Role of epithelial nitric oxide in airway viral infection

The airway mucosal epithelium is the first site of virus contact with the host, and the main site of infection and inflammation. Nitric oxide (NO) produced by the airway epithelium is vital to antiviral inflammatory and immune defense in the lung. Multiple mechanisms function coordinately to support high-level basal NO synthesis in healthy airway epithelium and further induction of NO synthesis in the infected airway of normal hosts. Hosts deficient in NO synthesis, such as those patients with cystic fibrosis, have impaired antiviral defense and may benefit from therapies to augment NO levels in the airways.

• Publication year

  2006

• Venue

  Free Radical Biology & Medicine

• Publication date

  2006-02-20

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.freeradbiomed.2006.01.037PMID 16781449PMCID 7127628
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003influential reference
• Viral respiratory tract infections: increasing importance and a new pathogen.

  2003cited by this paper
• Viral Respiratory Infections Due to Rhinoviruses: Current Knowledge, New Developments

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• Cystic fibrosis

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• Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-κB

  2001cited by this paper
• Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase1

  2000influential reference
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• Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases*

  2000cited by this paper
• Partial impairment of cytokine responses in Tyk2-deficient mice.

  2000cited by this paper
• Viral Double-Stranded RNA, Cytokines, and the Flu

  2000cited by this paper
• Measurements of exhaled nitric oxide with the single-breath technique and positive expiratory pressure in infants.

  1999cited by this paper
• Initial and innate responses to viral infections--pattern setting in immunity or disease.

  1999cited by this paper
• Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways.

  1999cited by this paper
• Bronchiolitis-associated hospitalizations among US children, 1980-1996.

  1999cited by this paper
• Nitric Oxide I . Physiological chemistry of nitric oxide and its metabolites : implications in inflammation

  1999cited by this paper
• Nitric oxide in septic shock.

  1999cited by this paper
• Inhibition of Influenza Virus Replication by Nitric Oxide

  1999cited by this paper
• Mammalian nitric oxide synthases.

  1999influential reference
• I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation.

  1999cited by this paper
• Exhaled nitric oxide concentrations during treatment of wheezing exacerbation in infants and young children.

  1999cited by this paper
• Mammalian nitric oxide synthases.

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• Pulmonary oxidative stress response in young children with cystic fibrosis.

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