High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2003-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1167/IOVS.02-1022PMID 12824263
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.

  2003cited by this paper
• Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.

  2002cited by this paper
• Diabetes‐induced nitrative stress in the retina, and correction by aminoguanidine

  2002cited by this paper
• Peroxynitrite (ONOO-) Increases Vascular Permeability in Experimental Diabetes by a Mechanism Involving Increased Expression of Urokinase Plasminogen Activator Receptor (uPAR)

  2002cited by this paper
• Beneficial effects of L-arginine supplementation in experimental hyperlipemia-hyperglycemia in the hamster

  2002cited by this paper
• High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells.

  2002cited by this paper
• Rapid Reversal of the Diabetic Endothelial Dysfunction by Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase

  2001cited by this paper
• Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.

  2001cited by this paper
• Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action

  2001cited by this paper
• Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice.

  2001cited by this paper
• Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

  2001cited by this paper
• Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca2+/Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway

  2001cited by this paper
• [Diabetic retinopathy].

  2001cited by this paper
• Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress

  2001cited by this paper
• Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine

  2000cited by this paper
• Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production.

  2000cited by this paper
• Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

  2000cited by this paper
• Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide.

  2000cited by this paper
• Induction of aldose reductase in cultured human microvascular endothelial cells by advanced glycation end products.

  2000cited by this paper
• Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells.

  2000cited by this paper
• Tyrosine Nitration by Peroxynitrite Formed from Nitric Oxide and Superoxide Generated by Xanthine Oxidase*

  2000cited by this paper
• Role of L‐arginine in the vascular actions and development of tolerance to nitroglycerin

  2000cited by this paper
• Time course of changes in endothelium-dependent and -independent relaxation of chronically diabetic aorta: role of reactive oxygen species.

  2000cited by this paper
• Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood–CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis

  2000cited by this paper
• Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies.

  1999cited by this paper
• Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function.

  1999influential reference
• Enzymatic function of nitric oxide synthases.

  1999cited by this paper
• VEGF-induced permeability increase is mediated by caveolae.

  1999cited by this paper
• Increased superoxide anion formation in endothelial cells during hyperglycemia: an adaptive response or initial step of vascular dysfunction?

  1999cited by this paper
• Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species.

  1998cited by this paper
• Diabetic retinopathy.

  1998cited by this paper
• Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.

  1998cited by this paper
• Protein kinase C activation and the development of diabetic complications.

  1998cited by this paper
• Characterization of the Cytoprotective Action of Peroxynitrite Decomposition Catalysts*

  1998cited by this paper
• Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products.

  1998cited by this paper
• Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin.

  1997cited by this paper
• Role of superoxide anions in changes of endothelial vasoactive response during acute hyperglycemia.

  1997cited by this paper
• High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells.

  1997cited by this paper
• Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat

  1997cited by this paper
• High D-Glucose–Induced Changes in Endothelial Ca2+/EDRF Signaling are Due to Generation of Superoxide Anions

  1996cited by this paper
• Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

  1996cited by this paper
• Peroxynitrite causes apoptosis in rat thymocytes.

  1995cited by this paper
• Molecular basis of osmotic regulation.

  1995cited by this paper
• DNA Damage and Oxidation of Thiols Peroxynitrite Causes in Rat Thymocytes

  1995cited by this paper
• Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected].

  1995cited by this paper
• A fluorometric assay for the measurement of nitrite in biological samples.

  1993cited by this paper
• Microdetermination of aldose and aldehyde reductases from human tissues.

  1987cited by this paper
• Direct Measurement of Polyol Pathway Activity in the Ocular Lens

  1984cited by this paper

• Molecular stress and neurovascular injury in the diabetic retina.

  2026cites this paper
• Citrulline Plus Arginine Induces an Angiogenic Response and Increases Permeability in Retinal Endothelial Cells via Nitric Oxide Production

  2025cites this paper
• Metabolic Pathways Involved in Retinal Angiogenesis: Molecular Mechanisms and Therapeutic Targets.

  2025cites this paper
• Physiological and Pathophysiological Relevance of Nitric Oxide Synthases (NOS) in Retinal Blood Vessels.

