Structural basis for DNA bridging by barrier-to-autointegration factor

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2005-09-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nsmb989PMID 16155580
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina.

  2005cited by this paper
• BAF: roles in chromatin, nuclear structure and retrovirus integration.

  2004cited by this paper
• Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

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• Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila

  2003cited by this paper
• Structure of a trapped endonuclease III–DNA covalent intermediate

  2003cited by this paper
• The Barrier-to-Autointegration Factor Is a Component of Functional Human Immunodeficiency Virus Type 1 Preintegration Complexes

  2003cited by this paper
• Regulatory Mechanisms by Which Barrier-to-Autointegration Factor Blocks Autointegration and Stimulates Intermolecular Integration of Moloney Murine Leukemia Virus Preintegration Complexes

  2002cited by this paper
• Structural basis of DNA bridging by barrier-to-autointegration factor.

  2000cited by this paper
• Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex.

  2000cited by this paper
• Common fold in helix-hairpin-helix proteins.

  2000cited by this paper
• DNA bending and a flip‐out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA

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• Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration

  1998cited by this paper
• A previously unidentified host protein protects retroviral DNA from autointegration.

  1998cited by this paper
• The barrier-to-autointegration protein is a host factor for HIV type 1 integration.

  1998cited by this paper
• The helix-hairpin-helix DNA-binding motif: a structural basis for non- sequence-specific recognition of DNA

  1996cited by this paper

• Nucleosome Bundling by Barrier-to-Autointegration Factor: Implications for Its Diverse Functions.

  2026cites this paper
• Phosphorylation of Barrier-to-Autointegration Factor (BAF) regulates anchoring of centromeric heterochromatin to the nuclear envelope (NE)

  2026cites this paper
• Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes

  2025cites this paper
• A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation

  2025cites this paper
• ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

  2025cites this paper
• VRK1 co-delivery mitigates DNA clustering by BAF in TFAMoplex transfection

  2025cites this paper
• A protein-DNA surface hydrogel mechanically reinforces the cell nucleus and protects the genome

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• Reversible DNA condensation drives natural transformation

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• A novel antiviral role of ankyrin repeat and LEM domain-containing 2 (ANKLE2) in restricting vaccinia virus through barrier to autointegration factor (BAF)

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• Pushing the envelope - How the genome interacts with the nuclear envelope in health and disease.

  2025cites this paper
• A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans

  2024cites this paper
• A human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans

  2024cites this paper
• Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin

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• Molecular functions of ANKLE2 and its implications in human disease

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• Nuclear functions regulated by the VRK1 kinase

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• Crosstalk between mitotic reassembly and repair of the nuclear envelope

  2024cites this paper
• Functional Interactions of BAF and LEM Proteins in the Formation of Germ Cells

  2023cites this paper
• Mono-phosphorylation at Ser4 of Barrier-to-autointegration Factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surface

  2023cites this paper
• How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions?

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• Hepatitis B Virus X Protein Inhibits the Expression of Barrier To Autointegration factor1 via Upregulating miR-203 Expression in Hepatic Cells

  2022cites this paper
• The conformation of the intrinsically disordered N-terminal region of Barrier-to-Autointegration factor (BAF) is regulated by pH and phosphorylation.

  2022cites this paper
• The BAF A12T mutation associated with premature aging impedes lamin A/C recruitment to sites of nuclear rupture, contributing to nuclear envelope fragility

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• The BAF A12T mutation reduces BAF affinity to lamin A/C, preventing its recruitment to nuclear ruptures in Nestor Guillermo Progeria Syndrome

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• Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase

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• The BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor–Guillermo progeria syndrome cells

  2022cites this paper
• The TFAMoplex—Conversion of the Mitochondrial Transcription Factor A into a DNA Transfection Agent

  2022cites this paper
• A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein translation

  2022cites this paper
• Molecular docking of brazilin and its analogs to barrier‐to‐autointegration factor 1 (BAF1)

  2022cites this paper
• The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function

  2021cites this paper
• Interaction of obtusilactone B and related butanolide lactones with the barrier-to-autointegration factor 1 (BAF1). A computational study

  2021influential citation
• Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners

  2021cites this paper
• Mus musculus Barrier-To-Autointegration Factor 2 (Banf2) is Not Essential for Spermatogenesis or Fertility

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• Interplay of cGAS with chromatin.

