Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Molecular Endocrinology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/MEND.11.1.9874PMID 8994186
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparative distribution of NURR1 and NUR77 nuclear receptors in the mouse central nervous system

  2007cited by this paper
• The Nuclear Hormone Receptor Superfamily: Structure and Function

  1996cited by this paper
• Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene.

  1996cited by this paper
• Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors.

  1996cited by this paper
• Expression of NOR-1 and its closely related members of the steroid/thyroid hormone receptor superfamily in human neuroblastoma cell lines.

  1995cited by this paper
• Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation.

  1995cited by this paper
• Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice

  1995influential reference
• The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor.

  1995cited by this paper
• A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

  1995cited by this paper
• The nuclear hormone receptor gene superfamily.

  1995cited by this paper
• NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.

  1994cited by this paper
• Characterization of a corticotropin-releasing hormone-responsive element in the rat proopiomelanocortin gene promoter and molecular cloning of its binding protein.

  1994cited by this paper
• Induction of multiple immediate early genes in rat hypothalamic paraventricular nucleus after stress.

  1994cited by this paper
• Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells.

  1994cited by this paper
• Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands

  1994cited by this paper
• Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses

  1993cited by this paper
• Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex.

  1993cited by this paper
• RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver.

  1993cited by this paper
• Novel glucocorticoid receptor complex with DNA element of the hormone‐repressed POMC gene.

  1993influential reference
• The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase

  1993cited by this paper
• Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus.

  1993influential reference
• A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry

  1993cited by this paper
• Identification of a new brain-specific transcription factor, NURR1.

  1992cited by this paper
• Orphan receptors: in search of a unifying hypothesis for activation.

  1992cited by this paper
• Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary glands of transgenic mice

  1992cited by this paper
• Identification of the DNA binding site for NGFI-B by genetic selection in yeast.

  1991cited by this paper
• Transcriptional activation by Nur77, a growth factor-inducible member of the steroid hormone receptor superfamily.

  1991cited by this paper
• Proopiomelanocortin gene promoter elements required for constitutive and glucocorticoid-repressed transcription.

  1991cited by this paper
• A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily.

  1990cited by this paper
• Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

  1989cited by this paper
• The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: genomic structure and expression in rat brain after seizure induction

  1989cited by this paper
• Induction of c‐fos and TIS genes in cultured rat astrocytes by neurotransmitters

  1989cited by this paper
• Gene regulation by steroid hormones.

  1989cited by this paper
• Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription

  1989cited by this paper
• A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

  1988cited by this paper
• Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.

  1988cited by this paper
• The steroid and thyroid hormone receptor superfamily.

  1988cited by this paper
• Nucleotide sequence of the gene coding for ovine corticotropin-releasing factor and regulation of its mRNA levels by glucocorticoids.

  1988cited by this paper
• Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

  1988cited by this paper
• A simple phase-extraction assay for chloramphenicol acyltransferase activity.

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

  1987influential reference
• Tissue-specific activity of the pro-opiomelanocortin gene promoter

  1987influential reference
• Complex Transcriptional Regulation by Glucocorticoids and Corticotropin-Releasing Hormone of Proopiomelanocortin Gene Expression in Rat Pituitary Cultures

  1987cited by this paper
• Tissue-specific regulation of pituitary proopiomelanocortin gene transcription by corticotropin-releasing hormone, 3',5'-cyclic adenosine monophosphate, and glucocorticoids.

  1987cited by this paper
• Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.

  1985cited by this paper
• Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro.

  1984cited by this paper
• Isolation and characterization of the mouse corticotropin‐β‐lipotropin precursor gene and a related pseudogene

  1983cited by this paper
• Mechanisms of action of corticotropin-releasing factor and other regulators of corticotropin release in rat pituitary cells.

  1983cited by this paper
• DNA sequences required for transcription in vivo of the human corticotropin‐beta‐lipotropin precursor gene.

  1982cited by this paper
• Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs.

  1982cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Neuroendocrine Regulation

  1970cited by this paper

• NR4A Receptors in Immunity: Bridging Neuroendocrine and Inflammatory Pathways

  2025cites this paper
• Parallel expression patterns of NR4A nuclear receptor family genes in the pituitary gland of proestrus rats

  2024cites this paper
• Gene fusions are frequent in ACTH-secreting neuroendocrine neoplasms of the pancreas, but not in their non-pancreatic counterparts

  2023cites this paper
• Potential role of inducible GPR3 expression under stimulated T cell conditions.

  2022cites this paper
• Consumption of dietary emulsifiers increases sensitivity to social stress in mice: a potential role for the COX molecular pathway

  2022influential citation
• Role of the nuclear receptor subfamily 4a in mast cells in the development of irritable bowel syndrome

  2022cites this paper
• Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.

