Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Glycoconjugate Journal

• Publication date

  2012-06-29

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s10719-012-9416-zPMID 22744837
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Soluble β‐glucan from Grifola frondosa induces proliferation and Dectin‐1/Syk signaling in resident macrophages via the GM‐CSF autocrine pathway

  2012cited by this paper
• The role of Dectin-1 in the host defence against fungal infections.

  2011cited by this paper
• A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer

  2010cited by this paper
• β‐glucan recognition by the innate immune system

  2009cited by this paper
• An unambiguous structural elucidation of a 1,3-beta-D-glucan obtained from liquid-cultured Grifola frondosa by solution NMR experiments.

  2009cited by this paper
• Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

  2009cited by this paper
• The effects of β-glucan on human immune and cancer cells

  2009cited by this paper
• Glucans as biological response modifiers.

  2009cited by this paper
• Regulation and function of NF-kappaB transcription factors in the immune system.

  2009cited by this paper
• Combined yeast-derived beta-glucan with anti-tumor monoclonal antibody for cancer immunotherapy.

  2009cited by this paper
• Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells1

  2009cited by this paper
• Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum.

  2009cited by this paper
• A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects

  2009cited by this paper
• Dietary modulation of immune function by beta-glucans.

  2008cited by this paper
• Differential High-Affinity Interaction of Dectin-1 with Natural or Synthetic Glucans Is Dependent upon Primary Structure and Is Influenced by Polymer Chain Length and Side-Chain Branching

  2008cited by this paper
• Exploring the full spectrum of macrophage activation

  2008cited by this paper
• Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans

  2007cited by this paper
• Blocking Effect of Anti-Dectin-1 Antibodies on the Anti-tumor Activity of 1,3-β-Glucan and the Binding of Dectin-1 to 1,3-β-Glucan

  2007cited by this paper
• Dectin-1 is required for beta-glucan recognition and control of fungal infection.

  2007cited by this paper
• Medicinal importance of fungal -(1?3), (1?6)-glucans

  2007cited by this paper
• NMR characterization of the structure of a beta-(1-->3)-D-glucan isolate from cultured fruit bodies of Sparassis crispa.

  2007cited by this paper
• Blocking effect of anti-Dectin-1 antibodies on the anti-tumor activity of 1,3-beta-glucan and the binding of Dectin-1 to 1,3-beta-glucan.

  2007cited by this paper
• Medicinal importance of fungal beta-(1-->3), (1-->6)-glucans.

  2007cited by this paper
• Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

  2006cited by this paper
• Isolation and characterization

  2006cited by this paper
• A beta-D-glucan isolated from the fruiting bodies of Hericium erinaceus and its aqueous conformation.

  2006cited by this paper
• Isolation and characterization of α-(1→6)-glucans from Cistanche deserticola

  2005cited by this paper
• Isolation and characterization of alpha-(1-->6)-glucans from Cistanche deserticola.

  2005cited by this paper
• Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa.

  2005cited by this paper
• Mango ripening--chemical and structural characterization of pectic and hemicellulosic polysaccharides.

  2005cited by this paper
• Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.

  2005cited by this paper
• Characterization of beta-glucan recognition site on C-type lectin, dectin 1.

  2004cited by this paper
• Characterization of β-Glucan Recognition Site on C-Type Lectin, Dectin 1

  2004cited by this paper
• Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages.

  2004cited by this paper
• Mushrooms, Tumors, and Immunity: An Update

  2004cited by this paper
• Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

  2003cited by this paper
• Fungal β-Glucans and Mammalian Immunity

  2003cited by this paper
• Fungal beta-glucans and mammalian immunity.

  2003cited by this paper
• Faculty Opinions recommendation of Dectin-1 is a major beta-glucan receptor on macrophages.

  2002cited by this paper
• Dectin-1 Is A Major β-Glucan Receptor On Macrophages

  2002cited by this paper
• Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

  2002cited by this paper
• Maitake extracts and their therapeutic potential.

  2001cited by this paper
• Structural Characterization and Chemical Modification of a Glucan from Spores of Ganoderma lucidum

  2001cited by this paper
• The use of mushroom glucans and proteoglycans in cancer treatment.

  2000cited by this paper
• Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans

  1997cited by this paper
• Nitric oxide synthesis in murine peritoneal macrophages by fungal beta-glucans.

  1997cited by this paper
• Structure-activity relationship of (1-->3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro.

