Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: evidence for additional susceptibility genes.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Human Molecular Genetics

• Publication date

  1997-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/6.13.2309PMID 9361038
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Haplotype and phenotype analysis of nine recurrent BRCA2 mutations in 111 families: results of an international study.

  1998cited by this paper
• Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes?

  1997cited by this paper
• A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families.

  1997cited by this paper
• Analysis of BRCA1 and BRCA2 mutations in Hungarian families with breast or breast-ovarian cancer.

  1997cited by this paper
• Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia.

  1997cited by this paper
• A low proportion of BRCA2 mutations in Finnish breast cancer families.

  1997cited by this paper
• Moderate frequency of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer.

  1997cited by this paper
• Population genetics of BRCA1 and BRCA2.

  1997cited by this paper
• BRCA2 in American families with four or more cases of breast or ovarian cancer: recurrent and novel mutations, variable expression, penetrance, and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2.

  1997cited by this paper
• Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer.

  1997cited by this paper
• Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population.

  1997cited by this paper
• A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes

  1996cited by this paper
• Cancer incidence in the first-degree relatives of ovarian cancer patients.

  1996cited by this paper
• Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2

  1996cited by this paper
• The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%

  1996cited by this paper
• Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families

  1996cited by this paper
• Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13.

  1996cited by this paper
• Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype.

  1996cited by this paper
• Genetic heterogeneity in hereditary breast cancer: role of BRCA1 and BRCA2.

  1996cited by this paper
• Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families: results of an international study.

  1996cited by this paper
• The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

  1996cited by this paper
• Breast cancer information on the web

  1995cited by this paper
• Rapid detection of BRCA1 mutations by the protein truncation test

  1995cited by this paper
• Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

  1995cited by this paper
• Identification of the breast cancer susceptibility gene BRCA2

  1995cited by this paper
• Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families.

  1995cited by this paper
• The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals

  1995cited by this paper
• Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

  1994cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• Current methods of mutation detection.

  1993cited by this paper
• Disease gene mapping in isolated human populations: the example of Finland.

  1993cited by this paper
• Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

  1993cited by this paper
• Closing in on a breast cancer gene on chromosome 17q.

  1992cited by this paper
• Genetic analysis of breast cancer in the cancer and steroid hormone study.

  1991cited by this paper
• Linkage of early-onset familial breast cancer to chromosome 17q21.

  1990cited by this paper
• Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families.

  1988cited by this paper
• RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.

  1987cited by this paper

• Ethnicity-specific BRCA1, BRCA2, PALB2, and ATM pathogenic alleles in breast and ovarian cancer patients from the North Caucasus

  2023cites this paper
• NTHL1 is a recessive cancer susceptibility gene

  2023cites this paper
• Familial aggregation of early‐onset cancers in early‐onset breast cancer families

  2023cites this paper
• BRCA1/2 Mutations in Vietnamese Patients with Hereditary Breast and Ovarian Cancer Syndrome

  2022cites this paper
• Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland

  2022cites this paper
• Pathogenic Variant Spectrum in Breast Cancer Risk Genes in Finnish Patients

  2022cites this paper
• Founder vs. non-founder BRCA1/2 pathogenic alleles: the analysis of Belarusian breast and ovarian cancer patients and review of other studies on ethnically homogenous populations

  2022cites this paper
• High miR-30 Expression Associates with Improved Breast Cancer Patient Survival and Treatment Outcome

  2021cites this paper
• Polygenic risk, susceptibility genes, and breast cancer over the life course

  2020cites this paper
• The role of polygenic risk and susceptibility genes in breast cancer over the course of life

  2020cites this paper
• Recurrent moderate‐risk mutations in Finnish breast and ovarian cancer patients

  2019cites this paper
• Genetics of Breast and Ovarian Cancer Predisposition with a Focus on RAD51C and RAD51D Genes

  2018cites this paper
• FANCM Mutations in Breast Cancer Risk and Survival

  2018cites this paper
• FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population

  2017cites this paper
• Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families

  2017cites this paper
• FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome

  2016cites this paper
• Inherited breast cancer predisposition in Asians: multigene panel testing outcomes from Singapore

  2016cites this paper
• Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility

  2016cites this paper
• Genetic epidemiology of BRCA 1 mutations in Norway

  2016cites this paper
• RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families

  2015cites this paper
• Comparison of Targeted Next-Generation and Sanger Sequencing for the BRCA1 and BRCA2 Mutation Screening

