Novel Immunolocalization of α‐Synuclein in Human Muscle of Inclusion‐Body Myositis, Regenerating and Necrotic Muscle Fibers, and at Neuromuscular Junctions

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Neuropathology and Experimental Neurology

• Publication date

  2000-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/JNEN/59.7.592PMID 10901230
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alpha-synuclein and the Lewy body disorders.

  2001cited by this paper
• Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro

  1999cited by this paper
• The genetics of disorders with synuclein pathology and parkinsonism.

  1999cited by this paper
• Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury.

  1999cited by this paper
• Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro.

  1999cited by this paper
• Non-A b Component of Alzheimer’s Disease Amyloid (NAC) Revisited NAC and a -Synuclein Are Not Associated with A b Amyloid

  1999cited by this paper
• Non-Aβ Component of Alzheimer's Disease Amyloid (NAC) Revisited: NAC and α-Synuclein Are Not Associated with Aβ Amyloid

  1999cited by this paper
• The synuclein family.

  1998cited by this paper
• Nitric oxide-induced oxidative stress in autosomal recessive and dominant inclusion-body myopathies.

  1998cited by this paper
• Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain. Recent approaches to diagnosis and pathogenesis, and relation to aging.

  1998cited by this paper
• Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.

  1998influential reference
• Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

  1998cited by this paper
• Filamentous nerve cell inclusions in neurodegenerative diseases.

  1998cited by this paper
• α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

  1998cited by this paper
• The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

  1998cited by this paper
• Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.

  1998cited by this paper
• Impaired innervation of cultured human muscle overexpressing βAPP experimentally and genetically: relevance to inclusion‐body myopathies

  1998cited by this paper
• Comparisons of the NACP Self-Oligomerizations Induced by Aβ25-35 in the Presence of Dicyclohexylcarbodiimide and N-(Ethoxycarbonyl)-2-Ethoxy-1,2-Dihydroquinoline

  1998cited by this paper
• Multiple-system atrophy: a new alpha-synuclein disease?

  1998cited by this paper
• Sporadic inclusion-body myositis and hereditary inclusion-body myopathies: diseases of oxidative stress and aging?

  1998cited by this paper
• Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy.

  1998cited by this paper
• Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease

  1998cited by this paper
• Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.

  1998cited by this paper
• Immunolocalization of transcription factor NF-κB in inclusion-body myositis muscle and at normal human neuromuscular junctions

  1998cited by this paper
• alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.

  1998cited by this paper
• Multiple-system atrophy: a new α-synuclein disease?

  1998cited by this paper
• α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

  1998cited by this paper
• Immunolocalization of transcription factor NF-kappaB in inclusion-body myositis muscle and at normal human neuromuscular junctions.

  1998cited by this paper
• Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC.

  1997cited by this paper
• βAPP gene transfer into cultured human muscle induces inclusion‐body myositis aspects

  1997cited by this paper
• α-Synuclein in Lewy bodies

  1997cited by this paper
• NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation.

  1997cited by this paper
• Binding of A β to α-and β-synucleins : identification of segments in α-synuclein / NAC precursor that bind A β and NAC

  1997cited by this paper
• Alpha-synuclein in Lewy bodies.

  1997cited by this paper
• Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle.

  1996cited by this paper
• Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease.

  1996cited by this paper
• Difference in Expression of Phosphorylated Tau Epitopes between Sporadic Inclusion‐body Myositis and Hereditary Inclusion‐body Myopathies

  1996cited by this paper
• Use of anti‐neurofilament antibody to identify paired‐helical filaments in inclusion‐body myositis

  1996cited by this paper
• Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

  1995cited by this paper
• Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic.

  1995cited by this paper
• The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

  1995cited by this paper
• NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation.

  1995cited by this paper
• Residues in the synuclein consensus motif of the alpha-synuclein fragment, NAC, participate in transglutaminase-catalysed cross-linking to Alzheimer-disease amyloid beta A4 peptide.

  1995cited by this paper
• Identification of two distinct synucleins from human brain

  1994cited by this paper
• Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

  1993influential reference
• Enhanced detection of Congo‐red‐positive amyloid deposits in muscle fibers of inclusion body myositis and brain of Alzheimer's disease using fluorescence technique

  1993cited by this paper
• beta-Amyloid precursor protein mRNA is increased in inclusion-body myositis muscle.

  1993cited by this paper
• Strong immunoreactivity of beta-amyloid precursor protein, including the beta-amyloid protein sequence, at human neuromuscular junctions.

  1992cited by this paper
• Strong immunoreactivity of β-amyloid precursor protein, including the β-amyloid protein sequence, at human neuromuscular junctions

  1992cited by this paper
• Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis.

  1992cited by this paper
• Letters to the editor: A technique of fiber selection from human muscle tissue cultures for histochemical-electronmicroscopic studies.

  1975cited by this paper
• Muscle biopsies in neuromuscular diseases.

  1967cited by this paper
• Rapid examination of muscle tissue

  1963cited by this paper

• Alpha‐Synuclein as a Potential Biomarker for Inclusion Body Myositis in Blood and Muscle

  2025cites this paper
• Sarcopenia in Parkinson's disease: From pathogenesis to interventions.

