Increased sputum amino acid concentrations and auxotrophy ofPseudomonas aeruginosa in severe cystic fibrosis lung disease

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Thorax

• Publication date

  2000-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1136/thorax.55.9.795PMID 10950901PMCID PMC1745865
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1996cited by this paper
• Effects of Pseudomonas aeruginosa colonization on lung function and anthropometric variables in children with cystic fibrosis

  1995cited by this paper
• Auxotrophic variants of Pseudomonas aeruginosa are selected from prototrophic wild-type strains in respiratory infections in patients with cystic fibrosis

  1995cited by this paper
• Chemotaxis to oligopeptides by Pseudomonas aeruginosa

  1994cited by this paper
• Lung function in white children aged 4 to 19 years: I--Spirometry.

  1993cited by this paper
• Adult cystic fibrosis: association of acute pulmonary exacerbations and increasing severity of lung disease with auxotrophic mutants of Pseudomonas aeruginosa.

  1993cited by this paper
• Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society.

  1993cited by this paper
• Lung volumes and forced ventilatory flows

  1993cited by this paper
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  1992cited by this paper

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  2025cites this paper
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  2023cites this paper
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