  1995cited by this paper
• Avoiding oxidative degradation during sodium hydroxide/methyl iodide-mediated carbohydrate methylation in dimethyl sulfoxide

  1993cited by this paper
• The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake).

  1987cited by this paper
• Host-mediated antitumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa.

  1987cited by this paper
• Characterization of the antitumor glucan obtained from liquid-cultured Grifola frondosa.

  1986cited by this paper
• Structural characterization and antitumor activity of the extracts from matted mycelium of cultured Grifola frondosa.

  1985cited by this paper
• Antitumor activity and structural characterization of glucans extracted from cultured fruit bodies of Grifola frondosa.

  1984cited by this paper

• New insights into extraction, isolation and characterization of β-glucan from edible and medicinal mushrooms

  2026cites this paper
• Neuroprotective effects of yeast β-glucan with different degrees of oxidation against Pb-induced toxicity in PC12 cells and cognitive impairment in mice.

  2026cites this paper
• 1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis

  2026cites this paper
• Structural characterization and immunomodulatory activity of a novel pectin polysaccharide extracted from Gardenia jasminoides fruit.

  2025cites this paper
• Generative Hyphal Stiffness and Cell Wall Thickening in Fungi

  2025cites this paper
• Recent innovations in Grifola frondosa polysaccharides: production, properties, and their biological activity

  2025cites this paper
• Structural Elucidation of Heteropolysaccharides from the Peach-Shaped Dictyophora indusiata and Its Anti-Inflammatory Activity

  2025cites this paper
• Effect of Grifola frondosa polysaccharide on immune function and gut microbiota in mice

  2025cites this paper
• Grifola Frondosa‐Derived Nanoparticles Modulate Tumor‐Associated Neutrophil Plasticity and Enhance Anti‐Tumor Immunity

  2025cites this paper
• Anticancer potential of dietary fiber for colorectal carcinoma: a narrative review

  2025cites this paper
• Mushroom β-glucans as immunomodulators: Elucidation of structure-function relationship.

  2025cites this paper
• Chemical structure characterization of edible mushroom-extracted beta-glucan and its bioactivity

  2024cites this paper
• Extraction and Identification of Polysaccharide from Lentinus edodes and Its Effect on Immunosuppression and Intestinal Barrier Injury Induced by Cyclophosphamide

  2024cites this paper
• Polysaccharide with anticancer activity from Grifola frondosa cultured in industrial wastewater of Agaricus bisporus.

  2024cites this paper
• GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation

  2024cites this paper
• Characterization and in vitro digestion of alkali-extracted polysaccharides from Grifola frondosa and its impacts on human gut microbiota

  2024cites this paper
• Extraction and Characterization of Beta-glucan Methyl Esters Derived From UV-mutated Marine Yeast and their Applications in Cosmetics

  2024cites this paper
• Potential promising anticancer applications of β-glucans: a review

  2023cites this paper
• Purification, characterization, and antioxidant activity of polysaccharides from Grifola frondosa by hydrogen peroxide/ascorbic acid-assisted extraction

  2023cites this paper
• Grifola frondosa polysaccharides: A review on structure/activity, biosynthesis and engineering strategies.

  2023cites this paper
• Extraction, purification, structure and bioactivities of polysaccharides from Grifola frondosa (maitake): a review

  2023cites this paper
• Cytotoxic properties of unfractionated and fractionated bromelain alone or in combination with chemotherapeutic agents in colorectal cancer cells

  2023cites this paper
• Fungi as a source of bioactive molecules for the development of longevity medicines.

  2023cites this paper
• From Cancer Therapy to Winemaking: The Molecular Structure and Applications of β-Glucans and β-1, 3-Glucanases

  2022cites this paper
• Bioactive mushroom polysaccharides: The structure, characterization and biological functions

  2022cites this paper
• Isolation and characterization of an anti-proliferative polysaccharide from the North American fungus Echinodontium tinctorium

  2022cites this paper
• Research progress on natural β-glucan in intestinal diseases.

  2022cites this paper
• β-Glucans from Yeast—Immunomodulators from Novel Waste Resources

  2022cites this paper
• Multifaceted efficacy of caspofungin against fungal infections in COVID-19 patients

  2022cites this paper
• Effects of cyclophosphamide on antioxidative and immune functions of Nile tilapia (Oreochromis Niloticus) via the TLR-NF-κB signaling pathway.

