Effects of glucosamine infusion on insulin secretion and insulin action in humans.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Diabetes

• Publication date

  2000-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/DIABETES.49.6.926PMID 10866044
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glucose toxicity.

  2001cited by this paper
• Hype about glucosamine.

  1999cited by this paper
• Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

  1999cited by this paper
• Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin.

  1999cited by this paper
• Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.

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• Changes in glucose transport and protein kinase Cβ2 in rat skeletal muscle induced by hyperglycaemia

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• Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.

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• Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

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• Expression of Glutamine:Fructose-6-Phosphate Amidotransferase in Human Tissues: Evidence for High Variability and Distinct Regulation in Diabetes

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• Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.

  1998cited by this paper
• Normal glucose-induced suppression of glucose production but impaired stimulation of glucose disposal in type 2 diabetes: evidence for a concentration-dependent defect in uptake.

  1998cited by this paper
• Glucosamine-induced Insulin Resistance in 3T3-L1 Adipocytes Is Caused by Depletion of Intracellular ATP*

  1998cited by this paper
• Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus.

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• A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

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• Glucose-induced glycogenesis in the liver involves the glucose-6-phosphate-dependent dephosphorylation of glycogen synthase.

  1997cited by this paper
• Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues.

  1997cited by this paper
• Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C.

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• The hot IVGTT two-compartment minimal model: indexes  of glucose effectiveness and insulin sensitivity.

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• Activation of the Hexosamine Pathway by Glucosamine in Vivo Induces Insulin Resistance in Multiple Insulin Sensitive Tissues.

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• Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.

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• Role of the glucosamine pathway in fat-induced insulin resistance.

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• Increased activity of the hexosamine synthesis pathway in muscles of insulin-resistant ob/ob mice.

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• Impaired Basal Glucose Effectiveness in NIDDM: Contribution of Defects in Glucose Disappearance and Production, Measured Using an Optimized Minimal Model Independent Protocol

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• Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance

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• Regulation of Glycogen Synthase and Protein Phosphatase-1 by Hexosamines

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• Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

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• Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal

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• Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin.

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• Differential Effects of GLUT1 or GLUT4 Overexpression on Hexosamine Biosynthesis by Muscles of Transgenic Mice*

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• Glucosamine-Induced Inhibition of Liver Glucokinase Impairs the Ability of Hyperglycemia to Suppress Endogenous Glucose Production

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• Increased Glutamine:Fructose-6-Phosphate Amidotransferase Activity in Skeletal Muscle of Patients With NIDDM

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• Hexosamines and Insulin Resistance

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• The hot but not the cold minimal model allows precise assessment of insulin sensitivity in NIDDM subjects.

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• Regulation of Glycogen Synthase by Glucose, Glucosamine, and Glutamine:Fructose-6-Phosphate Amidotransferase

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• Effects of Diabetes and Hyperglycemia on the Hexosamine Synthesis Pathway in Rat Muscle and Liver

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• Estimation of β-Cell Sensitivity From Intravenous Glucose Tolerance Test C-Peptide Data: Knowledge of the Kinetics Avoids Errors in Modeling the Secretion

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• Estimation of beta-cell sensitivity from intravenous glucose tolerance test C-peptide data. Knowledge of the kinetics avoids errors in modeling the secretion.

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• Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity.

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• Acute Hyperglycemia Provides an Insulin-Independent Inducer for GLUT4 Translocation in C2C12 Myotubes and Rat Skeletal Muscle

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• In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.

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• Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations

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• Glucosamine Inhibits Glucokinase In Vitro and Produces a Glucose-Specific Impairment of In Vivo Insulin Secretion in Rats

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• Pre-Exposure to Glucosamine Induces Insulin Resistance of Glucose Transport and Glycogen Synthesis in Isolated Rat Skeletal Muscles: Study of Mechanisms in Muscle and in Rat-1 Fibroblasts Overexpressing the Human Insulin Receptor

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• Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

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• Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

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• Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation.