  2024cites this paper
• Fenofibrate reduces glucose-induced barrier dysfunction in feline enteroids

  2023cites this paper
• Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers

  2023cites this paper
• Diabetes Modulates Iodothyronine Deiodinase 2 Expression in the Mouse Retina: A Role for Thyroid Hormone in the Pathogenesis of Diabetic Retinopathy

  2023cites this paper
• Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress

  2022cites this paper
• The protective action of carnosine against 4-hne and 3-nt in glucolipotoxic cellular model of insulin resistance

  2022cites this paper
• Açai (Euterpe oleracea Mart) modulates oxidative stress and inflammation by NF-κB inactivation and Nrf2 up-regulation in experimental diabetes

  2022cites this paper
• Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response

  2022cites this paper
• Study of various biochemical parameter on atrazine induced glucose-6-phosphate dehydrogenase deficiency in brain

  2022cites this paper
• Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

  2022cites this paper
• Topical Gynura procumbens as a Novel Therapeutic Improves Wound Healing in Diabetic Mice

  2021cites this paper
• Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies

  2021cites this paper
• Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress

  2021cites this paper
• Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure

  2021cites this paper
• Oxidative Stress and Vascular Dysfunction in the Retina: Therapeutic Strategies

  2020cites this paper
• Multiple Cell Signalling Pathways of Human Proinsulin C-Peptide in Vasculopathy Protection

  2020cites this paper
• Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels

  2020cites this paper
• Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

  2020cites this paper
• Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases

  2020cites this paper
• New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

  2020cites this paper
• Glucose-induced duration-dependent genome-wide DNA methylation changes in human endothelial cells.

  2020cites this paper
• Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status–Dependent Manner

  2019cites this paper
• Targeting VE-PTP phosphatase protects the kidney from diabetic injury

  2019cites this paper
• Time‐lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition

  2018cites this paper
• N-acetylcysteine protects against diabetic nephropathy through control of oxidative and nitrosative stress by recovery of nitric oxide in rats.

  2018cites this paper
• Effect of High Glucose on the Apoptosis and Senescence of Trabecular Meshwork Cells

  2018cites this paper
• High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells

  2018cites this paper
• Diabetes-Induced Tyrosine Nitration Impairs Glutamine Synthetase Activity and Exacerbates Neurotoxicity in a Rat Model

  2018cites this paper
• Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen

  2018cites this paper
• Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy

  2017cites this paper
• Metabolic perturbations of postnatal growth restriction and hyperoxia-induced pulmonary hypertension in a bronchopulmonary dysplasia model

  2017cites this paper
• Coronary microvascular disease as an early culprit in the pathophysiology of diabetes and metabolic syndrome

  2017cites this paper
• Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism

  2017cites this paper
• Glucose levels affect LL-37 expression in monocyte-derived macrophages altering the Mycobacterium tuberculosis intracellular growth control.

  2016cites this paper
• C-peptide protects against hyperglycemic memory and vascular endothelial cell apoptosis.

  2016cites this paper
• High glucose impairs acetylcholine-mediated vasodilation in isolated arteries from Mourning doves (Z. macroura).

  2016cites this paper
• Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles

  2016cites this paper
• Role of Adenosine Receptor A2A in Traumatic Optic Neuropathies (Addendum)

  2016cites this paper
• Correlation of biomarkers thiobarbituric acid reactive substance, nitric oxide and central subfield and cube average thickness in diabetic retinopathy: a cross-sectional study

  2016cites this paper
• High glucose-associated osmolality promotes adipocytogenic differentiation of primary rat osteoblasts in a protein kinase A and phosphatidylinositol 3-kinase/Akt-dependent manner

  2015cites this paper
• Bone's responses to mechanical loading are impaired in type 1 diabetes.

  2015cites this paper
• Role of Adenosine Receptor A2A in Traumatic Optic Neuropathies

  2015cites this paper
• State of the art management of diabetic macular edema

  2015cites this paper
• Genistein Treatment Confers Protection against Gliopathy and Vasculopathy of the Diabetic Retina in Rats

  2015cites this paper
• Molecular Mechanisms of Diabetic Retinopathy: Potential Therapeutic Targets

  2015cites this paper
• Association Between a 27-bp Variable Number of Tandem Repeat Polymorphism in Intron 4 of the eNOS Gene and Risk for Diabetic Retinopathy Type 2 Diabetes Mellitus: A Meta-Analysis

  2014cites this paper
• Role of microRNAs in the modulation of diabetic retinopathy.

  2014cites this paper
• Luminance flicker-induced retinal vasodilation in humans with and without type 1 diabetes

  2014cites this paper
• Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, rage, leukocytes, and aldose reductase.

  2014cites this paper
• Avaliação dos efeitos da variabilidade da pressão arterial sistêmica sobre a pressão de perfusão ocular e suas repercussões sobre o estresse oxidativo em retinas de ratos normotensos e hipertensos

  2014cites this paper
• Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms

  2014cites this paper
• Polyphenol-rich fruits attenuate impaired endothelial function induced by glucose and free fatty acids in vitro in human endothelial cells

  2014cites this paper
• Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy.