  2015cites this paper
• Screening of HELQ in breast and ovarian cancer families

  2015cites this paper
• BRCA1 and BRCA2 Mutations are they Related to Breast Cancer in a Sample of Tunisian Population

  2015cites this paper
• RAD50:n merkitys perinnöllisessä rintasyöpäalttiudessa

  2014cites this paper
• BRCA1/2 Germline Mutations and Their Clinical Importance in Turkish Breast Cancer Patients

  2014cites this paper
• PALB2 and RAP80 genes in hereditary breast cancer predisposition

  2013cites this paper
• Copy Number Variation Analysis in Familial BRCA1/2-Negative Finnish Breast and Ovarian Cancer

  2013cites this paper
• Frequency of 5382insC mutation of BRCA1 gene among breast cancer patients: an experience from Eastern India

  2013cites this paper
• Variation of the PALB2 and PTEN Genes and eIF4E Protein Expression as Prognostic Factors in Breast Cancer

  2013cites this paper
• BRCA1 and BRCA2 Gene Mutations Screening In Sporadic Breast Cancer Patients In Kazakhstan

  2013cites this paper
• Variation of the PALB 2 and PTEN Genes and eIF 4 E Protein Expression as Prognostic Factors in Breast Cancer

  2013cites this paper
• NQO1 expression correlates inversely with NFκB activation in human breast cancer

  2012cites this paper
• Glycodelin expression associates with differential tumour phenotype and outcome in sporadic and familial non-BRCA1/2 breast cancer patients

  2011cites this paper
• Glycodelin expression associates with differential tumour phenotype and outcome in sporadic and familial non-BRCA1/2 breast cancer patients

  2011cites this paper
• Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals

  2011influential citation
• The occurrence of germline BRCA1 and BRCA2 sequence alterations in Slovenian population

  2011cites this paper
• Founder BRCA1/2 mutations in the Europe: implications for hereditary breast-ovarian cancer prevention and control

  2010cites this paper
• Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility

  2010cites this paper
• BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications

  2010cites this paper
• Founder BRCA 1 / 2 mutations in the Europe : implications for hereditary breast-ovarian cancer prevention and control

  2010cites this paper
• The Breast Cancer Susceptibility Mutation PALB2 1592delT Is Associated with an Aggressive Tumor Phenotype

  2009cites this paper
• The role of BACH1 , BARD1 and TOPBP1 genes in familial breast cancer

  2009influential citation
• SELECÇÃO DAS MULHERES COM CRITÉRIOS PARA A PESQUISA DE MUTAÇÃO BRCA1/BRCA2 NO CENTRO HOSPITALAR DO PORTO

  2009cites this paper
• Mutation analysis of BRIP1/BACH1 in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives

  2009cites this paper
• Prevalence of BRCA1 and BRCA2 gene mutations in families with medium and high risk of breast and ovarian cancer in Brazil.

  2009cites this paper
• Familial Breast Cancers without Mutations in BRCA1 or BRCA2 Have Low Cyclin E and High Cyclin D1 in Contrast to Cancers in BRCA Mutation Carriers

  2009cites this paper
• A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population

  2009cites this paper
• Aberrations of the MRE11–RAD50–NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer‐predisposing gene

  2008cites this paper
• ATM, RAD50 and p53 in breast cancer

  2008cites this paper
• The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

  2008cites this paper
• Comprehensive analysis of NuMA variation in breast cancer

  2008cites this paper
• Familial Breast Cancers without Mutations in BRCA1 or BRCA2 Have Low Cyclin E and High Cyclin D1 in Contrast to Cancers in BRCA Mutation Carriers

  2008cites this paper
• Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families

  2008cites this paper
• Is BRCA1-5083del19, identified in breast cancer patients of Sicilian origin, a Calabrian founder mutation?

  2008cites this paper
• Application of multiplex PCR with histopathologic features for detection of familial breast cancer in formalin-fixed, paraffin-embedded histological specimens

  2008cites this paper
• Basal cytokeratins in breast tumours among BRCA1, BRCA2 and mutation-negative breast cancer families

  2008cites this paper
• Mutation screening of the BRCA1 gene in sporadic breast cancer in southern Chinese populations.

  2008cites this paper
• CHEK2 in Breast and Colorectal Cancer

  2007cites this paper
• The prognostic role of matrix metalloproteinases MMP-2 and -9 and their tissue inhibitors TIMP-1 and -2 in primary breast carcinoma

  2007cites this paper
• The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovarian cancer families.