  2021cites this paper
• A barrier-to-autointegration factor promotes white spot syndrome virus infection in a crustacean Cherax quadricarinatus.

  2020cites this paper
• DNA unchained: two assays to discover and study inhibitors of the DNA clustering function of barrier-to-autointegration factor

  2020cites this paper
• Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor.

  2020cites this paper
• Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication

  2020cites this paper
• LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation.

  2020cites this paper
• K6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells

  2020cites this paper
• LEM2 phase separation governs ESCRT-mediated nuclear envelope reformation

  2020cites this paper
• Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage

  2019cites this paper
• A poxvirus pseudokinase represses viral DNA replication via a pathway antagonized by its paralog kinase

  2019cites this paper
• A role for liquid-liquid phase separation in ESCRT-mediated nuclear envelope reformation

  2019cites this paper
• Rare BANF1 Alleles and Relatively Frequent EMD Alleles Including ‘Healthy Lipid’ Emerin p.D149H in the ExAC Cohort

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• An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress

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• 1 An emerin LEM-domain mutation impairs cell 2 response to mechanical stress 3

  2019cites this paper
• Mechanosensitive recruitment of BAF to the nuclear membrane inhibits nuclear E2F1 and Yap levels

  2019cites this paper
• Transport and Communication Across the Nuclear Envelope

  2018cites this paper
• Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases

  2018cites this paper
• How chromosomes unite

  2017cites this paper
• Establishment and Enhancement of Mu in vitro DNA Transposition Applications: Novel Procedures and New Tools

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• The Barrier to Autointegration Factor: Interlocking Antiviral Defense with Genome Maintenance

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• Necrotic pyknosis is a morphologically and biochemically distinct event from apoptotic pyknosis

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  2016cites this paper
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  2015cites this paper
• Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters

  2015cites this paper
• Finding optimal interaction interface alignments between biological complexes

  2015cites this paper
• Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes

  2015cites this paper
• A novel pathway to detect and cope with exogenous dsDNA

  2015cites this paper
• Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation

  2014influential citation
• Cell- and Virus-Mediated Regulation of the Barrier-to-Autointegration Factor's Phosphorylation State Controls Its DNA Binding, Dimerization, Subcellular Localization, and Antipoxviral Activity

  2014cites this paper
• Molecular simulation investigation on the interaction between barrier-to-autointegration factor or its Gly25Glu mutant and DNA

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
• Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer

  2013influential citation
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  2013cites this paper
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  2013cites this paper
• O-Linked β-N-Acetylglucosamine (O-GlcNAc) Regulates Emerin Binding to Barrier to Autointegration Factor (BAF) in a Chromatin- and Lamin B-enriched “Niche”*

  2013cites this paper
• Dephosphorylation of Barrier-to-autointegration Factor by Protein Phosphatase 4 and Its Role in Cell Mitosis*

  2013cites this paper
• Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase.

  2013cites this paper
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  2012cites this paper
• Proteomics analysis of human umbilical vein endothelial cells treated with resveratrol

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• NMR Spectroscopy as a Tool to Provide Mechanistic Clues About Protein Function and Disease Pathogenesis

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  2012cites this paper
• No Interaction of Barrier-to-Autointegration Factor (BAF) with HIV-1 MA, Cone-Rod Homeobox (Crx) or MAN1-C in Absence of DNA

  2011cites this paper
• Barrier-to-Autointegration Factor influences specific histone modifications

  2011cites this paper
• Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.

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• Roles of VRK1 as a new player in the control of biological processes required for cell division.

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• The Mitotic Chromosome: Structure and Mechanics

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• Cellular Cofactors of HIV Integration

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• Molecular Characterization of the Host Defense Activity of the Barrier to Autointegration Factor against Vaccinia Virus

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• Immunity of replicating Mu to self-integration: a novel mechanism employing MuB protein

  2010cites this paper
• Lamin A precursor induces barrier-to-autointegration factor nuclear localization

  2010cites this paper
• Genome-nuclear lamina interactions and gene regulation.

  2010cites this paper
• Functional Disruption of the Moloney Murine Leukemia Virus Preintegration Complex by Vaccinia-related Kinases*

  2010cites this paper
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  2009cites this paper
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