  2022cites this paper
• Dietary emulsifier consumption alters gene expression in the amygdala and paraventricular nucleus of the hypothalamus in mice

  2022cites this paper
• Synergistic Effects of Combined Nurr1 Overexpression and Natural Inducers on the More Efficient Production of Dopaminergic Neuron-Like Cells From Stem Cells

  2022cites this paper
• Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

  2022cites this paper
• Developmental single-cell transcriptomics of hypothalamic POMC progenitors reveal the genetic trajectories of multiple neuropeptidergic phenotypes

  2021cites this paper
• Dual origin and multiple neuropeptidergic trajectories of hypothalamic POMC 1 progenitors revealed by developmental single-cell transcriptomics

  2021cites this paper
• Variability in Behavioral Phenotypes after Forced Swimming-Induced Stress in Rats Is Associated with Expression of the Glucocorticoid Receptor, Nurr1, and IL-1β in the Hippocampus

  2021cites this paper
• Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.

  2021cites this paper
• (3α,5α)3-Hydroxypregnan-20-one (3α,5α-THP) regulation of hypothalamic and extrahypothalamic corticotropin releasing factor (CRF): Sexual dimorphism and brain region specificity in Sprague Dawley rats.

  2021influential citation
• Epinephrine May Contribute to the Persistence of Traumatic Memories in a Post-traumatic Stress Disorder Animal Model

  2020cites this paper
• Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription

  2020influential citation
• Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience.

  2020cites this paper
• Targeting Corticotroph HDAC and PI3-Kinase in Cushing Disease.

  2020cites this paper
• Molecular Mechanisms of Glucocorticoid Resistance in Corticotropinomas: New Developments and Drug Targets

  2020cites this paper
• NURR1 Alterations in Perinatal Stress: A First Step towards Late-Onset Diseases? A Narrative Review

  2020cites this paper
• Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.

  2019cites this paper
• Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements

  2019cites this paper
• Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter

  2019cites this paper
• Structure‐dependent activation of gene expression by bis‐indole and quinoline‐derived activators of nuclear receptor 4A2

  2019influential citation
• N-3 (Omega-3) Fatty Acids: Effects on Brain Dopamine Systems and Potential Role in the Etiology and Treatment of Neuropsychiatric Disorders.

  2018cites this paper
• The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.

  2018cites this paper
• Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.

  2017cites this paper
• Transcriptional profiling of human femoral mesenchymal stem cells in osteoporosis and its association with adipogenesis.

  2017cites this paper
• SUMOylation atypique du récepteur nucléaire Nor-1

  2016cites this paper
• Active coping of prenatally stressed rats in the forced swimming test: involvement of the Nurr1 gene

  2016cites this paper
• Molecular characterization and analysis of the porcine NURR1 gene

  2016cites this paper
• Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin-releasing factor gene promoter region in the adult rat brain

  2015cites this paper
• Effects of chronic psychosocial stress on HPA axis functionality in male C57BL/6 mice and the impact of trait anxiety on the individual stress vulnerability

  2015cites this paper
• The role of time in biological systems: a computational analysis ranging from molecular dynamics to biological network simulations.

  2015cites this paper
• TMEFF 2 is an endogenous inhibitor of the CRH signal transduction pathway

  2015cites this paper
• TMEFF2 is an endogenous inhibitor of the CRH signal transduction pathway.

  2015cites this paper
• MEF2 (Myocyte Enhancer Factor 2) un nouveau facteur de transcription clé pour la cellule de Leydig

  2015influential citation
• Computational Approaches to Address the Next-Generation Sequencing Era

  2015cites this paper
• The Effects of Ethanol and Nicotine on Hepatic and Brain CYP2 Family Enzymes in African Green Monkeys

  2014cites this paper
• Stress and glucocorticoid regulation of NR4A genes in mice

  2014influential citation
• Design and Analysis of a Petri Net Model of the Von Hippel-Lindau (VHL) Tumor Suppressor Interaction Network

  2014cites this paper
• EFFECTS OF A UNILATERAL INTRASTRIATAL 6-HYDROXYDOPAMINE MODEL OF EARLY PARKINSON'S DISEASE ON MIDBRAIN DOPAMINE NEURONS IN RATS: A STEREOLOGICAL STUDY

  2013cites this paper
• Nur transcription factors in stress and addiction

  2013influential citation
• NR4A orphan nuclear receptors in glucose homeostasis: a minireview.

  2013cites this paper
• Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells.

  2013cites this paper
• MicroRNA 375 Mediates the Signaling Pathway of Corticotropin-releasing Factor (CRF) Regulating Pro-opiomelanocortin (POMC) Expression by Targeting Mitogen-activated Protein Kinase 8*

  2013cites this paper
• An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis.

  2013cites this paper
• Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice.

  2012cites this paper
• The Acth Axis: Pathogenesis, Diagnosis and Treatment

  2012cites this paper
• Génomique fonctionnelle des cellules corticotropes hypophysaires : contrôle génétique de la gestion systémique des stress

  2012cites this paper
• Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization[S]

  2012cites this paper
• An Investigation of CYP2B in Rat Brain: Regulation and Role in Drug and Toxin Response

  2012cites this paper
• Cellular and molecular specificity of pituitary gland physiology.