  2025cites this paper
• The humoral immune landscape in Parkinson's disease: Unraveling antibody and B cell changes

  2024cites this paper
• Alpha-synuclein shapes monocyte and macrophage cell biology and functions by bridging alterations of autophagy and inflammatory pathways

  2024cites this paper
• Deficiency of muscle-generated brain-derived neurotrophic factor causes inflammatory myopathy through reactive oxygen species-mediated necroptosis and pyroptosis

  2024cites this paper
• Therapeutic Potential of Baicalein in Parkinson’s Disease: Focus on Inhibition of α-Synuclein Oligomerization and Aggregation

  2023cites this paper
• Mutations in PTPN11 could lead to a congenital myasthenic syndrome phenotype: a Noonan syndrome case series

  2023cites this paper
• Impaired skeletal muscle health in Parkinsonian syndromes: clinical implications, mechanisms and potential treatments

  2023influential citation
• Electroencephalographic Characterization by Covariance Analysis in Men with Parkinson’s Disease Reveals Sex- and Age-Related Differences

  2023cites this paper
• Coenzyme Q10: A Biomarker in the Differential Diagnosis of Parkinsonian Syndromes

  2023cites this paper
• Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system

  2023cites this paper
• Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease

  2022cites this paper
• Skeletal Muscle is a Source of α-Synuclein with a Sarcolemmal Non-Lipid Raft Distribution.

  2022cites this paper
• The Roles of ATP13A2 Gene Mutations Leading to Abnormal Aggregation of α-Synuclein in Parkinson’s Disease

  2022cites this paper
• Synuclein Analysis in Adult Xenopus laevis

  2022cites this paper
• Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease.

  2022cites this paper
• Surgical Trauma in Mice Modifies the Content of Circulating Extracellular Vesicles

  2022cites this paper
• The intestinal luminal sources of α-synuclein: a gastroenterologist perspective.

  2021cites this paper
• Neurons and Glia Interplay in α-Synucleinopathies

  2021cites this paper
• [18F]FDG PET/CT Studies in Transgenic Hualpha-Syn (A53T) Parkinson’s Disease Mouse Model of α-Synucleinopathy

  2021cites this paper
• Updates on the Immunopathology in Idiopathic Inflammatory Myopathies

  2021cites this paper
• Diabetes mellitus and Parkinson’s disease: dangerous liaisons between insulin and dopamine

  2021cites this paper
• Metal ions shape α-synuclein

  2020cites this paper
• Respiratory Function and Dysfunction in Parkinson-Type Neurodegeneration.

  2020cites this paper
• Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease

  2020cites this paper
• Chaperones in sporadic inclusion body myositis—Validation of proteomic data

  2020cites this paper
• Therapeutic Potential of Baicalein in Parkinson’s Disease: Focus on Inhibition of α-Synuclein Oligomerization and Aggregation

  2019cites this paper
• Autophagy–lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease

  2019cites this paper
• Reducing effect of insulin resistance on alpha-synuclein gene expression in skeletal muscle

  2019cites this paper
• α-Synuclein 2.0 - Moving towards Cell-Type Specific Pathophysiology.

  2019cites this paper
• Alpha‐synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease

  2019cites this paper
• Neuronal cell lipidomics and role of cholesterol in α-synuclein binding and aggregation

  2019cites this paper
• α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration

  2018cites this paper
• Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

  2018cites this paper
• Cell Biology and Pathophysiology of α-Synuclein.

  2018cites this paper
• Constipation in Parkinson’s Disease: a Nuisance or Nuanced Answer to the Pathophysiological Puzzle?

  2018cites this paper
• Vertebrate food products as a potential source of prion-like α-synuclein

  2017cites this paper
• Immune and myodegenerative pathomechanisms in inclusion body myositis

  2017cites this paper
• Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.

  2017cites this paper
• Gut Feelings About α‐Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?

  2016cites this paper
• Molecular events linking cholesterol to Alzheimer's disease and inclusion body myositis in a rabbit model.

  2016cites this paper
• The Synaptic Function of α-Synuclein

  2015cites this paper
• Sporadic inclusion-body myositis: A degenerative muscle disease associated with aging, impaired muscle protein homeostasis and abnormal mitophagy.

  2015cites this paper
• A clinicopathological study of inclusion body myositis

  2014cites this paper
• 2 Sporadic inclusion-body myositis: A degenerative muscle disease 3 associated with aging, impaired muscle protein homeostasis and

  2014cites this paper
• Multiple System Atrophy and Parkinson ’ s disease

  2013cites this paper
• Fluorescent thiophene-based ligands for detection and characterization of disease-associated protein aggregates

  2013cites this paper
• Alpha-synuclein as a regulator of synaptic signalling

  2013cites this paper
• Micropublications: a semantic model for claims, evidence, arguments and annotations in biomedical communications

  2013cites this paper
• Chaperone‐mediated autophagy components are upregulated in sporadic inclusion‐body myositis muscle fibres

  2013cites this paper
• Luminescent Conjugated Oligothiophenes for Sensitive Fluorescent Assignment of Protein Inclusion Bodies

  2013cites this paper
• Parkinson's disease redefined.

