Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Antimicrobial Chemotherapy

• Publication date

  2004-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/JAC/DKH456PMID 15486081
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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• Isolation and nucleotide sequence of an autonomously replicating sequence (ARS) element functional in Candida albicans and Saccharomyces cerevisiae

  1990cited by this paper
• Enzymes of N-acetylglucosamine metabolism during germ-tube formation in Candida albicans.

  1982cited by this paper
• National Committee for Clinical Laboratory Standards.

  1980cited by this paper
• Induction of N-acetylglucosamine-catabolic pathway in spheroplasts of Candida albicans.

  1979cited by this paper
• Candida and candidosis

  1979cited by this paper
• Yeast-mycelial conversion induced by N-acetyl-D-glucosamine in Candida albicans

  1974cited by this paper
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