  2021cites this paper
• Beta-glucans is a potential inhibitor of ovarian cancer: based on molecular and biological aspects.

  2021cites this paper
• Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics.

  2021cites this paper
• Advances in dietary polysaccharides as anticancer agents: Structure-activity relationship

  2021cites this paper
• β-glucan, “the knight of health sector”: critical insights on physiochemical heterogeneities, action mechanisms and health implications

  2021cites this paper
• Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

  2021cites this paper
• Methyl gallate, gallic acid-derived compound, inhibit cell proliferation through increasing ROS production and apoptosis in hepatocellular carcinoma cells

  2021cites this paper
• Promising Potential of Crude Polysaccharides from Sparassis crispa against Colon Cancer: An In Vitro Study

  2021cites this paper
• Antitumor effect of soluble β-glucan as an immune stimulant.

  2021cites this paper
• β-Glucans as a panacea for a healthy heart? Their roles in preventing and treating cardiovascular diseases.

  2021cites this paper
• Biologically active polysaccharide from edible mushrooms: A review.

  2021cites this paper
• Yarrowia lipolytica N6-glucan protects goat leukocytes against Escherichia coli by enhancing phagocytosis and immune signaling pathway genes.

  2021cites this paper
• Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake)

  2021cites this paper
• A Review on the Structure and Anti-Diabetic (Type 2) Functions of β-Glucans

  2021cites this paper
• The β-1,3-glucan synthase gene GFGLS2 plays major roles in mycelial growth and polysaccharide synthesis in Grifola frondosa

  2021cites this paper
• Preparation and structural properties of selenium modified heteropolysaccharide from the fruits of Akebia quinata and in vitro and in vivo antitumor activity.

  2021cites this paper
• New light on Grifola frondosa polysaccharides as biological response modifiers

  2021cites this paper
• Beta-Glucans

  2021cites this paper
• How Does Herbal Medicine Treat Idiopathic Membranous Nephropathy?

  2020cites this paper
• A (1→6)-Branched (1→4)-β-d-Glucan from Grifola frondosa Inhibits Lipopolysaccharide-Induced Cytokine Production in RAW264.7 Macrophages by Binding to TLR2 Rather than Dectin-1 or CR3 Receptors.

  2020cites this paper
• A β-glucan from Grifola frondosa effectively delivers therapeutic oligonucleotide into cells via dectin-1 receptor and attenuates TNFα gene expression.

  2020cites this paper
• Hippocampal subfield transcriptome analysis in schizophrenia psychosis

  2020cites this paper
• Differences in anti-inflammatory properties of water soluble and insoluble bioactive polysaccharides in lipopolysaccharide-stimulated RAW264.7 macrophages

  2020cites this paper
• Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: Possible involvement of the spleen tyrosine kinase pathway.

  2020cites this paper
• Mushrooms and immunity.

  2020cites this paper
• β-Glucan Metabolic and Immunomodulatory Properties and Potential for Clinical Application

  2020cites this paper
• Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways.

  2019cites this paper
• Structural studies of a water insoluble β-glucan from Pleurotus djamor and its cytotoxic effect against PA1, ovarian carcinoma cells.

  2019cites this paper
• The cooperative induction of macrophage activation by fucoidan derived from Cladosiphon okamuranus and β-glucan derived from Saccharomyces cerevisiae.

  2019cites this paper
• The anti-inflammatory effects of low- and high-molecular-weight beta-glucans from Agrobacterium sp. ZX09 in LPS-induced weaned piglets.

  2019cites this paper
• Mushrooms reishi (Ganoderma lucidum), shiitake (Lentinela edodes), maitake (Grifola frondosa)

  2019cites this paper
• β-Glucan from Saccharomyces cerevisiae induces SBD-1 production in ovine ruminal epithelial cells via the Dectin-1-Syk-NF-κB signaling pathway.

  2019cites this paper
• NF‐κB activation mediates LPS‐or zymosan‐induced hypotension and inflammation reversed by BAY61‐3606, a selective Syk inhibitor, in rat models of septic and non‐septic shock

  2019cites this paper
• β-Glucan and Parasites

  2018cites this paper
• Beta-Glucans and Their Derivatives

  2018cites this paper
• Preparation and characterisation of a novel hydrogel based on Auricularia polytricha β-glucan and its bio-release property for vitamin B12 delivery.

