Circulating (cell‐free) nucleic acids – A promising, non‐invasive tool for early detection of several human diseases

No abstract is available for this paper.

• Publication year

  2007

• Venue

  FEBS Letters

• Publication date

  2007-03-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2007.01.051PMID 17289032
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999influential reference
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  1999cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• FEBS Letters

  1987cited by this paper
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  1980cited by this paper
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  1977cited by this paper
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  1977influential reference
• Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system.

  1975cited by this paper
• Nucleic acids spontaneously released by living frog auricles.

  1972cited by this paper
• The relationship of desoxyribonuclease inhibitor levels in human sera to the occurrence of antinuclear antibodies.

  1968cited by this paper
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  1966cited by this paper
• The purple color reaction given by diphenylamine reagent. I. With normal and rheumatic fever sera.

  1951cited by this paper
• Occurrence and Distribution of an Inhibitor for Desoxyribonuclease in Animal Tissues.∗

  1950cited by this paper
• Les acides nucleiques du plasma sanguin chez l' homme

  1948cited by this paper
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  year unknowninfluential reference

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