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• Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

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• Glucose Toxicity

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• Differential roles of splanchnic and peripheral tissues in the pathogenesis of impaired glucose tolerance.

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• Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis

  2025cites this paper
• Adjuvant therapies for management of hemorrhagic shock: a narrative review

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• Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank

  2025cites this paper
• Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity

  2025cites this paper
• REDOX SIGNALLING IN THE PANCREAS IN HEALTH AND DISEASE.

  2024cites this paper
• Relationship between Type 2 Diabetes Mellitus and Osteoarthritis

  2023cites this paper
• The Hexosamine Biosynthesis Pathway: Regulation and Function

  2023cites this paper
• Glucosamine Use Is Associated with a Higher Risk of Cardiovascular Diseases in Patients with Osteoarthritis: Results from a Large Study in 685,778 Subjects

  2022cites this paper
• O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease

  2022cites this paper
• Imaging of sugar‐based contrast agents using their hydroxyl proton exchange properties

  2022cites this paper
• Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats

  2021cites this paper
• Identification of longevity compounds with minimized probabilities of side effects

  2020cites this paper
• Expression and Bioinformatics-Based Functional Analysis of UAP1 in Lung Adenocarcinoma

  2020cites this paper
• Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank

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• O-GlcNAcylation and Diabetes

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• Subchronic toxicity evaluation of glucosamine and glucosamine in combination with chondroitin sulfate in obese Zucker rats.

  2020cites this paper
• Expression and Bioinformatics-Based Functional Analysis of UAP1 in Lung Adenocarcinoma

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• Molecular imaging of cancer by glucosamine chemical exchange saturation transfer MRI: A preclinical study

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  2019cites this paper
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• Safety of glucosamine, examined on ants as models

  2018cites this paper
• Exercise training ameliorates glucosamine-induced insulin resistance in ovariectomized rats

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• Drug-Induced Hyperglycemia and Diabetes Mellitus

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• Lipopolysaccharide (LPS)-stimulated iNOS Induction Is Increased by Glucosamine under Normal Glucose Conditions but Is Inhibited by Glucosamine under High Glucose Conditions in Macrophage Cells*

  2016cites this paper
• Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells.

  2016cites this paper
• Consumer perception of the efficacy and tolerance of glucosamine in joint diseases

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• Oral Glucosamine Effect on Blood Glucose and Insulin Levels in Patients With Non-Diabetic Osteoarthritis: A Double-Blind, Placebo-Controlled Clinical Trial.

  2016cites this paper
• Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors

  2016cites this paper
• Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway

  2015cites this paper
• Case Report: Atrioventricular Block Related to Glucosamine/Chondroitin in a Patient Presented with Syncope Complaint

  2015cites this paper
• SUPPLEMENTATION WITH GLUCOSAMINE HAS NO ADVERSE EFFECTS ON GLYCEMIC LEVEL AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS

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• Glucosamine for Osteoarthritis: Biological Effects, Clinical Efficacy, and Safety on Glucose Metabolism

  2014cites this paper
• The effect of peri‐conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence

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• Investigation into the role of the hexosamine biosynthesis pathway in hyperglycemia-induced atherosclerosis

  2014cites this paper
• Mechanismen der Lebensverlängerung durch D-Glucosamin und Ritalin

  2014cites this paper
• Oral glucosamine sulfate supplementation does not induce endoplasmic reticulum stress or activate the unfolded protein response in circulating leukocytes of human subjects.

  2014cites this paper
• UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation

  2014cites this paper
• D-Glucosamine supplementation extends life span of nematodes and of ageing mice

  2014cites this paper
• 17&bgr;-Estradiol protects against glucosamine-induced pancreatic &bgr;-cell dysfunction

  2014cites this paper
• Short-term glucosamine infusion increases islet blood flow in anesthetized rats

  2013cites this paper
• A novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB.

  2013cites this paper
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  2013cites this paper
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