  2013cites this paper
• Muscle Aging, Inclusion-Body Myositis and Myopathies: Askanas/Muscle Aging, Inclusion-Body Myositis and Myopathies

  2012cites this paper
• Pathogenic Considerations in Sporadic Inclusion-Body Myositis, a Degenerative Muscle Disease Associated With Aging and Abnormalities of Myoproteostasis

  2012cites this paper
• Molecular Mechanism of Active Zone Organization at Vertebrate Neuromuscular Junctions

  2012cites this paper
• Alpha-synuclein truncation and disease

  2012cites this paper
• The role of α-synuclein in neurodegeneration — An update

  2012cites this paper
• Pink1 RNAi and Parkin Expression in Drosophila melanogaster

  2011influential citation
• Sporadic inclusion-body myositis: conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-β42 oligomers and phosphorylated tau.

  2011cites this paper
• Pathogenesis of Sporadic Inclusion‐Body Myositis: Role of Aging and Muscle‐Fiber Degeneration, and Accumulation of the Same Proteins as in Alzheimer and Parkinson Brains

  2011cites this paper
• Neuromuscular pathology in mice lacking alpha-synuclein.

  2011cites this paper
• Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis

  2011cites this paper
• Essential muscle pathology for the rheumatologist.

  2011cites this paper
• Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.

  2010cites this paper
• Myopathy causing camptocormia in idiopathic Parkinson's disease: A multidisciplinary approach

  2010cites this paper
• Sporadic inclusion body myositis: possible pathogenesis inferred from biomarkers.

  2010cites this paper
• How citation distortions create unfounded authority: analysis of a citation network

  2009cites this paper
• How citation distortions create unfounded authority : analysis of a citation network

  2009cites this paper
• Inclusion Body Myositis: A Degenerative Muscle Disease Associated with Intra‐Muscle Fiber Multi‐Protein Aggregates, Proteasome Inhibition, Endoplasmic Reticulum Stress and Decreased Lysosomal Degradation

  2009cites this paper
• p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis

  2009influential citation
• Roles of VCP in human neurodegenerative disorders.

  2008cites this paper
• Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-II muscle fibre atrophy.

  2008cites this paper
• In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized.

  2008cites this paper
• Atypical Parkinsonism in distal myopathy with rimmed vacuoles

  2008cites this paper
• Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer’s and Parkinson’s disease brains

  2008cites this paper
• Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase‐3β

  2008cites this paper
• Inclusion-body myositis, a multifactorial muscle disease associated with aging: current concepts of pathogenesis

  2007cites this paper
• Myostatin precursor protein is increased and associates with amyloid‐β precursor protein in inclusion‐body myositis culture model

  2007cites this paper
• Genetics of inclusion‐body myositis

  2007cites this paper
• Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage.

  2007cites this paper
• Homocysteine‐induced endoplasmic reticulum protein (Herp) is up‐regulated in sporadic inclusion‐body myositis and in endoplasmic reticulum stress‐induced cultured human muscle fibers

  2006influential citation
• Brain and brawn

  2006cites this paper
• Inclusion-body myositis

  2006cites this paper
• Myostatin is increased and complexes with amyloid-β within sporadic inclusion-body myositis muscle fibers

  2005cites this paper
• Molecular study of cell culture models of Parkinson's disease and Huntington's disease.

  2005cites this paper
• Molecular pathology and pathogenesis of inclusion‐body myositis

  2005cites this paper
• Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers.

  2005cites this paper
• Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.

  2004cites this paper
• Alpha-synuclein: normal function and role in neurodegenerative diseases.

  2004cites this paper
• -Synuclein: Normal Function and Role in Neurodegenerative Diseases

  2004cites this paper
• Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies

  2004cites this paper
• Cystatin C colocalizes with amyloid-beta and coimmunoprecipitates with amyloid-beta precursor protein in sporadic inclusion-body myositis muscles.

  2003cites this paper
• Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-&bgr;, misfolded proteins, predisposing genes, and aging

  2003cites this paper
• Expression of α- and β-synucleins in cultured astrocytes and the effects of inflammatory cytokines

  2003cites this paper
• Widespread expression of α-synuclein in neuronal cytoplasm and glial cells in the central and peripheral nervous systems in human

  2003cites this paper
• Cystatin C colocalizes with amyloid‐β and coimmunoprecipitates with amyloid‐β precursor protein in sporadic inclusion‐body myositis muscles

  2003cites this paper
• Demonstration of α-Synuclein Immunoreactivity in Neuronal and Glial Cytoplasm in Normal Human Brain Tissue Using Proteinase K and Formic Acid Pretreatment

  2002cites this paper
• α-Synuclein immunoreactivity in normal and neoplastic Schwann cells

  2002cites this paper
• Inclusion body myositis-like phenotype induced by transgenic overexpression of βAPP in skeletal muscle

  2002cites this paper
• Sporadic inclusion body myositis and hereditary inclusion body myopathy.

  2002cites this paper