  2014cites this paper
• Spironolactone improves endothelial dysfunction in streptozotocin-induced diabetic rats

  2014cites this paper
• Visual Psychophysics and Physiological Optics Diabetes-Induced Impairment in Visual Function in Mice : Contributions of p 38 MAPK , RAGE , Leukocytes , and Aldose Reductase

  2014cites this paper
• Arginase as a Mediator of Diabetic Retinopathy

  2013cites this paper
• Deletion of Aldose Reductase from Mice Inhibits Diabetes-Induced Retinal Capillary Degeneration and Superoxide Generation

  2013cites this paper
• Requirement of NOX2 Expression in Both Retina and Bone Marrow for Diabetes-Induced Retinal Vascular Injury

  2013cites this paper
• Oxidative Stress in Diabetes: Implications for Vascular and Other Complications

  2013cites this paper
• Diabetes-Induced Superoxide Anion and Breakdown of the Blood-Retinal Barrier: Role of the VEGF/uPAR Pathway

  2013cites this paper
• Intravitreal Bevacizumab for Treatment of Diabetic Macular Oedema

  2013cites this paper
• Peroxynitrite Mediates Testosterone-Induced Vasodilation of Microvascular Resistance Vessels

  2013cites this paper
• Oxidative Stress and Apoptotic Biomarkers in Diabetic Retinopathy

  2013cites this paper
• Effect of Dipyridamole on the Reactive Oxygen Species and Oxidative Stress in Trabecular Meshwork Cells

  2013cites this paper
• Vascular stem cells in diabetic complications: evidence for a role in the pathogenesis and the therapeutic promise

  2012cites this paper
• The Isolation and Characterization of β-Glucogallin as a Novel Aldose Reductase Inhibitor from Emblica officinalis

  2012cites this paper
• Diabetes exacerbates retinal oxidative stress, inflammation, and microvascular degeneration in spontaneously hypertensive rats

  2012cites this paper
• Oxidant stress and skeletal muscle microvasculopathy in the metabolic syndrome.

  2012cites this paper
• Peroxynitrite-driven mechanisms in diabetes and insulin resistance - the latest advances.

  2011cites this paper
• Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia

  2011cites this paper
• Vasculopathy in type 2 diabetes mellitus: role of specific angiogenic modulators

  2011cites this paper
• Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury

  2011cites this paper
• Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation.

  2011cites this paper
• Aldose reductase / polyol inhibitors for diabetic retinopathy.

  2011cites this paper
• Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications.

  2011cites this paper
• Inflammation in diabetic retinopathy.

  2011cites this paper
• Alterations to the Blood–Retinal Barrier in Diabetes: Cytokines and Reactive Oxygen Species

  2011cites this paper
• L¿ATTIVAZIONE DI TSPO E DI LXR STIMOLA LA NEUROSTEROIDOGENESI ED E¿ PROTETTIVA IN UN MODELLO DI NEUROPATIA PERIFERICA DI RATTO DIABETICO

  2011cites this paper
• How to overcome retinal neuropathy: The fight against angiogenesisrelated blindness

  2010cites this paper
• Diabetic macular oedema: physical, physiological and molecular factors contribute to this pathological process

  2010cites this paper
• CAPACIDAD OXIDANTE DE LA SANGRE DE PACIENTES CON DIABETES TIPO 2 SOBRE LA INSULINA

  2010cites this paper
• Effect of Glucose on the Production of Reactive Oxygen Species in Retinal Pigment Epithelial Cells

  2010cites this paper
• Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.

  2010cites this paper
• Endoplasmic reticulum stress in diabetes: New insights of clinical relevance

  2010cites this paper
• Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina.

  2010cites this paper
• More severe type 2 diabetes‐associated ischemic stroke injury is alleviated in aldose reductase‐deficient mice

  2010cites this paper
• Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers

  2010cites this paper
• Effect of High Glucose on the Production of Reactive Oxygen Species in R28 Cells

  2010cites this paper
• Effect of High Glucose on the Production of Reactive Oxygen Species in Trabecular Meshwork Cells

  2010cites this paper
• Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation

  2010cites this paper
• Hemodynamic Regulation of Endothelial Cell Gene Expression: Effects of p65 Expression Level on Constitutive and TNFα Induced NF-κB Signalling

  2009cites this paper
• Methylglyoxal-induced increase in peroxynitrite and inflammation related to diabetes

  2009cites this paper
• Acute Inflammatory Responses in the Lung Novel Role for Aldose Reductase in Mediating

  2009cites this paper
• Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice

  2009cites this paper
• Novel Role for Aldose Reductase in Mediating Acute Inflammatory Responses in the Lung1

  2009cites this paper
• Effect of High Glucose on the Oxidative Stress in Trabecular Meshwork Cells

  2009cites this paper
• Early Intervention of Tyrosine Nitration Prevents Vaso-Obliteration and Neovascularization in Ischemic Retinopathy

  2009cites this paper