  2007cites this paper
• Israeli ‘cancer shift’ over heart disease mortality may be led by greater risk in women with high intake of n-6 fatty acids

  2007cites this paper
• Origin and distribution of the BRCA2-8765delAG mutation in breast cancer

  2007cites this paper
• Prognostic Role of HuR in Hereditary Breast Cancer

  2007cites this paper
• Screening for BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families

  2007influential citation
• A BRCA2 mutation, 4088insA, in a Finnish breast and ovarian cancer family associated with favourable clinical course.

  2007cites this paper
• Genetic Predisposition to Breast and Ovarian Cancer in Eastern Finnish

  2007cites this paper
• BRCA1 and TP53 mutation spectrum of breast carcinoma in an ethnic population of Kashmir, an emerging high-risk area.

  2007cites this paper
• Genome Wide Screening of CAG Trinucleotide Repeat Lengths in Breast Cancer

  2007cites this paper
• Characterisation of BRCA1 genomic rearrangements in South African breast and/or ovarian cancer families

  2007cites this paper
• CHEK 2 in Breast and Colorectal Cancer

  2007cites this paper
• Study designs to enhance identification of genetic factors in healthy aging.

  2007cites this paper
• ATM , ATR and Mre11 complex genes in hereditary susceptibility to breast cancer

  2007cites this paper
• FAMILY HISTORY AND BREAST CANCER SUSCEPTIBILITY

  2006cites this paper
• BARD1 variants Cys557Ser and Val507Met in breast cancer predisposition

  2006cites this paper
• Evaluation of RAD50 in familial breast cancer predisposition

  2006cites this paper
• ATM variants and cancer risk in breast cancer patients from Southern Finland

  2006cites this paper
• Implication of the BRCA2 and Putative “BRCA3” Genes in Dukes’ Stage C, Replication Error–Negative Colon Cancer

  2006cites this paper
• ERCC4 associated with breast cancer risk: a two-stage case-control study using high-throughput genotyping.

  2006cites this paper
• The Role Of Fumarase (FH) In Tumorigenesis

  2006cites this paper
• Advances in Brief Genetic Changes in Inherited and Sporadic Ovarian Carcinomas by Comparative Genomic Hybridization : Extensive Similarity Except for a Difference at Chromosome 2 q 24-q 32 *

  2006cites this paper
• BACH1 Ser919Pro variant and breast cancer risk

  2006cites this paper
• Large genomic BRCA2 rearrangements and male breast cancer.

  2006cites this paper
• Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer families.

  2006cites this paper
• Balanced t(11;15)(q23;q15) in a TP53+/+ breast cancer patient from a Li-Fraumeni syndrome family.

  2006cites this paper
• Large genomic BRCA 2 rearrangements and male breast cancer

  2006cites this paper
• Novel Germline BRCA1 and BRCA2 Mutations in Turkish Women with Breast and/or Ovarian Cancer and Their Relatives

  2006cites this paper
• Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients

  2006cites this paper
• Heterogeneity in Genetic Susceptibility to Prostate Cancer

  2006cites this paper
• A population-based assessment of the clustering of breast cancer in families eligible for testing of BRCA 1 and BRCA 2 mutations

  2005influential citation
• An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in eastern Finland: three candidate regions found.

  2005cites this paper
• Breast Cancer Patients with p53 Pro72 Homozygous Genotype Have a Poorer Survival

  2005cites this paper
• Relationship of patients' age to histopathological features of breast tumours in BRCA1 and BRCA2 and mutation-negative breast cancer families

  2005cites this paper
• No germline FH mutations in familial breast cancer patients

  2005cites this paper
• No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer

  2005cites this paper
• Cooperation sought for gastric-MALT-lymphoma trial

  2005cites this paper
• Spectrum and prevalence of BRCA1 and BRCA2 germline mutations in Sardinian patients with breast carcinoma through hospital‐based screening

  2005cites this paper
• A population-based assessment of the clustering of breast cancer in families eligible for testing of BRCA1 and BRCA2 mutations.

  2005cites this paper
• Search for large genomic alterations of the BRCA1 gene in a Finnish population.

  2005cites this paper
• No MSH 6 germline mutations in breast cancer families with colorectal and / or endometrial cancer

  2005cites this paper
• Cancer Diagnostics

  2004cites this paper