Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs

We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial β-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro.

• Publication year

  2013

• Venue

  PLoS ONE

• Publication date

  2013-06-14

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1371/journal.pone.0064871PMID 23798996PMCID 3683053
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Aspergillus felis grows at 45 degrees C but not 50 degrees C, distinguishing it from Aspergillus viridinutans and Aspergillus fumigatus, and itraconazole and voriconazole cross-resistance was common in vitro.

  Confidence 0.94

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• Aspergillus felis has a fully functioning sexual reproductive cycle, as shown by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro, and ascospore germination.

  Confidence 0.96

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• Four human isolates previously reported as Aspergillus viridinutans were reidentified as Aspergillus felis by comparative sequence analysis of partial beta-tubulin and calmodulin genes.

  Confidence 0.97

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• Aspergillus felis is a novel heterothallic species associated with invasive aspergillosis in humans, cats, and dogs.

  Confidence 0.99

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review

• aspergillus felis

  species

  A fungal species in Aspergillus section Fumigati.

  Aliases: A. felis, Aspergillus felis sp. nov.

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• heterothallic mold

  reproductive traits

  A heterothallic fungus that requires compatible mating types for sexual reproduction.

  Aliases: heterothallic species

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• invasive aspergillosis

  diseases

  An invasive infection caused by Aspergillus species.

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• itraconazole and voriconazole cross-resistance

  resistance phenotypes

  Reduced in vitro susceptibility to both itraconazole and voriconazole.

  Aliases: itraconazole-voriconazole cross-resistance

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• mating-type analysis

  methods

  An assay used to determine the mating type of a fungal isolate.

  Aliases: mating type analysis

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• partial beta-tubulin and calmodulin genes

  genes

  Partial beta-tubulin and calmodulin gene sequences used as molecular markers for isolate comparison.

  Aliases: partial beta-tubulin and/or calmodulin genes

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• sexual reproductive cycle

  processes

  The sexual phase of a fungal life cycle, including teleomorph formation and ascospore germination.

  Aliases: fully functioning reproductive cycle

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review
• temperature growth phenotype

  phenotypes

  The ability of an isolate to grow at elevated temperatures.

  뀨 (7c402c1b98) extraction박진우 (dztg5apj7m) reviewAK (4715169a40) reviewKiller Whale (322360f1c1) review

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