  2012cites this paper
• Pituitary Adenylate Cyclase‐Activating Polypeptide Controls Stimulus‐Transcription Coupling in the Hypothalamic‐Pituitary‐Adrenal Axis to Mediate Sustained Hormone Secretion During Stress

  2011cites this paper
• The human POMC gene promoter: Where do we stand?

  2011cites this paper
• THE FUNCTION OF NR3B AND NR4A ORPHAN NUCLEAR RECEPTORS IN OSTEOBLASTS

  2011cites this paper
• The interaction between A20 and the NR4A subfamily of nuclear receptors in the pathogenesis of rheumatoid arthritis

  2011cites this paper
• Stem cell potential in Parkinson's disease and molecular factors for the generation of dopamine neurons.

  2011cites this paper
• Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis

  2011influential citation
• A Role for Type 1 (cid:2) Corticotropin-Releasing Hormone Receptors in Mediating Local Changes in Chronically Inflamed Tissue

  2010cites this paper
• NOD proteins and their functional relevance to normal and adenomatous pituitary

  2010influential citation
• NR4A orphan nuclear receptors in immediate early regulation of retinoid signaling and neuroprotection

  2010cites this paper
• Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.

  2010cites this paper
• The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells.

  2010cites this paper
• Comparative study of the molecular mechanism of action of the synthetic progestins, Medroxyprogesterone acetate and Norethisterone acetate

  2010cites this paper
• Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland

  2010cites this paper
• Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases.

  2010cites this paper
• Identification of NURR1 as a mediator of MIF signaling during chronic arthritis: effects on glucocorticoid-induced MKP1.

  2010cites this paper
• Physiology and Pathophysiology of the HPA Axis

  2010cites this paper
• Structural and Functional Evolution of Vertebrate Neuroendocrine Stress Systems

  2009cites this paper
• Involvement of Nuclear Factor-ĸB and Nurr-1 in Cytokine-Induced Transcription of Proopiomelanocortin Gene in AtT20 Corticotroph Cells

  2009cites this paper
• COX-2 as a novel target of CRF family peptides' participating in inflammation.

  2009cites this paper
• Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis.

  2009cites this paper
• UvA-DARE ( Digital Academic Repository ) TR 3 nuclear orphan receptor in cardiovascular disease

  2009cites this paper
• Expression of Nuclear receptors TR3, MINOR and NOT in in-stent restenosis and genes downstream of TR3: p27, cyclin A, adrenomedullin and protein kinase C-delta

  2009cites this paper
• TIF1β/KAP-1 Is a Coactivator of the Orphan Nuclear Receptor NGFI-B/Nur77*

  2009cites this paper
• Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas

  2009cites this paper
• Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice.

  2009cites this paper
• Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action.

  2009cites this paper
• Expression of the Orphan Nuclear Receptor NR4A in a Putative Adenohypophyseal Homologue of Amphioxus

  2009cites this paper
• Regulation of Nur77 gene expression by prostanoids in cementoblastic cells.

  2009cites this paper
• Orphan nuclear receptor subfamily NR4A their interplay with other nuclear receptors and functions in osteoblasts

  2008cites this paper
• Protein kinase A serves as a primary pathway in activation of Nur77 expression by gonadotropin-releasing hormone in the LbetaT2 mouse pituitary gonadotroph tumor cell line.

  2008cites this paper
• Role of DAX-1 in PKA- and PKC-Mediated Regulation of the Steroidogenic Acute Regulatory Protein Expression in Mouse Leydig Tumor Cells: Mechanism of Action

  2008cites this paper
• Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition.

  2008influential citation
• HARACTERIZATION OF THE HYPOTHALAMIC ROOPIOMELANOCORTIN GENE AND-ENDORPHIN EXPRESSION IN HE HYPOTHALAMIC ARCUATE NUCLEUS OF MICE ELICITED BY NFLAMMATORY PAIN

  2008cites this paper
• Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway.

  2008cites this paper
• Regulation of the adrenal androgen biosynthesis.

  2008cites this paper
• NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain.

  2008cites this paper
• A Role for Type 1 (cid:1) Corticotropin-Releasing Hormone Receptors in Mediating Local Changes in Chronically Inflamed Tissue

  2007cites this paper
• Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic‐deficit adenovirus containing the NURR1 gene

  2007cites this paper
• Reversal of glucocorticoids-dependent proopiomelanocortin gene inhibition by leukemia inhibitory factor.

  2007cites this paper
• A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling

  2007cites this paper
• Regulation of vertebrate corticotropin-releasing factor genes.

  2007cites this paper
• Molecular mechanisms for corticotropin-releasing hormone gene repression by glucocorticoid in BE(2)C neuronal cell line.

  2007cites this paper
• Inflammatory Mediator Action on the Anterior Pituitary Gland

  2007cites this paper
• Bedeutung von Leber und intestinaler Mukosa für die Aktivierung und Funktion von T-Lymphozyten im murinen Infektionsmodell

  2007cites this paper
• Analyse structurale et fonctionnelle du récepteur nucléaire orphelin NOR-1 et inactivation du gène chez la souris

  2006cites this paper
• The NR4A subgroup: immediate early response genes with pleiotropic physiological roles

  2006cites this paper