Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Blood

• Publication date

  2015-01-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1182/blood-2014-06-581793PMID 25352130PMCID PMC4296017
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

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• Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes.

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• Risk factors for acute GVHD and survival after hematopoietic cell transplantation.

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• Graft-versus-host disease.

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• Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.

  1997cited by this paper
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• Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.

  1995influential reference
• Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

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• T cell subsets involved in lethal graft-versus-host disease directed to immunodominant minor histocompatibility antigens.

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  1991cited by this paper
• Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences

  1986cited by this paper

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