BAF-1 mobility is regulated by environmental stresses

D. Bar,M. Davidovich,Ayelet T. Lamm,H. Zer,K. Wilson,Y. Gruenbaum

Published 2014 in Molecular Biology of the Cell

ABSTRACT

Barrier to autointegration factor (BAF) is an essential mobile protein that binds lamins, LEM-domain proteins, histones, and DNA. Under environmental stress, BAF becomes immobile. This phenomenon is not shared with other chromatin-binding proteins. The ability of BAF mutants to be immobilized by heat shock in gut cells correlated with normal or increased affinity for emerin.

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