulation.

  2016cites this paper
• Mitochondria in lung disease.

  2016cites this paper
• Mechanisms of Superoxide Generation and Signaling in Cytochrome bc Complexes

  2016cites this paper
• Roles of different mitochondrial electron transport chain complexes in hypoxia‐induced pulmonary vasoconstriction

  2016influential citation
• Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

  2015cites this paper
• To decipher the hypoxic pulmonary hypertension: Vascular heterogeneity and the hypothesis of hypoxic responsive threshold

  2015cites this paper
• Measurement of ROS Levels and Membrane Potential Dynamics in the Intact Carotid Body Ex Vivo.

  2015cites this paper
• c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity.

  2015cites this paper
• NADPH oxidases—do they play a role in TRPC regulation under hypoxia?

  2015cites this paper
• Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction

  2015cites this paper
• Type I cell ROS kinetics under hypoxia in the intact mouse carotid body ex vivo: a FRET-based study.

  2015cites this paper
• Redox Regulation of Ion Channels in the Pulmonary Circulation

  2015cites this paper
• Hypoxia-Dependent Reactive Oxygen Species Signaling in the Pulmonary Circulation: Focus on Ion Channels

  2015cites this paper
• Mechanisms Responsible for Decreased Rat Pulmonary Arterial H2O2 Levels in a Model of Chronic Hypoxia-Induced Pulmonary Hypertension

  2014cites this paper
• Oxidase Interactions in Cardiovascular Disease 37

  2014cites this paper
• Mitochondria in lung biology and pathology: more than just a powerhouse.

  2014cites this paper
• Ceramide Mediates Acute Oxygen Sensing in Vascular Tissues

  2014cites this paper
• The placental pursuit for an adequate oxidant balance between the mother and the fetus

  2014cites this paper
• A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21WAF1/Cip1 Induction and Mitochondrial Dysfunction

  2014cites this paper
• Genetically Modeled Mice with Mutations in Mitochondrial Metabolic Enzymes for the Study of Cancer

  2014cites this paper
• Cellular and Molecular Mechanisms of O2 Sensing

  2014cites this paper
• Mitochondrial Function in Lung Health and Disease

  2014cites this paper