  2018cites this paper
• Chemical structure of a partially 3-O-methylated mannofucogalactan from edible mushroom Grifola frondosa.

  2018cites this paper
• Debaryomyces hansenii CBS 8339 &bgr;‐glucan enhances immune responses and down‐stream gene signaling pathways in goat peripheral blood leukocytes

  2018cites this paper
• Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment.

  2018cites this paper
• Purification, characterization and immunomodulatory activity of a novel polysaccharide from Grifola frondosa.

  2018cites this paper
• The role of Syk/IĸB‐α/NF‐ĸB pathway activation in the reversal effect of BAY 61‐3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan‐induced non‐septic shock

  2018cites this paper
• Production of low-molecular weight soluble yeast β-glucan by an acid degradation method.

  2018cites this paper
• Characterization of a pectin from Lonicera japonica Thunb. and its inhibition effect on Aβ42 aggregation and promotion of neuritogenesis.

  2018cites this paper
• Modulation of an innate immune response by soluble yeast β-glucan prepared by a heat degradation method.

  2017cites this paper
• Uptake of intraperitoneally administrated triple helical β-glucan for antitumor activity in murine tumor models.

  2017cites this paper
• Structure and Biological Functions of d-Glucans and Their Applications

  2017cites this paper
• Structural elucidation and antioxidant activity a novel Se-polysaccharide from Se-enriched Grifola frondosa.

  2017cites this paper
• β-(1→6)-d-glucan secreted during the optimised production of exopolysaccharides by Paecilomyces variotii has immunostimulatory activity

  2017cites this paper
• Protective effects of the exopolysaccharide Lasiodiplodan against DNA damage and inflammation induced by doxorubicin in rats: Cytogenetic and gene expression assays.

  2017cites this paper
• Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review.

  2017cites this paper
• Identification of inflammatory factor TNFα inhibitor from medicinal herbs.

  2016cites this paper
• Ganoderma lucidum polysaccharide exerts anti-tumor activity via MAPK pathways in HL-60 acute leukemia cells

  2016cites this paper
• The Prefrontal Dectin-1/AMPA Receptor Signaling Pathway Mediates The Robust and Prolonged Antidepressant Effect of Proteo-β-Glucan from Maitake

  2016cites this paper
• Characterization and enzymatic hydrolysis of hydrothermally treated β-1,3–1,6-glucan from Aureobasidium pullulans

  2016cites this paper
• A comb-like branched β-D-glucan produced by a Cordyceps sinensis fungus and its protective effect against cyclophosphamide-induced immunosuppression in mice.

  2016cites this paper
• Anticancer properties of low molecular weight oat beta-glucan – An in vitro study.

  2015cites this paper
• Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

  2015cites this paper
• In vitro and in vivo immunostimulatory activity of an exopolysaccharide‐enriched fraction from Bacillus subtilis

  2015cites this paper
• Zymosan and PMA activate the immune responses of Mutz3-derived dendritic cells synergistically.

  2015cites this paper
• Molecular Interactions of β-(1→3)-Glucans with Their Receptors

  2015cites this paper
• β-(1→3),(1→6)-Glucans: medicinal activities, characterization, biosynthesis and new horizons

  2015influential citation
• Carboxymethylation of (1 → 6)-β-glucan (lasiodiplodan): Preparation, characterization and antioxidant evaluation.

  2015cites this paper
• Beta-glucans from edible and medicinal mushrooms: Characteristics, physicochemical and biological activities

  2015cites this paper
• Preparation and Characterization of Polysaccharides from Mushrooms

  2015cites this paper
• The WNT Signaling Pathway Contributes to Dectin-1-Dependent Inhibition of Toll-Like Receptor-Induced Inflammatory Signature

  2014cites this paper
• Bioprodução de β -(1→6)-D-Glucana e obtenção de derivado por carboximetilação visando atividade biológica

  2014cites this paper
• The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound β-glucan

  2014cites this paper
• Effect of Glucans from Caripia montagnei Mushroom on TNBS-Induced Colitis

  2014cites this paper
• Water-insoluble glucans from the edible fungus Ramaria botrytis

  2014cites this paper
• Grifola frondosa extract induced acute hepatic injury.

  2014cites this paper
• Structural characterization and immunostimulatory activity of a novel protein-bound polysaccharide produced by Hirsutella sinensis Liu, Guo, Yu & Zeng.

  2013cites this paper